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Original Articles

Involvement of superoxide in malaoxon-induced toxicity in primary cultures of cortical neurons

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References

  • Alvanja, M. C. R., and M. R. Bonner. 2012. Occupational pesticide exposures and cancer risk: A review. J. Toxicol. Environ. Health B 15:238–263. doi:10.1080/10937404.2012.632358.
  • Angoa-Pérez, M., C. W. Kreipke, D. M. Thomas, K. E. Van Shura, M. Lyman, J. H. McDonough, and D. M. Kuhn. 2010. Soman increases neuronal COX-2 levels: Possible link between seizures and protracted neuronal damage. Neurotoxicol. 31:738–746. doi:10.1016/j.neuro.2010.06.007.
  • Argentin, G., M. Divizia, and R. Cicchetti. 2015. Oxidative stress, cytotoxicity, and genotoxicity induced by methyl parathion in human gingival fibroblasts: Protective role of epigallocatechin-3-gallate. J. Toxicol. Environ. Health Part A 78:1227–1240. doi:10.1080/15287394.2015.1079582.
  • Assini, F. L., K. D. Zanette, P. S. Brocardo, P. Pandolfo, A. L. S. Rodrigues, and R. N. Takahashi. 2005. Behavioral effects and ChE measures after acute and repeated administration of malathion in rats. Environ. Toxicol. Pharmacol. 20:443–449. doi:10.1016/j.etap.2005.05.007.
  • Bajgar, J. 2004. Organophosphates/nerve agent poisoning: Mechanism of action, diagnosis, prophylaxis, and treatment. Adv. Clin. Chem. 38:151–216.
  • Bindokas, V. P., J. Jordán, C. C. Lee, and R. J. Miller. 1996. Superoxide production in rat hippocampal neurons: Selective imaging with hydroethidine. J. Neurosci. 16:1324–1336.
  • Briz, V., M. Galofré, and C. Suñol. 2010. Reduction of glutamatergic neurotransmission by prolonged exposure to dieldrin involves NMDA receptor internalization and metabotropic glutamate receptor 5 downregulation. Toxicol. Sci. 113:138–149. doi:10.1093/toxsci/kfp244.
  • Brocardo, P. S., P. Pandolfo, R. N. Takahashi, A. L. S. Rodrigues, and A. L. Dafre. 2005. Antioxidant defenses and lipid peroxidation in the cerebral cortex and hippocampus following acute exposure to malathion and/or zinc chloride. Toxicol. 207:283–291. doi:10.1016/j.tox.2004.09.012.
  • Brown, M. A., and K. A. Brix. 1998. Review of health consequences from high-, intermediate- and low-level exposure to organophosphorus nerve agents. J. Appl. Toxicol 18:393–408. doi:10.1002/(ISSN)1099-1263.
  • Buratti, F. M., C. Leoni, and E. Testai. 2006. Foetal and adult human CYP3A isoforms in the bioactivation of organophosphorothionate insecticides. Toxicol. Lett. 167:245–255. doi:10.1016/j.toxlet.2006.10.006.
  • Burns, C. J., L. J. McIntosh, P. J. Mink, A. M. Jurek, and A. A. Li. 2013. Pesticide exposure and neurodevelopmental outcomes: Review of the epidemiologic and animal studies. J. Toxicol. Environ. Health B 16:127–283. doi:10.1080/10937404.2013.783383.
  • Chen, Y. 2012. Organophosphate-induced brain damage: Mechanisms, neuropsychiatric and neurological consequences, and potential therapeutic strategies. Neurotoxicol. 33:391–400. doi:10.1016/j.neuro.2012.03.011.
  • Chuang, C.-S., H.-L. Su, C.-L. Lin, and C.-H. Kao. 2016. Risk of Parkinson disease after organophosphate or carbamate poisoning. Acta Neurol. Scand. doi:10.1111/ane.12707.
  • Costa, L. G. 2006. Current issues in organophosphate toxicology. Clin. Chim. Acta Int. J. Clin. Chem. 366:1–13. doi:10.1016/j.cca.2005.10.008.
  • De Felice, A., A. Greco, G. Calamandrei, and L. Minghetti. 2016. Prenatal exposure to the organophosphate insecticide chlorpyrifos enhances brain oxidative stress and prostaglandin E2 synthesis in a mouse model of idiopathic autism. J. Neuroinflammation 13:149. doi:10.1186/s12974-016-0617-4.
  • Dos Santos, A. A., A. A. Naime, J. De Oliveira, D. Colle, D. B. Dos Santos, M. A. Hort, E. L. G. Moreira, C. Suñol, A. F. De Bem, and M. Farina. 2016. Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: Evidence of hippocampal mitochondrial dysfunction, astrogliosis and apoptotic events. Arch. Toxicol. 90:647–660. doi:10.1007/s00204-015-1466-0.
  • El-Ebiary, A. A., R. E. Elsharkawy, N. A. Soliman, M. A. Soliman, and A. A. Hashem. 2016. N-acetylcysteine in acute organophosphorus pesticide poisoning: A randomized, clinical trial. Basic Clin. Pharmacol. Toxicol. 119:222–227. doi:10.1111/bcpt.2016.119.issue-2.
  • Ellman, G. L., K. D. Courtney, V. Andres, and R. M. Feather-Stone. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:88–95. doi:10.1016/0006-2952(61)90145-9.
  • Ferguson, K. K., M. S. O’Neill, and J. D. Meeker. 2013. Environmental contaminant exposures and preterm birth: A comprehensive review. J. Toxicol. Environ. Health B 16:69–113. doi:10.1080/10937404.2013.775048.
  • Gultekin, F., M. Ozturk, and M. Akdogan. 2000. The effect of organophosphate insecticide chlorpyrifos-ethyl on lipid peroxidation and antioxidant enzymes (in vitro). Arch. Toxicol. 74:533–538. doi:10.1007/s002040000167.
  • Gupta, J., C. Datta, A. Sarkar, and D. Sengupta. 1992. Effect of malathion on antioxidant defence system in human fetus–an in vitro study. Indian J. Exp. Biol. 30:352–354.
  • Jamal, G. A., S. Hansen, and P. O. O. Julu. 2002. Low level exposures to organophosphorus esters may cause neurotoxicity. Toxicol. 181–182:23–33. doi:10.1016/S0300-483X(02)00447-X.
  • Johnson, M. K., D. Jacobsen, T. J. Meredith, P. Eyer, A. J. Heath, D. A. Ligtenstein, T. C. Marrs, L. Szinicz, J. A. Vale, and J. A. Haines. 2000. Evaluation of antidotes for poisoning by organophosphorus pesticides. Emerg. Med. 12:22–37. doi:10.1046/j.1442-2026.2000.00087.x.
  • Kalender, S., F. G. Uzun, D. Durak, F. Demir, and Y. Kalender. 2010. Malathion-induced hepatotoxicity in rats: The effects of vitamins C and E. Food Chem. Toxicol. 48:633–638. doi:10.1016/j.fct.2009.11.044.
  • Kwong, T. C. 2002. Organophosphate pesticides: Biochemistry and clinical toxicology. Ther. Drug Monit. 24:144–149. doi:10.1097/00007691-200202000-00022.
  • LaVerda, N. L., D. F. Goldsmith, M. C. Alavanja, and K. L. Hunting. 2015. Pesticide exposures and body mass index (BMI) of pesticide applicators from the Agricultural Health Study. J. Toxicol. Environ. Health Part A 78:1255–1276. doi:10.1080/15287394.2015.1074844.
  • Li, D., Q. Huang, M. Lu, L. Zhang, Z. Yang, M. Zong, and L. Tao. 2015. The organophosphate insecticide chlorpyrifos confers its genotoxic effects by inducing DNA damage and cell apoptosis. Chemosphere 135:387–393. doi:10.1016/j.chemosphere.2015.05.024.
  • Maroni, M., C. Colosio, A. Ferioli, and A. Fait. 2000. Biological monitoring of pesticide exposure: A review. Introduction. Toxicol. 143:1–118.
  • Mishra, V., and N. Srivastava. 2015. Organophosphate pesticides-induced changes in the redox status of rat tissues and protective effects of antioxidant vitamins. Environ. Toxicol. 30:472–482. doi:10.1002/tox.v30.4.
  • Moore, P. D., C. G. Yedjou, and P. B. Tchounwou. 2010. Malathion-induced oxidative stress, cytotoxicity, and genotoxicity in human liver carcinoma (HepG2) cells. Environ. Toxicol. 25:221–226. doi:10.1002/tox.20492.
  • Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Meth. 65:55–63. doi:10.1016/0022-1759(83)90303-4.
  • Muñoz-Quezada, M. T., B. A. Lucero, V. P. Iglesias, M. P. Muñoz, C. A. Cornejo, E. Achu, B. Baumert, A. Hanchey, C. Concha, A. M. Brito, and M. Villalobos. 2016. Chronic exposure to organophosphate (OP) pesticides and neuropsychological functioning in farm workers: A review. Int. J. Occup. Environ. Health 22:68–79. doi:10.1080/10773525.2015.1123848.
  • Nagaraju, R., A. K. R. Joshi, and P. S. Rajini. 2015. Organophosphorus insecticide, monocrotophos, possesses the propensity to induce insulin resistance in rats on chronic exposure. J. Diabetes 7:47–59. doi:10.1111/1753-0407.12158.
  • Narra, M. R. 2017. Haematological and immune upshots in Clarias batrachus exposed to dimethoate and defying response of dietary ascorbic acid. Chemosphere 168:988–995. doi:10.1016/j.chemosphere.2016.10.112.
  • Narra, M. R., K. Rajender, R. Rudra Reddy, J. V. Rao, and G. Begum. 2015. The role of vitamin C as antioxidant in protection of biochemical and haematological stress induced by chlorpyrifos in freshwater fish Clarias batrachus. Chemosphere 132:172–178. doi:10.1016/j.chemosphere.2015.03.006.
  • Ojha, A., S. K. Yaduvanshi, S. C. Pant, V. Lomash, and N. Srivastava. 2013. Evaluation of DNA damage and cytotoxicity induced by three commonly used organophosphate pesticides individually and in mixture, in rat tissues. Environ. Toxicol. 28:543–552. doi:10.1002/tox.v28.10.
  • Paul, K. C., J. S. Sinsheimer, S. L. Rhodes, M. Cockburn, J. Bronstein, and B. Ritz. 2016. Organophosphate pesticide exposures, nitric oxide synthase gene variants, and gene-pesticide interactions in a case-control study of Parkinson’s disease, California (USA). Environ. Health Persp 124:570–577.
  • Pope, C. N. 1999. Organophosphorus pesticides: Do they all have the same mechanism of toxicity? J. Toxicol. Environ. Health B 2:161–182. doi:10.1080/109374099281205.
  • Regueiro, J., N. Olguín, J. Simal-Gándara, and C. Suñol. 2015. Toxicity evaluation of new agricultural fungicides in primary cultured cortical neurons. Environ. Res. 140:37–44. doi:10.1016/j.envres.2015.03.013.
  • Rinsky, J. L., J. A. Hoppin, A. Blair, K. He, L. E. Beane Freeman, and H. Chen. 2013. Agricultural exposures and stroke mortality in the Agricultural Health Study. J. Toxicol. Environ. Health Part A 76:798–814. doi:10.1080/15287394.2013.819308.
  • Rohlman, D. S., W. K. Anger, and P. J. Lein. 2011. Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure. Neurotoxicol. 32:268–276. doi:10.1016/j.neuro.2010.12.008.
  • Rosenstock, L., M. Keifer, W. E. Daniell, R. McConnell, and K. Claypoole. 1991. Chronic central nervous system effects of acute organophosphate pesticide intoxication. The Pesticide Health Effects Study Group. Lancet 338:223–227. doi:10.1016/0140-6736(91)90356-T.
  • Sánchez-Santed, F., M. T. Colomina, and E. Herrero Hernández. 2016. Organophosphate pesticide exposure and neurodegeneration. Cortex J. Devoted Study Nerv. Syst. Behav 74:417–426. doi:10.1016/j.cortex.2015.10.003.
  • Santos, D. B., K. C. Peres, R. P. Ribeiro, D. Colle, A. A. Dos Santos, E. L. G. Moreira, D. O. G. Souza, C. P. Figueiredo, and M. Farina. 2012. Probucol, a lipid-lowering drug, prevents cognitive and hippocampal synaptic impairments induced by amyloid β peptide in mice. Exp. Neurol. 233:767–775. doi:10.1016/j.expneurol.2011.11.036.
  • Savage, E. P., T. J. Keefe, L. M. Mounce, R. K. Heaton, J. A. Lewis, and P. J. Burcar. 1988. Chronic neurological sequelae of acute organophosphate pesticide poisoning. Arch. Environ. Health 43:38–45. doi:10.1080/00039896.1988.9934372.
  • Singh, S., and N. Sharma. 2000. Neurological syndromes following organophosphate poisoning. Neurol. India 48:308–313.
  • Singh, V., and R. Panwar. 2014. In vivo antioxidative and neuroprotective effect of 4-Allyl-2-methoxyphenol against chlorpyrifos-induced neurotoxicity in rat brain. Mol. Cell. Biochem. 388:61–74. doi:10.1007/s11010-013-1899-9.
  • Solà, C. R., C. Suñol, and C. Sanfeliu. 2011. Primary cultures for neurotoxicity testing. In Cell culture techniques, eds M. Aschner, C. Suñol, and A. Bal-Price, 87–103. Humana Press, New York.
  • Stephens, R., A. Spurgeon, I. A. Calvert, J. Beach, L. S. Levy, H. Berry, and J. M. Harrington. 1995. Neuropsychological effects of long-term exposure to organophosphates in sheep dip. Lancet 345:1135–1139. doi:10.1016/S0140-6736(95)90976-1.
  • Taherdehi, F. G., M. R. Nikravesh, M. Jalali, and A. Fazel. 2016. Evaluating the protective effects of vitamin C on serum and erythrocyte cholinesterase activity of male rats exposed to malathion. Electron. Physician 8:2633–2638. doi:10.19082/2633.
  • Takahashi, N., and M. Hashizume. 2014. A systematic review of the influence of occupational organophosphate pesticides exposure on neurological impairment. Br Med J Open 4:e004798.
  • Terry, A. V. 2012. Functional consequences of repeated organophosphate exposure: Potential non-cholinergic mechanisms. Pharmacol. Ther. 134:355–365. doi:10.1016/j.pharmthera.2012.03.001.
  • Trevisan, R., M. Uliano-Silva, P. Pandolfo, J. L. Franco, P. S. Brocardo, A. R. S. Santos, M. Farina, A. L. S. Rodrigues, R. N. Takahashi, and A. L. Dafre. 2008. Antioxidant and acetylcholinesterase response to repeated malathion exposure in rat cerebral cortex and hippocampus. Basic Clin. Pharmacol. Toxicol. 102:365–369. doi:10.1111/j.1742-7843.2007.00182.x.
  • Varol, S., S. K. Başarslan, U. Fırat, H. Alp, E. Uzar, A. Arıkanoğlu, O. Evliyaoğlu, A. Acar, Y. Yücel, E. Kıbrıslı, and O. Gökalp. 2015. Detection of borderline dosage of malathion intoxication in a rat’s brain. Eur. Rev. Med. Pharmacol. Sci. 19:2318–2323.
  • Verma, R. S., A. Mehta, and N. Srivastava. 2009. Comparative studies on chlorpyrifos and methyl parathion induced oxidative stress in different parts of rat brain: Attenuation by antioxidant vitamins. Pest. Biochem. Physiol. 95:152–158. doi:10.1016/j.pestbp.2009.08.004.
  • Worek, F., H. Thiermann, and T. Wille. 2016. Oximes in organophosphate poisoning: 60 years of hope and despair. Chem. Biol. Interact. 259:93–98. doi:10.1016/j.cbi.2016.04.032.

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