Assays to Determine DNA Repair Ability

REFERENCES

• Alcalay , J. , Freeman , S. E. , Goldberg , L. H. and Wolf , J. E. 1990 . Excision repair of pyrimidine dimers induced by simulated solar radiation in the skin of patients with basal cell carcinoma . J. Invest. Dermatol. , 95 : 506 – 9 .
   PubMed Web of Science ®Google Scholar
• Atanassov , B. S. , Ninova , P. D. , Anachkova , B. B. and Russev , G. C. 2003 . Relationship between DNA repair capacity and resistance to genotoxins in four human cell lines . Cancer Detect. Prev. , 27 : 24 – 29 .
   PubMedGoogle Scholar
• Athas , W. F. , Hedayati , M. A. , Matanoski , G. M. , Farmer , E. R. and Grossman , L. 1991 . Development and field-test validation of an assay for DNA repair in circulating human lymphocytes . Cancer Res. , 51 : 5786 – 93 .
   PubMed Web of Science ®Google Scholar
• Au , W. W. 1993 . Abnormal chromosome repair and risk of developing cancer . Environ. Health Perspect. , 101 : 303 – 8 .
   PubMed Web of Science ®Google Scholar
• Au , W. W. 2003 . Mutagen sensitivity assays in population studies . Mutat. Res. , 544 : 273 – 77 .
   PubMed Web of Science ®Google Scholar
• Au , W. W. , Bechtold , W. E. , Whorton , E. B. Jr. and Legator , M. S. 1995b . Chromosome aberrations and response to gamma-ray challenge in lymphocytes of workers exposed to 1,3-butadiene . Mutat. Res. , 334 : 125 – 30 .
   PubMed Web of Science ®Google Scholar
• Au , W. W. , Heo , M. Y. and Chiewchanwit , T. 1994 . Toxicological interactions between nickel and radiation on chromosome damage and repair . Environ. Health Perspect. , 102 : 73 – 77 .
   PubMed Web of Science ®Google Scholar
• Au , W. W. , Lane , R. G. , Legator , M. S. , Whorton , E. B. , Wilkinson , G. S. and Gabehart , G. J. 1995a . Biomarker monitoring of a population residing near uranium mining activities . Environ. Health Perspect. , 103 : 466 – 70 .
   PubMed Web of Science ®Google Scholar
• Au , W. W. , Walker , D. M. , Ward , J. B. Jr. , Whorton , E. , Legator , M. S. and Singh , V. 1991 . Factors contributing to chromosome damage in lymphocytes of cigarette smokers . Mutat. Res. , 260 : 137 – 44 .
   PubMed Web of Science ®Google Scholar
• Au , W. W. , Wilkinson , G. S. , Tyring , S. K. , Legator , M. S. , Zein , R. , Hallberg , L. and Heo , M. Y. 1996 . Monitoring populations for DNA repair deficiency and for cancer susceptibility . Environ. Health Perspect. , 104 : 579 – 84 .
   PubMed Web of Science ®Google Scholar
• Barile , F. A. 2008 . Principles of toxicology testing , Boca Raton, FL : CRC Press .
   Google Scholar
• Berwick , M. and Vineis , P. 2000 . Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review . JNCI , 92 : 874 – 97 .
   PubMed Web of Science ®Google Scholar
• Bykov , V. J. , Jansen , C. T. and Hemminki , K. 1998 . High levels of dipyrimidine dimers are induced in human skin by solar-simulating UV radiation . Cancer Epidemiol. Biomarkers Prev. , 7 : 199 – 202 .
   PubMed Web of Science ®Google Scholar
• Bykov , V. J. , Sheehan , J. M. , Hemminki , K. and Young , A. R. 1999 . In situ repair of cyclobutane pyrimidine dimers and 6–4 photoproducts in human skin exposed to solar simulating radiation . J. Invest. Dermatol. , 112 : 326 – 31 .
   PubMed Web of Science ®Google Scholar
• Cebulska-Wasilewska , A. , Panek , A. , Zabiński , Z. , Moszczyński , P. and Au , W. W. 2005a . Occupational exposure to mercury vapour on genotoxicity and DNA repair . Mutat. Res. , 586 : 102 – 14 .
   PubMed Web of Science ®Google Scholar
• Cebulska-Wasilewska , A. , Wiecheć , A. , Panek , A. , Binková , B. , Srám , R. J. and Farmer , P. B. 2005b . Influence of environmental exposure to PAHs on the susceptibility of lymphocytes to DNA-damage induction and on their repair capacity . Mutat. Res. , 588 : 73 – 81 .
   PubMed Web of Science ®Google Scholar
• Celotti , L. , Ferraro , P. and Biasin , M. R. 1992 . Detection by fluorescence analysis of DNA unwinding and unscheduled DNA synthesis, of DNA damage and repair induced in vitro by direct-acting mutagens on human lymphocytes . Mutat. Res. , 281 : 17 – 23 .
   PubMedGoogle Scholar
• Cherry , L. M. and Hsu , T. C. 1983 . Bleomycin-induced chromosome damage in lymphocytes of medullary thyroid carcinoma patients and their family members . Anticancer Res. , 3 : 367 – 72 .
   PubMed Web of Science ®Google Scholar
• Christiansen , M. , Stevnsner , T. , Bohr , V. A. , Clark , B. F. C. and Rattan , S. I. S. 2000 . Gene-specific DNA repair of pyrimidine dimers does not decline during cellular aging in vitro . Exp. Cell Res. , 256 : 308 – 14 .
   PubMed Web of Science ®Google Scholar
• Cloos , J. , de Boer , W. P. , Snel , M. H. , van den Ijssel , P. , Ylstra , B. , Leemans , C. R. , Brakenhoff , R. H. and Braakhuis , B. J. 2006 . Microarray analysis of bleomycin-exposed lymphoblastoid cells for identifying cancer susceptibility genes . Mol. Cancer Res. , 4 : 71 – 77 .
   PubMed Web of Science ®Google Scholar
• Collini , M. , Caccia , M. , Chirico , G. , Barone , F. , Dogliotti , E. and Mazzei , F. 2005 . Two-photon fluorescence cross-correlation spectroscopy as a potential tool for high-throughput screening of DNA repair activity . Nucleic Acids Res. , 33 : e165
   Web of Science ®Google Scholar
• Collins , A.R. , Dusinská , M. , Horváthová , E. , Munro , E. , Savio , M. and Stětina , R. 2001 . Inter-individual differences in repair of DNA base oxidation, measured in vitro with the comet assay . Mutagenesis , 16 : 297 – 301 .
   PubMed Web of Science ®Google Scholar
• Cornetta , T. , Festa , F. , Testa , A. and Cozzi , R. 2006 . DNA damage repair and genetic polymorphisms: assessment of individual sensitivity and repair capacity . Int. J. Radiat. Oncol. Biol. Phys. , 66 : 537 – 45 .
   PubMed Web of Science ®Google Scholar
• Crallan , R. A. , Lord , P. G. , Rees , R. W. and Southgate , J. 2002 . Inter-individual variation in urothelial DNA repair gene expression in vitro . Toxicol. In Vitro , 16 : 383 – 87 .
   PubMed Web of Science ®Google Scholar
• Danaee , H. , Nelson , H. H. , Liber , H. , Little , J. B. and Kelsey , K. T. 2004 . Low dose exposure to sodium arsenite synergistically interacts with UV radiation to induce mutations and alter DNA repair in human cells . Mutagenesis , 19 : 143 – 48 .
   PubMed Web of Science ®Google Scholar
• D'Errico , M. , Calcagnile , A. , Iavarone , I. , Sera , F. , Baliva , G. , Chinni , L.M. , Corona , R. , Pasquini , P. and Dogliotti , E. 1999 . Factors that influence the DNA repair capacity of normal and skin cancer-affected individuals . Cancer Epidemiol. Biomarkers Prev. , 8 : 553 – 59 .
   PubMed Web of Science ®Google Scholar
• Digweed , M. 2003 . Response to environmental carcinogens in DNA-repair-deficient disorders . Toxicology , 193 : 111 – 24 .
   PubMed Web of Science ®Google Scholar
• Erdei , E. , Lee , S. J. , Wei , Q. , Wang , L. E. , Song , Y. S. , Bovbjerg , D. and Berwick , M. 2006 . Reliability of mutagen sensitivity assay: an inter-laboratory comparison . Mutagenesis , 21 : 261 – 64 .
   PubMed Web of Science ®Google Scholar
• Fan , Y. H. , Hu , Z. , Li , C. , Wang , L. E. , Guo , Z. , Qiao , Y. , Zhang , L. , Zhang , W. , Mao , L. and Wei , Q. 2007 . In vitro expression levels of cell-cycle checkpoint proteins are associated with cellular DNA repair capacity in peripheral blood lymphocytes: a multivariate analysis . J. Proteome Res. , 6 : 1560 – 67 .
   PubMed Web of Science ®Google Scholar
• Filatov , M. V. , Pantina , R. A. and Noskin , L. A. 1998 . Methods for registration of spontaneous DNA instability in mammalian cells . Mutat. Res. , 403 : 95 – 101 .
   PubMed Web of Science ®Google Scholar
• Fischer , J. L. , Mihelc , E. M. , Pollok , K. E. and Smith , M. L. 2007 . Chemotherapeutic selectivity conferred by selenium: a role for p53-dependent DNA repair . Mol. Cancer Ther. , 6 : 355 – 61 .
   PubMed Web of Science ®Google Scholar
• Fleck , O. and Nielsen , O. 2004 . DNA repair . J. Cell Sci. , 117 : 515 – 17 .
   PubMed Web of Science ®Google Scholar
• Friedberg , E. C. 2001 . How nucleotide excision repair protects against cancer . Nat. Rev. Cancer , 1 : 22 – 33 .
   PubMed Web of Science ®Google Scholar
• Glei , M. and Pool-Zobel , B. L. 2006 . The main catechin of green tea, (-)-epigallocatechin-3-gallate (EGCG), reduces bleomycin-induced DNA damage in human leucocytes . Toxicol. In Vitro , 20 : 295 – 300 .
   PubMed Web of Science ®Google Scholar
• Goode , E. L. , Ulrich , C. M. and Potter , J. D. 2002 . Polymorphisms in DNA repair genes and associations with cancer risk . Cancer Epidemiol. Biomarkers Prev. , 11 : 1513 – 30 .
   PubMed Web of Science ®Google Scholar
• Grossman , L. , Matanoski , G. , Farmer , E. , Hedyati , E. , Ray , S. , Trock , B. , Hanfelt , J. , Rossh , G. , Berwick , M. and Hu , J. 1999 . “ DNA repair as a susceptibility factor in chronic diseases in human populations ” . In Advances in DNA damage and repair , Edited by: Dizdaroglu , M. and Karakaya , E. 149 – 67 . New York : Kluwer Academic/Plenum Publishers .
   Google Scholar
• Hartmann , A. and Speit , G. 1996 . Effect of arsenic and cadmium on the persistence of mutagen-induced DNA lesions in human cells . Environ. Mol. Mutagen. , 27 : 98 – 104 .
   PubMed Web of Science ®Google Scholar
• Hengstler , J. G. , Bolm Audorff , U. , Faldum , A. , Janssen , K. , Reifenrath , M. , Gotte , W. , Jung , D. , Mayer-Popken , O. , Fuchs , J. , Gebhard , S. , Bienfait , H.G. , Schlink , K. , Dietrich , C. , Faust , D. , Epe , B. and Oesch , F. 2003 . Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected . Carcinogenesis , 24 : 63 – 73 .
   PubMed Web of Science ®Google Scholar
• Herman , M. , Weinstein , T. , Korzets , A. , Chagnac , A. , Ori , Y. , Zevin , D. , Malachi , T. and Gafter , U. 2001 . Effect of cyclosporin A on DNA repair and cancer incidence in kidney transplant recipients . J. Lab. Clin. Med. , 137 : 14 – 20 .
   PubMed Web of Science ®Google Scholar
• Hoeijmakers , J. H. 2001 . DNA repair mechanisms . Maturitas , 38 : 17 – 22 .
   PubMed Web of Science ®Google Scholar
• Hu , J. J. , Hall , M. C. , Grossman , L. , Hedayati , M. , McCullough , D. L. , Lohman , K. and Case , L. D. 2004 . Deficient nucleotide excision repair capacity enhances human prostate cancer risk . Cancer Res. , 64 : 1197 – 201 .
   PubMed Web of Science ®Google Scholar
• Huang , L. L. , Hess , J. L. and Bunce , G. E. 1990 . DNA damage, repair, and replication in selenite-induced cataract in rat lens . Curr. Eye Res. , 9 : 1041 – 50 .
   PubMed Web of Science ®Google Scholar
• Hung , R. J. , Hall , J. , Brennan , P. and Boffetta , P. 2005 . Genetic polymorphisms in the base excision repair pathway and cancer risk: A HuGE review . Am. J. Epidemiol. , 162 : 925 – 42 .
   PubMed Web of Science ®Google Scholar
• Kennedy , D. O. , Agrawal , M. , Shen , J. , Terry , M. B. , Zhang , F. F. , Senie , R. T. , Motykiewicz , G. and Santella , R. M. 2005 . DNA repair capacity of lymphoblastoid cell lines from sisters discordant for breast cancer . JNCI , 97 : 127 – 32 .
   PubMedGoogle Scholar
• King , T. M. , Trizna , Z. , Wu , X. , Amos , C. I. , Fueger , R. H. , Fueger , J. J. , Fritsche , H. A. , Hsu , T. C. , Winn , R. and Spitz , M. R. 1997 . A clinical trial to evaluate the effect of vitamin C supplementation on in vitro mutagen sensitivity . Cancer Epidemiol. Biomarkers Prev. , 6 : 537 – 42 .
   PubMed Web of Science ®Google Scholar
• Korzets , A. , Chagnac , A. , Weinstein , T. , Ori , Y. , Malachi , T. and Gafter , U. 1999 . H2O2 induces DNA repair in mononuclear cells: evidence for association with cytosolic Ca2þ fluxes . J. Lab. Clin. Med. , 133 : 362 – 69 .
   PubMed Web of Science ®Google Scholar
• Laffon , B. , Valdiglesias , V. , Pásaro , E. and Méndez , J. 2010 . The organic selenium compound selenomethionine modulates bleomycin-induced DNA damage and repair . Biol. Trace. Element Res. , 133 : 12 – 19 .
   PubMed Web of Science ®Google Scholar
• Landi , M. T. , Baccarelli , A. , Tarone , R. E. , Pesatori , A. , Tucker , M. A. , Hedayati , M. and Grossman , L. 2002 . DNA repair, dysplastic nevi, and sunlight sensitivity in the development of cutaneous malignant melanoma . JNCI , 94 : 94 – 101 .
   PubMedGoogle Scholar
• Langie , S. A. , Knaapen , A. M. , Brauers , K. J. , van Berlo , D. , van Schooten , F. J. and Godschalk , R. W. 2006 . Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair . Mutagenesis , 21 : 153 – 58 .
   PubMed Web of Science ®Google Scholar
• Larsen , N. B. , Rasmussen , M. and Rasmussen , L. J. 2005 . Nuclear and mitochondrial DNA repair: similar pathways? . Mitochondrion , 5 : 89 – 108 .
   PubMed Web of Science ®Google Scholar
• LeBoeuf , R. A. , Laishes , B. A. and Hoekstra , W. G. 1985 . Effects of selenium on cell proliferation in rat liver and mammalian cells as indicated by cytokinetic and biochemical analysis . Cancer Res. , 45 : 5496 – 504 .
   PubMed Web of Science ®Google Scholar
• Li , C. , Wang , L. E. and Wei , Q. 2009 . DNA repair phenotype and cancer susceptibility—A mini review . Int. J. Cancer , 124 : 999 – 1007 .
   PubMed Web of Science ®Google Scholar
• Li , D. , Firozi , P. F. , Chang , P. , Wang , L. E. , Xiong , P. , Sturgis , E. M. , Eicher , S. A. , Spitz , M. R. , Hong , W. K. and Wei , Q. 2001 . In vitro BPDE-induced DNA adducts in peripheral lymphocytes as a risk factor for squamous cell carcinoma of the head and neck . Int. J. Cancer , 93 : 436 – 40 .
   PubMed Web of Science ®Google Scholar
• Li , D. , Wang , L. E. , Chang , P. , El-Naggar , A. K. , Sturgis , E. M. and Wei , Q. 2007 . In vitro benzo[a]pyrene diol epoxide-induced DNA adducts and risk of squamous cell carcinoma of head and neck . Cancer Res. , 67 : 5628 – 34 .
   PubMed Web of Science ®Google Scholar
• Lieber , M. R. , Ma , Y. , Pannicke , U. and Schwarz , K. 2003 . Mechanism and regulation of human non-homologous DNA end-joining . Nat. Rev. Mol. Cell Biol. , 4 : 712 – 20 .
   PubMed Web of Science ®Google Scholar
• Madle , S. , Dean , S. W. , Andrae , U. , Brambilla , G. , Burlinson , B. , Doolittle , D. J. , Furihata , C. , Hertner , T. , McQueen , C. A. and Mori , H. 1994 . Recommendations for the performance of UDS tests in vitro and in vivo . Mutat. Res. , 312 : 263 – 85 .
   PubMed Web of Science ®Google Scholar
• Mehta , M. , Chen , L. C. , Gordon , T. , Rom , W. and Tang , M. S. 2008 . Particulate matter inhibits DNA repair and enhances mutagenesis . Mutat. Res. , 657 : 116 – 21 .
   PubMed Web of Science ®Google Scholar
• Milic , M. 2010 . Genome instability and bleomycin sensitivity test . Arh. Hig. Rada. Toksikol. , 61 : 257 – 66 .
   PubMed Web of Science ®Google Scholar
• Miranda , D. D. , Arçari , D. P. , Pedrazzoli , J. Jr , Carvalho , P. O. , Cerutti , S. M. , Bastos , D. H. and Ribeiro , M. L. 2008 . Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice . Mutagenesis , 23 : 261 – 65 .
   PubMed Web of Science ®Google Scholar
• Møller , P. , Knudsen , L. E. , Frentz , G. , Dybdahl , M. , Wallin , H. and Nexø , B. A. 1998 . Seasonal variation of DNA damage and repair in patients with non-melanoma skin cancer and referents with and without psoriasis . Mutat Res. , 407 : 25 – 34 .
   PubMed Web of Science ®Google Scholar
• Motykiewicz , G. , Faraglia , B. , Wang , L. W. , Terry , M. B. , Senie , R. T. and Santella , R. M. 2002 . Removal of benzo(a)pyrene diol epoxide (BPDE)-DNA adducts as a measure of DNA repair capacity in lymphoblastoid cell lines from sisters discordant for breast cancer . Environ. Mol. Mutagen. , 40 : 93 – 100 .
   PubMed Web of Science ®Google Scholar
• Naccarati , A. , Pardini , B. , Hemminki , K. and Vodicka , P. 2007 . Sporadic colorectal cancer and individual susceptibility: A review of the association studies investigating the role of DNA repair genetic polymorphisms . Mutat. Res. , 635 : 118 – 45 .
   PubMed Web of Science ®Google Scholar
• Navasumrit , P. , Margison , G. P. and O'Connor , P. J. 2001 . Ethanol modulates rat hepatic DNA repair functions . Alcohol Alcohol. , 36 : 369 – 76 .
   PubMed Web of Science ®Google Scholar
• Oberheitmann , B. , Schäfer , J. , Dally , H. , Garms , A. , Frentzel-Beyme , R. and Hoffmann , W. 1999 . The chromosome-based challenge assay using fluorescence in situ hybridization: a possible test for increased cancer susceptibility . Mutat. Res. , 428 : 157 – 64 .
   PubMed Web of Science ®Google Scholar
• Organization for Economic Cooperation and Development . 1986 . Genetic toxicology: DNA damage and repair, unscheduled DNA synthesis in mammalian cells in vitro , Paris : OECD . OECD guidelines for testing of chemicals, no. 482
   Google Scholar
• Ori , Y. , Herman , M. , Weinstein , T. , Chagnac , A. , Zevin , D. , Milo , G. , Gafter , U. and Malachi , T. 2004 . Spontaneous DNA repair in human peripheral blood mononuclear cells . Biochem. Biophys. Res. Commun. , 320 : 578 – 86 .
   PubMed Web of Science ®Google Scholar
• Paz-Elizur , T. , Sevilya , Z. , Leitner-Dagan , Y. , Elinger , D. , Roisman , L. C. and Livneh , Z. 2008 . DNA repair of oxidative DNA damage in human carcinogenesis: Potential application for cancer risk assessment and prevention . Cancer Lett. , 266 : 60 – 72 .
   PubMed Web of Science ®Google Scholar
• Pero , R. W. , Miller , D. G. , Lipkin , M. , Markowitz , M. , Gupta , S. , Winawer , S. J. , Enker , W. and Good , R. 1983 . Reduced capacity for DNA repair synthesis in patients with or genetically predisposed to colorectal cancer . JNCI , 70 : 867 – 75 .
   PubMedGoogle Scholar
• Qiao , Y. , Spitz , M. R. , Guo , Z. , Hadeyati , M. , Grossman , L. , Kraemer , K. H. and Wei , Q. 2002 . Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes . Mutat. Res. , 509 : 165 – 74 .
   PubMed Web of Science ®Google Scholar
• Rajaee-Behbahani , N. , Schmezer , P. , Risch , A. , Rittgen , W. , Kayser , K. W. , Dienemann , H. , Schulz , V. , Drings , P. , Thiel , S. and Bartsch , H. 2001 . Altered DNA repair capacity and bleomycin sensitivity as risk markers for non-small cell lung cancer . Int. J. Cancer Pred. Oncol. , 95 : 86 – 91 .
   PubMed Web of Science ®Google Scholar
• Ramos , J. M. , Ruiz , A. , Colen , R. , Lopez , I. D. , Grossman , L. and Matta , J. L. 2004 . DNA repair and breast carcinoma susceptibility in women . Cancer , 100 : 1352 – 57 .
   PubMed Web of Science ®Google Scholar
• Roguev , A. and Russev , G. 2000 . A two wave-length fluorescence assay for DNA repair . Anal. Biochem. , 287 : 313 – 18 .
   PubMed Web of Science ®Google Scholar
• Roth , M. , Müller , H. and Boyle , J. M. 1987 . Immunochemical determination of an initial step in thymine dimer excision repair in xeroderma pigmentosum variant fibroblasts and biopsy material from the normal population and patients with basal cell carcinoma and melanoma . Carcinogenesis , 8 : 1301 – 7 .
   PubMed Web of Science ®Google Scholar
• Schantz , S. P. and Hsu , T. C. 1989 . Mutagen-induced chromosome fragility within peripheral blood lymphocytes of head and neck cancer patients . Head Neck , 11 : 337 – 42 .
   PubMed Web of Science ®Google Scholar
• Schärer , O. D. 2003 . Chemistry and biology of DNA repair . Angew. Chem. Int. Ed. Engl. , 42 : 2946 – 74 .
   PubMed Web of Science ®Google Scholar
• Seo , Y. R. , Christopher , S. and Smith , M. L. 2002 . Selenomethionine induction of DNA repair response in human fibroblasts . Oncogene , 21 : 3663 – 69 .
   PubMed Web of Science ®Google Scholar
• Shen , J. , Desai , M. , Agrawal , M. , Kennedy , D. O. , Senie , R. T. , Santella , R. M. and Terry , M. B. 2006 . Polymorphisms in nucleotide excision repair genes and DNA repair capacity phenotype in sisters discordant for breast cancer . Cancer Epidemiol. Biomarkers Prev. , 15 : 161419
   Web of Science ®Google Scholar
• Shi , Q. , Wang , L. E. , Bondy , M. L. , Brewster , A. , Singletary , S. E. and Wei , Q. 2004 . Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients . Carcinogenesis , 25 : 1695 – 700 .
   PubMed Web of Science ®Google Scholar
• Spencer , D. M. , Bilardi , R. A. , Koch , T. H. , Post , G. C. , Nafie , J. W. , Kimura , K. , Cutts , S. M. and Phillips , D. R. 2008 . DNA repair in response to anthracycline–DNA adducts: A role for both homologous recombination and nucleotide excision repair . Mutat Res. , 638 : 110 – 21 .
   PubMed Web of Science ®Google Scholar
• Spitz , M. R. , Fueger , J. J. , Halabi , S. , Schantz , S. P. , Sample , D. and Hsu , T. C. 1993 . Mutagen sensitivity in upper aerodigestive tract cancer: a case–control analysis . Cancer Epidemiol. Biomarkers Prev. , 2 : 329 – 33 .
   PubMed Web of Science ®Google Scholar
• Spitz , M. R. , Hoque , A. , Trizna , Z. , Schantz , S. P. , Amos , C. I. , King , T. M. , Bondy , M. L. , Hong , W. K. and Hsu , T. C. 1994 . Mutagen sensitivity as a risk factor for second malignant tumors following malignancies of the upper aerodigestive tract . JNCI , 86 : 1681 – 84 .
   PubMed Web of Science ®Google Scholar
• Spitz , M. R. , Wei , Q. , Dong , Q. , Amos , C. I. and Wu , X. 2003 . Genetic susceptibility to lung cancer: the role of DNA damage and repair . Cancer Epidemiol. Biomarkers Prev. , 2 : 689 – 98 .
   Google Scholar
• Tang , M. S. , Pierce , J. R. , Doisy , R. P. , Nazimiec , M. E. and MacLeod , M. C. 1992 . Differences and similarities in the repair of two benzo[a]pyrene diol epoxide isomers induced DNA adducts by uvrA, uvrB, and uvrC gene products . Biochemistry , 31 : 8429 – 36 .
   PubMed Web of Science ®Google Scholar
• Tolcher , A. W. , Gerson , S. L. , Denis , L. , Geyer , C. , Hammond , L. A. , Patnaik , A. , Goetz , A. D. , Schwartz , G. , Edwards , T. , Reyderman , L. , Statkevich , P. , Cutler , D. L. and Rowinsky , E. K. 2003 . Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules . Br. J. Cancer , 88 : 1004 – 11 .
   PubMed Web of Science ®Google Scholar
• Van Den Neste , E. , Cardoen , S. , Husson , B. , Rosier , J. F. , Delacauw , A. , Ferrant , A. , Van den Berghe , G. and Bontemps , F. 2002 . 2-Chloro-20-deoxyadenosine inhibits DNA repair synthesis and potentiates UVC cytotoxicity in chronic lymphocytic leukemia B lymphocytes . Leukemia , 16 : 36 – 43 .
   PubMed Web of Science ®Google Scholar
• Verma , A. , Atten , M. J. , Atter , B. M. and Holian , O. 2004 . Selenomethionine stimulates MAPK (ERK) phosphorylation, protein oxidation, and DNA synthesis in gastric cancer cells . Nutr. Cancer , 49 : 184 – 90 .
   PubMed Web of Science ®Google Scholar
• Wang , L. E. , Hsu , T. C. , Xiong , P. , Strom , S. S. , Duvic , M. , Clayman , G. L. , Weber , R. S. , Lippman , S. M. , Goldberg , L. H. and Wei , Q. 2007 . 4-Nitroquinoline-1-oxide-induced mutagen sensitivity and risk of nonmelanoma skin cancer: A case-control analysis . J. Invest. Dermatol. , 127 : 196 – 205 .
   PubMed Web of Science ®Google Scholar
• Wang , L. E. , Sturgis , E. M. , Eicher , S. A. , Spitz , M. R. , Hong , W. K. and Wei , Q. 1998 . Mutagen sensitivity to benzo(a)pyrene diol epoxide and the risk of squamous cell carcinoma of the head and neck . Clin. Cancer Res. , 4 : 1773 – 78 .
   PubMed Web of Science ®Google Scholar
• Wang , L. E. , Xiong , P. , Zhao , H. , Spitz , M. R. , Sturgis , E. M. and Wei , Q. 2008 . Chromosome instability and risk of squamous cell carcinomas of head and neck . Cancer Res. , 68 : 4479 – 85 .
   PubMed Web of Science ®Google Scholar
• Wei , Q. , Cheng , L. , Amos , C. I. , Wang , L. E. , Guo , Z. , Hong , W. K. and Spitz , M. R. 2000 . Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: A molecular epidemiologic study . JNCI , 92 : 1764 – 72 .
   PubMedGoogle Scholar
• Wei , Q. , Cheng , L. , Hong , W. K. and Spitz , M. R. 1996 . Reduced DNA repair capacity in lung cancer patients . Cancer Res. , 56 : 4103 – 7 .
   PubMed Web of Science ®Google Scholar
• Wei , Q. , Lee , J. E. , Gershenwald , J. E. , Ross , M. I. , Mansfield , P. F. , Strom , S. S. , Wang , L. E. , Guo , Z. , Qiao , Y. , Amos , C. I. , Spitz , M. R. and Duvic , M. 2003 . Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma . JNCI , 95 : 308 – 15 .
   PubMedGoogle Scholar
• Wei , Z. , Lifen , J. , Jiliang , H. , Jianlin , L. , Baohong , W. and Hongping , D. 2005 . Detecting DNA repair capacity of peripheral lymphocytes from cancer patients with UVC challenge test and bleomycin challenge test . Mutagenesis , 20 : 271 – 77 .
   PubMed Web of Science ®Google Scholar
• Wood , R. D. , Mitchell , M. , Sgouros , J. and Lindahl , T. 2001 . Human DNA repair genes . Science , 291 : 1284 – 89 .
   PubMed Web of Science ®Google Scholar
• Wu , X. , Gu , J. and Spitz , M. R. 2007 . Mutagen sensitivity: A genetic predisposition factor for cancer . Cancer Res. , 67 : 3493 – 95 .
   PubMed Web of Science ®Google Scholar
• Xiong , P. , Bondy , M. L. , Li , D. , Shen , H. , Wang , L. E. , Singletary , S. E. , Spitz , M. R. and Wei , Q. 2001 . Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study . Cancer Res. , 61 : 8465 – 69 .
   PubMed Web of Science ®Google Scholar
• Xu , G. , Snellman , E. , Bykov , V. J. , Jansen , C. T. and Hemminki , K. 2000a . Cutaneous malignant melanoma patients have normal repair kinetics of ultraviolet-induced DNA damage in skin in situ . J. Invest. Dermatol. , 114 : 628 – 31 .
   PubMed Web of Science ®Google Scholar
• Xu , G. , Snellman , E. , Jansen , C. T. and Hemminki , K. 2000b . Levels and repair of cyclobutane pyrimidine dimers and 6-4 photoproducts in skin of sporadic basal cell carcinoma patients . J. Invest. Dermatol. , 115 : 95 – 99 .
   PubMed Web of Science ®Google Scholar
• Ziegel , R. , Shallop , A. , Jones , R. and Tretyakova , N. 2003 . K-ras gene sequence effects on the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)–DNA adducts . Chem. Res. Toxicol. , 16 : 541 – 50 .
   PubMed Web of Science ®Google Scholar