390
Views
38
CrossRef citations to date
0
Altmetric
Original Articles

Lead (Pb) exposure induces disturbances in epigenetic status in workers exposed to this metal

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, , ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all

References

  • Agency for Toxic Substances and Disease Registry (ASTDR). 2007. Toxicological profile for lead. U.S. Department of Health and Human Services, Public Health Service: Atlanta, Georgia, USA.
  • Ahamed, M., and M. K. J. Siddiqui. 2007. Low level lead exposure and oxidative stress: current opinions. Clin. Chim. Acta 383:57–64.
  • Batista, B. L., J. L. Rodrigues, J. A. Nunes, V. C. Souza, and F. Barbosa, Jr. 2009a. Exploiting dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS) for sequential determination of trace elements in blood using a dilute-and-shoot procedure. Anal. Chim. Acta 639:13–18.
  • Batista, B. L., J. L. Rodrigues, L. Tormen, A. J. Curtius, and F. Barbosa, Jr. 2009b. Reference concentrations for trace elements in urine for the Brazilian population based on q-ICP-MS with a simple dilute-and-shoot procedure. J. Braz. Chem. Soc. 20:1406–1413.
  • Bergdahl, I. A., L. Gerhardsson, A. Schütz, R. J. Desnick, J. G. Wetmur, and S. Skerfving. 1997. Delta-aminolevulinic acid dehydratase polymorphism: influence on lead levels and kidney function in humans. Arch. Environ. Health 52:91–96.
  • Bonetta, L. 2008. Epigenomics: detailed analysis. Nature 454:795–798.
  • Bradham, K. D., W. Green, H. Hayes, C. Nelson, P. Alava, J. Misenheimer, G. L. Diamond, W. C. Thayer, and D. J. Thomas. 2016. Estimating relative bioavailability of soil lead in the mouse. J. Toxicol. Environ. Health Part A 79:1179–1182.
  • Center for Disease Control and Prevention (CDC). 2005. Blood lead levels- Unites States 1999 2002. Mmwr 54:513–516.
  • Chanda, S., U. B. Dasgupta, D. Guhamazumder, M. Gupta, U. Chaudhuri, S. Lahiri, S. Das, N. Ghosh, and D. Chatterjee. 2006. DNA hypermethylation of promoter of gene p53 and p16 in arsenic-exposed people with and without malignancy. Toxicol. Sci. 89:431–437.
  • Cheng, T. F., S. Choudhuri, and K. Muldoon-Jacobs. 2012. Epigenetic targets of some toxicologically relevant metals: A review of the literature. J. Appl. Toxicol. 32:643–653.
  • Chinde, S., M. Kumari, K. R. Devi, U. S. Murty, M. F. Rahman, S. I. Kumari, M. Mahboob, and P. Grover. 2014. Assessment of genotoxic effects of lead in occupationally exposed workers. Environ. Sci. Pollut. Res. Int. 21:11469–11480.
  • Desideri, D., C. Cantaluppi, F. Ceccotto, M. A. Meli, C. Roselli, and L. Feduzi. 2016. Essential and toxic elements in seaweeds for human consumption. J. Toxicol. Environ. Health Part A 79:112–122.
  • Faulk, C., and D. C. Dolinoy. 2011. Timing is everything: the when and how of environmentally induced changes in the epigenome of animals. Epigenetics 6:791–797.
  • Fernandes, K. C. M., A. C. Martins, Jr., A. A. S. Oliveira, L. M. G. Antunes, I. M. S. Cólus, F. Barbosa, Jr., and G. R. M. Barcelos. 2016. Polymorphism of metallothionein 2A modifies lead body burden in workers chronically exposed to the metal. Publ. Health Genom. 19:47–52.
  • Flora, G., D. Gupta, and A. Tiwari. 2012. Toxicity of lead: a review with recent updates. Interdiscip Toxicol. 5:47–58.
  • Gomes, W. G., P. P. Devoz, M. L. Araújo, B. L. Batista, F. Barbosa, Jr., and G. R. M. Barcelos. 2016. Milk and dairy products intake is associated with low levels of lead (Pb) in workers highly exposed to the metal. Biol. Trace Elem. Res. doi:10.1007/s12011-016-0913-y.
  • Goodrich, J. M., N. Basu, A. Franzblau, and D. C. Dolinoy. 2013. Mercury biomarkers and DNA methylation among Michigan dental professionals. Environ. Mol. Mutagen. 54:195–203.
  • Hanna, C. W., M. S. Bloom, W. P. Robinson, D. Kim, P. J. Parsons, F. S. Vom Saal, J. A. Taylor, A. J. Steuerwald, and V. Y. Fujimoto. 2012. DNA methylation changes in whole blood is associated with exposure to the environmental contaminants, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF. Hum. Reprod. 27:1401–1410.
  • International Agency for Research on Cancer (IARC). 2006. Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 87. Lyon, France: IARC Press.
  • Koh, D. H., S. J. Locke, Y. C. Chen, M. P. Purdue, and M. C. Friesen 2015. Lead exposure in US worksites: A literature review and development of an occupational lead exposure database from the published literature. Am J Ind Med 58: 605–616.
  • Leroyer, A., B. Leleu, B. Dehon, P. Frimat, F. Broly, and C. Nisse. 2013. Influence of delta-aminolevulinic acid dehydratase gene polymorphism on selected lead exposure biomarkers in a cohort of ex-smelter workers. J. Toxicol. Environ. Health Part A 76:895–906.
  • Li, C., X. Yang, M. Xu, J. Zhang, and N. Sun. 2013. Epigenetic marker (LINE-1 promoter) methylation level was associated with occupational lead exposure. Clin. Toxicol. 51:225–229.
  • Lieb, J. D., S. Beck, M. L. Bulyk, P. Farnham, N. Hattori, S. Henikoff, X. S. Liu, K. Okumura, K. Shiota, T. Ushijima, and J. M. Greally. 2006. Applying whole-genome studies of epigenetic regulation to study human disease. Cytogen Genome Res. 114:1–15.
  • MAK Value Documentation. Lead and its inorganic compounds (inhalable fraction). 2012. The MAK Collection for Occupational Health and Safety, 166–192. WILEY-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany.
  • Martins, A. C., Jr., G. R. M. Barcelos, A. L. J. Ferreira, M. F. De Souza, I. M. S. Cólus, L. M. G. Antunes, M. M. B. Paoliello, J. A. Adeyemi, and F. Barbosa, Jr. 2015. Effects of lead exposure and genetic polymorphisms on ALAD and GPx activities in Brazilian battery workers. J. Toxicol. Environ. Health Part. 78:1073–1081.
  • Ministério do Trabalho e Emprego, Portaria n° 3.214 de 08 de junho de. 1978. Norma Reguladora 7 (NR-7): Programa de Controle Médico em Saúde Ocupacional. Modificada pela Portaria SSST n.º 24, de 29 de dezembro de 1994 [in Portuguese]. Diário Oficial da União: Brasília, Brazil.
  • Nersesyan, A., M. Kundi, M. Waldherr, T. Setayesh, M. Mišík, G. Wultsch, M. Filipic, G. R. M. Barcelos, and S. Knasmueller. 2016. Results of micronucleus assays with individuals who are occupationally and environmentally exposed to mercury, lead and cadmium. Mutat. Res. 770:119–139.
  • NTP. 2012. National Toxicology Program: NTP Monograph on health effects of low-level lead. Access on March 31, 2017. https://ntp.niehs.nih.gov/pubhealth/hat/noms/lead/index.html.
  • Nye, M. D., C. Hoyo, and S. K. Murphy. 2015. In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST. Toxicol. In Vitro 29:544–550.
  • Occupational Safety and Health Administration (OSHA). 2012. Regulations (Standards - 29 CFR). https://www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=standards&p_id=10030. Access on 21 Mar 2017.
  • Ortega, F., S. A. Counter, L. H. Buchanan, A. M. Parra, M. A. Collaguaso, and A. B. Jacobs. 2013. Tracking blood lead and zinc protoporphyrin levels in Andean adults working in a lead contaminated environment. J. Toxicol. Environ. Health Part A 76:1111–1120.
  • Pilsner, J. R., H. Hu, A. Ettinger, B. N. Sánchez, R. O. Wright, D. Cantonwine, A. Lazarus, H. Lamadrid-Figueroa, A. Mercado-García, M. M. Téllez-Rojo, and M. Hernández-Avila. 2009. Influence of prenatal lead exposure on genomic methylation of cord blood DNA. Environ. Health Persp. 117:1466–1471.
  • Ray, P. D., A. Yosim, and R. C. Fry. 2014. Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges. Front Genet. 5:201.
  • Reichard, J. F., M. Schnekenburger, and A. Puga. 2007. Long term low-dose arsenic exposure induces loss of DNA methylation. Biochem. Biophys. Res. Commun. 352:188–192.
  • Roselli, C., D. Desideri, M. A. Meli, I. Fagiolino, and L. Feduzi. 2016. Essential and toxic elements in meat of wild birds. J. Toxicol. Environ. Health Part A 79:1008–1014.
  • Sanchez, O. F., J. Lee, N. Yu King, S. E. Kim, J. L. Freeman, and C. Yuan. 2017. Lead (Pb) exposure reduces global DNA methylation level by non-competitive inhibition and alteration of DNMT expression. Metallomics 229:149–160.
  • Sanders, A. P., L. Smeester, D. Rojas, T. DeBussycher, M. C. Wu, F. A. Wright, Y. H. Zhou, J. E. Laine, J. E. Rager, G. K. Swamy, A. Ashley-Koch, M. Lynn Miranda, and R. C. Fry. 2014. Cadmium exposure and the epigenome: exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs. Epigenetics 9:212–221.
  • Scheckel, K. G., G. L. Diamond, M. F. Burgess, J. M. Klotzbach, M. Maddaloni, B. W. Miller, C. R. Partridge, and S. M. Serda. 2013. Amending soils with phosphate as means to mitigate soil lead hazard: a critical review of the state of the science. J. Toxicol. Environ. Health B 16:337–380.
  • Schwartz, B. S., B. K. Lee, G. S. Lee, W. F. Stewart, D. Simon, K. Kelsey, and A. C. Todd. 2000. Associations of blood lead, dimercaptosuccinic acid chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and [delta]-aminolevulinic acid dehydratase genes. Environ. Health Persp108:949–954.
  • Sen, A., P. Cingolani, M. C. Senut, S. Land, A. Mercado-Garcia, M. M. Tellez-Rojo, A. A. Baccarelli, R. O. Wright, and D. M. Ruden. 2015. Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood. Epigenetics 10:607–621.
  • Senut, M. C., A. Sen, P. Cingolani, A. Shaik, S. J. Land, and D. M. Ruden. 2014. Lead exposure disrupts global DNA methylation in human embryonic stem cells and alters their neuronal differentiation. Toxicol. Sci. 139:142–161.
  • Štrbac, S., M. Gavrilović, and L. Budakov. 2016. Bioaccumulation of metals in the trees of Novi Sad, Serbia. J. Toxicol. Environ. Health Part A 79:804–807.
  • Štrbac, S., M. Kašanin-Grubin, B. Jovančićević, and P. Simonović. 2015. Bioaccumulation of heavy metals and microelements in Silver Bream (Brama brama L.), Northern Pike (Esox lucius L.), Sterlet (Acipenser ruthenus L.), and Common Carp (Cyprinus carpio L.) from Tisza River, Serbia. J. Toxicol. Environ. Health Part A 78:663–665.
  • Szymańska-Chabowska, A., Ł. Łaczmański, I. Jędrychowska, M. Chabowski, P. Gać, A. Janus, K. Gosławska, B. Smyk, U. Solska, G. Mazur, and R. Poręba. 2015. The relationship between selected VDR, HFE and ALAD gene polymorphisms and several basic toxicological parameters among persons occupationally exposed to lead. Toxicology 334:12–21.
  • Tagne-Fotso, R., A. Leroyer, M. Howsam, B. Dehon, L. C. Richeva, and C. Nisse. 2016. Current sources of lead exposure and their relative contributions to the blood lead levels in the general adult population of Northern France: the IMEPOGE Study, 2008-2010. J. Toxicol. Environ. Health Part A. 79:245–265.
  • Vandenbroucke, J. P., E. Von Elm, D. G. Altman, P. C. Gøtzsche, C. D. Mulrow, S. J. Pocock, C. Poole, J. J. Schlesselman, M. Egger, and S. T. R. O. B. E. Initiative. 2007. Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration. PLoS Med. 4:e297.
  • Von Elm, E., D. G. Altman, M. Egger, S. J. Pocock, P. C. Gøtzsche, and J. P. Vandenbroucke; STROBE Initiative. 2007. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Med. 4:e296.
  • Were, F. H., M. C. Moturi, P. Gottesfeld, G. A. Wafula, G. N. Kamau, and P. M. Shiundu. 2014. Lead exposure and blood pressure among workers in diverse industrial plants in Kenya. J. Occup. Environ. Hyg. 11:706–715.
  • World Health Organization (WHO). 2010. Exposure to lead: a major public health concern. Access on March 30, 2017. http://www.who.int/ipcs/features/lead.pdf?ua=1.
  • Wright, R. O., J. Schwartz, R. J. Wright, V. Bollati, L. Tarantini, S. K. Park, and A. Baccarelli. 2010. Biomarkers of lead exposure and DNA methylation within retrotransposons. Environ. Health Persp. 118:790–795.
  • Xu, L. H., F. F. Mu, J. H. Zhao, Q. He, C. L. Cao, H. Yang, and S. J. Sun. 2015. Lead induces apoptosis and histone hyperacetylation in rat cardiovascular tissues. PLoS One. 10:0129091.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.