Particulate Matter From Saudi Arabia Induces Genes Involved in Inflammation, Metabolic Syndrome and Atherosclerosis

REFERENCES

• Afridi, H. I., Kazi, T. G., Kazi, N., Kandhro, G. A., Baig, J. A., Jamali, M. K., Arain, M. B., Shah, A. Q., Shah, F., Khan, S., and Kolachi, N. F. 2011. Association of environmental toxic elements in biological samples of myocardial infarction patients at different stages. Biol. Trace Elem. Res. 141: 26–40.
   PubMed Web of Science ®Google Scholar
• Al-Malki, J. S., Al-Jaser, M. H., and Warsy, A. S. 2003. Overweight and obesity in Saudi females of childbearing age. Int. J. Obes. Related Metab. Disorders 27: 134–139.
   PubMed Web of Science ®Google Scholar
• Al-Othaimeen AI, A.-N. M., Osman AK. 2007. Obesity: an emerging problem in Saudi Arabia. Analysis of data from the National Nutrition Survey. East Mediterr Health J 13: 441–448.
   PubMedGoogle Scholar
• Alqurashi, K. A., Aljabri, K. S., Bokhari, S. A. 2011. Prevalence of diabetes mellitus in a Saudi community. Ann. Saudi Med. 31: 19–23.
   PubMed Web of Science ®Google Scholar
• Araujo, J. A., and Nel, A. E. 2009. Particulate matter and atherosclerosis: Role of particle size, composition and oxidative stress. Part. Fibre Toxicol. 6: 24.
   PubMed Web of Science ®Google Scholar
• Ather, J. L., Ckless, K., Martin, R., Foley, K. L., Suratt, B. T., Boyson, J. E., Fitzgerald, K. A., Flavell, R. A., Eisenbarth, S. C., and Poynter, M. E. 2011. Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice. J. Immunol. 187: 64–73.
   PubMed Web of Science ®Google Scholar
• Beckerman, B. S., Jerrett, M., Finkelstein, M., Kanaroglou, P., Brook, J. R., Arain, M. A., Sears, M. R., Stieb, D., Balmes, J., Chapman, K. 2012. The association between chronic exposure to traffic-related air pollution and ischemic heart disease. J. Toxicol. Environ. Health A 75: 402–411.
   PubMed Web of Science ®Google Scholar
• Benjamini, H. Y. 1995. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B (Methodological): 289–300.
   Google Scholar
• Bolstad, B. M., Irizarry, R. A., Astrand, M., and Speed, T. P. 2003. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19: 185–193.
   PubMed Web of Science ®Google Scholar
• Bombini, G., Canetti, C., Rocha, F. A., and Cunha, F. Q. 2004. Tumour necrosis factor-alpha mediates neutrophil migration to the knee synovial cavity during immune inflammation. Eur. J. Pharmacol. 496: 197–204.
   PubMed Web of Science ®Google Scholar
• Brook, R. D., Cakmak, S., Turner, M. C., Brook, J. R., Crouse, D. L., Peters, P. A., van Donkelaar, A., Villeneuve, P. J., Brion, O., Jerrett, M., Martin, R. V., Rajagopalan, S., Goldberg, M. S., Pope, C. A. 3rd, and Burnett, R. T. 2013. Long-term fine particulate matter exposure and mortality from diabetes mellitus in Canada. Diabetes Care 36: 3313–3320.
   PubMed Web of Science ®Google Scholar
• Brook, R. D., Rajagopalan, S., Pope, C. A. 3rd, Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., Peters, A., Siscovick, D., Smith, S. C., Jr., Whitsel, L., Kaufman, J. D. 2010. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation 121: 2331–2378.
   PubMed Web of Science ®Google Scholar
• Campen, M. J., Nolan, J. P., Schladweiler, M. C., Kodavanti, U. P., Evansky, P. A., Costa, D. L., Watkinson, W. P. 2001. Cardiovascular and thermoregulatory effects of inhaled PM-associated transition metals: A potential interaction between nickel and vanadium sulfate. Toxicol. Sci. 64: 243–252.
   PubMed Web of Science ®Google Scholar
• Chang, C. C., Kuo, C. C., Liou, S. H., and Yang, C. Y. 2013. Fine particulate air pollution and hospital admissions for myocardial infarction in a subtropical city: Taipei, Taiwan. J. Toxicol. Environ. Health A 76: 440–448.
   PubMed Web of Science ®Google Scholar
• Chiu, H. F., Tsai, S. S., Weng, H. H., and Yang, C. Y. 2013. Short-term effects of fine particulate air pollution on emergency room visits for cardiac arrhythmias: A case-crossover study in Taipei. J. Toxicol. Environ. Health A 76: 614–623.
   PubMed Web of Science ®Google Scholar
• Colucci, M. E., Veronesi, L., Roveda, A. M., Marangio, E., and Sansebastiano, G. 2006. [Particulate matter (PM10) air pollution, daily mortality, and hospital admissions: recent findings]. Ig. Sanita Pubbl. 62: 289–304.
   PubMedGoogle Scholar
• Crespo, E., Macias, M., Pozo, D., Escames, G., Martin, M., Vives, F., Guerrero, J. M., and Acuna-Castroviejo, D. 1999. Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. FASEB J. 13: 1537–1546.
   PubMed Web of Science ®Google Scholar
• Cybulsky, M. I., Iiyama, K., Li, H., Zhu, S., Chen, M., Iiyama, M., Davis, V., Gutierrez-Ramos, J. C., Connelly, P. W., and Milstone, D. S. 2001. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J. Clin. Invest. 107: 1255–1262.
   PubMed Web of Science ®Google Scholar
• de Beer, M. C., Kindy, M. S., Lane, W. S., and de Beer, F. C. 1994. Mouse serum amyloid A protein (SAA5) structure and expression. J. Biol. Chem. 269: 4661–4667.
   PubMed Web of Science ®Google Scholar
• Degousee, N., Ghomashchi, F., Stefanski, E., Singer, A., Smart, B. P., Borregaard, N., Reithmeier, R., Lindsay, T. F., Lichtenberger, C., Reinisch, W., Lambeau, G., Arm, J., Tischfield, J., Gelb, M. H., and Rubin, B. B. 2002. Groups IV, V, and X phospholipases A2s in human neutrophils: Role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. J. Biol. Chem. 277: 5061–5073.
   PubMed Web of Science ®Google Scholar
• Delfino, R. J., Wu, J., Tjoa, T., Gullesserian, S. K., Nickerson, B., and Gillen, D. L. 2014. Asthma morbidity and ambient air pollution: Effect modification by residential traffic-related air pollution. Epidemiology 25: 48–57.
   PubMed Web of Science ®Google Scholar
• Dong, Z., Wu, T., Qin, W., An, C., Wang, Z., Zhang, M., Zhang, Y., Zhang, C., and An, F. 2011. Serum amyloid A directly accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Mol. Med. 17: 1357–1364.
   PubMed Web of Science ®Google Scholar
• Eberle, D., Hegarty, B., Bossard, P., Ferre, P., and Foufelle, F. 2004. SREBP transcription factors: Master regulators of lipid homeostasis. Biochimie 86: 839–848.
   PubMed Web of Science ®Google Scholar
• Elassouli, S. M., Alqahtani, M. H., and Milaat, W. 2007. Genotoxicity of air borne particulates assessed by comet and the Salmonella mutagenicity test in Jeddah, Saudi Arabia. Int. J. Environ. Res. Public Health 4: 216–233.
   PubMedGoogle Scholar
• Farooqui, A. A. 2013. Lipid mediators in metabolic syndrome and neurological disorders. In Metabolic syndrome, 103–141. New York: Springer.
   Google Scholar
• Fasshauer, M., Klein, J., Kralisch, S., Klier, M., Lossner, U., Bluher, M., and Paschke, R. 2004. Serum amyloid A3 expression is stimulated by dexamethasone and interleukin-6 in 3T3-L1 adipocytes. J. Endocrinol. 183: 561–567.
   PubMed Web of Science ®Google Scholar
• Flohe, S., Dominguez Fernandez, E., Ackermann, M., Hirsch, T., Borgermann, J., and Schade, F. U. 1999. Endotoxin tolerance in rats: Expression of TNF-alpha, IL-6, IL-10, VCAM-1 AND HSP 70 in lung and liver during endotoxin shock. Cytokine 11: 796–804.
   PubMed Web of Science ®Google Scholar
• Frikke-Schmidt, R. 2000. Context-dependent and invariant associations between APOE genotype and levels of lipoproteins and risk of ischemic heart disease: A review. Scand. J. Clin. Lab. Invest. Suppl. 233: 3–25.
   PubMedGoogle Scholar
• Gan, W. Q., Fitzgerald, J. M., Carlsten, C., Sadatsafavi, M., and Brauer, M. 2013. Associations of ambient air pollution with chronic obstructive pulmonary disease hospitalization and mortality. Am. J. Respir. Crit. Care Med. 187: 721–727.
   PubMed Web of Science ®Google Scholar
• Gautier, L., Cope, L., Bolstad, B. M., and Irizarry, R. A. 2004. Affy—Analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20: 307–315.
   PubMed Web of Science ®Google Scholar
• Ghio, A. J., Carraway, M. S., and Madden, M. C. 2012. Composition of air pollution particles and oxidative stress in cells, tissues, and living systems. J. Toxicol. Environ. Health B 15: 1–21.
   PubMed Web of Science ®Google Scholar
• Ghoshal, K., Majumder, S., Zhu, Q., Hunzeker, J., Datta, J., Shah, M., Sheridan, J. F., and Jacob, S. T. 2001. Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms. Mol. Cell. Biol. 21: 8301–8317.
   PubMed Web of Science ®Google Scholar
• Gil, G., Faust, J. R., Chin, D. J., Goldstein, J. L., and Brown, M. S. 1985. Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme. Cell 41: 249–258.
   PubMed Web of Science ®Google Scholar
• Huang, Y. C., Karoly, E. D., Dailey, L. A., Schmitt, M. T., Silbajoris, R., Graff, D. W., and Devlin, R. B. 2011. Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter. J. Toxicol. Environ. Health A 74: 296–312.
   PubMed Web of Science ®Google Scholar
• Kaplanski, G., Marin, V., Montero-Julian, F., Mantovani, A., and Farnarier, C. 2003. IL-6: A regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol. 24: 25–29.
   PubMed Web of Science ®Google Scholar
• Kappos, A. D., Bruckmann, P., Eikmann, T., Englert, N., Heinrich, U., Höppe, P., Koch, E., Krause, G. H., Kreyling, W. G., Rauchfuss, K., Rombout, P., Schulz-Klemp, V., Thiel, W. R., and Wichmann, H. E. 2004. Health effects of particles in ambient air. Int. J. Hyg. Environ. Health 207: 399–407.
   PubMed Web of Science ®Google Scholar
• Karakatsani, A., Analitis, A., Perifanou, D., Ayres, J. G., Harrison, R. M., Kotronarou, A., Kavouras, I. G., Pekkanen, J., Hameri, K., Kos, G. P., de Hartog, J. J., Hoek, G., and Katsouyanni, K. 2012. Particulate matter air pollution and respiratory symptoms in individuals having either asthma or chronic obstructive pulmonary disease: A European multicentre panel study. Environ. Health 11: 75.
   PubMed Web of Science ®Google Scholar
• Keith, R., Miller, Y., Hudish, T., Girod, C., Sotto-Santiago, S., Franklin, W., Nemenoff, R., March, T., Nana-Sinkam, S., and Geraci., M. 2004. Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice. Cancer Res. 64:5897–6904.
   PubMed Web of Science ®Google Scholar
• Khaidakov, M., Mitra, S., Kang, B. Y., Wang, X., Kadlubar, S., Novelli, G., Raj, V., Winters, M., Carter, W. C., and Mehta, J. L. 2011. Oxidized LDL receptor 1 (OLR1) as a possible link between obesity, dyslipidemia and cancer. PLoS One 6: e20277.
   PubMed Web of Science ®Google Scholar
• Khodeir, M., Shamy, M., Alghamdi, M., Zhong, M., Sun, H., Costa, M., Chen, L. C., and Maciejczyk, P. 2012. Source apportionment and elemental composition of PM2.5 and PM10 in Jeddah City, Saudi Arabia. Atmos. Pollut. Res. 3: 331–340.
   PubMed Web of Science ®Google Scholar
• Kooter, I., Pennings, J., Opperhuizen, A., and Cassee, F. 2005. Gene expression pattern in spontaneously hypertensive rats exposed to urban particulate matter (EHC-93). Inhal. Toxicol. 17: 53–65.
   PubMed Web of Science ®Google Scholar
• Kumosani, T. A., Alama, M. N., and Iyer, A. 2011. Cardiovascular diseases in Saudi Arabia. Prime Res. Med. 1: 1–6.
   Google Scholar
• Lippmann, M., Ito, K., Hwang, J. S., Maciejczyk, P., and Chen, L. C. 2006. Cardiovascular effects of nickel in ambient air. Environ. Health Perspect. 114: 1662–1669.
   PubMed Web of Science ®Google Scholar
• Liu, C., Xu, X., Bai, Y., Wang, T. Y., Rao, X., Wang, A., Sun, L., Ying, Z., Gushchina, L., Maiseyeu, A., Morishita, M., Sun, Q., Harkema, J. R., and Rajagopalan, S. 2013. Air pollution-mediated susceptibility to inflammation and insulin resistance: Influence of CCR2 pathways in mice. Environ. Health Perspect 122: 17–26.
   PubMed Web of Science ®Google Scholar
• Madani, K. A., al-Amoudi, N. S., and Kumosani, T. A. 2000. The state of nutrition in Saudi Arabia. Nutr. Health 14: 17–31.
   PubMedGoogle Scholar
• Marcazzan, G. M., Ceriani, M., Valli, G., and Vecchi, R. 2003. Source apportionment of PM10 and PM2.5 in Milan (Italy) using receptor modelling. Sci. Total Environ. 317: 137–147.
   PubMed Web of Science ®Google Scholar
• Mazzoli-Rocha, F., Fernandes, S., Einicker-Lamas, M., and Zin, W. A. 2010. Roles of oxidative stress in signaling and inflammation induced by particulate matter. Cell Biol. Toxicol. 26: 481–498.
   PubMed Web of Science ®Google Scholar
• Mehta, J. L., Chen, J., Hermonat, P. L., Romeo, F., and Novelli, G. 2006. Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): A critical player in the development of atherosclerosis and related disorders. Cardiovasc. Res. 69: 36–45.
   PubMed Web of Science ®Google Scholar
• Mehta, J. L., Sanada, N., Hu, C. P., Chen, J., Dandapat, A., Sugawara, F., Satoh, H., Inoue, K., Kawase, Y., Jishage, K., Suzuki, H., Takeya, M., Schnackenberg, L., Beger, R., Hermonat, P. L., Thomas, M., and Sawamura, T. 2007. Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ. Res. 100: 1634–1642.
   PubMed Web of Science ®Google Scholar
• Menschikowski, M., Hagelgans, A., Fuessel, S., Mareninova, O. A., Asatryan, L., Wirth, M. P., and Siegert, G. 2013. Serum amyloid A, phospholipase A2-IIA and C-reactive protein as inflammatory biomarkers for prostate diseases. Inflamm. Res. 62: 1063–1072.
   PubMed Web of Science ®Google Scholar
• Moldes, M., Lasnier, F., Gauthereau, X., Klein, C., Pairault, J., Feve, B., and Chambaut-Guerin, A. M. 2001. Tumor necrosis factor-alpha-induced adipose-related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-alpha and adipose conversion. J. Biol. Chem. 276: 33938–33946.
   PubMed Web of Science ®Google Scholar
• Motta, V., Angelici, L., Nordio, F., Bollati, V., Fossati, S., Frascati, F., Tinaglia, V., Bertazzi, P. A., Battaglia, C., and Baccarelli, A. A. 2013. Integrative analysis of miRNA and inflammatory gene expression after acute particulate matter exposure. Toxicol. Sci. 132: 307–316.
   PubMed Web of Science ®Google Scholar
• Nakashima, Y., Raines, E. W., Plump, A. S., Breslow, J. L., and Ross, R. 1998. Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arterioscler. Thromb. Vasc. Biol. 18: 842–851.
   PubMed Web of Science ®Google Scholar
• Nanfang, L., Yanying, G., Hongmei, W., Zhitao, Y., Juhong, Z., Ling, Z., and Wenli, L. 2010. Variations of six transmembrane epithelial antigen of prostate 4 (STEAP4) gene are associated with metabolic syndrome in a female Uygur general population. Arch. Med. Res. 41: 449–456.
   PubMed Web of Science ®Google Scholar
• Nascimento, L. F., and Francisco, J. B. 2013. Particulate matter and hospital admission due to arterial hypertension in a medium-sized Brazilian city. Cad. Saude Publica 29: 1565–1571.
   PubMed Web of Science ®Google Scholar
• Nasralla, M. M. 1983. Air pollution in the semitropical Saudi urban area. Environ. Int. 9: 225–264.
   Web of Science ®Google Scholar
• Nishiwaki, Y., Michikawa, T., Takebayashi, T., Nitta, H., Iso, H., Inoue, M., and Tsugane, S. 2013. Long-term exposure to particulate matter in relation to mortality and incidence of cardiovascular disease: The JPHC Study. J. Atheroscler. Thromb. 20:296–309.
   PubMed Web of Science ®Google Scholar
• Palmieri, V. O., Coppola, B., Grattagliano, I., Casieri, V., Cardinale, G., Portincasa, P., Palasciano, G., and Di Serio, F. 2013. Oxidized LDL receptor 1 gene polymorphism in patients with metabolic syndrome. Eur. J. Clin. Invest. 43: 41–48.
   PubMed Web of Science ®Google Scholar
• Pedersen, M., Giorgis-Allemand, L., Bernard, C., Aguilera, I., Andersen, A. M., Ballester, F., Beelen, R. M., Chatzi, L., Cirach, M., Danileviciute, A., Dedele, A., Eijsden, M., Estarlich, M., Fernandez-Somoano, A., Fernandez, M. F., Forastiere, F., Gehring, U., Grazuleviciene, R., Gruzieva, O., Heude, B., Hoek, G., de Hoogh, K., van den Hooven, E. H., Haberg, S. E., Jaddoe, V. W., Klumper, C., Korek, M., Kramer, U., Lerchundi, A., Lepeule, J., Nafstad, P., Nystad, W., Patelarou, E., Porta, D., Postma, D., Raaschou-Nielsen, O., Rudnai, P., Sunyer, J., Stephanou, E., Sorensen, M., Thiering, E., Tuffnell, D., Varro, M. J., Vrijkotte, T. G., Wijga, A., Wilhelm, M., Wright, J., Nieuwenhuijsen, M. J., Pershagen, G., Brunekreef, B., Kogevinas, M., and Slama, R. 2013. Ambient air pollution and low birthweight: A European cohort study (ESCAPE). Lancet Respir. Med. 1: 695–704.
   Google Scholar
• Rodriguez, S., Querol, X., Alastuey, A., Viana, M. M., Alarcon, M., Mantilla, E., and Ruiz, C. R. 2004. Comparative PM10-PM2.5 source contribution study at rural, urban and industrial sites during PM episodes in Eastern Spain. Sci. Total Environ. 328: 95–113.
   PubMed Web of Science ®Google Scholar
• Rosen, M. B., Thibodeaux, J. R., Wood, C. R., Zehr, R. D., Schmid, J. E., and Lau, C. 2007. Gene expression profiling in the lung and liver of PFOA-exposed mouse. fetuses. Toxicology 239: 15–33.
   PubMed Web of Science ®Google Scholar
• Rosenblum, M. G., and Donato, N. J. 1989. Tumor necrosis factor alpha: A multifaceted peptide hormone. Crit. Rev. Immunol. 9: 21–44.
   PubMed Web of Science ®Google Scholar
• Samet, J., and Krewski, D. 2007. Health effects associated with exposure to ambient air pollution. J. Toxicol. Environ. Health A 70: 227–242.
   PubMed Web of Science ®Google Scholar
• Scapini, P., Lapinet-Vera, J. A., Gasperini, S., Calzetti, F., Bazzoni, F., and Cassatella, M. A. 2000. The neutrophil as a cellular source of chemokines. Immunol. Rev. 177: 195–203.
   PubMed Web of Science ®Google Scholar
• Schivo, M., Aksenov, A. A., Yeates, L. C., Pasamontes, A., and Davis, C. E. 2013. Diabetes and the metabolic syndrome: Possibilities of a new breath test in a dolphin model. Front. Endocrinol. (Lausanne) 4.
   Google Scholar
• Simkhovich, B. Z., Kleinman, M. T., and Kloner, R. A. 2008. Air pollution and cardiovascular injury epidemiology, toxicology, and mechanisms. J. Am. Coll. Cardiol. 52: 719–726.
   PubMed Web of Science ®Google Scholar
• Smythe, G. K., Gentleman, S., Dudoit, R. I., and Huber, W. 2005. Limma: Linear models for microarray data. In Bioinformatics and computational biology solutions using R and Bioconductor, 397–420.
   Google Scholar
• Sun, H., Shamy, M., Kluz, T., Munoz, A. B., Zhong, M., Laulicht, F., Alghamdi, M. A., Khoder, M. I., Chen, L. C., and Costa, M. 2012. Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia. Toxicol. Appl. Pharmacol. 265: 147–157.
   PubMed Web of Science ®Google Scholar
• Sun, Q., Yue, P., Deiuliis, J. A., Lumeng, C. N., Kampfrath, T., Mikolaj, M. B., Cai, Y., Ostrowski, M. C., Lu, B., Parthasarathy, S., Brook, R. D., Moffatt-Bruce, S. D., Chen, L. C., and Rajagopalan, S. 2009. Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 119: 538–546.
   PubMed Web of Science ®Google Scholar
• Tagaris, E., Liao, K. J., DeLucia, A. J., Deck, L., Amar, P., and Russell, A. G. 2010. Sensitivity of air pollution-induced premature mortality to precursor emissions under the influence of climate change. Int. J. Environ. Res. Public Health 7: 2222–2237.
   PubMed Web of Science ®Google Scholar
• Thomson, E. M., Vladisavljevic, D., Mohottalage, S., Kumarathasan, P., and Vincent, R. 2013. Mapping acute systemic effects of inhaled particulate matter and ozone: multiorgan gene expression and glucocorticoid activity. Toxicol. Sci. 135: 169–181.
   PubMed Web of Science ®Google Scholar
• Uhlar, C. M., and Whitehead, A. S. 1999. Serum amyloid A, the major vertebrate acute-phase reactant. Eur. J. Biochem. 265: 501–523.
   PubMedGoogle Scholar
• Vigotti, M. A., Chiaverini, F., Biagiola, P., and Rossi, G. 2007. Urban air pollution and emergency visits for respiratory complaints in Pisa, Italy. J. Toxicol. Environ. Health A 70: 266–269.
   PubMed Web of Science ®Google Scholar
• Wente, W., Brenner, M. B., Zitzer, H., Gromada, J., and Efanov, A. M. 2007. Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells. Endocrinology 148: 1843–1849.
   PubMed Web of Science ®Google Scholar
• Xu, X., Liu, C., Xu, Z., Tzan, K., Zhong, M., Wang, A., Lippmann, M., Chen, L. C., Rajagopalan, S., and Sun, Q. 2011. Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue. Toxicol. Sci. 124: 88–98.
   PubMed Web of Science ®Google Scholar
• Yanagi, Y., Assuncao, J. V., and Barrozo, L. V. 2012. The impact of atmospheric particulate matter on cancer incidence and mortality in the city of Sao Paulo, Brazil. Cad. Saude Publica 28: 1737–1748.
   PubMed Web of Science ®Google Scholar
• Yatera, K., Hsieh, J., Hogg, J. C., Tranfield, E., Suzuki, H., Shih, C. H., Behzad, A. R., Vincent, R., and van Eeden, S. F. 2008. Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques. Am. J. Physiol. Heart Circ. Physiol. 294: H944–H953.
   PubMed Web of Science ®Google Scholar
• Yatkin, S., and Bayram, A. 2008. Source apportionment of PM(10) and PM(2.5) using positive matrix factorization and chemical mass balance in Izmir, Turkey. Sci. Total Environ. 390: 109–123.
   PubMed Web of Science ®Google Scholar
• Zhang, H. G., Zhou, T., Yang, P., Edwards, C. K. 3rd, Curiel, D. T., and Mountz, J. D. 1998. Inhibition of tumor necrosis factor alpha decreases inflammation and prolongs adenovirus gene expression in lung and liver. Hum. Gene Ther. 9: 1875–1884.
   PubMed Web of Science ®Google Scholar
• Zhang, Z., Chau, P. Y., Lai, H. K., and Wong, C. M. 2009. A review of effects of particulate matter-associated nickel and vanadium species on cardiovascular and respiratory systems. Int. J. Environ. Health Res. 19: 175–185.
   PubMed Web of Science ®Google Scholar