Impact of Repeated Nicotine and Alcohol Coexposure on in Vitro and in Vivo Chlorpyrifos Dosimetry and Cholinesterase Inhibition

REFERENCES

• Bachtell , R. K. and Ryabinin , A. E. 2001 . Interactive effects of nicotine and alcohol co-administration on expression of inducible transcription factors in mouse brain . Neuroscience , 103 : 941 – 954 .
   Google Scholar
• Bakke , J. E. , Feil , V. J. and Price , C. E. 1976 . Rat urinary metabolites from O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphorothioate . J. Environ. Sci. Health B , 11 : 225 – 230 .
   PubMed Web of Science ®Google Scholar
• Batel , P. , Pessione , F. , Maitre , C. and Rueff , B. 1995 . Relationship between alcohol and tobacco dependencies among alcoholics who smoke . Addiction , 90 : 977 – 980 .
   PubMed Web of Science ®Google Scholar
• Benowitz , N. L. 2009 . Pharmacology of nicotine: Addiction, smoking-induced disease, and therapeutics . Annu. Rev. Pharmacol. Toxicol. , 49 : 57 – 71 .
   PubMed Web of Science ®Google Scholar
• Bien , T. H. and Burge , R. 1990 . Smoking and drinking: A review of the literature . Int. J. Addict. , 25 : 1429 – 1454 .
   PubMed Web of Science ®Google Scholar
• Blomqvist , O. , Ericson , M. , Johnson , D. H. and Engel , J. A. Söpalm, B.. 1996. Voluntary ethanol intake in the rat: Effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment . Eur. J. Pharmacol. , 314 257 – 267 .
   Google Scholar
• Brzak , K. A. , Harms , D. W. , Bartels , M. J. and Nolan , R. J. 1998 . Determination of chlorpyrifos, chlorpyrifos oxon, and 3,5,6-trichloro-2-pyridinol in rat and human blood . J. Anal. Toxicol. , 22 : 203 – 210 .
   PubMed Web of Science ®Google Scholar
• Buisson , B. and Bertrand , D. 2001 . Chronic exposure to nicotine upregulates the human α 4 β 2 nicotinic acetylcholine receptor function . J. Neurosci. , 21 : 1819
   PubMedGoogle Scholar
• Buratti , F. M. , Volpe , M. T. , Meneguz , A. , Vittozzi , L. and Testai , E. 2003 . CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes . Toxicol.Appl. Pharmacol. , 186 : 143 – 154 .
   PubMed Web of Science ®Google Scholar
• Campbell , J. A. , Timchalk , C. , Kousba , A. A. , Wu , H. , Valenzuela , B. R. and Hoppe , E. W. 2005 . Negative ion chemical ionization mass spectrometry for the analysis of 3,5,6-trichloro-2-pyridinol in saliva of rats exposed to chlorpyrifos . Anal. Lett. , 38 : 939 – 949 .
   Web of Science ®Google Scholar
• Carpenter , D. O. , Arcaro , K. and Spink , D. C. 2002 . Understanding the human health effects of chemical mixtures . Environ. Health Perspect. , 110 ( suppl. 1 ) : 25
   PubMed Web of Science ®Google Scholar
• Chambers , J. E. and Chambers , H. W. 1989 . Oxidative desulfuration of chlorpyrifos, chlorpyrifos-methyl, and leptophos by rat-brain and liver . J. Biochem. Toxicol. , 4 : 201 – 203 .
   PubMedGoogle Scholar
• Chatonnet , A. and Lockridge , O. 1989 . Comparison of butyrylcholinesterase and acetylcholinesterase . Biochem. J. , 260 : 625 – 634 .
   PubMed Web of Science ®Google Scholar
• Chen , J. , Kumar , M. , Chan , W. , Berkowitz , G. and Wetmur , J. G. 2003 . Increased influence of genetic variation on PON1 activity in neonates . Environ. Health Perspect. , 111 : 1403 – 1409 .
   PubMed Web of Science ®Google Scholar
• Clegg , D. J. and van Gemert , M. 1999 . Expert panel report of human studies on chlorpyrifos and/or other organophosphate exposures . J. Toxicol. Environ. Health B , 2 : 257 – 279 .
   PubMed Web of Science ®Google Scholar
• Cometa , M. F. , Buratti , F. M. , Fortuna , S. , Lorenzini , P. , Volpe , M. T. , Parisi , L. , Testai , E. and Meneguz , A. 2007 . Cholinesterase inhibition and alterations of hepatic metabolism by oral acute and repeated chlorpyrifos administration to mice . Toxicology , 234 : 90 – 102 .
   PubMed Web of Science ®Google Scholar
• De Leon , J. , Rendon , D. M. , Baca-Garcia , E. , Aizpuru , F. , Pinto , Gonzalez- , Anitua , C. and Diaz , F. J. 2007 . Association between smoking and alcohol use in the general population: Stable and unstable odds ratios across two years in two different countries . Alcohol Alcohol , 42 : 252 – 257 .
   PubMed Web of Science ®Google Scholar
• Dohrman , D. P. and Reiter , C. K. 2003 . Ethanol modulates nicotine-induced upregulation of nAChRs . Brain Res. , 975 : 90 – 98 .
   Google Scholar
• Ellman , G. L. , Courtney , K. D. , Andres , V. and Featherstone , R.M. 1961 . A new and rapid colorimetric determination of acetylcholinesterase activity . Biochem. Pharmacol. , 7 : 88 – 95 .
   PubMed Web of Science ®Google Scholar
• Faustman , E. M. , Silbernagel , S. M. , Fenske , R. A. , Burbacher , T. M. and Ponce , R. A. 2000 . Mechanisms underlying children's susceptibility to environmental toxicants . Environ. Health Perspect. , 108 : 13 – 21 .
   PubMed Web of Science ®Google Scholar
• Feron , V. J. , Cassee , F. R. , Groten , J. P. , van Vliet , P. W. and van Zorge , J. A. 2002 . International issues on human health effects of exposure to chemical mixtures . Environ. Health Perspect. , 110 ( suppl. 6 ) : 893 – 899 .
   PubMed Web of Science ®Google Scholar
• Feron , V. J. and Groten , J. P. 2002 . Toxicological evaluation of chemical mixtures . Food Chem. Toxicol. , 40 : 825 – 839 .
   PubMed Web of Science ®Google Scholar
• Florek , E. , Piekoszewski , W. , Kulza , M. , Szindzikaszwili , T. , Gomolka , E. , Chuchracki , M. and Sedziak , A. 2008 . Interaction between tobacco smoke and alcohol in animal models . Pharmacol. Rep. , 60 : 985 – 990 .
   Google Scholar
• Fuhr , U. 2000 . Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans . Clin. Pharmacokinet. , 38 : 493 – 504 .
   PubMed Web of Science ®Google Scholar
• Funk , D. , Marinelli , P. W. and Le , A. D. 2006 . Biological processes underlying co-use of alcohol and nicotine: Neuronal mechanisms, cross-tolerance, and genetic factors . Alcohol Res. Health , 29 : 186
   PubMedGoogle Scholar
• Gelman , A. , Bois , F. and Jiang , J. M. 1996 . Physiological pharmacokinetic analysis using population modeling and informative prior distributions . J. Am. Stat. Assoc. , 91 : 1400 – 1412 .
   Web of Science ®Google Scholar
• Guengerich , F. P. 1994 . Analysis and characterization of enzymes. In Principles and methods of toxicology , Edited by: Hayes , A. W. 1259 – 1303 . New York : Raven Press .
   Google Scholar
• Howard , L. A. , Micu , A. L. , Sellers , E. M. and Tyndale , R. F. 2001 . Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver . J. Pharmacol. Exp. Ther. , 299 : 542 – 550 .
   PubMed Web of Science ®Google Scholar
• Howard , L. A. , Sellers , E. M. and Tyndale , R. F. 2002 . The role of pharmacogenetically-variable cytochrome P450 enzymes in drug abuse and dependence . Pharmacogenomics , 3 : 185 – 199 .
   PubMed Web of Science ®Google Scholar
• Husain , K. , Scott , B. R. , Reddy , S. K. and Somani , S. M. 2001 . Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system . Alcohol , 25 : 89 – 97 .
   PubMed Web of Science ®Google Scholar
• Kousba , A. A. , Poet , T. S. and Timchalk , C. 2007 . Age-related brain cholinesterase inhibition kinetics following in vitro incubation with chlorpyrifos-oxon and diazinon-oxon . Toxicol. Sci . , 95 : 147 – 155 .
   PubMed Web of Science ®Google Scholar
• Le Houezec , J. , Jacob , P. 3rd and Benowitz , N. L. 1993 . A clinical pharmacological study of subcutaneous nicotine . Eur. J. Clin. Pharmacol. , 44 : 225 – 230 .
   Google Scholar
• Lee , S. , Busby , A. L. , Timchalk , C. and Poet , T. S. 2009 . Effects of nicotine exposure on in vitro metabolism of chlorpyrifos in male Sprague-Dawley rats . J. Toxicol. Environ. Health A , 72 : 74 – 82 .
   Google Scholar
• Lee , S , Poet , T. S. , Smith , J. N. , Busby-Hjerpe , A. L. and Timchalk , C. 2010 . Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats . Chem. Biol. Interact. , 184 : 449 – 457 .
   Google Scholar
• Li , T. K. , Volkow , N. D. , Baler , R. D. and Egli , M. 2007 . The biological bases of nicotine and alcohol co-addiction . Biol. Psychiat. , 61 : 1 – 3 .
   PubMed Web of Science ®Google Scholar
• Lieber , C. S. 1997 . Cytochrome P-4502E1: Its physiological and pathological role . Physiol. Rev. , 77 : 517 – 544 .
   PubMed Web of Science ®Google Scholar
• Littleton , J. , Barron , S. , Prendergast , M. and Nixon , S. J. 2007 . Smoking kills (alcoholics)! Shouldn't we do something about it? . Alcohol Alcoholism , 42 : 167 – 173 .
   PubMed Web of Science ®Google Scholar
• Lu , C. S. , Toepel , K. , Irish , R. , Fenske , R. A. , Barr , D. B. and Bravo , R. 2006 . Organic diets significantly lower children's dietary exposure to organophosphorus pesticides . Environ. Health Perspect. , 114 : 260 – 263 .
   PubMed Web of Science ®Google Scholar
• Matta , S. G. , Balfour , D. J. , Benowitz , N. L. , Boyd , R. T. , Buccafusco , J. J. , Caggiula , A. R. , Craig , C. R. , Collins , A. C. , Damaj , M. I. , Donny , E. C. , Gardiner , P. S. , Grady , S. R. , Heberlein , U. , Leonard , S. S. , Levin , E. D. , Lukas , R. J. , Markou , A. , Marks , M. J. , McCallum , S. E. , Parameswaran , N. , Perkins , K. A. , Picciotto , M. R. , Quik , M. , Rose , J. E. , Rothenfluh , A. , Schafer , W. R. , Stolerman , I. P. , Tyndale , R. F. , Wehner , J. M. and Zirger , J. M. 2007 . Guidelines on nicotine dose selection for in vivo research . Psychopharmacology (Berl.) , 190 : 269 – 319 .
   PubMed Web of Science ®Google Scholar
• Miksys , S. L. and Tyndale , R. F. 2002 . Drug-metabolizing cytochrome P450s in the brain . J. Psychiat. Neurosci. , 27 : 406 – 415 .
   PubMed Web of Science ®Google Scholar
• Morgan , M. K. , Sheldon , L. S. , Croghan , C. W. , Jones , P. A. , Robertson , G. L. , Chuang , J. C. , Wilson , N. K. and Lyu , C. W. 2004 . Exposures of preschool children to chlorpyrifos and its degradation product 3,5,6-trichloro-2-pyridinol in their everyday environments . J. Expos. Anal. Environ. Epidemiol. , 15 : 297 – 309 .
   Google Scholar
• Mutch , E. and Williams , F. M. 2006 . Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver . Toxicology , 224 : 22 – 32 .
   PubMed Web of Science ®Google Scholar
• Nolan , R. J. , Rick , D. L. , Freshour , N. L. and Saunders , J. H. 1984 . Chlorpyrifos: Pharmacokinetics in human volunteers . Toxicol. Appl. Pharmacol. , 73 : 8 – 15 .
   PubMed Web of Science ®Google Scholar
• O‘Shaughnessy , J.A. and Sultatos , L. G. 1995 . Interaction of ethanol and the organophosphorus insecticide parathion . Biochem. Pharmacol. , 50 : 1925 – 1932 .
   PubMedGoogle Scholar
• Omura , T. and Sato , R. 1964 . The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature . J. Biol. Chem. , 239 : 2370 – 2378 .
   PubMed Web of Science ®Google Scholar
• Poet , T. S. , Wu , H. , Kousba , A. A. and Timchalk , C. 2003 . In vitro rat hepatic and intestinal metabolism of the organophosphate pesticides chlorpyrifos and diazinon . Toxicol. Sci. , 72 : 193 – 200 .
   PubMed Web of Science ®Google Scholar
• Pohl , R. J. and Fouts , J. R. 1980 . A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions . Anal. Biochem. , 107 : 150 – 155 .
   PubMed Web of Science ®Google Scholar
• Pope , C. N. 1999 . Organophosphorus pesticides: Do they all have the same mechanism of toxicity? . J. Toxicol. Environ. Health B , 2 : 161 – 181 .
   PubMed Web of Science ®Google Scholar
• Quandt , S. A. , Arcury , T. A. , Rao , P. , Snively , B. M. , Camann , D. E. , Doran , A. M. , Yau , A. Y. , Hoppin , J. A. and Jackson , D. S. 2004 . Agricultural and residential pesticides in wipe samples from farmworker family residences in North Carolina and Virginia . Environ. Health Perspect. , 112 : 382 – 387 .
   PubMed Web of Science ®Google Scholar
• Reinke , L. A. and Moyer , M. J. 1985 . p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol . Drug. Metab. Dispos. , 13 : 548 – 552 .
   PubMed Web of Science ®Google Scholar
• Richardson , R. J. 1995 . Assessment of the neurotoxic potential of chlorpyrifos relative to other organophosphorus compounds: A critical review of the literature . J. Toxicol. Environ. Health , 44 : 135 – 165 .
   PubMed Web of Science ®Google Scholar
• Rubin , E. and Lieber , C. S. 1968 . Hepatic microsomal enzymes in man and rat: Induction and inhibition by ethanol . Science , 162 : 690 – 691 .
   PubMed Web of Science ®Google Scholar
• Sadler , D. W. , Girela , E. and Pounder , D. J. 1996 . Post mortem markers of chronic alcoholism . Forensic Sci. Int. , 82 : 153 – 163 .
   Google Scholar
• Sams , C. , Mason , H. J. and Rawbone , R. 2000 . Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes . Toxicol. Lett. , 116 : 217 – 221 .
   PubMed Web of Science ®Google Scholar
• Schlorff , E. C. , Husain , K. and Somani , S. M. 1999 . Dose- and time-dependent effects of ethanol on plasma antioxidant system in rat . Alcohol , 17 : 97 – 105 .
   PubMed Web of Science ®Google Scholar
• Schoedel , K. A. and Tyndale , R. F. 2003 . Induction of nicotine-metabolizing CYP2B1 by ethanol and ethanol-metabolizing CYP2E1 by nicotine: Summary and implications . Biochim. Biophys. Acta , 1619 : 283 – 290 .
   PubMed Web of Science ®Google Scholar
• Smith , J. N. , Campbell , J. A. , Busby-Hjerpe , A. L. , Lee , S. , Poet , T. S. , Barr , D. B. and Timchalk , C. 2009 . Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat . Toxicology , 261 : 47 – 58 .
   PubMed Web of Science ®Google Scholar
• Söderpalm , B. , Ericson , M. , Olausson , P. , Blomqvist , O. and Engel , J. A. 2000 . Nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanol . Behav. Brain Res. , 113 : 85 – 96 .
   PubMed Web of Science ®Google Scholar
• Sultatos , L. G. 1994 . Mammalian toxicology of organophosphorus pesticides . J. Toxicol. Environ. Health , 43 : 271 – 289 .
   PubMed Web of Science ®Google Scholar
• Tabershaw , I. R. and Cooper , W. C. 1966 . Sequelae of acute organic phosphate poisoning . J. Occup. Med. , 8 : 5 – 20 .
   PubMedGoogle Scholar
• Tang , J. , Cao , Y. , Rose , R. L. , Brimfield , A. A. , Dai , D. , Goldstein , J. A. and Hodgson , E. 2001 . Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes . Drug Metab. Dispos. , 29 : 1201 – 1204 .
   PubMed Web of Science ®Google Scholar
• Timchalk , C. , Busby , A. , Campbell , J. A. , Needham , L. L. and Barr , D. B. 2007 . Comparative pharmacokinetics of the organophosphorus insecticide chlorpyrifos and its major metabolites diethylphosphate, diethylthiophosphate and 3,5,6-trichloro-2-pyridinol in the rat . Toxicology , 237 : 145 – 157 .
   PubMed Web of Science ®Google Scholar
• Timchalk , C. , Kousba , A. and Poet , T. S. 2002a . Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model . Toxicol. Lett. , 135 : 51 – 59 .
   PubMed Web of Science ®Google Scholar
• Timchalk , C. , Nolan , R. J. , Mendrala , A. L. , Dittenber , D. A. , Brzak , K. A. and Mattsson , J. L. 2002b . A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans . Toxicol. Sci. , 66 : 34 – 53 .
   PubMed Web of Science ®Google Scholar
• Timchalk , C. and Poet , T. S. 2008 . Development of a physiologically basedpharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat . Neurotoxicology , 29 : 428 – 443 .
   PubMed Web of Science ®Google Scholar
• Trauth , J. A. , Seidler , F. J. and Slotkin , T. A. 2000 . Persistent and delayed behavioral changes after nicotine treatment in adolescent rats . Brain Res. , 880 : 167 – 172 .
   PubMedGoogle Scholar
• Tricker , A. R. 2003 . Nicotine metabolism, human drug metabolism polymorphisms, and smoking behaviour . Toxicology , 183 : 151 – 173 .
   PubMed Web of Science ®Google Scholar
• Tsutsumi , M. , Lasker , J. M. , Takahashi , T. and Lieber , C. S. 1993 . In vivo induction of hepatic p4502e1 by ethanol: Role of increased enzyme synthesis . Arch. Biochem. Biophys. , 304 : 209 – 218 .
   PubMed Web of Science ®Google Scholar
• Yue , J. , Miksys , S. , Hoffmann , E. and Tyndale , R. F. 2008 . Chronic nicotine treatment induces rat CYP2D in the brain but not in the liver: An investigation of induction and time course . J. Psychiat. Neurosci. , 33 : 54 – 63 .
   PubMed Web of Science ®Google Scholar
• Yue , J. , Khokhar , J. , Miksys , S. and Tyndale , R. F. 2009 . Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake . Eur. J. Pharmacol. , 609 : 88 – 95 .
   PubMed Web of Science ®Google Scholar