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Original Articles

Effects of Testosterone Treatment on Synaptic Plasticity and Behavior in Senescence Accelerated Mice

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REFERENCES

  • Carafoli, E., Santella, L., Branca, D., and Brini, M. 2001. Generation, control, and processing of cellular calcium signals. Crit. Rev. Biochem. Mol. Biol. 36: 107–260.
  • Cherrier, M.M., Asthana, S., Plymate, S., Baker, L., Matsumoto, A.M., Peskind, E., Raskind, M.A., Brodkin, K., Bremner, W., Petrova, A., LaTendresse, S., and Craft, S. 2001. Testosterone supplementation improves spatial and verbal memory in healthy older men. Neurology 57: 80–88.
  • Choi, J., Silverman, I. 2002. The relationship between testosterone and route-learning strategies in humans. Brain Cognition 50: 116–120.
  • Chrivia, J. C., Kwok, R. P., Lamb, N., Hagiwara, M., Montminy, M. R., and Goodman, R. H. 1993. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365: 855–859.
  • De Felice, F. G., Velasco, P. T., Lambert, M. P., Viola, K., Fernandez, S. J., Ferreira, S. T., and Klein, W. L. 2007. A-beta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J. Biol. Chem. 282: 11590–11601.
  • Driscoll, I., Hamilton, D. A., Yeo, R. A., Brooks, W. M., and Sutherland, R. J. 2005. Virtual navigation in humans: the impact of age, sex, and hormones on place learning. Horm. Behav. 47: 326–335.
  • Edinger, K. L., and Frye, C. A. 2004. Testosterone’s analgesic, anxiolytic, and cognitive enhancing effects may be due in part to actions of its 5a-reduced metabolites in the hippocampus. Behav. Neurosci. 118: 1352–1364.
  • Enslen, H., Sun, P., Brickey, D., Soderling, S. H., Klamo, E., and Soderling, T. R. 1994. Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation. J. Biol. Chem. 269: 15520–15527.
  • Frye, C. A., Edinger, K. L., Seliga, A. M., and Wawrzycki, J. M. 2004. 5-Alpha-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats. Psychoneuroendocrinology 29: 1019–1027.
  • Gittins, R., and Harrison, P. J. 2004. Neuronal density, size and shape in the human anterior cingulate cortex: A comparison of Nissl and NeuN staining. Brain Res. Bull. 63: 155–160.
  • Hardingham, G. E., Chawla, S., Johnson, C. M., and Bading, H. 1997. Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature 385: 260–265.
  • Holland, J., Bandelow, S., and Hogervorst, E. 2011. Testosterone levels and cognition in elderly men: A review. Maturitas 69: 322–337.
  • Janz, R., Siidhof, T. C., Hammer, R. E., Unni, V., Siegelbaum, S. A., and Bolshakov, V. Y. 1999. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron 24: 687–700.
  • Jia, J. X., Kang, L., Li, S., Geng, D. D., Fan, P., Wang, L., and Cui, H. X. 2013. Amelioratory effects of testosterone treatment on cognitive performance deficits induced by soluble Aβ1–42 oligomers injected into the hippocampus. Horm. Behav. 64: 477–486.
  • Kerr, J. E., Allore, R. J., Beck, S. G., and Handa, R. J. 1995. Distribution of hormonal regulation of androgen receptor (AR) and AR messenger ribonucleic acid in the rat hippocampus. Endocrinology 136: 3213–3221.
  • Lacor, P. N., Buniel, M. C., Furlow, P. W., Clemente, A. S., Velasco, P. T., Wood, M., Viola, K. L., and Klein, W. L. 2007. A-beta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer’s disease. J. Neurosci. 27: 796–807.
  • Lau, C. G., and Zukin, R. S. 2007. NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat. Rev. Neurosci. 8: 413–426.
  • Leranth, C., Prange-Kiel, J., Frick, K. M., and Horvath, T. L. 2004. Low CA1 spine synapse density is further reduced by castration in male non-human primates. Cereb. Cortex 14: 503–510.
  • Leranth, C., Petnehazy, O., and MacLusky, N. J. 2003. Gonadal hormones affect spine synaptic density in the CA1 hippocampal subfield of male rats. J. Neurosci. 23: 1588–1592.
  • Liu, L., Orozco, I. J., Planel, E., Wen, Y., Bretteville, A., Krishnamurthy, P., Wang, L., Herman, M., Figueroa, H., Yu, W. H., Arancio, O., and Duff, K. 2008. A transgenic rat that develops Alzheimer’s disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment. Neurobiol. Dis. 31: 46–57.
  • Lonze, B. E., Riccio, A., Cohen, S., and Ginty, D. D. 2002. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron 34: 371–385.
  • Mantamadiotis, T., Lemberger, T., Bleckmann, S.C., Kern, H., Kretz, O., Martin Villalba, A., Tronche, F., Kellendonk, C., Gau, D., Kapfhammer, J., Otto, C., Schmid, W., and Schütz, G. 2002. Disruption of CREB function in brain leads to neurodegeneration. Nat. Genet. 31: 47–54.
  • Marron, T. U., Guerini, V., Rusmini, P., Sau, D., Brevini, T. A., Martini, L., and Poletti, A. 2005. Androgen-induced neurite outgrowth is mediated by neuritin in motor neurones. J. Neurochem. 92: 10–20.
  • Mayr, B., and Montminy, M. 2001. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell. Biol. 2: 599–609.
  • Milner, B., Squire, L. R., and Kandel, E. R. 1998. Cognitive neuroscience and the study of memory. Neuron 20: 445–468.
  • Morley, J.E., Farr, S.A., Kumar, V.B., and Armbrecht, H. J. 2012. The SAMP8 mouse: A model to develop therapeutic interventions for Alzheimer’s disease. Curr. Pharm. Design 18:1123–1130.
  • Mukai, H., Kimoto, T., Hojo, Y., Kawato, S., Murakami, G., Higo, S., Hatanaka, Y., and Ogiue-Ikeda, M. 2010. Modulation of synaptic plasticity by brain estrogen in the hippocampus. Biochim. Biophys. Acta 1800: 1030–1044.
  • Naghdi, N., Nafisy, N., and Majlessi, N. 2001. The effects of intrahippocampal testosterone and flutamide on spatial localization in the Morris water maze. Brain Res. 897: 44–51.
  • Nunez, J. L., Jurgens, H. A., and Juraska, J. M. 2000. Androgens reduce cell death in the developing rat visual cortex. Dev. Brain Res. 125: 83–88.
  • Parameshwaran, K., Dhanasekaran, M., and Suppiramaniam, V. 2008. Amyloid beta peptides and glutamatergic synaptic dysregulation. Exp. Neurol. 210: 7–13.
  • Perez-Otano, I., and Ehlers, M. D. 2005. Homeostatic plasticity and NMDA receptor trafficking. Trends Neurosci. 28: 229–238.
  • Pike, C. J., Rosario, E. R., and Nguyen, T. V. 2006. Androgens, aging, and Alzheimer’s disease. Endocrine 29: 233–241.
  • Pyter, L. M., Trainor, B. C., and Nelson, R. J. 2006. Testosterone and photoperiod interact to affect spatial learning and memory in adult male white-footed mice (Peromyscus leucopus). Eur. J. Neurosci. 23: 3056–3062.
  • Sandstrom, N. J., Kim, J. H., and Wasserman, M. A 2006. Testosterone modulates performance on a spatial working memory task in male rats. Horm. Behav. 50: 18–26.
  • Sonmez, A., Sayın, O., Gurgen, S. G., and Calisir, M. 2015. Neuroprotective effects of MK-801 against traumatic brain injury in immature rats. Neurosci. Lett. 597: 137–142.
  • Spritzer, M. D., Daviau, E. D., Coneeny, M. K., Engelman, S. M., Prince, W. T., and Rodriguez-Wisdom, K. N. 2011. Effects of testosterone on spatial learning and memory in adult male rats. Horm. Behav. 59: 484–496.
  • Spritzer, M. D., and Galea, L. 2007. Testosterone and dihydrotestosterone, but not estradiol, enhance survival of new hippocampal neurons in adult male rats. Dev. Neurobiol. 67: 1321–1333.
  • Zu, H., Wu, J. Zhang, J., Yu, M., and Hong, Z. 2012. Testosterone up-regulates seladin-1 expression by iAR and PI3-K/Akt signaling pathway in C6 cells. Neurosci. Lett. 514: 122–126.

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