Methionine-supplemented diet affects the expression of cardiovascular disease-related genes and increases inflammatory cytokines in mice heart and liver

References

• Aissa, A. F., T. D. Gomes, M. R. Almeida, L. C. Hernandes, J. D. Darin, M. L. Bianchi, and L. M. Antunes. 2013. Methionine concentration in the diet has a tissue-specific effect on chromosomal stability in female mice. Food Chem. Toxicol. 62:456–462.
   PubMed Web of Science ®Google Scholar
• Aissa, A. F., V. Tryndyak, A. De Conti, S. Melnyk, T. D. Gomes, M. L. Bianchi, S. J. James, F. A. Beland, L. M. Antunes, and I. P. Pogribny. 2014. Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice. Mol. Nutr. Food Res. 58:1502–1512.
   PubMed Web of Science ®Google Scholar
• Ait-Oufella, H., S. Taleb, Z. Mallat, and A. Tedgui. 2011. Recent advances on the role of cytokines in atherosclerosis. Arteriosclerosis Thromb. Vasc. Biol. 31:969–979.
   PubMed Web of Science ®Google Scholar
• Alkhoury, K., S. M. Parkin, S. Homer-Vanniasinkam, and A. M. Graham. 2011. Chronic homocysteine exposure upregulates endothelial adhesion molecules and mediates leukocyte: endothelial cell interactions under flow conditions. Eur. J. Vasc. Endovasc. Surg. 41:429–435.
   PubMed Web of Science ®Google Scholar
• Angulo, P. 2002. Nonalcoholic fatty liver disease. N. Engl. J. Med. 346:1221–1231.
   PubMed Web of Science ®Google Scholar
• Atta, H. M., M. A. El-Rehani, S. A. Raheim, and A. M. F. Galal. 2008. Lowering homocysteine decreases levels and expression of VEGF(165) and endostatin. J. Surg. Res. 146:202–210.
   PubMed Web of Science ®Google Scholar
• Barandier, C., J. P. Montani, and Z. Yang. 2005. Mature adipocytes and perivascular adipose tissue stimulate vascular smooth muscle cell proliferation: effects of aging and obesity. Am. J. Physiol. Heart Circ. Physiol. 289:H1807–H1813.
   PubMed Web of Science ®Google Scholar
• Beauchamp, N. J., T. A. E. Van Achterberg, M. A. Engelse, H. Pannekoek, and C. J. M. De Vries. 2003. Gene expression profiling of resting and activated vascular smooth muscle cells by serial analysis of gene expression and clustering analysis. Genomics 82:288–299.
   PubMed Web of Science ®Google Scholar
• Corbin, K. D., and S. H. Zeisel. 2012. Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr. Opin. Gastroenterol. 28:159–165.
   PubMed Web of Science ®Google Scholar
• Daher, C. F., R. Slaiby, N. Haddad, K. Boustany, and G. M. Baroody. 2006. Effect of acute and chronic moderate red or white wine consumption on fasted and postprandial lipemia in the rat. J. Toxicol. Environ. Health Part A 69:1117–1131.
   PubMed Web of Science ®Google Scholar
• De Alwis, N. M. W., and C. P. Day. 2008. Non-alcoholic fatty liver disease: the mist gradually clears. J. Hepatol. 48:S104–S112.
   PubMed Web of Science ®Google Scholar
• Duan, J. L., T. Murohara, H. Ikeda, K. Sasaki, S. Shintani, T. Akita, T. Shimada, and T. Imaizumi. 2000. Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia. Arteriosclerosis Thromb. Vasc. Biol. 20:2579–2585.
   PubMed Web of Science ®Google Scholar
• Elshorbagy, A. K., M. Valdivia-Garcia, H. Refsum, A. D. Smith, D. A. L. Mattocks, and C. E. Perrone. 2010. Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia. Nutrition 26:1201–1204.
   PubMed Web of Science ®Google Scholar
• Finkelstein, J. D., J. J. Martin, and B. J. Harris. 1988. Methionine metabolism in mammals. The methionine-sparing effect of cystine. J. Biol. Chem. 263:11750–11754.
   PubMed Web of Science ®Google Scholar
• Fito, M., and V. Konstantinidou. 2016. Nutritional genomics and the Mediterranean diet’s effects on human cardiovascular health. Nutrients 8:218.
   PubMed Web of Science ®Google Scholar
• Fito, M., O. Melander, J. A. Martinez, E. Toledo, C. Carpene, and D. Corella. 2016. Advances in integrating traditional and omic biomarkers when analyzing the effects of the Mediterranean diet intervention in cardiovascular prevention. Int. J. Mol. Sci. 17:9.
   Web of Science ®Google Scholar
• Ford, A. H., L. Flicker, K. McCaul, F. Van Bockxmeer, S. Hegarty, V. Hirani, S. Fenner, and O. P. Almeida. 2010. The B-VITAGE trial: A randomized trial of homocysteine lowering treatment of depression in later life. Trials 11:8.
   PubMed Web of Science ®Google Scholar
• Ford, A. H., G. J. Garrido, C. Beer, N. T. Lautenschlager, L. Arnolda, L. Flicker, and O. P. Almeida. 2012. Homocysteine, grey matter and cognitive function in adults with cardiovascular disease. PloS One 7:3.
   Web of Science ®Google Scholar
• Frolova, E. G., E. Pluskota, I. Krukovets, T. Burke, C. Drumm, J. D. Smith, L. Blech, M. Febbraio, P. Bornstein, E. F. Plow, and O. I. Stenina. 2010. Thrombospondin-4 regulates vascular inflammation and atherogenesis. Circ. Res. 107:1313–1325.
   PubMed Web of Science ®Google Scholar
• Garelnabi, M., K. Lor, J. Jin, F. Chai, and N. Santanam. 2013. The paradox of ApoA5 modulation of triglycerides: evidence from clinical and basic research. Clin. Biochem. 46:12–19.
   PubMed Web of Science ®Google Scholar
• Ghosh, S., D. Wanders, K. P. Stone, N. T. Van, C. C. Cortez, and T. W. Gettys. 2014. A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats. Faseb J. 28:2577–2590.
   PubMed Web of Science ®Google Scholar
• Glenn, D. J., M. C. Cardema, W. Ni, Y. Zhang, Y. Yeghiazarians, D. Grapov, O. Fiehn, and D. G. Gardner. 2015. Cardiac steatosis potentiates angiotensin II effects in the heart. Am. J. Physiol. Heart Circ. Physiol. 308:H339–H350.
   PubMed Web of Science ®Google Scholar
• Gomez-Guerrero, C., B. Mallavia, and J. Egido. 2012. Targeting inflammation in cardiovascular diseases. Still a neglected field? Cardiovasc. Ther. 30:e189–e197.
   PubMed Web of Science ®Google Scholar
• Haas, M. E., A. D. Attie, and S. B. Biddinger. 2013. The regulation of ApoB metabolism by insulin. Trends Endocrinol. Metab. 24:391–397.
   PubMed Web of Science ®Google Scholar
• Hansson, G. K. 2005. Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med. 352:1685–1695.
   PubMed Web of Science ®Google Scholar
• Hasuike, Y., Y. Hama, H. Nonoguchi, K. Hori, M. Tokuyama, K. Toyoda, S. Hazeki, M. Nanami, Y. Otaki, T. Kuragano, and T. Nakanishi. 2012. Persistent homocysteine metabolism abnormality accelerates cardiovascular disease in hemodialyzed patients–the Nishinomiya Study. J. Renal. Nutr. 22:12–8e1.
   PubMed Web of Science ®Google Scholar
• Holm, P. W., R. H. J. A. Slart, C. J. Zeebregts, J. L. Hillebrands, and R. A. Tio. 2009. Atherosclerotic plaque development and instability: A dual role for VEGF. Ann. Med. 41:257–264.
   PubMed Web of Science ®Google Scholar
• Huang, X. S., S. P. Zhao, M. Hu, L. Bai, Q. Zhang, and W. Zhao. 2010. Decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity. Atherosclerosis 210:563–568.
   PubMed Web of Science ®Google Scholar
• Ingenbleek, Y., and K. S. McCully. 2012. Vegetarianism produces subclinical malnutrition, hyperhomocysteinemia and atherogenesis. Nutrition 28:148–153.
   PubMed Web of Science ®Google Scholar
• Jiang, Y. D., T. Sun, J. T. Xiong, J. Cao, G. Z. Li, and S. R. Wang. 2007. Hyperhomocysteinemia-mediated DNA hypomethylation and its potential epigenetic role in rats. Acta Biochim. Biophys. Sinica 39:657–667.
   PubMed Web of Science ®Google Scholar
• Juan, W., M. Nakazawa, K. Watanabe, M. Ma, M. I. I. Wahed, G. Hasegawa, M. Naito, T. Yamamoto, K. Fuse, K. Kato, M. Kodama, and Y. Aizawa. 2003. Quinapril inhibits progression of heart failure and fibrosis in rats with dilated cardiomyopathy after myocarditis. Mol. Cell. Biochem. 251:77–82.
   PubMed Web of Science ®Google Scholar
• Kluger, M., J. Heeren, and M. Merkel. 2008. Apoprotein A-V: an important regulator of triglyceride metabolism. J. Inherit. Metab. Dis. 31:281–288.
   PubMed Web of Science ®Google Scholar
• Kotronen, A., and H. Yki-Jarvinen. 2008. Fatty liver - A novel component of the metabolic syndrome. Arteriosclerosis Thromb. Vasc. Biol. 28:27–38.
   PubMed Web of Science ®Google Scholar
• Leach, N. V., E. Dronca, S. C. Vesa, D. P. Sampelean, E. C. Craciun, M. Lupsor, D. Crisan, R. Tarau, R. Rusu, I. Para, and M. Grigorescu. 2014. Serum homocysteine levels, oxidative stress and cardiovascular risk in non-alcoholic steatohepatitis. Eur. J. Intern. Med. 25:762–767.
   PubMed Web of Science ®Google Scholar
• Lee, S. A. 2009. Gene-diet interaction on cancer risk in epidemiological studies. J. Prev. Med. Public Health 42:360–370.
   PubMedGoogle Scholar
• Libby, P. 2012. Inflammation in atherosclerosis. Arteriosclerosis Thromb. Vasc. Biol. 32:2045–2051.
   PubMed Web of Science ®Google Scholar
• Libby, P., P. M. Ridker, and A. Maseri. 2002. Inflammation and atherosclerosis. Circulation 105:1135–1143.
   PubMed Web of Science ®Google Scholar
• Lu, S. C. 2009. Regulation of glutathione synthesis. Mol. Aspects Med. 30:42–59.
   PubMed Web of Science ®Google Scholar
• Machado, M. V., G. A. Michelotti, G. Xie, T. P. De Almeida, J. Boursier, B. Bohnic, C. D. Guy, and A. M. Diehl. 2015. Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease. PLoS ONE 10:e0127991.
   PubMed Web of Science ®Google Scholar
• Malloy, V. L., R. A. Krajcik, S. J. Bailey, G. Hristopoulos, J. D. Plummer, and N. Orentreich. 2006. Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction. Aging Cell 5:305–314.
   PubMed Web of Science ®Google Scholar
• Mannam, V. K., R. E. Lewis, and J. M. Cruse. 2013. The fate of renal allografts hinges on responses of the microvascular endothelium. Exp. Mol. Pathol. 94:398–411.
   PubMed Web of Science ®Google Scholar
• Marchesini, G., S. Moscatiello, S. Di Domizio, and G. Forlani. 2008. Obesity-associated liver disease. J. Clin. Endocrinol. Metab. 93 (Suppl 1):S74–S80.
   PubMed Web of Science ®Google Scholar
• Matteini, A. M., J. D. Walston, K. Bandeen-Roche, D. E. Arking, R. H. Allen, L. P. Fried, A. Chakravarti, S. P. Stabler, and M. D. Fallin. 2010. Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty. J. Nutr. Health Aging 14:73–77.
   PubMed Web of Science ®Google Scholar
• Mazza, A., A. F. Cicero, E. Ramazzina, S. Lenti, L. Schiavon, E. Casiglia, and G. Gussoni. 2016. Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk: A multicenter, randomized clinical trial. J. Biol. Reg. Homeost. Agents 30:921–927.
   PubMed Web of Science ®Google Scholar
• Nishina, K., T. Unno, Y. Uno, T. Kubodera, T. Kanouchi, H. Mizusawa, and T. Yokota. 2008. Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol. Mol. Ther. 16:734–740.
   PubMed Web of Science ®Google Scholar
• Orentreich, N., J. R. Matias, A. DeFelice, and J. A. Zimmerman. 1993. Low methionine ingestion by rats extends life span. J. Nutr. 123:269–274.
   PubMed Web of Science ®Google Scholar
• Orgeron, M. L., K. P. Stone, D. Wanders, C. C. Cortez, N. T. Van, and T. W. Gettys. 2014. The impact of dietary methionine restriction on biomarkers of metabolic health. Prog. Mol. Biol. Translational Sci. 121:351–376.
   PubMed Web of Science ®Google Scholar
• Packard, R. R. S., and P. Libby. 2008. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin. Chem. 54:24–38.
   PubMed Web of Science ®Google Scholar
• Palazhy, S., P. Kamath, and D. M. Vasudevan. 2015. Elevated oxidative stress among coronary artery disease patients on statin therapy: A cross sectional study. Indian Heart J. 67:227–232.
   PubMedGoogle Scholar
• Park, C. M., C. W. Cho, M. E. Rosenfeld, and Y. S. Song. 2008. Methionine supplementation accelerates oxidative stress and nuclear factor kappaB activation in livers of C57BL/6 mice. J. Med. Food 11:667–674.
   PubMed Web of Science ®Google Scholar
• Pogribny, I. P., S. J. James, and F. A. Beland. 2012. Molecular alterations in hepatocarcinogenesis induced by dietary methyl deficiency. Mol. Nutr. Food Res. 56:116–125.
   PubMed Web of Science ®Google Scholar
• Rahman, I., A. Kode, and S. K. Biswas. 2006. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat. Protoc. 1:3159–3165.
   PubMed Web of Science ®Google Scholar
• Reeves, P. G., F. H. Nielsen, and G. C. Fahey. 1993. Ain-93 purified diets for laboratory rodents - Final Report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the Ain-76a Rodent Diet. J. Nutr. 123:1939–1951.
   PubMed Web of Science ®Google Scholar
• Sharma, M., S. K. Rai, M. Tiwari, and R. Chandra. 2007. Effect of hyperhomocysteinemia on cardiovascular risk factors and initiation of atherosclerosis in Wistar rats. Eur. J. Pharmacol. 574:49–60.
   PubMed Web of Science ®Google Scholar
• Soyupek, F., S. Cerci, S. Yidiz, M. Yildiz, and B. Gurnus. 2007. Effect of homocysteine on bone mineral density of rats. Biol. Trace Element Res. 118:255–259.
   PubMed Web of Science ®Google Scholar
• Splaver, A., G. A. Lamas, and C. H. Hennekens. 2004. Homocysteine and cardiovascular disease: biological mechanisms, observational epidemiology, and the need for randomized trials. Am. Heart J. 148:34–40.
   PubMed Web of Science ®Google Scholar
• Tang, B., A. Mustafa, S. Gupta, S. Melnyk, S. J. James, and W. D. Kruger. 2010. Methionine-deficient diet induces post-transcriptional downregulation of cystathionine [beta]-synthase. Nutrition 26:1170–1175.
   PubMed Web of Science ®Google Scholar
• Targher, G., F. Marra, and G. Marchesini. 2008. Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon? Diabetologia 51:1947–1953.
   PubMed Web of Science ®Google Scholar
• Tomaschitz, A., S. Pilz, E. Ritz, T. Grammer, K. Amrein, S. Merger, A. Meinitzer, B. R. Winkelmann, B. O. Boehm, and W. Marz. 2011. Relationship between plasma aldosterone concentration and soluble cellular adhesion molecules in patients referred to coronary angiography. Exp. Clin. Endocrinol. Diabetes 119:649–655.
   PubMed Web of Science ®Google Scholar
• Tyagi, N., K. C. Sedoris, M. Steed, A. V. Ovechkin, K. S. Moshal, and S. C. Tyagi. 2005. Mechanisms of homocysteine-induced oxidative stress. Am. J. Physiol. Heart Circ. Physiol. 289:H2649–H6456.
   PubMed Web of Science ®Google Scholar
• Van Mil, N. H., A. M. Oosterbaan, and R. P. M. Steegers-Theunissen. 2010. Teratogenicity and underlying mechanisms of homocysteine in animal models: A review. Reprod. Toxicol. 30:520–531.
   PubMed Web of Science ®Google Scholar
• Veeranna, V., S. K. Zalawadiya, A. Niraj, J. Pradhan, B. Ference, R. C. Burack, S. Jacob, and L. Afonso. 2011. Homocysteine and reclassification of cardiovascular disease risk. J. Am. Coll. Cardiol. 58:1025–1033.
   PubMed Web of Science ®Google Scholar
• Wald, D. S., N. J. Wald, J. K. Morris, and M. Law. 2006. Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence. Br. Med. J. 333:1114–1117.
   PubMed Web of Science ®Google Scholar
• Wanders, D., S. Ghosh, K. P. Stone, N. T. Van, and T. W. Gettys. 2014. Transcriptional impact of dietary methionine restriction on systemic inflammation: relevance to biomarkers of metabolic disease during aging. BioFactors 40:13–26.
   PubMed Web of Science ®Google Scholar
• Wang, X., L. Cui, J. Joseph, B. Jiang, D. Pimental, D. E. Handy, R. Liao, and J. Loscalzo. 2012. Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress. J. Mol. Cell. Cardiol. 52:753–760.
   PubMed Web of Science ®Google Scholar
• WHO. 2016. World Health Organization - Cardiovascular diseases fact sheet, Sep 2016. Accessed November 2016. http://www.who.int/mediacentre/factsheets/fs317/en/.
   Google Scholar
• Wu, S., F. Wu, Y. Ding, J. Hou, J. Bi, and Z. Zhang. 2016. Association of non-alcoholic fatty liver disease with major adverse cardiovascular events: A systematic review and meta-analysis. Sci. Rep. 6:33386.
   PubMed Web of Science ®Google Scholar
• Xu, X., and J. Chen. 2009. One-carbon metabolism and breast cancer: an epidemiological perspective. J. Genet. Genom. 36:203–214.
   PubMed Web of Science ®Google Scholar
• YalçInkaya, S., Y. Ünlüçerçi, M. Giris, V. Olgaç, S. Dogru-Abbasoglu, and M. Uysal. 2009. Oxidative and nitrosative stress and apoptosis in the liver of rats fed on high methionine diet: protective effect of taurine. Nutrition 25:436–444.
   PubMed Web of Science ®Google Scholar
• Yang, M., and K. H. Vousden. 2016. Serine and one-carbon metabolism in cancer. Nat. Rev. Cancer 16:650–662.
   PubMed Web of Science ®Google Scholar
• Zhang, R. F., J. Ma, M. Xia, H. L. Zhu, and W. H. Ling. 2004. Mild hyperhomocysteinemia induced by feeding rats diets rich in methionine or deficient in folate promotes early atherosclerotic inflammatory processes. J. Nutr. 134:825–830.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., J. W. Kent, 2nd, A. Lee, D. Cerjak, O. Ali, R. Diasio, M. Olivier, J. Blangero, M. A. Carless, and A. H. Kissebah. 2013. Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a Northern European family population. BMC Med. Genomics 6:9.
   PubMed Web of Science ®Google Scholar
• Zheng, X. Y., S. P. Zhao, and H. Yan. 2013. The role of apolipoprotein A5 in obesity and the metabolic syndrome. Biol. Rev. Cambridge Philos. Soc. 88:490–498.
   PubMed Web of Science ®Google Scholar