Protective action of Omega-3 on paraquat intoxication in Drosophila melanogaster

References

• Aguiar, L. M., F. H. Figueira, M. S. Gottschalk, and C. E. Rosa. 2016. Glyphosate-based herbicide exposure causes antioxidant defenceresponses in the fruit fly Drosophila melanogaster. Comp. Biochem. Physiol. Part. C 185-186:94–101.
   PubMed Web of Science ®Google Scholar
• Alaraby, M., B. Annangi, R. Marcos, and A. Hernández. 2016. Drosophila melanogaster as a suitable in vivo model to determine potential side effects of nanomaterials: A review. J. Toxicol. Environ. Health. B 19:65–104. doi:10.1080/10937404.2016.1166466.
   PubMed Web of Science ®Google Scholar
• Alcaro, S., R. Arcone, I. Vecchio, F. Ortuso, A. Gallelli, R. Pasceri, A. Procopio, and M. Iannone. 2007. Molecular modelling and enzymatic studies of acetylcholinesterase and butyrylcholinesterase recognition with paraquat and related compounds. SAR QSAR Environ. Res. 18:595–602. doi:10.1080/10629360701428433.
   PubMed Web of Science ®Google Scholar
• Aldunate, R., J. C. Casar, E. Brandan, and N. C. Inestrosa. 2004. Structural and functional organization of synaptic acetylcholinesterase. Brain Res. Rev. 47:96–104. doi:10.1016/j.brainresrev.2004.07.019.
   PubMedGoogle Scholar
• Arsenault, D., C. Julien, C. Tremblay, and F. Calon. 2011. DHA improves cognition and prevents dysfunction of entorhinal córtex neurons in 3xTg-AD mice. PLoS One 6:e17397.
   PubMed Web of Science ®Google Scholar
• Baggio, F., A. Bratic, A. Mourier, T. E. S. Kauppila, L. S. Tain, C. Kukat, B. Habermann, L. Partridge, and N. G. Larsson. 2014. Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation. Nucleic Acids Res. 42:13920–13938.
   PubMed Web of Science ®Google Scholar
• Baker, M. J., T. Tatsuta, and T. Langer. 2011. Quality control of mitochondrial proteostasis. Cold Spring Harbor Perpect Biol. 3:a007559.
   PubMed Web of Science ®Google Scholar
• Baltazar, M. T., R. J. D. Oliveira, M. L. Bastos, A. M. Tsatsakis, J. A. Duarte, and F. Carvalho. 2014. Pesticides exposure as etiological factors of Parkinson’s disease and other neurodegenerative diseases - A mechanistic approach. Toxicol. Lett. 230:85–103.
   PubMed Web of Science ®Google Scholar
• Blanco-Ayala, T. B., A. C. A. Romero, and J. P. Chaverri. 2014. New insights into antioxidant strategies against paraquat toxicity. Free Radic. Res. 48:623–640.
   PubMed Web of Science ®Google Scholar
• Bosco, G., M. Clamer, E. Messulam, C. Dare, Z. Yang, M. Zordan, C. Reggiani, Q. Hu, and A. Megighian. 2015. Effects of oxygen concentration and pressure on Drosophila melanogaster: oxidative stress, mitochondrial activity, and survivorship. Arch. Insect Biochem. Physiol. 88:222–234.
   PubMed Web of Science ®Google Scholar
• Bunkar, N., A. Bhargave, N. K. Khare, and P. K. Mishra. 2016. Mitochondrial anomalies: driver to age associated degenerative human ailments. Front. Biosci. 21:769–793.
   Web of Science ®Google Scholar
• Busquets-Cortés, C., X. Capó, M. Martorell, J. A. Tur, A. Sureda, and A. Pons. 2016. Training enhances imune cells mitochondrial biosynthesis, fission, fusion, and their antioxidante capabilities synergistically with dietary docosahexaenoic supplementation. Oxid. Med. Cell Longev. 2016:8950384.
   PubMed Web of Science ®Google Scholar
• Calder, P. C., and P. Yaqoob. 2009. Understanding omega-3 polyunsaturated fatty acids. Postgrad. Med. 121:148–157.
   PubMed Web of Science ®Google Scholar
• Calon, F., G. P. Lim, F. Yang, T. Morihara, B. Teter, O. Ubeda, P. Rostaing, A. Triller, N. Salem, Jr., K. H. Ashe, S. A. Frautschy, and G. M. Cole. 2004. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer’s disease mouse model. Neuron 43:633–645.
   PubMed Web of Science ®Google Scholar
• Casey, S. C., M. Vaccari, F. Al-Mulla, R. Al-Temaimi, A. Amedei, M. H. Barcellos-Hoff, D. G. Brown, M. Chapellier, J. Christopher, C. S. Curran, S. Forte, R. A. Hamid, P. Heneberg, D. C. Koch, P. K. Krishnakumar, E. Laconi, V. Maguer-Satta, F. Marongiu, L. Memeo, C. Mondello, J. Raju, J. Roman, R. Roy, E. P. Ryan, S. Ryeom, H. K. Salem, A. I. Scovassi, N. Singh, L. Soucek, L. Vermeulen, J. R. Whitfield, J. Woodrick, A. M. Colacci, W. H. Bisson, and D. W. Felsher. 2015. The effect of environmental chemicals on the tumor microenvironment. Carcinogenesis 36:S160–183.
   PubMed Web of Science ®Google Scholar
• Chakraborty, R., V. Vepuri, S. D. Mhatre, B. E. Paddock, S. Miller, S. J. Michelson, R. Delvadia, A. Desai, M. Vinokur, D. J. Melicharek, S. Utreja, P. Khandelwal, S. Ansaloni, L. E. Goldstein, R. D. Moir, J. C. Lee, L. P. Tabb, A. J. Saunders, and D. R. Marenda. 2011. Characterization of a Drosophila Alzheimer’s disease model: pharmacological rescue of cognitive defects. PLoS One 6:e20799.
   PubMed Web of Science ®Google Scholar
• Chambers, D. B., A. Androschuk, C. Rosenfelt, S. Langer, M. Harding, and F. V. Bolduc. 2015. Insulin signaling is acutely required for long-term memory in Drosophila. Front Neural Circuits 9:1–7.
   PubMed Web of Science ®Google Scholar
• Chan, F., N. Z. Lax, C. H. Davies, D. M. Turnbull, and M. O. Cunningham. 2015. Neuronal oscillations: A physiological correlate for targeting mitochondrial dysfunction in neurodegenerative disease? Neuropharmacology 102:48–58.
   PubMed Web of Science ®Google Scholar
• Chinnery, P. F. 2015. Mitochondrial disease in adults: what’s old and what’s new? EMBO Mol. Med. 7:1503–1512.
   PubMed Web of Science ®Google Scholar
• Cho, J., J. H. Hur, and D. W. Walker. 2011. The role of mitochondria in Drosophila aging. Exp. Gerontol. 46:331–334.
   PubMed Web of Science ®Google Scholar
• Cochemé, H. M., and M. P. Murphy. 2008. Complex I is the major site of mitochondrial superoxide production by paraquat. J. Biol. Chem. 283:1786–1798.
   PubMed Web of Science ®Google Scholar
• Cole, G. M., Q. L. Ma, and S. A. Frautschy. 2010. Dietary fatty acids and the aging brain. Nutr. Rev. 68:S102–S111.
   PubMed Web of Science ®Google Scholar
• Costa, A. C., S. Loh, and M. Martins. 2013. Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson’s disease. Cell Death Dis. 4:1–10.
   Web of Science ®Google Scholar
• Costa, R., E. Speretta, D. C. Crowther, and I. Cardoso. 2011. Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer Disease. J. Biol. Chem. 286:41647–41655.
   PubMed Web of Science ®Google Scholar
• Czerniczyniec, A., A. G. Karadayian, J. Bustamante, R. A. Cutrera, and S. Lores-Arnaiz. 2011. Paraquat induces behavioral changes and cortical and striatal mitochondrial dysfunction. Free Radic. Biol. Med. 51:1428–1436.
   PubMed Web of Science ®Google Scholar
• Deacon, G., C. Kettle, D. Hayes, C. Dennis, and J. Tucci. 2017. Omega 3 polyunsaturated fatty acids and the treatment of depression. Crit. Rev. Food Sci. 57:212–223.
   PubMed Web of Science ®Google Scholar
• Denny Joseph, K. M., and M. Muralidhara. 2013. Enhanced neuroprotective effect of fish oil in combination with quercetin against 3-nitropropionic acid induced oxidative stress in rat brain. Prog. Neuropsychopharmacol. Biol. Psychiat 40:83–92.
   PubMed Web of Science ®Google Scholar
• Dinis-Oliveira, R. J., F. Remiao, H. Carmo, J. A. Duarte, A. S. Navarro, M. L. Bastos, and F. Carvalho. 2006. Paraquat exposure as an etiological factor of Parkinson’s disease. Neurotoxicology 27:1110–1122.
   PubMed Web of Science ®Google Scholar
• Ellman, G. L., K. D. Courtney, V. A. Jr, and R. M. Featherstone. 1961. A new and rapid colorimetric determination of acethylcholinesterase activity. Biochem. Pharmacol. 7:88–95.
   PubMed Web of Science ®Google Scholar
• Ferreira-Vieira, T. H., I. M. Guimaraes, F. R. Silva, and F. M. Ribeiro. 2016. Alzheimer’s disease: targeting the cholinergic system. Curr. Neuropharmacol. 14:101–115.
   PubMed Web of Science ®Google Scholar
• Galvao, T. F., R. J. Khairallah, E. R. Dabkowski, B. H. Brown, P. A. Hecker, K. A. O’Connel, K. M. O’Shea, H. N. Sabbah, S. Rastogi, C. Daneault, C. D. Rosiers, and W. C. Stanley. 2013. Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival. Am. J. Physiol. Heart Circ. Physiol. 304:H12–H21.
   PubMed Web of Science ®Google Scholar
• Gogus, U., and C. Smith. 2010. n-3 Omega fatty acids: A review of current knowledge. Int. J. Food Sci. Technol. 45:471–536.
   Web of Science ®Google Scholar
• Green, K. N., H. Martinez-Coria, H. Khashwji, E. B. Hall, K. A. Yurko-Mauro, L. Ellis, and F. M. LaFerla. 2007. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J. Neurosci. 27:4385–4395.
   PubMed Web of Science ®Google Scholar
• Grimm, M. O., J. Kuchenbecker, S. Grosgen, V. K. Burg, B. Hundsdörfer, T. L. Rothhaar, P. Friess, M. C. De Wilde, L. M. Broersen, B. Penke, M. Peter, L. V´Igh, H. S. Grimm, and T. Hartmann. 2011. Docosahexaenoic acid reduces amyloid betaproduction via multiple pleiotropic mechanisms. J. Biol. Chem. 286:14028–14039.
   PubMed Web of Science ®Google Scholar
• He, Y., and H. Jasper. 2014. Studying aging in Drosophila. Methods 68:129–133.
   PubMed Web of Science ®Google Scholar
• Heylings, J. R. 1991. Gastrointestinal absorption of paraquat in the isolated mucosa of the rat. Toxicol. Appl. Pharmacol. 107:482–493.
   PubMed Web of Science ®Google Scholar
• Hirth, F. 2010. Drosophila melanogaster in the study of human neurodegeneration. CNS Neurol. Disord. Drug Targets 9:504–523.
   PubMed Web of Science ®Google Scholar
• Hissin, P. J., and R. Hilf. 1976. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74:214–226.
   PubMed Web of Science ®Google Scholar
• Högyes, E., C. Nyakas, A. Kiliaan, T. Farkas, B. Penke, and P. G. Luiten. 2003. Neuroprotective effect of developmental docosahexaenoic acid supplement against excitotoxic brain damage in infant rats. Neuroscience 119:999–1012.
   PubMed Web of Science ®Google Scholar
• Hosamani, R., and Muralidhara. 2013. Neuroprotective efficacy of Bacopa monnieri against rotenone induced oxidative stress and neurotoxicity in Drosophila melanogaster. Neurotoxicology 30:977–985.
   Web of Science ®Google Scholar
• Idid, S. Z., and C. Y. Lee. 1996. Effects of fuller’s Earth and activated charcoal on oral absorption of paraquat in rabbits. Clin. Exp. Pharmacol. Physiol. 23:679–681.
   PubMed Web of Science ®Google Scholar
• Innis, S. M. 2008. Dietary omega-3 fatty acids and the developing brain. Brain Res. 1237:35–43.
   PubMed Web of Science ®Google Scholar
• Kandimalla, R., and H. Reddy. 2016. Multiple faces of dynamin-related protein 1 and its role in Alzheimer’s disease pathogenesis. Biochim. Biophys. Acta 1862:814–828.
   PubMed Web of Science ®Google Scholar
• Kim, Y. H., D. H. Kwon, H. M. Ahn, Y. H. Koh, and S. H. Lee. 2014. Induction of soluble AChE expression via alternative splicing by chemical stress in Drosophila melanogaster. Insect Biochem. Mol. Biol. 48:75–82.
   PubMed Web of Science ®Google Scholar
• Kimura, K., Y. Katsumata, T. Ozawa, S. Tawara, K. Igarashi, Y. Cho, N. Shibata, F. Hakuno, S. I. Takahashi, and A. Takenaka. 2010. Effect of Paraquat-induced oxidative stress on insulin regulation of insuline-like growth fator-binding protein-1 gene expression. J. Clin. Biochem. Nutr. 46:157–167.
   PubMed Web of Science ®Google Scholar
• Kowaltowski, A. J., R. F. Castilho, and A. E. Vercesi. 2001. Mitochondrial permeability transition and oxidative stress. FEBS Lett. 495:12–15.
   PubMed Web of Science ®Google Scholar
• Le Bourg, E., F. A. Lints, N. Fresquet, and P. Bullens. 1993. Hypergravity, aging and longevity in Drosophila melanogaster. Comp. Biochem. Physiol. 105:389–396.
   Google Scholar
• Lim, G. P., F. Calon, T. Morihara, F. Yang, B. Teter, O. Ubeda, N. Salem, Jr., S. A. Frautschy, and G. M. Cole. 2005. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J. Neurosci. 25:3032–3040.
   PubMed Web of Science ®Google Scholar
• Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Meth. Meth. 25:402–408.
   PubMed Web of Science ®Google Scholar
• Machado, M. C., S. Octacilio-Silva, M. S. Costa, and R. G. Ramos. 2011. RST transcriptional activity influences kirre mRNA concentration in the Drosophila pupal retina during the final steps of ommatidial patterning. PLoS One 6:e22536.
   PubMed Web of Science ®Google Scholar
• Martins, T. 2013. Herbicide Paraquat: concepts, mode of action and related diseases. Semina: Ciências Biol. Saúde 34:175–186.
   Google Scholar
• Matsuoka, Y., K. Hamazaki, D. Nishi, and T. Hamazaki. 2016. Change in blood levels of eicosapentaenoic acid and posttraumatic stress symptom: A secondary analysis of data from a placebo-controlled trial of omega-3 supplements. J. Affective Disord. 205:289–291.
   PubMed Web of Science ®Google Scholar
• McNamara, R. K. 2016. Role of omega-3 fatty acids in the etiology, treatment, and prevention of depression: current status and future directions. J. Nutr. Intermed Metab. 5:96–106.
   PubMedGoogle Scholar
• Medina-Leendertz, S., M. Paz, M. Mora, E. Bonilla, Y. Bravo, J. L. Arcaya, R. Terán, and V. Villalobos. 2014. Longterm melatonina administration alleviates paraquat mediated oxidative stress in Drosophila melanogaster. Invest. Clin. 55:352–364.
   PubMed Web of Science ®Google Scholar
• Mei-Ling, A. J., and O. M. Koval. 2014. CaMKII and stress mix it up in mitochondria. Front Pharmacol. 5:1–5.
   PubMed Web of Science ®Google Scholar
• Murakami, K., M. Haneda, T. Makino, and M. Yoshino. 2006. Protective effect of NADP-isocitrate dehydrogenase on the paraquat-mediated oxidative inactivation of aconitase in heart mitochondria. Environ. Toxicol. Pharmacol. 22:148–152.
   PubMed Web of Science ®Google Scholar
• Nall, A., and A. Sehgal. 2014. Monoamines and sleep in Drosophila. Behav. Neurosci. 128:264–272.
   PubMed Web of Science ®Google Scholar
• Neves, F. F., R. B. Sousa, A. Pazin-Filho, P. Cupo, J. E. Júnior, and M. H. Nogueira-Barbosa. 2010. Severe paraquat poisoning: clinical and radiological findings in a survivor. J. Bras. Pneumol. 36:513–516.
   PubMed Web of Science ®Google Scholar
• Oka, S., J. Hirai, T. Yasukawa, Y. Nakahara, and Y. H. Inoue. 2015. A correlation of reactive oxygen species accumulation by depletion of superoxide dismutases with age-dependent impairment in the nervous system and muscles of Drosophila adults. Biogereontology 16:485–501.
   PubMed Web of Science ®Google Scholar
• Pawelczyk, T., M. Grancow-Grabka, M. Kotlicka-Antczak, E. Trafalska, and A. Pawelczyk. 2016. A randomized controlled study of the efficacy of six-month supplementation with concentrated fish oil rich in omega-3 polyunsaturated fatty acids in first episode schizophrenia. J. Psychiat Res. 73:34–44.
   PubMed Web of Science ®Google Scholar
• Pei, L., Y. Mu, M. Leblanc, W. Alaynick, G. D. Barish, M. Pankratz, T. W. Tseng, S. Kaufman, C. Liddle, R. T. Yu, M. Downes, S. L. Pfaff, J. Auwerx, F. H. Gage, and R. M. Evans. 2015. Dependence of hippocampal function on ERRγ-Regulated mitochondrial metabolism. Cell Metab. 21:628–636.
   PubMed Web of Science ®Google Scholar
• Peleg, S., C. Feller, I. Forne, E. Schiller, D. C. Sévin, T. Schauer, C. Regnard, T. Straub, M. Prestel, C. Klima, M. S. Nogueira, L. Becker, T. Klopstock, U. Sauer, P. B. Becker, A. Imhof, and A. G. Ladurner. 2016. Life span extension by targeting a link between metabolism and histone acetylation in Drosophila. EMBO Rep. 17:455–469.
   PubMed Web of Science ®Google Scholar
• Pichaud, N., J. W. O. Ballard, R. M. Tanguay, and P. U. Blier. 2011. Thermal sensitivity of mitochondrial functions in permeabilized muscle fibers from two populations of Drosophila simulans with divergent mitotypes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 301:48–59.
   PubMed Web of Science ®Google Scholar
• Ponton, F., M. P. Chapuis, M. Pernice, G. A. Sword, and S. J. Simpson. 2011. Evaluation of potential reference genes for reverse transcription-qPCR studies of physiological responses in Drosophila melanogaster. J. Insect Physiol. 57:840–850.
   PubMed Web of Science ®Google Scholar
• Prübing, K., A. Voigt, and J. B. Schulz. 2013. Drosophila melanogaster as a model organism for Alzheimer’s disease. Mol. Neurodegenerat 8:35.
   PubMed Web of Science ®Google Scholar
• Rajasekaran, A., G. Venkatasubramanian, M. Berk, and M. Debnath. 2015. Mitochondrial dysfunction in Schizophrenia: pathways, mechanisms and implications. Neurosci. Biobehav. Rev. 48:10–21.
   PubMed Web of Science ®Google Scholar
• Rebrin, I., A. C. V. Bayne, R. J. Mockett, W. C. Orr, and R. S. Sohal. 2004. Free aminothiols, glutathione redox state and protein mixed disulphides in aging Drosophila melanogaster. Biochem. J. 382:131–136.
   PubMed Web of Science ®Google Scholar
• Reznick, A. Z., and L. Packer. 1994. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Meth. Enzymol. 233:357–363.
   PubMed Web of Science ®Google Scholar
• Rhee, S. G., T. S. Chang, W. Jeong, and D. Kang. 2010. Methods for detection and measurement of hydrogen peroxide inside and outside of cells. Mol. Cells 29:539–549.
   PubMed Web of Science ®Google Scholar
• Santalla, M., C. A. Valverde, E. Harnichar, E. Lacunza, J. A. Fuente, A. Mattiazzi, and P. Ferrero. 2014. Aging and CaMKII alter intracelular Ca transient and heart rhythm in Drosophila melanogaster. PLoS One 9:1–10.
   Web of Science ®Google Scholar
• Silva, E. P., Jr, R. T. Nachbar, A. C. Levada-Pires, S. M. Hirabara, and R. H. Lambertucci. 2016. Omega-3 fatty acids differentially modulate enzymatic anti-oxidant systems in skeletal muscle cells. Cell. Stress Chaperon 21:87–95.
   PubMed Web of Science ®Google Scholar
• Simon, A. F., M. T. Chou, E. D. Salazar, T. Nicholson, N. Saini, S. Metchev, and D. E. Krantz. 2012. A simple assay to study social behavior in Drosophila: measurement of social space within a group. Genes Brain Behav. 11:243–252.
   PubMed Web of Science ®Google Scholar
• Simoncini, C., D. Orsucci, E. C. Ieno, G. Siciliano, U. Bonuccelli, and M. Mancuso. 2015. Alzheimer’s pathogenesis and its link to the mitochondrion. Oxid. Med. Cell Longev. 2015: 803942.
   PubMed Web of Science ®Google Scholar
• Smith, L. L. 1987. Mechanism of paraquat toxicity in lung and its relevance to treatment. Hum. Toxicol. 6 (1):31–36.
   PubMedGoogle Scholar
• Srere, P. A. 1969. Citrate synthase. Method Enzymol. 13:3–11.
   Google Scholar
• Suliman, H. B., and C. A. Piantadosi. 2016. Mitochondrial quality control as a therapeutic target. Pharmacol. Rev. 68:20–48.
   PubMed Web of Science ®Google Scholar
• Swanson, D., R. Block, and S. A. Mousa. 2012. Omega-3 fatty acids EPA and DHA: health benefits throughout life. Adv. Nutr. 3:1–7.
   PubMed Web of Science ®Google Scholar
• Toygar, M., I. Aydin, M. Agili, F. N. Aydin, M. Oztosun, H. Gul, E. Macit, Y. Karslioglu, T. Topal, B. Uysal, and M. Honca. 2015. The relation between oxidative stress, inflammation, and neopterin in the paraquat-induced lung toxicity. Hum. Exp. Toxicol. 34:198–204.
   PubMed Web of Science ®Google Scholar
• Triruchelvam, M., A. McCormack, E. K. Richfield, R. B. Baggs, A. W. Tank, D. A. Di Monte, and D. A. Cory-Slechta. 2003. Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson’s disease phenotype. Eur. J. Neurosci. 18:589–600.
   PubMed Web of Science ®Google Scholar
• Vogel, P. A., X. Yang, N. G. Moss, and W. J. Arendshorst. 2015. Superoxide enhances Ca2+ entry through L-type channels in the renal afferent arteriole. Hypertension 66:374–381.
   PubMed Web of Science ®Google Scholar
• Wang, Q., L. Yang, Y. Hua, S. Nair, X. Xu, and J. Ren. 2014. AMP-activated protein kinase deficiency rescues paraquat-induced cardiac contractile dysfunction through an autophagy-dependent mechanism. Toxicol. Sci. 142:6–20.
   PubMed Web of Science ®Google Scholar
• Wani, A. L., S. A. Bhat, and A. Ara. 2015. Omega-3 fatty acids and the treatment of depression: A review of scientific evidence. Integr. Med. Res. 4:132–141.
   PubMed Web of Science ®Google Scholar
• Wu, Z., P. Puigserver, U. Andersson, C. Zhang, G. Adelmant, V. Mootha, A. Troy, S. Cinti, B. Lowell, R. C. Scarpulla, and B. M. Spiegelman. 1999. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98:115–124.
   PubMed Web of Science ®Google Scholar
• Yang, W., and E. Tiffany-Castiglioni. 2005. The bipyridyl herbicide paraquat produces oxidative stress-mediated toxicity in human neuroblastoma SH-SY5Y cells: relevance to the dopaminergic pathogenesis. J. Toxicol. Environ. Health Part A 68:1939–1961.
   PubMed Web of Science ®Google Scholar
• Yang, W., and E. Tiffany-Castiglioni. 2007. The bipyridyl herbicide paraquat induces proteasome dysfunction in human neuroblastoma SH-SY5Y cells. J. Toxicol. Environ. Health Part A 70:1849–1857.
   PubMed Web of Science ®Google Scholar
• Yun, B., H. Lee, M. Ghosh, B. F. Cravatt, K. L. Hsu, J. V. Bonventre, H. Ewing, M. H. Gelb, and C. C. Leslie. 2013. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. J. Biol. Chem. 289:1491–1504.
   PubMed Web of Science ®Google Scholar
• Zarrouk, A., J. M. Riedinger, S. H. Ahmed, S. Hammami, W. Chaabane, M. Debbabi, S. Ben Ammou, O. Rouaud, M. Frih, G. Lizard, and M. Hammami. 2015. Fatty acid profiles in demented patients: identification of hexacosanoic acid (C26:0) as a blood lipid biomarker of dementia. J. Alzheimers Dis. 44:1349–1359.
   PubMed Web of Science ®Google Scholar
• Zhang, S. X., D. Rogulja, and M. A. Crickmore. 2016. Dopaminergic circuity underlying mating drive. Neuron 91:1–14.
   PubMed Web of Science ®Google Scholar
• Zhang, T., L. S. Maier, N. D. Dalton, S. Miyamoto, J. Ross, Jr., D. M. Bers, and J. H. Brown. 2003. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ. Res. 92:912–919.
   PubMed Web of Science ®Google Scholar
• Zhang, W., P. Li, X. Hu, F. Zhang, J. Chen, and Y. Gao. 2011. Omega-3 polyunsaturated fatty acids in the brain: metabolism and neuroprotection. Front. Biosci. 16:2653–2670.
   Web of Science ®Google Scholar
• Zhang, W., H. Wang, H. Zhang, R.K. Leak, Y. Shi, X. Hu, Y. Gao, J. Chen. 2015. Dietary supplementation with omega-3 polyunsaturated fatty acids robustly promotes neurovascular restorative dynamics and improves neurological functions after stroke. Exp Neurol. 272:170–180.
   PubMed Web of Science ®Google Scholar
• Zhou, Q., B. Kan, X. Jian, W. Zhang, H. Liu, and Z. Zhang. 2013. Paraquat poisoning by skin absorption: two case reports and a literature review. Exp. Ther. Med. 6:1504–1506.
   PubMed Web of Science ®Google Scholar
• Ziegler, A. B., C. Ménagé, S. Grégoire, T. Garcia, J. F. Ferveur, L. Bretillon, and Y. Grosjean. 2015. Lack of dietary polyunsaturated fatty acids causes synapse dysfunction in the Drosophila visual system. PLoS One 10:1–15.
   Web of Science ®Google Scholar