779
Views
83
CrossRef citations to date
0
Altmetric
Original Articles

Toxicity of Zinc Oxide Nanoparticles in Rats Treated by Two Different Routes: Single Intravenous Injection and Single Oral Administration

, , , , , , & show all
Pages 226-243 | Received 21 May 2014, Accepted 26 Jul 2014, Published online: 12 Feb 2015

REFERENCES

  • Adamcakova-Dodd, A., L. V. Stebounova, J. S. Kim, S. U. Vorrink, A. P. Ault, P. T. O’Shaughnessy, V. H. Grassian, and P. S. Thorne. 2014. Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models. Part. Fibre Toxicol. 11: 15.
  • Baek, M., H. E. Chung, J. Yu, J. A. Lee, T. H. Kim, J. M. Oh, W. J. Lee, S. M. Paek, J. K. Lee, J. Jeong, J. H. Choy, and S. J. Choi. 2012. Pharmacokinetics, tissue distribution, and excretion of zinc oxide nanoparticles. Int. J. Nanomed. 7: 3081–3097.
  • Baky, N. A., L. M. Faddah, N. M. Al-Rasheed, and A. J. Fatani. 2013. Induction of inflammation, DNA damage and apoptosis in rat heart after oral exposure to zinc oxide nanoparticles and the cardioprotective role of α-lipoic acid and vitamin E. Drug Res. (Stuttgart) 63: 228–236.
  • Boreiko, C. J. 2010. Overview of health risk assessments for zinc. J. Toxicol. Environ. Health A 73: 166–174.
  • Cho, W. S., B. C. Kang, J. K. Lee, J. Jeong, J. H. Che, and S. H. Seok. 2013. Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration. Part. Fibre Toxicol. 10: 9.
  • Demir, E., A. Creus, and R. Marcos. 2014. Genotoxicity and DNA repair processes of zinc oxide nanoparticles. J. Toxicol. Environ. Health A 77: 1292–1303.
  • Esmaeillou, M., M. Moharamnejad, R. Hsankhani, A. A. Tehrani, and H. Maadi. 2013. Toxicity of ZnO nanoparticles in healthy adult mice. Environ. Toxicol. Pharmacol. 35: 67–71.
  • Hackenberg, S., and N. Kleinsasser. 2012. Dermal toxicity of ZnO nanoparticles: A worrying feature of sunscreen? Nanomedicine London) 7: 461–463.
  • Heng, B. C., X. Zhao, S. Xiong, K. W. Ng, F. W. Boey, and J. S. Loo. 2010. Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stress. Food Chem. Toxicol. 48: 1762–1766.
  • Ho, M., K. Y. Wu, H. M. Chein, L. C. Chen, and T. J. Cheng. 2011. Pulmonary toxicity of inhaled nanoscale and fine zinc oxide particles: Mass and surface area as an exposure metric. Inhal. Toxicol. 23: 947–956.
  • Kao, Y. Y., T. J. Cheng, D. M. Yang, C. T. Wang, Y. M. Chiung, and P. S. Liu. 2012. Demonstration of an olfactory bulb-brain translocation pathway for ZnO nanoparticles in rodent cells in vitro and in vivo. J. Mol. Neurosci. 48:464–471.
  • Li, C.H., C. C. Shen, Y. W. Cheng, S. H. Huang, C. C. Wu, C. C. Kao, J. W. Liao, and J. J. Kang. 2012. Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice. Nanotoxicology 6: 746–756.
  • Ludi, B., and M. Niederberger. 2013. Zinc oxide nanoparticles: Chemical mechanisms and classical and non-classical crystallization. Dalton Trans. 42: 12554–12568.
  • Ma, H., P. L. Williams, and S. A. Diamond. 2013. Ecotoxicity of manufactured ZnO nanoparticles—A review. Environ. Pollut. 172: 76–85.
  • Nohynek, G. J., and E. K. Dufour. 2012. Nano-sized cosmetic formulations or solid nanoparticles in sunscreens: A risk to human health? Arch. Toxicol. 86: 1063–1075.
  • Osmond, M. J., and M. J. McCall. 2010. Zinc oxide nanoparticles in modern sunscreens: An analysis of potential exposure and hazard. Nanotoxicology 4: 15–41.
  • Paek, H. J., Y. J. Lee, H. E. Chung, N. H. Yoo, J. A. Lee, M. K. Kim, J. K. Lee, J. Jeong, and S. J. Choi. 2013. Modulation of the pharmacokinetics of zinc oxide nanoparticles and their fates in vivo. Nanoscale 5: 11416–11427.
  • Park, K., and Y. Lee. 2013. The stability of citrate-capped silver nanoparticles in isotonic glucose solutioin for intravenous injection. J. Environ. Toxicol. Health A 76: 1236–1245.
  • Pasupuleti, S., S. Alapati, S. Ganapathy, G. Anumolu, N. R. Pully, and B. M. Prakhya. 2012. Toxicity of zinc oxide nanoparticles through oral route. Toxicol. Ind. Health 28: 675–686.
  • Patra, P., S. Mitra, N. Debnath, and A. Goswami. 2012. Biochemical-, biophysical-, and microarray-based antifungal evaluation of the buffer-mediated synthesized nano zinc oxide: An in vivo and in vitro toxicity study. Langmuir 28: 16966–16978.
  • Reed, R.B., D. A. Ladner, C. P. Higgins, P. Westerhoff, and J. F. Ranville. 2012. Solubility of nano-zinc oxide in environmentally and biologically important matrices. Environ. Toxicol. Chem. 31: 93–99.
  • Roy, R., A. Tripathi, M. Das, and P. D. Dwivedi. 2011. Cytotoxicity and uptake of zinc oxide nanoparticles leading to enhanced inflammatory cytokines levels in murine macrophages: Comparison with bulk zinc oxide. J. Biomed. Nanotechnol. 7: 110–111.
  • Sahu, D. L., G. M. Kannan, and R. Vijayaraghavan. 2014. Size-dependent effect of zinc oxide on toxicity and inflammatory potential of human monocytes. J. Toxicol. Environ. Health A 77: 177–191.
  • Seok, S. H., W. S. Cho, J. S. Park, Y. Na, A. Jang, H. Kim, Y. Cho, T. Kim, J. R. You, S. Ko, B. C. Kang, J. K. Lee, J. Jeong, and J. H. Che. 2013. Rat pancreatitis produced by 13-week administration of zinc oxide nanoparticles: Biopersistence of nanoparticles and possible solutions. J. Appl. Toxicol. 33: 1089–1096.
  • Sharma, V., S. K. Singh, D. Anderson, D. J. Tobin, and A. Dhawan. 2011a. Zinc oxide nanoparticle induced genotoxicity in primary human epidermal keratinocytes. J. Nanosci. Nanotechnol. 11: 3782–3788.
  • Sharma, V., D. Anderson, and A. Dhawan. 2011b. Zinc oxide nanoparticles induce oxidative stress and genotoxicity in human liver cells (HepG2). J. Biomed. Nanotechnol. 7: 98–99.
  • Sharma, V., P. Singh, A. K. Pandey, and A. Dhawan. 2012. Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles. Mutat. Res. 745: 84–91.
  • Song, W., J. Zhang, J. Guo, J. Zhang, F. Ding, L. Li, and Z. Sun. 2010. Role of the dissolved zinc ion and reactive oxygen species in cytotoxicity of ZnO nanoparticles. Toxicol. Lett. 199: 389–397.
  • Surekha, P., A. S. Kishore, A. Srinivas, G. Selvam, A. Goparaju, P. N. Reddy, and P. B. Murthy. 2012. Repeated dose dermal toxicity study of nano zinc oxide with Sprague-Dawley rats. Cutan. Ocul. Toxicol. 31: 26–32.
  • Umrani, R. D., and K. M. Paknikar. 2014. Zinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Types-1 and 2 diabetic rats. Nanomedicine (London) 9: 89–104.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.