Pulmonary toxicity and global gene expression changes in response to sub-chronic inhalation exposure to crystalline silica in rats

References

• Alayash, A. I. , C. B. Andersen , S. K. Moestrup , and L. Bulow . 2013. Haptoglobin: The hemoglobin detoxifier in plasma. Trends in Biotechnology 31:2–3. doi:10.1016/j.tibtech.2012.10.003.
   PubMed Web of Science ®Google Scholar
• Alwahsh, S. M. , M. Xu , H. A. Seyhan , S. Ahmad , S. Mihm , G. Ramadori , and F. C. Schultze . 2014. Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver. World Journal of Gastroenterology : WJG 20:1807–1821. doi:10.3748/wjg.v20.i7.1807.
   PubMed Web of Science ®Google Scholar
• Angelini, D. J. , Q. Su , K. Yamaji-Kegan , C. Fan , J. T. Skinner , H. C. Champion , M. T. Crow , and R. A. Johns . 2009. Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMalpha) induces the vascular and hemodynamic changes of pulmonary hypertension. American Journal Physiological Lung Cellular Molecular Physiological 296:L582–L593. doi:10.1152/ajplung.90526.2008.
   PubMed Web of Science ®Google Scholar
• Antonini, J. M. , and J. R. Roberts . 2007. Chromium in stainless steel welding fume suppresses lung defense responses against bacterial infection in rats. Journal Immunotoxicol 4:117–127. doi:10.1080/15476910701336953.
   PubMed Web of Science ®Google Scholar
• Archer, A. , E. Stolarczyk , M. L. Doria , L. Helguero , R. Domingues , J. K. Howard , A. Mode , M. Korach-Andre , and J. A. Gustafsson . 2013. LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice. Journal of Lipid Research 54:1300–1311. doi:10.1194/jlr.M033977.
   PubMed Web of Science ®Google Scholar
• Belcher, J. D. , C. Chen , J. Nguyen , P. Zhang , F. Abdulla , P. Nguyen , T. Killeen , P. Xu , G. O’Sullivan , K. A. Nath , and G. M. Vercellotti . 2016. Control of oxidative stress and inflammation in sickle cell disease with the Nrf2 activator dimethyl fumarate. Antioxidants & Redox Signaling 26:748–762. doi:10.1089/ars.2015.6571.
   PubMed Web of Science ®Google Scholar
• Benjamini, Y. , and Y. Hochberg . 1995. Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal Roy Statistical Social Series 57:289–300.
   Web of Science ®Google Scholar
• Brazma, A. , P. Hingamp , J. Quackenbush , G. Sherlock , P. Spellman , C. Stoeckert , J. Aach , W. Ansorge , C. A. Ball , H. C. Causton , T. Gaasterland , P. Glenisson , F. C. Holstege , I. F. Kim , V. Markowitz , J. C. Matese , H. Parkinson , A. Robinson , U. Sarkans , S. Schulze-Kremer , J. Stewart , R. Taylor , J. Vilo , and M. Vingron . 2001. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nature Genetics 29:365–371. doi:10.1038/ng1201-365.
   PubMed Web of Science ®Google Scholar
• Bushel, P. R. , A. N. Heinloth , J. Li , L. Huang , J. W. Chou , G. A. Boorman , D. E. Malarkey , C. D. Houle , S. M. Ward , R. E. Wilson , R. D. Fannin , M. W. Russo , P. B. Watkins , R. W. Tennant , and R. S. Paules . 2007. Blood gene expression signatures predict exposure levels. Proceedings Natural Academic Sciences USA 104:18211–18216. doi:10.1073/pnas.0706987104.
   PubMed Web of Science ®Google Scholar
• Cantin, A. M. , P. Larivee , M. Martel , and R. Begin . 1992. Hyaluronan (hyaluronic acid) in lung lavage of asbestos-exposed humans and sheep. Lung 170:211–220. doi:10.1007/BF00174118.
   PubMed Web of Science ®Google Scholar
• Carosino, C. M. , K. J. Bein , L. E. Plummer , A. R. Castaneda , Y. Zhao , A. S. Wexler , and K. E. Pinkerton . 2015. Allergic airway inflammation is differentially exacerbated by daytime and nighttime ultrafine and submicron fine ambient particles: Heme oxygenase-1 as an indicator of PM-mediated allergic inflammation. Journal of Toxicology and Environmental Health. Part A 78:254–266. doi:10.1080/15287394.2014.959627.
   PubMed Web of Science ®Google Scholar
• Castranova, V. 2004. Signaling pathways controlling the production of inflammatory mediators in response to crystalline silica exposure: Role of reactive oxygen/nitrogen species. Free Radical Biology & Medicine 37:916–925. doi:10.1016/j.freeradbiomed.2004.05.032.
   PubMed Web of Science ®Google Scholar
• Chen, B. T. , D. Schwegler-Berry , W. McKinney , S. Stone , J. L. Cumpston , S. Friend , D. W. Porter , V. Castranova , and D. G. Frazer . 2012. Multi-walled carbon nanotubes: Sampling criteria and aerosol characterization. Inhal Toxicogical 24:798–820. doi:10.3109/08958378.2012.720741.
   PubMed Web of Science ®Google Scholar
• Chen, G. Y. , and G. Nunez . 2010. Sterile inflammation: Sensing and reacting to damage. Nature Reviews. Immunology 10:826–837. doi:10.1038/nri2873.
   PubMed Web of Science ®Google Scholar
• Chiaverini, N. , and M. De Ley . 2010. Protective effect of metallothionein on oxidative stress-induced DNA damage. FreeRadical Research 44:605–613. doi:10.3109/10715761003692511.
   PubMed Web of Science ®Google Scholar
• Cooper, G. S. , F. W. Miller , and D. R. Germolec . 2002. Occupational exposures and autoimmune diseases. International Immunopharmacology 2:303–313. doi:10.1016/S1567-5769(01)00181-3.
   PubMed Web of Science ®Google Scholar
• Eklund, A. , G. Tornling , E. Blaschke , and T. Curstedt . 1991. Extracellular matrix components in bronchoalveolar lavage fluid in quartz exposed rats. British Journal Industrial Medica 48:776–782.
   PubMedGoogle Scholar
• Esswein, E. J. , M. Breitenstein , J. Snawder , M. Kiefer , and W. K. Sieber . 2013. Occupational exposures to respirable crystalline silica during hydraulic fracturing. Journal Occupational Environment Hygiene 10:347–356. doi:10.1080/15459624.2013.788352.
   PubMed Web of Science ®Google Scholar
• Fan, B. , L. Ma , Q. Li , L. Wang , J. Zhou , and J. Wu . 2013. Correlation between platelet-derived growth factor signaling pathway and inflammation in desoxycorticosterone-induced salt-sensitive hypertensive rats with myocardial fibrosis. International Journal Clinical Experiments Pathologists 6:2468–2475.
   PubMed Web of Science ®Google Scholar
• Furuhashi, K. , T. Suda , Y. Nakamura , N. Inui , D. Hashimoto , S. Miwa , H. Hayakawa , H. Kusagaya , Y. Nakano , H. Nakamura , and K. Chida . 2010. Increased expression of YKL-40, a chitinase-like protein, in serum and lung of patients with idiopathic pulmonary fibrosis. Respiratory Medica 104:1204–1210. doi:10.1016/j.rmed.2010.02.026.
   PubMed Web of Science ®Google Scholar
• Gentleman, R. C. , V. J. Carey , D. M. Bates , B. Bolstad , M. Dettling , S. Dudoit , B. Ellis , L. Gautier , Y. Ge , J. Gentry , K. Hornik , T. Hothorn , W. Huber , S. Iacus , R. Irizarry , F. Leisch , C. Li , M. Maechler , A. J. Rossini , G. Sawitzki , C. Smith , G. Smyth , L. Tierney , J. Y. Yang , and J. Zhang . 2004. Bioconductor: Open software development for computational biology and bioinformatics. Genome Biology 5:R80. doi:10.1186/gb-2004-5-10-r80.
   PubMed Web of Science ®Google Scholar
• Gulumian, M. , P. J. Borm , V. Vallyathan , V. Castranova , K. Donaldson , G. Nelson , and J. Murray . 2006. Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker’s pneumoconiosis: A comprehensive review. Journal Toxicogical Environment Health B 9:357–395. doi:10.1080/15287390500196537.
   PubMed Web of Science ®Google Scholar
• Guo, N. L. , Y. W. Wan , J. Denvir , D. W. Porter , M. Pacurari , M. G. Wolfarth , V. Castranova , and Y. Qian . 2012. Multiwalled carbon nanotube-induced gene signatures in the mouse lung: Potential predictive value for human lung cancer risk and prognosis. Journal of Toxicology and Environmental Health. Part A 75:1129–1153. doi:10.1080/15287394.2012.699852.
   PubMed Web of Science ®Google Scholar
• Heinloth, A. N. , R. D. Irwin , G. A. Boorman , P. Nettesheim , R. D. Fannin , S. O. Sieber , M. L. Snell , C. J. Tucker , L. Li , G. S. Travlos , G. Vansant , P. E. Blackshear , R. W. Tennant , M. L. Cunningham , and R. S. Paules . 2004. Gene expression profiling of rat livers reveals indicators of potential adverse effects. Toxicological Sciences : an Official Journal of the Society of Toxicology 80:193–202. doi:10.1093/toxsci/kfh145.
   PubMed Web of Science ®Google Scholar
• Hnizdo, E. , and V. Vallyathan . 2003. Chronic obstructive pulmonary disease due to occupational exposure to silica dust: A review of epidemiological and pathological evidence. Occupational Environment Medica 60:237–243. doi:10.1136/oem.60.4.237.
   PubMed Web of Science ®Google Scholar
• Huang, Y. C. 2013. The role of in vitro gene expression profiling in particulate matter health research. Journal Toxicogical Environment Health B 16:381–394. doi:10.1080/10937404.2013.832649.
   PubMed Web of Science ®Google Scholar
• IARC (International Agency for Research on Cancer) . 1997. IARC monographs on the evaluation of carcinogenic risk to humans: Silica, some silicates, coal dust and para-aramid fibrils , vol. 68. Lyon, France: World halth Organization, International Agency for Resaerch on Cancer.
   Google Scholar
• Ihaka, R. , and R. Gentleman . 1996. R: A language for data analysis and graphics. Journal Computation Graph Statistical 5:299–314.
   Google Scholar
• Joseph, P. , Q. He , and C. Umbright . 2008. Heme-oxygenase 1 gene expression is a marker for hexavalent chromium-induced stress and toxicity in human dermal fibroblasts. Toxicological Sciences : An Official Journal of the Society of Toxicology 103:325–334. doi:10.1093/toxsci/kfn048.
   PubMed Web of Science ®Google Scholar
• Kang, H. R. , S. J. Cho , C. G. Lee , R. J. Homer , and J. A. Elias . 2007. Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12. The Journal of Biological Chemistry 282:7723–7732. doi:10.1074/jbc.M610764200.
   PubMed Web of Science ®Google Scholar
• Klaper, R. , D. Arndt , J. Bozich , and G. Dominguez . 2014. Molecular interactions of nanomaterials and organisms: Defining biomarkers for toxicity and high-throughput screening using traditional and next-generation sequencing approaches. Analyst 139:882–895. doi:10.1039/C3AN01644G.
   PubMed Web of Science ®Google Scholar
• Kurfurstova, D. , J. Bartkova , R. Vrtel , A. Mickova , A. Burdova , D. Majera , M. Mistrik , M. Kral , F. R. Santer , J. Bouchal , and J. Bartek . 2016. DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer. Molecular Oncology 10:879–894. doi:10.1016/j.molonc.2016.02.005.
   PubMed Web of Science ®Google Scholar
• Lasagni, L. , M. Francalanci , F. Annunziato , E. Lazzeri , S. Giannini , L. Cosmi , C. Sagrinati , B. Mazzinghi , C. Orlando , E. Maggi , F. Marra , S. Romagnani , M. Serio , and P. Romagnani . 2003. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. The Journal of Experimental Medicine 197:1537–1549. doi:10.1084/jem.20021897.
   PubMed Web of Science ®Google Scholar
• Laskin, D. L. , V. R. Sunil , C. R. Gardner , and J. D. Laskin . 2011. Macrophages and tissue injury: Agents of defense or destruction? Annual Review of Pharmacology and Toxicology 51:267–288. doi:10.1146/annurev.pharmtox.010909.105812.
   PubMed Web of Science ®Google Scholar
• Leung, C. C. , I. T. Yu , and W. Chen . 2012. Silicosis. Lancet 379:2008–2018. doi:10.1016/S0140-6736(12)60235-9.
   PubMed Web of Science ®Google Scholar
• Liao, C. T. , M. Rosas , L. C. Davies , P. J. Giles , V. J. Tyrrell , V. B. O’Donnell , N. Topley , I. R. Humphreys , D. J. Fraser , S. A. Jones , and P. R. Taylor . 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46:2222–2232. doi:10.1002/eji.201646528.
   PubMed Web of Science ®Google Scholar
• Liu, T. , H. Yu , M. Ullenbruch , H. Jin , T. Ito , Z. Wu , J. Liu , and S. H. Phan . 2014. The in vivo fibrotic role of FIZZ1 in pulmonary fibrosis. PLoS One 9:e88362. doi:10.1371/journal.pone.0088362.
   PubMed Web of Science ®Google Scholar
• Lobenhofer, E. K. , J. T. Auman , P. E. Blackshear , G. A. Boorman , P. R. Bushel , M. L. Cunningham , J. M. Fostel , K. Gerrish , A. N. Heinloth , R. D. Irwin , D. E. Malarkey , B. A. Merrick , S. O. Sieber , C. J. Tucker , S. M. Ward , R. E. Wilson , P. Hurban , R. W. Tennant , and R. S. Paules . 2008. Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype. Genome Biology 9:R100. doi:10.1186/gb-2008-9-6-r100.
   PubMed Web of Science ®Google Scholar
• Madala, S. K. , J. T. Pesce , T. R. Ramalingam , M. S. Wilson , S. Minnicozzi , A. W. Cheever , R. W. Thompson , M. M. Mentink-Kane , and T. A. Wynn . 2010. Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis. Journal of Immunology (Baltimore, Md. : 1950) 184:3955–3963. doi:10.4049/jimmunol.0903008.
   PubMed Web of Science ®Google Scholar
• Madl, A. K. , E. P. Donovan , S. H. Gaffney , M. A. McKinley , E. C. Moody , J. L. Henshaw , and D. J. Paustenbach . 2008. State-of-the-science review of the occupational health hazards of crystalline silica in abrasive blasting operations and related requirements for respiratory protection. Journal Toxicogical Environment Health B 1:548–608. doi:10.1080/10937400801909135.
   Web of Science ®Google Scholar
• Manicone, A. M. , and J. K. McGuire . 2008. Matrix metalloproteinases as modulators of inflammation. Seminars in Cell & Developmental Biology 19:34–41. doi:10.1016/j.semcdb.2007.07.003.
   PubMed Web of Science ®Google Scholar
• Matute-Bello, G. , M. M. Wurfel , J. S. Lee , D. R. Park , C. W. Frevert , D. K. Madtes , S. D. Shapiro , and T. R. Martin . 2007. Essential role of MMP-12 in Fas-induced lung fibrosis. American JRespir Cellular Molecular Biologic 37:210–221. doi:10.1165/rcmb.2006-0471OC.
   PubMed Web of Science ®Google Scholar
• Mazurek, J. M. , P. L. Schleiff , J. M. Wood , S. A. Hendricks , and A. Weston ; Control Centers for Disease, and Prevention . 2015. Notes from the field: Update: Silicosis mortality - United States, 1999–2013. Morb Mortal Wkly Reports 64:653–654.
   PubMed Web of Science ®Google Scholar
• McGeer, E. G. , A. Klegeris , and P. L. McGeer . 2005. Inflammation, the complement system and the diseases of aging. Neurobiology of Aging 26 (Suppl 1):94–97. doi:10.1016/j.neurobiolaging.2005.08.008.
   PubMedGoogle Scholar
• McKinney, W. , B. Chen , and D. Frazer . 2009. Computer controlled multi-walled carbon nanotube inhalation exposure system. Inhal Toxicogical 21:1053–1061. doi:10.1080/08958370802712713.
   PubMed Web of Science ®Google Scholar
• Min, K. J. , K. H. Cho , and T. K. Kwon . 2012. The effect of oxidized low density lipoprotein (oxLDL)-induced heme oxygenase-1 on LPS-induced inflammation in RAW 264.7 macrophage cells. Cellular Signalling 24:1215–1221. doi:10.1016/j.cellsig.2012.02.001.
   PubMed Web of Science ®Google Scholar
• Nakao, I. , S. Kanaji , S. Ohta , H. Matsushita , K. Arima , N. Yuyama , M. Yamaya , K. Nakayama , H. Kubo , M. Watanabe , H. Sagara , K. Sugiyama , H. Tanaka , S. Toda , H. Hayashi , H. Inoue , T. Hoshino , A. Shiraki , M. Inoue , K. Suzuki , H. Aizawa , S. Okinami , H. Nagai , M. Hasegawa , T. Fukuda , E. D. Green , and K. Izuhara . 2008. Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease. Journal of Immunology (Baltimore, Md. : 1950) 180:6262–6269. doi:10.4049/jimmunol.180.9.6262.
   PubMed Web of Science ®Google Scholar
• Ning, R. B. , J. Zhu , D. J. Chai , C. S. Xu , H. Xie , X. Y. Lin , J. Z. Zeng , and J. X. Lin . 2013. RXR agonists inhibit high glucose-induced upregulation of inflammation by suppressing activation of the NADPH oxidase-nuclear factor-kappaB pathway in human endothelial cells. Genetics and Molecular Research : GMR 12:6692–6707. doi:10.4238/2013.December.13.3.
   PubMed Web of Science ®Google Scholar
• NIOSH (National Institute for Occupational Safety and Health) . 2002. Hazard review: Health effects of occupational exposures to respirable crystalline silica. US Department of Health and Human Services (NIOSH) Publication No. 2002-129. Available from: http://www.cdc.gov/niosh/docs/2002-129/02-129a.html.
   Google Scholar
• O’Regan, A. 2003. The role of osteopontin in lung disease. Cytokine & Growth Factor Reviews 14:479–488. doi:10.1016/S1359-6101(03)00055-8.
   PubMed Web of Science ®Google Scholar
• Ogino, K. , N. Takahashi , T. Takigawa , Y. Obase , and D. H. Wang . 2011. Association of serum arginase I with oxidative stress in a healthy population. FreeRadical Research 45:147–155. doi:10.3109/10715762.2010.520318.
   PubMed Web of Science ®Google Scholar
• Olsson, M. G. , M. Allhorn , L. Bulow , S. R. Hansson , D. Ley , M. L. Olsson , A. Schmidtchen , and B. Akerstrom . 2012. Pathological conditions involving extracellular hemoglobin: Molecular mechanisms, clinical significance, and novel therapeutic opportunities for alpha(1)-microglobulin. Antioxidants Redox Signalling 17:813–846. doi:10.1089/ars.2011.4282.
   PubMed Web of Science ®Google Scholar
• OSHA (Occupational Safety and Health Administration) . 2016. Occupational exposure to crystalline silica: Final rule. Available from: www.federal register.gov/articles/2016/03/25/2016-04800/2016-04800/occupational-exposure-to-crystalline-silica.
   Google Scholar
• Pardo, A. , K. Gibson , J. Cisneros , T. J. Richards , Y. Yang , C. Becerril , S. Yousem , I. Herrera , V. Ruiz , M. Selman , and N. Kaminski . 2005. Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis. PLoS Medicine 2:e251. doi:10.1371/journal.pmed.0020251.
   PubMed Web of Science ®Google Scholar
• Parks, W. C. , C. L. Wilson , and Y. S. Lopez-Boado . 2004. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nature Reviews. Immunology 4:617–629. doi:10.1038/nri1418.
   PubMed Web of Science ®Google Scholar
• Pavan, C. , V. Rabolli , M. Tomatis , B. Fubini , and D. Lison . 2014. Why does the hemolytic activity of silica predict its pro-inflammatory activity? Particle Fibre Toxicogical 11:76. doi:10.1186/s12989-014-0076-y.
   PubMed Web of Science ®Google Scholar
• Pavilonis, B. T. , and F. E. Mirer . 2017. Respirable dust and silica exposure among world trade center cleanup workers. Journal Occupational Environment Hygiene 14:187–194. doi:10.1080/15459624.2016.1237773.
   PubMed Web of Science ®Google Scholar
• Peluso, M. E. , A. Munnia , R. W. Giese , E. Chellini , M. Ceppi , and F. Capacci . 2015. Oxidatively damaged DNA in the nasal epithelium of workers occupationally exposed to silica dust in Tuscany region, Italy. Mutagenesis 30:519–525. doi:10.1093/mutage/gev014.
   PubMed Web of Science ®Google Scholar
• Pollard, K. M. 2016. Silica, silicosis, and autoimmunity. Frontiers Immunology 7:97. doi:10.3389/fimmu.2016.00097.
   PubMed Web of Science ®Google Scholar
• Porter, D. W. , A. F. Hubbs , R. Mercer , V. A. Robinson , D. Ramsey , J. McLaurin , A. Khan , L. Battelli , K. Brumbaugh , A. Teass , and V. Castranova . 2004. Progression of lung inflammation and damage in rats after cessation of silica inhalation. Toxicological Sciences : An Official Journal of the Society of Toxicology 79:370–380. doi:10.1093/toxsci/kfh110.
   PubMed Web of Science ®Google Scholar
• Porter, D. W. , D. Ramsey , A. F. Hubbs , L. Battelli , J. Ma , M. Barger , D. Landsittel , V. A. Robinson , J. McLaurin , A. Khan , W. Jones , A. Teass , and V. Castranova . 2001. Time course of pulmonary response of rats to inhalation of crystalline silica: Histological results and biochemical indices of damage, lipidosis, and fibrosis. Journal of Environmental Pathology, Toxicology and Oncology 20 (Suppl 1):1–14. doi:10.1615/JEnvironPatholToxicolOncol.v20.iSuppl.1.
   PubMedGoogle Scholar
• Rees, D. , and J. Murray . 2007. Silica, silicosis and tuberculosis. The International Journal of Tuberculosis and Lung Disease 11:474–484.
   PubMed Web of Science ®Google Scholar
• Sabo-Attwood, T. , M. E. Ramos-Nino , M. Eugenia-Ariza , M. B. Macpherson , K. J. Butnor , P. C. Vacek , S. P. McGee , J. C. Clark , C. Steele , and B. T. Mossman . 2011. Osteopontin modulates inflammation, mucin production, and gene expression signatures after inhalation of asbestos in a murine model of fibrosis. The American Journal of Pathology 178:1975–1985. doi:10.1016/j.ajpath.2011.01.048.
   PubMed Web of Science ®Google Scholar
• Schunke, K. J. , L. Coyle , G. F. Merrill , and D. T. Denhardt . 2013. Acetaminophen attenuates doxorubicin-induced cardiac fibrosis via osteopontin and GATA4 regulation: Reduction of oxidant levels. Journal Cellular Physiological 228:2006–2014. doi:10.1002/jcp.24367.
   PubMed Web of Science ®Google Scholar
• Sellamuthu, R. , C. Umbright , S. Li , M. Kashon , and P. Joseph . 2011a. Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling. Inhal Toxicogical 23:927–937.
   PubMed Web of Science ®Google Scholar
• Sellamuthu, R. , C. Umbright , J. R. Roberts , R. Chapman , S. H. Young , D. Richardson , J. Cumpston , W. McKinney , B. T. Chen , D. Frazer , S. Li , M. Kashon , and P. Joseph . 2012. Transcriptomics analysis of lungs and peripheral blood of crystalline silica-exposed rats. Inhal Toxicogical 24:570–579. doi:10.3109/08958378.2012.697926.
   PubMed Web of Science ®Google Scholar
• Sellamuthu, R. , C. Umbright , J. R. Roberts , R. Chapman , S. H. Young , D. Richardson , H. Leonard , W. McKinney , B. Chen , D. Frazer , S. Li , M. Kashon , and P. Joseph . 2011b. Blood gene expression profiling detects silica exposure and toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology 122:253–264. doi:10.1093/toxsci/kfr125.
   PubMed Web of Science ®Google Scholar
• Sellamuthu, R. , C. Umbright , J. R. Roberts , A. Cumpston , W. McKinney , B. T. Chen , D. Frazer , S. Li , M. Kashon , and P. Joseph . 2013. Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats. Journal Applications Toxicogical 33:301–312. doi:10.1002/jat.v33.4.
   PubMed Web of Science ®Google Scholar
• Sellamuthu, R. , C. Umbright , J. R. Roberts , S. H. Young , D. Richardson , W. McKinney , B. T. Chen , S. Li , M. Kashon , and P. Joseph . 2017. Molecular mechanisms of pulmonary response progression in crystalline silica exposed rats. Inhal Toxicogical 29:53–64. doi:10.1080/08958378.2017.1282064.
   PubMed Web of Science ®Google Scholar
• Shaik-Dasthagirisaheb, Y. B. , G. Varvara , G. Murmura , A. Saggini , G. Potalivo , A. Caraffa , P. Antinolfi , S. Tete , D. Tripodi , F. Conti , E. Cianchetti , E. Toniato , M. Rosati , P. Conti , L. Speranza , A. Pantalone , R. Saggini , T. C. Theoharides , and F. Pandolfi . 2013. Vascular endothelial growth factor (VEGF), mast cells and inflammation. International Journal Immunopathol Pharmacology 26:327–335. doi:10.1177/039463201302600206.
   PubMed Web of Science ®Google Scholar
• Shannahan, J. H. , O. Alzate , W. M. Winnik , D. Andrews , M. C. Schladweiler , A. J. Ghio , S. H. Gavett , and U. P. Kodavanti . 2012. Acute phase response, inflammation and metabolic syndrome biomarkers of Libby asbestos exposure. Toxicology and Applied Pharmacology 260:105–114. doi:10.1016/j.taap.2012.02.006.
   PubMed Web of Science ®Google Scholar
• Shi, G. , D. J. Field , X. Long , D. Mickelsen , K. A. Ko , S. Ture , V. A. Korshunov , J. M. Miano , and C. N. Morrell . 2013. Platelet factor 4 mediates vascular smooth muscle cell injury responses. Blood 121:4417–4427. doi:10.1182/blood-2012-09-454710.
   PubMed Web of Science ®Google Scholar
• Shi, X. , V. Castranova , B. Halliwell , and V. Vallyathan . 1998. Reactive oxygen species and silica-induced carcinogenesis. Journal Toxicogical Environment Health B 1:181–197. doi:10.1080/10937409809524551.
   PubMed Web of Science ®Google Scholar
• Steenland, K. , and D. F. Goldsmith . 1995. Silica exposure and autoimmune diseases. American Journal of Industrial Medicine 28:603–608. doi:10.1002/(ISSN)1097-0274.
   PubMed Web of Science ®Google Scholar
• Subra, J. F. , G. Renier , P. Reboul , F. Tollis , R. Boivinet , P. Schwartz , and A. Chevailler . 2001. Lymphopenia in occupational pulmonary silicosis with or without autoimmune disease. Clinical and Experimental Immunology 126:540–544. doi:10.1046/j.1365-2249.2001.01696.x.
   PubMed Web of Science ®Google Scholar
• Teng, X. , D. Li , H. C. Champion , and R. A. Johns . 2003. FIZZ1/RELMalpha, a novel hypoxia-induced mitogenic factor in lung with vasoconstrictive and angiogenic properties. Circulation Research 92:1065–1067. doi:10.1161/01.RES.0000073999.07698.33.
   PubMed Web of Science ®Google Scholar
• Thomas, R. M. , C. Schmedt , M. Novelli , B. K. Choi , J. Skok , A. Tarakhovsky , and J. Roes . 2004. C-terminal SRC kinase controls acute inflammation and granulocyte adhesion. Immunity 20:181–191. doi:10.1016/S1074-7613(04)00023-8.
   PubMed Web of Science ®Google Scholar
• Todoric, J. , L. Antonucci , and M. Karin . 2016. Targeting inflammation in cancer prevention and therapy. Cancer Prevention Researcher 9:895–905. doi:10.1158/1940-6207.CAPR-16-0209.
   PubMed Web of Science ®Google Scholar
• Umbright, C. , R. Sellamuthu , S. Li , M. Kashon , M. Luster , and P. Joseph . 2010. Blood gene expression markers to detect and distinguish target organ toxicity. Molecular and Cellular Biochemistry 335:223–234. doi:10.1007/s11010-009-0272-5.
   PubMed Web of Science ®Google Scholar
• Vupputuri, S. , C. G. Parks , L. A. Nylander-French , A. Owen-Smith , S. L. Hogan , and D. P. Sandler . 2012. Occupational silica exposure and chronic kidney disease. Renal Fail 34:40–46. doi:10.3109/0886022X.2011.623496.
   PubMed Web of Science ®Google Scholar
• Winterbourn, C. C. , and D. Metodiewa . 1999. Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide. Free Radical Biology & Medicine 27:322–328. doi:10.1016/S0891-5849(99)00051-9.
   PubMed Web of Science ®Google Scholar
• Xu, H. , F. Yang , Y. Sun , Y. Yuan , H. Cheng , Z. Wei , S. Li , T. Cheng , D. Brann , and R. Wang . 2012. A new antifibrotic target of Ac-SDKP: Inhibition of myofibroblast differentiation in rat lung with silicosis. PLoS One 7:e40301. doi:10.1371/journal.pone.0040301.
   PubMed Web of Science ®Google Scholar
• Yamaji-Kegan, K. , Q. Su , D. J. Angelini , H. C. Champion , and R. A. Johns . 2006. Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2. American Journal Physiological Lung Cellular Molecular Physiological 291:L1159–L1168. doi:10.1152/ajplung.00168.2006.
   PubMed Web of Science ®Google Scholar
• Yamamoto, A. , R. Takeya , M. Matsumoto , K. I. Nakayama , and H. Sumimoto . 2013. Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1. The FEBS Journal 280:5145–5159. doi:10.1111/febs.2013.280.issue-20.
   PubMed Web of Science ®Google Scholar