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Original Articles

DNA Damage and Susceptibility Assessment in Industrial Workers Exposed to Styrene

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Pages 735-746 | Published online: 12 Jul 2012

REFERENCES

  • ACGIH and American Conference of the Governmental Industrial Hygienists . 2003 . Styrene, monomer in ACGIH documentation of the threshold limit values and biological exposure indices , Cincinnati , OH : Science Group ACGIH .
  • Barale , R. 1991 . The genetic toxicology of styrene and styrene oxide . Mutat. Res. , 257 : 107 – 26 .
  • Benhamou , S. , Reinikainen , M. , Bouchardy , C. , Dayer , P. and Hirvonen , A. 1998 . Association between lung cancer and microsomal epoxide hydrolase genotypes . Cancer Res. , 58 : 5291 – 93 .
  • Betti , C. , Davini , T. , Giannessi , L. , Loprieno , N. and Barale , R. 1994 . Microgel electrophoresis assay (comet test) and SCE analysis in human lymphocytes from 100 normal subjects . Mutat. Res. , 307 : 323 – 33 .
  • Bolognesi , C. , Lando , C. , Forni , A. , Landini , E. , Scarpato , R. , Migliore , L. and Bonassi , S. 1999 . Chromossomal damage and ageing: Effect on micronuclei frequency in peripheral blood lymphocytes . Age Ageing , 28 : 393 – 97 .
  • Bolognesi , C. , Merlo , F. , Rabboni , R. , Valério , F. and Abbondandolo , A. 1997 . Cytogenetic biomonitoring in traffic police workers: Micronucleus test in peripheral blood lymphocytes . Environ. Mol. Mutagen. , 30 : 396 – 402 .
  • Bonassi , S. , Bolognesi , C. , Abbondandolo , A. , Barale , R. , Bigatti , P. , Camurri , L. , Dalpra , L. , Ferrari , M. D. , Forni , A. and Lando , C. 1995 . Influence of sex on cytogenetic end points: Evidence from a large human sample and review of the literature . Cancer Epidemiol. Biomarkers Prev. , 4 : 671 – 79 .
  • Bosnes , R. W. and Tausky , H. H. 1945 . On the colorimetric determination of creatinine by the Jaffé reaction . J. Biol. Chem. , 158 : 581 – 600 .
  • Brenner , D. D. , Jeffrey , A. M. , Latriano , L. , Wazneh , L. , Warburton , D. , Toor , M. , Pero , R. W. , Andrews , L. R. , Walles , S. and Perera , F. P. 1991 . Biomarkers in styrene-exposed boatbuilders . Mutat. Res. , 26 : 225 – 36 .
  • Brooks , S. M. , Anderson , L. , Emmett , E. , Carson , A. , Tsay , J. Y. , Elia , V. , Buncher , R. and Karbowsky , R. 1980 . The effects of protective equipment on styrene exposure in workers in the reinforced plastics industry . Arch. Environ. Health , 35 : 287 – 94 .
  • Buschini , A. , De Palma , G. , Poli , P. , Martino , A. , Mozzoni , P. , Scotti , E. , Búzio , L. , Bergamaschi , E. and Mutti , A. 2003 . Genetic polymorphism of drug-metabolizing enzymes and styrene-induced DNA damage . Environ. Mol. Mutagen. , 41 : 243 – 52 .
  • Calvert , G. M. , Talaska , G. , Mueller , C. A. , Ammenheuser , M. M. , Au , W. W. , Fajen , J. M. , Fleming , L. E. , Briggle , T. and Ward , E. 1998 . Genotoxicity in workers exposed to methyl bromide . Mutat. Res. , 417 : 115 – 128 .
  • Carbonell , E. , Peris , F. , Xamena , N. , Creus , A. and Marcos , R. 1995 . SCE analysis in human lymphocytes of a Spanishcontrol population . Mutat. Res. , 335 : 35 – 46 .
  • Cohen , J. T. , Carlson , G. , Charnley , G. , Coggon , D. , Delzell , E. , Graham , J. D. , Greim , H. , Krewski , D. , Medinsky , M. , Monson , R. , Paustenbach , D. , Petersen , B. , Rappaport , S. , Rhomberg , L. , Ryan , P. B. and Thompson , K. 2002 . A comprehensive evaluation of the potential health risks associated with occupational and environmental exposure to styrene . J. Toxicol. Environ. Health B. , 5 : 1 – 263 .
  • Costa , C. , Teixeira , J. P. , Silva , S. , Roma-Torres , J. , Coelho , P. , Gaspar , J. , Alves , M. , Laffon , B. , Rueff , J. and Mayan , O. 2006 . Cytogenetic and molecular biomonitoring of a Portuguese population exposed to pesticides . Mutagenesis , 21 : 343 – 50 .
  • Costa , S. , Coelho , P. , Costa , C. , Silva , S. , Mayan , O. , Santos , L. , Gaspar , J. and Teixeira , J. P. 2008 . Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde . Toxicology , 252 : 40 – 48 .
  • Di Giorgio , C. , De Meo , M. P. , Laget , M. , Guiraud , H. , Botta , A. and Dumenil , G. 1994 . The micronucleus assay in human lymphocytes: Screening for inter-individual variability and application to biomonitoring . Carcinogenesis. , 15 : 313 – 17 .
  • Duffaud , F. , Orsiere , T. , Digue , L. , Favre , R. and Botta , A. 1998 . Interet du test des micronoyaux dans les lymphocytes T binuclees en culture pour la mise en evidence d'un evenement genotoxique chez les patients cancereux . Bull. Cancer , 85 : 267 – 71 .
  • Fenech , M. 1998 . Important variables that influence base-line micronucleus frequency incytokinesis-blocked lymphocytes—A biomarker for DNA damage in human populations . Mutat. Res. , 404 : 155 – 65 .
  • Fenech , M. , Neville , S. and Rinaldi , J. 1994 . Sex is an important variable affecting spontaneous micronucleus frequency in cytokinesis-blocked lymphocytes . Mutat. Res. , 313 : 203 – 7 .
  • Fenech , M. , Chang , P. , Kirsch-Volders , M. , Holland , N. , Bonassi , S. and Zeiger , E. 2003 . Human project: Detailed description of the scoring criteria for cytokinesis-block micronucleus assay using isolated human lymphocyte cultures . Mutat. Res. , 534 : 65 – 75 .
  • Gaspar , J. , Rodrigues , S. , Gil , O. , Manita , I. , Cruz , T. , Limbert , E. , Gonçalves , L. , Pina , J. and Rueff , J. 2004 . Combined effects of glutathione S-transferase GSTM1, GSTT1, and GSTP1 polymorphisms and thyroid cancer risk . Cancer Genet. Cytogenet. , 151 : 60 – 67 .
  • Ginsberg , G. , Smolenski , S. , Neafsey , P. , Hattis , D. , Walker , K. , Guyton , K. Z. , Johns , D. O. and Sonawane , B. 2009 . The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes . J. Toxicol. Environ. Health B , 12 : 307 – 33 .
  • Hallier , E. , Goergens , H. W. , Hallier , K. and Bolt , H. M. 1994 . Intervention study on the influence of reduction of occupational exposure to styrene on sister chromatid exchanges in lymphocytes . Int. Arch. Occup. Environ. Health , 66 : 167 – 72 .
  • Haufroid , V. , Jakubowski , M. , Janasik , B. , Ligocka , D. , Buchet , J. P. , Bergamaschi , E. , Manini , P. , Mutti , A. , Ghittori , S. , Arand , M. , Hangen , N. , Oesch , F. , Hirvonen , A. and Lison , D. 2002 . Interest of genotyping and phenotyping of drug-metabolizing enzymes for the interpretation of biological monitoring of exposure to styrene . Pharmacogenetics , 12 : 691 – 702 .
  • Hoffmann , D. and Hoffmann , I. 1997 . The changing cigarette, 1950–1995 . J. Toxicol. Environ. Health , 50 : 307 – 64 .
  • Holz , O. , Scherer , G. , Brodtmeier , S. , Koops , F. , Warncke , K. , Krause , T. , Austen , A. , Angerer , J. , Tricker , A. R. , Adlkofer , F. and Rüdiger , H. W. 1995 . Determination of low level exposure to volatile aromatic hydrocarbons and genotoxic effects in workers at a styrene plant . Occup. Environ. Med. , 52 : 420 – 28 .
  • IARC . 2002 . IARC Monographs on the Evaluation of Carcinogenic Risk to Humans , Vol. 82 , Lyon : International Agency for Research on Cancer .
  • Karahalil , B. , Burgaz , S. , Fisek , G. and Karakaya , A. E. 1998 . Biological monitoring of young workers exposed to polycyclic aromatic hydrocarbons in engine repair workshops . Mutat. Res. , 412 : 261 – 69 .
  • Kevekordes , S. , Gebel , T. W. , Hellwig , M. , Dames , W. and Dunkelberg , H. 1998 . Human effect monitoring in cases of occupational exposure to antineoplastic drugs: A method comparison . Occup. Environ. Med. , 55 : 145 – 49 .
  • Kirkwood , T. B. 1988 . DNA, mutations and aging . Mutat.Res. , 219 : 7 – 13 .
  • Kogevinas , M. , Ferro , G. , Andersen , A. , Bellander , T. , Biocca , M. , Coggon , D. , Gennaro , V. , Hutchings , S. , Kolstad , H. and Lundberg , I. 1994 . Cancer mortality in a historical cohort study of workers exposed to styrene . Scand. J. Work Environ. Health , 20 : 251 – 61 .
  • Laffon , B. , Lema , M. and Méndez , J. 2001 . Simultaneous high-performance liquid chromatographic determination of urinary mandelic and phenylglyoxylic acids as indirect evaluation of styrene exposure . J. Chromatogr. B , 753 : 385 – 93 .
  • Laffon , B. , Pásaro , E. and Méndez , J. 2002a . DNA damage and repair in human leukocytes exposed to styrene-7,8-oxide measured by the comet assay . Toxicol. Lett. , 126 : 61 – 68 .
  • Laffon , B. , Pasaro , E. and Mendez , J. 2002b . Evaluation of genotoxic effects in a group of workers exposed to low levels of styrene . Toxicology , 171 : 175 – 86 .
  • Laffon , B. , Pérez-Cadahía , B. , Pásaro , E. and Méndez , J. 2003 . Individual sensitivity to DNA damage induced by styrene in vitro: Influence of cytochrome p450, epoxide hydrolase and glutathione S-transferase genotypes . Toxicology , 186 : 131 – 41 .
  • Laffon , B. , Teixeira , J. P. , Silva , S. , Roma-Torres , J. , Pérez-Cadahía , B. , Méndez , J. , Pásaro , E. and Mayan , O. 2006 . Assessment of occupational genotoxic risk in the production of rubber tyres . Ann. Occup. Hyg. , 50 : 583 – 92 .
  • Lazutka , J. R. , Dedonyte , V. and Krapavickaite , D. 1994 . Sister chromatid exchanges and their distribution in human lymphocytes in relation to age, sex and smoking . Mutat. Res. , 306 : 173 – 80 .
  • Maki-Paakkanen , J. , Walles , S. , Osterman-Golkar , S. and Norppa , H. 1991 . Single-strand breaks, chromosome aberrations, sister-chromatid exchange, and micronuclei in blood lymphocytes of workers exposed to styrene during the production of reinforced plastics . Environ. Mol. Mutagen. , 17 : 27 – 31 .
  • Moller , P. , Knudsen , L. E. , Loft , S. and Wallin , H. 2000 . The comet assay as a rapid testin biomonitoring occupational exposure to DNA-damaging agents and effect of counfounding factors . Cancer Epidemiol. Biomarkers Prev. , 9 : 1005 – 15 .
  • NIOSH . 1994 . Manual of analytical methods , Cincinnati , OH : U.S. Department of Health and Human Services-Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health .
  • Norppa , H. 2003 . Genetic susceptibility, biomarker responses, and cancer . Mutat. Res. , 544 : 339 – 348 .
  • Palus , J. , Dziubaltowska , E. and Rydzynski , K. 1999 . DNA damage detected by the comet assay in the white blood cells of workers in a wooden furniture plant . Mutat. Res. , 444 : 61 – 74 .
  • Pavanello , S. and Clonfero , E. 2000 . Biological indicators of genotoxic risk and metabolic polymorphisms . Mutat. Res. , 463 : 285 – 308 .
  • Rappaport , S. M. , Yeowell-O'Connell , K. , Bodell , W. , Yager , J. W. and Symanski , E. 1996 . An investigation of multiple biomarkers among workers exposed to styrene and styrene-7,8-oxide . Cancer Res. , 56 : 5410 – 16 .
  • Rihs , H.-P. , Triebig , G. , Werner , P. , Rabstein , S. , Heinze , E. , Pesch , B. and Bruning , T. 2008 . Association between genetic polymorphism in styrene-metabolizing enzymes and biomarkers in styrene-exposed workers . J. Toxicol. Environ. Health A , 71 : 866 – 73 .
  • Sardas , S. , Gok , S. and Karakaya , A. E. 1991 . Increased frequency of sister chromatid exchanges in the peripheral lymphocytes of cigarette smokers . Toxicol. In Vitro , 5 : 263 – 65 .
  • Sarmanova , J. , Tynkova , L. , Susova , S. , Gut , I. and Soucek , P. 2000 . Genetic polymorphisms of biotransformation enzymes: Allele frequencies in the population of the Czech Republic . Pharmacogenetics. , 10 : 781 – 88 .
  • Scott , D. and Preston , R. J. 1994 . A re-evaluation of the cytogenetic effects of styrene . Mutat. Res. , 318 : 175 – 203 .
  • Singh , N. P. , McCoy , M. T. , Tice , R. R. and Schneider , E. L. 1988 . A simple technique for quantitation of low levels of DNA damage in individual cells . Exp. Cell Res. , 175 : 184 – 91 .
  • Somorovska , M. , Jahnova , E. , Tulinska , J. , Zamecnikova , M. , Sarmanova , J. , Terenova , A. , Vodickova , L. , Liskova , A. , Vallova , B. , Soucek , P. , Hemminki , K. , Norppa , H. , Hirvonen , A. , Tates , A. D. , Fuortes , L. , Dusinska , M. and Vodicka , P. 1999 . Biomonitoring of occupational exposure to styrene in a plastics lamination plant . Mutat. Res. , 428 : 255 – 69 .
  • Sorsa , M. , Anttila , A. , Jarventaus , H. , Kubiak , R. , Norppa , H. , Nylander , L. , Pekari , K. , Pfaffli , P. and Vainio , H. 1991 . Styrene revisited—Exposure assessment and risk estimation in reinforced plastics industry . Prog. Clin. Biol. Res. , 372 : 187 – 95 .
  • Speit , G. and Henderson , L. 2005 . Review of the in vivo genotoxicity tests performed with styrene . Mutat. Res. , 589 : 67 – 79 .
  • Srám , R. J. and Binková , B. 2000 . Molecular epidemiology studies on occupational and environmental exposure to mutagens and carcinogens, 1997–1999 . Environ. Health Persp. , 108 : 57 – 70 .
  • Sumner , J. S. and Fennell , T. R. 1994 . Review of the metabolic fate of styrene . Crit. Rev. Toxicol. , 24 : S11 – 33 .
  • Tates , A. D. , Grummt , T. , van Dam , F. J. , de Zwart , F. , Kasper , F. J. , Rothe , R. , Stirn , H. , Zwinderman , A. H. and Natarajan , A. T. 1994 . Measurement of frequencies of HPRT mutants, chromosomal aberrations, micronuclei, sister-chromatid exchanges and cells with high frequencies of SCEs in styrene/dichloromethane-exposed workers . Mutat. Res. , 313 : 249 – 262 .
  • Teixeira , J. P. , Gaspar , J. , Silva , S. , Torres , J. , Silva , S. N. , Azevedo , M. C. , Neves , P. , Laffon , B. , Mendez , J. , Goncalves , C. , Mayan , O. , Farmer , P. B. and Rueff , J. 2004 . Occupational exposure to styrene: modulation of cytogenetic damage and levels of urinary metabolites of styrene by polymorphisms in genes CYP2E1, EPHX1, GSTM1, GSTT1 and GSTP1 . Toxicology , 195 : 231 – 42 .
  • Teixeira , J. P. , Gaspar , J. , Roma-Torre , J. , Silva , S. , Costa , C. , Roach , J. , Mayan , O. , Rueff , J. and Farmer , P. B. 2007 . Styrene-oxide N-terminal valine haemoglobin adducts in reinforced plastic workers: Possible influence of genetic polymorphism of drug-metabolising enzymes . Toxicology , 237 : 58 – 64 .
  • Tucker , J. , Nath , J. and Hando , J. C. 1996 . Activation status of the X chromosome human micronucleated lymphocytes. Human Genetics 97:471--475.
  • Van Hummelen , P. , Severi , M. , Pauwels , W. , Roosels , D. , Veulemans , H. and Kirsch-Volders , M. 1994 . Cytogenetic analysis of lymphocytes from fiberglass-reinforced plastics workers occupationally exposed to styrene . Mutat. Res. , 310 : 157 – 65 .
  • Vodicka , P. , Bastlova , T. , Vodickova , L. , Peterkova , K. , Lambert , B. and Hemminki , K. 1995 . Biomarkers of styrene exposure in lamination workers: levels of O6-guanine DNA adducts, DNA strand breaks and mutant frequencies in the hypoxanthine guanine phosphoribosyltransferase gene in T-lymphocytes . Carcinogenesis. , 16 : 1473 – 81 .
  • Vodicka , P. , Tvrdik , T. , Osterman-Golkar , S. , Vodickova , L. , Peterkova , K. , Soucek , P. , Sarmanova , J. , Farmer , P. B. , Granath , F. , Lambert , B. and Hemminki , K. 1999 . An evaluation of styrene genotoxicity using several biomarkers in a 3-year follow-up study of hand-lamination workers . Mutat. Res. , 445 : 205 – 24 .
  • Vodicka , P. , Soucek , P. , Tates , A. D. , Dusinska , M. , Sarmanova , J. , Zameenikova , M. , Vodickova , L. , Koskinen , M. , De Zwart , F. A. , Natarajan , A. T. and Hemminki , K. 2001 . Association between genetic polymorphisms and biomarkers in styrene-exposed workers . Mutat. Res. , 482 : 89 – 103 .
  • Vodicka , P. , Tuimala , J. , Stetina , R. , Kumar , R. , Manini , P. , Naccarati , A. , Maestri , L. , Vodickova , L. , Kuricova , M. , Järventaus , H. , Majvaldova , Z. , Hirvonen , A. , Imbriani , M. , Mutti , A. , Migliore , L. , Norppa , H. and Hemmink , K. 2004 . Cytogenetic markers, DNA single-strand breaks, urinary metabolites, and DNArepair rates in styrene-exposed lamination workers . Environ. Health Persp. , 112 : 867 – 71 .
  • Yager , J. W. , Paradisin , W. M. and Rappaport , S. M. 1993 . Sister-chromatid exchanges in lymphocytes are increased in relation to longitudinally measured occupational exposure to low concentrations of styrene . Mutat. Res. , 319 : 155 – 65 .
  • Zhu , C. Q. , Lam , T. H. , Jiang , C. Q. , Wei , B. X. , Lou , X. , Liu , W. W. , Lao , X. Q. and Chen , Y. H. 1999 . Lymphocyte DNA damage in cigarette factory workers measured by the Comet assay . Mutat. Res. , 444 : 1 – 6 .
  • Zijno , A. , Leopardi , P. , Marcon , F. and Crebelli , R. 1996 . Sex chromosome loss and non-disjunction in women: Analysis of chromosomal segregation in binucleated lymphocytes . Chromosoma (Berlin) , 104 : 461 – 67 .

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