248
Views
35
CrossRef citations to date
0
Altmetric
Original Articles

Antigenotoxic Effects of (–)-Epigallocatechin-3-Gallate (EGCG), Quercetin, and Rutin on Chromium Trioxide-Induced Micronuclei in the Polychromatic Erythrocytes of Mouse Peripheral Blood

, , &
Pages 324-336 | Received 07 Nov 2013, Accepted 08 Nov 2013, Published online: 04 Mar 2014

REFERENCES

  • Adler , I.-D. , Bootman , J. , Favor , J. , Hook , G. , Schriever-Schwemmer , G. , Welzl , G. , Whorton , E. , Yoshimura , I. and Hayashi , M. 1998 . Recommendations for statistical designs of in vivo mutagenicity tests with regard to subsequent statistical analysis . Mutat. Res , 417 : 19 – 30 .
  • Aherne , S. A. and O´Brien , N. M. 2000 . Mechanism of protection by the flavonoids, quercetin and rutin, against tert-butylhydroperoxide- and menadione-induced DNA single strand breaks in Caco-2 cells . Free Radical Biol. Med , 29 : 507 – 514 .
  • Barcelos , G. R. , Angeli , J. P. , Serpeloni , J. M. , Grotto , D. , Rocha , B. A. , Bastos , J. K. , Knasmüller , S. and Júnior , F. B. 2011 . Quercetin protects human-derived liver cells against mercury-induced DNA-damage and alterations of the redox status . Mutat. Res , 726 : 109 – 115 .
  • Bjelakovic , G. , Nikolova , D. , Gluud , L. L. , Simonetti , R. G. and Gluud , C. 2007 . Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis . J. Am. Med. Assoc , 297 : 842 – 857 .
  • Blasiak , J. 2001 . DNA-Damaging effect of cadmium and protective action of quercetin . Pol. J. Environ. Stud , 10 : 437 – 442 .
  • Boots , A. W. , Li , H. , Schins , R. P. , Duffin , R. , Heemskerk , J. W. , Bast , A. and Haenen , G. R. 2007 . The quercetin paradox . Toxicol Appl Phamacol , 222 : 89 – 96 .
  • Cabrera , C. , Artacho , R. and Giménez , R. 2006 . Beneficial effects of green tea—A review . J Am Coll Nutr , 25 : 79 – 99 .
  • Cadenas , E. and Packer , L. 2002 . Handbook of antioxidants , 2nd ed , New York , NY : Marcel Dekker .
  • Caillet , S. , Yu , H. , Lessard , S. , Lamoureux , G. , Ajdukovic , D. and Lacroix , M. 2007 . Fenton reaction applied for screening natural antioxidants . Food Chem , 100 : 542 – 552 .
  • Chromium Draft for Public Comment . February 18 1993 . U.S. Department of Health and Human Services Public Health Service Agency for Toxic Substances and Disease Registry. Comment Period Ends February 18 , http://www.emla.hu/korkep/chems/tfacts7.html
  • Collaborative Study Group for the Micronucleus Test . 1995 . Protocol recommended by the CSGMT/JEMS.MMS for the short-term mouse peripheral blood micronucleus test. The Mammalian Mutagenesis Study Group of the Environmental Mutagen Society of Japan, CSGMT/JEMS.MMS . Mutagenesis , 10 : 153 – 159 .
  • da Silva , J. , Herrmann , S. M. , Heuser , V. , Peres , W. , Possa , M. N. , González-Gallego , J. and Erdtmann , B. 2002 . Evaluation of the genotoxic effect of rutin and quercetin by comet assay and micronucleus test . Food Chem. Toxicol , 40 : 941 – 947 .
  • Ellinger , S. , Müller , N. , Stehle , P. and Ulrich-Merzenich , G. 2011 . Consumption of green tea or green tea products: Is there an evidence for antioxidant effects from controlled interventional studies? . Phytomedicine , 18 : 903 – 915 .
  • Food and Drug Administration . 2000 . Guidelines for reproduction studies for safety evaluations of drugs for human use , U.S. FDA .
  • García-Rodríguez , M. C. , López-Santiago , V. and Altamirano-Lozano , M. 2001 . Effect of chlorophyllin on chromium trioxide-induced micronuclei in polychromatic erythrocytes in mouse peripheral blood . Mutat. Res , 496 : 145 – 151 .
  • García-Rodríguez , M. C. and Altamirano-Lozano , M. 2006 . Study of effects chlorophyllin on genotoxic and teratogenic damage induced by chromium (VI) . Environ. Mol. Mutagen , 47 : 460
  • García-Rodríguez , M. C. , Vilches-Larrea , R. E. , Nicolás-Mendez , T. and Altamirano-Lozano , M. A. 2012a . Green tea and its role on chemoprevention in vivo of genotoxic damage induced by carcinogenic metals (chromium [VI]) . Nutr. Hosp , 27 : 1204 – 1212 .
  • García-Rodríguez , M. C. , Montaño-Rodríguez , A. R. and Altamirano-Lozano , M. 2012b . Pro-oxidant effect of EGCG on genotoxicity of hexavalent chromium in mice in vivo . Free Radical Biol. Med , 53 : 218 – 219 .
  • Glei , M. and Pool-Zobel , B. L. 2006 . The main catechin of green tea, (–)-epigallocatechin-3-gallate (EGCG), reduces bleomycin-induced DNA damage in human leucocytes . Toxicol. In Vitro , 20 : 295 – 300 .
  • Griffiths , L. A. 1982 . “ Mammalian metabolism of flavonoids ” . In The flavonoids: Advances in research , Edited by: Harbone , J. and Mabry , T. 681 – 718 . London , UK : Chapman and Hall .
  • Harwood , M. , Danielewska-Nikiel , B. , Borzelleca , J. F. , Flamm , G. W. , Williams , G. M. and Lines , T. C. 2007 . A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties . Food Chem. Toxicol , 45 : 2179 – 2205 .
  • Hayashi , M. , Sutou , S. , Shimada , H. , Sato , S. , Sasaki , Y. F. and Wakata , A. 1989 . Difference between intraperitoneal and oral gavage application in the micronucleus test. The 3rd collaborative study by CSGMT/JEMS.MMS. Collaborative Study Group for the Micronucleus Test/Mammalian Mutagenesis Study Group of the Environmental Mutagen Society of Japan . Mutat. Res , 223 : 329 – 344 .
  • Hayashi , M. , Morita , T. , Kodama , Y. , Sofuni , T. and Ishidate , M. 1990 . The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides . Mutat. Res , 245 : 245 – 249 .
  • Hayashi , M. , Tice , R. , MacGregor , J. , Anderson , D. , Blakey , D. , Kirsh-Volders , M. , Oleson , F. , Pacchierotti , F. , Romagna , F. , Shimada , H. , Sutou , S. and Vannier , B. 1994 . In vivo rodent erythrocyte micronucleus assay . Mutat. Res , 312 : 293 – 304 .
  • Heddle , J. A. , Hite , M. , Kirkhart , B. , Mavournin , K. , MacGregor , J. T. , Newell , G. W. and Salamone , M. F. 1983 . “ The induction of micronuclei as a measure of genotoxicity: A report of the U.S. Environmental Protection Agency Gene-Tox Program ” . In Mutat. Res Vol. 123 , 61 – 118 .
  • Holmann , P. C. and Katan , M. B. 1997 . Absorption, metabolism and health effects of dietary flavonoids in man . Biomed. Pharmacother , 51 : 305 – 310 .
  • Holmann , P. C. and Katan , M. B. 1999 . Dietary flavonoids: Intake, health effects and bioavailability . Food Chem. Toxicol , 37 : 937 – 942 .
  • Karakaya , S. 2004 . Bioavailability of phenolic compounds . Crit. Rev. Food Sci. Nutr , 44 : 453 – 464 .
  • Kapiszewska , M. , Cierniak , A. , Papiez , M. A. , Pietrzycka , A. , Stepniewski , M. and Lomnicki , A. 2007 . Prolonged quercetin administration diminishes the etoposide-induced DNA damage in bone marrow cells of rats . Drug Chem. Toxicol , 30 : 67 – 81 .
  • Khalaf , A. A. , Moselhy , W. A. and Abdel-Hamed , M. I. 2012 . The protective effect of green tea extract on lead induced oxidative and DNA damage on rat brain . Neurotoxicology , 33 : 280 – 289 .
  • Kivits , G. A. , van der Sman , F. J. P. and Tijburg , L. B. M. 1997 . Analysis of catechins from green and black tea in humans . Int. J. Food Sci. Nutr , 48 : 387 – 392 .
  • Knasmüller , S. , Steinkellner , H. , Majer , B. J. , Nobis , E. C. , Scharf , G. and Kassie , F. 2002 . Search for dietary antimutagens and anticarcinogens: Methodological aspects and extrapolation problems . Food Chem. Toxicol , 40 : 1051 – 1062 .
  • Komes , D. , Horžic , D. , Belšcak , A. , Ganic , K. K. and Vulic , I. 2010 . Green tea preparation and its influence on the content of bioactive compounds . Food Res. Int , 43 : 167 – 176 .
  • Krishna , G. and Hayashi , M. 2000 . In vivo rodent micronucleus assay: Protocol, conduct and data interpretation . Mutat. Res , 455 : 155 – 166 .
  • Kumar , M. , Sharma , V. L. , Sehgal , A. and Jain , M. 2012 . Protective effects of green and white tea against benzo(a)pyrene induced oxidative stress and DNA damage in murine model . Nutr. Cancer , 64 : 300 – 306 .
  • Maeng , S. H. , Chung , H. W. , Yu , I. J. , Kim , H. Y. , Lim , C. H. , Kim , K. J. , Kim , S. J. , Ootsuyama , Y. and Kasai , H. 2003 . Changes of 8-OH-dG levels in DNA and its base excision repair activity in rat lungs after inhalation exposure to hexavalent chromium . Mutat. Res , 539 : 109 – 116 .
  • Manach , C. , Morand , C. , Demigné , C. , Texier , O. , Régérat , F. and Rémésy , C. 1997 . Bioavailability of rutin and quercetin in rats . FEBS Lett , 409 : 12 – 16 .
  • Manach , C. , Texier , O. , Morand , C. , Crespy , V. , Régérat , F. , Demigné , C. and Rémésy , C. 1999 . Comparison of the bioavailability of quercetin and catechin in rats . Free Radical Biol. Med , 27 : 1259 – 1266 .
  • Mazumdar , M. , Giri , S. and Giri , A. 2011 . Role of quercetin on mitomycin C induced genotoxicity: analysis of micronucleus and chromosome aberrations in vivo . Mutat. Res , 721 : 147 – 152 .
  • O´Brien , T. J. , Ceryak , S. and Patierno , S. R. 2003 . Complexities of chromium carcinogenesis: Role of cellular response, repair and recovery mechanisms . Mutat. Res , 533 : 3 – 36 .
  • Organization for Economic Cooperation and Development . 1997 . Guideline for the testing of chemicals , mammalian erythrocyte micronucleus test. Guideline 474. OECD . http://www.oecd.org/chemicalsafety/risk-assessment/1948442.pdf
  • Patlolla , A. K. , Barnes , C. , Hackett , D. and Tchounwou , P. B. 2009 . Potassium dichromate induced cytotoxicity, genotoxicity and oxidative stress in human liver carcinoma (HepG2) cells . Int J Environ Res Public Health , 6 : 643 – 653 .
  • Poljšak , B. , Gazdag , Z. , Pesti , M. , Filipič , M. , Fujs , S. , Farkas , N. , Plesničar , S. and Raspor , P. 2006 . Role of the vitamin E model compound trolox in the prevention of Cr(VI)-induced cellular damage . Toxicol. Environ. Chem , 88 : 141 – 157 .
  • Resende , F. A. , Vilegas , W. , Dos Santos , L. C. and Varanda , E. A. 2012 . Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test . Molecules , 17 : 5255 – 5268 .
  • Robaszkiewicz , A. , Balcerczyk , A. and Bartosz , G. 2007 . Antioxidative and prooxidative effects of quercetin on A549 cells . Cell Biol. Int , 31 : 1245 – 1250 .
  • Rowbotham , A. L. , Levy , L. S. and Shuker , L. K. 2000 . Chromium in the environment: An evaluation of exposure of the UK general population and possible adverse health effects . J. Toxicol. Environ. Health B , 3 : 145 – 1778 .
  • Roy , M. , Chakrabarty , S. , Sinha , D. , Bhattacharya , R. K. and Siddiqi , M. 2003 . Anticlastogenic, antigenotoxic and apoptotic activity of epigallocatechin gallate: A green tea polyphenol . Mutat. Res , 523–524 : 33 – 41 .
  • Shi , X. L. 1992 . Reduction of chromium(VI) and its relationship to carcinogenesis . J Toxicol Environ Health B , 2 : 87 – 104 .
  • Singh , J. , Carlisle , D. L. , Pritchard , D. E. and Patierno , S. R. 1998 . Chromium-induced genotoxicity and apoptosis: relationship to chromium carcinogenesis (review) . Oncol. Rep , 5 : 1307 – 1318 .
  • Sugisawa , A. , Kimura , M. , Fenech , M. and Umegaki , K. 2004 . Anti-genotoxic effects of tea catechins against reactive oxygen species in human lymphoblastoid cells . Mutat. Res , 559 : 97 – 103 .
  • Surh , Y. J. and Ferguson , L. R. 2003 . Dietary and medicinal antimutagens and anticarcinogens: Molecular mechanisms and chemopreventive potential—Highlights of a symposium . Mutat. Res , 523–524 : 1 – 8 .
  • Tamura , T. , Mitsumori , K. , Muto , S. , Kasahara , H. , Kobayashi , S. , Okuhara , Y. , Hayashi , M. , Nagasawa , T. , Onozato , T. and Kuroda , J. 2010 . Fifty-two week chronic toxicity of enzymatically decomposed rutin in Wistar rats . Food Chem. Toxicol , 48 : 2312 – 2318 .
  • Tripathy , D. R. , Roy , A. S. and Dasgupta , S. 2011 . Complex formation of rutin and quercetin with copper alters the mode of inhibition of ribonuclease A . FEBS Lett , 585 : 3270 – 3276 .
  • Tsou , T. C. , Chen , C. L. , Liu , T. Y. and Yang , J. L. 1996 . Induction of 8-Hydroxydeoxyguanosine in DNA by chromium (III) plus hydrogen peroxide and its prevention by scavengers . Carcinogenesis , 17 : 103 – 108 .
  • Undeğer , U. , Aydin , S. , Başaran , A. A. and Başaran , N. 2004 . The modulating effects of quercetin and rutin on the mitomycin C induced DNA damage . Toxicol. Lett , 151 : 143 – 149 .
  • U.S. Environmental Protection Agency. 1998. Health effects test guidelines OPPTS 870.5395. Mammalian erythrocyte micronucleus test. Office of Prevention. Pesticides and toxic substances (7101) EPA 712-C-98-226 http://www.epa.gov/opptsfrs/publications/OPPTS.Harmonized/870.Health.Effects.Test.Guidelines/Series/870-5395.pdf (http://www.epa.gov/opptsfrs/publications/OPPTS.Harmonized/870.Health.Effects.Test.Guidelines/Series/870-5395.pdf)
  • Uzun , F. G. , Demir , F. , Kalender , S. , Bas , H. and Kalender , Y. 2010 . Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats . Food Chem. Toxicol , 48 : 1714 – 1720 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.