332
Views
19
CrossRef citations to date
0
Altmetric
Original Articles

Evaluation of the Mutagenic Activity of Chrysin, a Flavonoid Inhibitor of the Aromatization Process

, , , , &
Pages 1000-1011 | Published online: 01 Aug 2012

REFERENCES

  • Bernstein , L. , Kaldor , J. , McCann , J. and Pike , M. C. 1982 . An empirical approach to the statistical analysis of mutagenesis data from Salmonella test . Mutation Res. , 97 : 267 – 81 .
  • Bjeldanes , L. F. and Chang , G. W. 1977 . Mutagenic activity of quercetin and related compounds . Science , 197 : 577 – 78 .
  • Braylan , R. C. , Benson , N. A. , Norse , V. and Kruth , H. S. 1982 . Correlated analysis of cellular DNA membrane antigens, and light scatter of human lymphoid cells . Cytometry. , 2 : 337 – 43 .
  • Crissman , H. A. and Steinkamp , J. A. 1973 . Rapid simultaneous measurement of DNA, protein, and cell volume in single cell from large mammalian cell populations . J. Cell Biol. , 59 : 766
  • Czeczot , H. , Tudek , B. , Kusztelak , J. , Szymczyk , T. , Dobrowolska , B. , Glinkowska , G. , Malinowski , J. and Strzelecka , H. 1990 . Isolation and studies of the mutagenic activity in the Ames test of flavonoids naturally occurring in medical herbs . Mutat. Res. , 240 : 209 – 16 .
  • Dhawan , K. , Kumar , S. and Sharma , A. 2002 . Beneficial effects of chrysin and benzoflavone on virility in 2-year-old male rats . J. Med. Food , 5 : 43 – 48 .
  • Fenech , M. , Chang , W.P. , Kirsch-Volders , M. , Holland , N. , Bonassi , S. and Zeiger , E. 2003 . Human project: Detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures . Mutat Res. , 534 : 65 – 75 .
  • Fujimoto , K. , Hosotani , R. , Doi , R. , Wada , M. , Lee , J. , Koshiba , T. , Miyamoto , Y. , Tsuji , S. , Sakajima , S. and Imamura , M. 1999 . Induction of cell-cycle arrest and apoptosis by novel retinobenzoic-acid derivative, TAC-101 in human pancreatic-cancer cell . Int. J. Cancer , 81 : 634 – 44 .
  • Gambelunghe , C. , Rossi , R. , Sommavilla , M. , Ferranti , C. , Ciculi , C. , Gizzi , S , Micheletti , A. and Rufini , S. 2003 . Effects of chrysin on urinary testosterone levels in human males . J. Med. Food , 6 : 387 – 90 .
  • Hartmann , A. , Elhajouji , A. , Kiskinis , E. , Poetter , F. , Marins , H. , Fjallman , A. , Frieau , W. and Suter , W. 2001 . Use of the alkaline comet assay for industrial genotoxicity screening: Comparative investigation with the micronucleus test . Food Chem. Toxicol. , 39 : 843 – 58 .
  • Hong , T. B. , Rahumatullah , A. , Yogarajah , T. , Ahmad , M. and Yin , K. B. 2010 . Potential effects of chrysin on MDA-MB-231 cells . Int. J. Mol. Sci. , 11 : 1057 – 69 .
  • Johnson , P. A. , Clements , P. , Hudson , K. and Caldecott , K. W. 1999 . A mitotic spindle requirement for DNA damage-induced apoptosis in Chinese hamster ovary cells . Cancer Res. , 59 : 2696 – 700 .
  • Kao , Y. , Zhou , C. , Sherman , M. , Laughton , C. A. and Chen , S. 1998 . Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study . Environ. Health Perspect. , 106 : 85 – 92 .
  • Kessel , D. and Luo , Y. 2000 . Cell in cryptophycin-induced cell cycle arrest are susceptible to apoptosis . Cancer Cell. , 151 : 25 – 29 .
  • Khoo , B. Y. , Chua , S. L. and Balaram , P. 2010 . Apoptotic effects of chrysin in human cancer cell lines . Int. J. Mol. Sci. , 11 : 2188 – 99 .
  • Knasmuller , S. , Parzefall , W. , Sanyal , R. , Ecker , S. , Schwab , C. , Uhl , M. , Mersch-Sundermann , V. , Williamson , G. , Hietsch , G. , Langer , T. , Darroudi , F. and Adayapalam , A. T. 1998 . Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens . Mutat. Res. , 402 : 185 – 202 .
  • Lautraite , S. , Musonda , A. C. , Doehmer , J. , Edwards , G. O and Chipman , J. K. 2002 . Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1 . Mutagenesis , 17 : 45 – 53 .
  • Lin , Z. X. , Hoult , J. R. S. and Raman , A. 1999 . Sulphorhodamine B assay for measuring proliferation of a pigmented melanocyte cell line and its application to the evaluation of crude drugs used in the treatment of vitiligo . J. Ethnopharmacol. , 66 : 141 – 50 .
  • Lorge , E. , Hayashi , M. , Albertini , S. and Kirkland , D. 2008 . Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test. I. Theoretical aspects . Mutat. Res. , 655 : 1 – 38 .
  • MacGregor , J. T. and Jurd , L. 1978 . Mutagenicity of plant flavonoids: structural requirements for mutagenic activity in Salmonella typbimurium . Mutat. Res. , 54 : 297 – 309 .
  • Majer , B. J. , Mersch-Sundermann , V. , Darroudi , F. , Laky , B. , Wit , K. and Knasmuller , S. 2004 . Genotoxic effects of dietary and lifestyle related carcinogens in human derived hepatoma (HepG2, Hep3B) cells . Mutat. Res. , 551 : 153 – 66 .
  • Maron , D. M. and Ames , B. N. 1983 . Revised methods for the Salmonella mutagenicity test . Mutat. Res. , 113 : 173 – 214 .
  • Mortelmans , K. and Zeiger , E. 2000 . The Ames Salmonella/microsome mutagenicity assay . Mutat. Res. , 455 : 29 – 60 .
  • Natarajan , A. T. and Darroudi , F. 1991 . Use of human hepatoma cells for in vitro metabolic activation of chemical mutagen/carcinogens . Mutagenesis , 6 : 399 – 403 .
  • Oren , D. K. , Petersen , L. N. and Bohr , V. A. 1997 . Persistent DNA damage inhibits S-phase and G2 progression and results in apoptosis . Mol. Biol. Cell. , 8 : 1129 – 42 .
  • Purohit , A. , Hejas , H. , Walden , L. , MacCartthy-Morrong , L. , Packham , G. , Potter , B. V. L. and Reed , M. J. 2000 . The effect of 2-methoxioestrone 3-sulphamate on the growth of breast cancer cell and induced mammary tumor . Int. J. Cancer , 85 : 584 – 90 .
  • Sanderson , J. T. , Hordijk , J. , Denison , M. S. , Springsteel , M. F. , Nantz , M. H. and Van den Berg , M. 2004 . Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells . Toxicol. Sci. , 82 : 70 – 79 .
  • Silva , I. D. , Rodrigues , A. S. , Gaspar , J. , Maia , R. , Laires , A. and Rueff , J. 1997 . Involvement of rat cytochrome 1A1 in the biotransformation of kaempferol to quercetin: Relevance to the genotoxicity of kaempferol . Mutagenesis , 12 : 383 – 90 .
  • Simons , A. L. , Renouf , M. , Hendrich , S. and Murphy , P. A. 2005 . Human gut microbial degradation of flavonoids: Structure-function relationships . J. Agric. Food Chem. , 53 : 4258 – 63 .
  • Skehan , P. , Storeng , R. , Scudiero , D , Monks , A. , Mcmahon , J. , Vistica , D. , Warren , J. T. , Bokesch , H. , Kenney , S. and Boyd , R. M. 1990 . New colorimetric cytotocity assay for anticancer-drug screening . J. Natl. Cancer Inst. , 82 : 1107 – 12 .
  • Surrallés , J. , Xamena , N. , Creus , A. , Catalán , J. , Norppa , H. and Marcos , R. 1995 . Induction of micronuclei by five pyrethroid insecticides in whole-blood and isolated human lymphocyte cultures . Mutat. Res. , 341 : 169 – 84 .
  • Ta , N. and Walle , T. 2007 . Aromatase inhibition by bioavailable methylated flavones . J. Steroid Biochem. Mol. Biol. , 107 : 127 – 29 .
  • Tsuji , P. A. and Walle , T. 2008 . Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line . Chem-Biol. Interact. , 171 : 37 – 44 .
  • Walle , T. , Otake , Y. , Brubaker , J. A. , Walle , U. K. and Halushka , P. V. 2001 . Disposition and metabolism of the flavonoid chrysin in normal volunteers . Br. J. Clin.Pharmacol. , 51 : 143 – 46 .
  • Weinberg , O. K. , Marquez-Garban , D. C. , Fishbein , M. C. , Goodglick , L. , Garban , H. J. , Dubinett , S. M. and Pietras , R. J. 2005 . Aromatase inhibitors in human lung cancer therapy . Cancer Res. , 65 : 11287 – 91 .
  • Weng , M. S. , Ho , Y. S. and Lin , J. K. 2005 . Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: Involvement of p38 mitogen-activated protein kinase . Biochem. Pharmacol , 69 : 1815 – 27 .
  • XinWu , Y. and Fang , X. 2010 . Apigenin, chrysin, and luteolin selectively inhibit chymotrypsin-like and trypsin-like proteasome catalytic activities in tumor cells . Planta. Med. , 76 : 128 – 32 .
  • Yao , R. , Yasuoka , A. , Kamei , A. , Kitagawa , Y. , Tateishi , N. , Tsuruoka , N. , Kiso , Y. , Sueyoshi , T. , Negishi , M. , Misaka , T. and Abe , K. 2010 . Dietary flavonoids activate the constitutive androstane receptor CAR . J. Agric. Food Chem. , 58 : 2168 – 73 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.