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Original Articles

Toxicity and occupational exposure assessment for Fischer-Tropsch synthetic paraffinic kerosene

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Pages 774-791 | Received 16 Apr 2018, Accepted 15 Jun 2018, Published online: 09 Jul 2018

References

  • ACGIH. 2003. Kerosene/Jet Fuels. In Documentation of TLVs and BEIs. Cincinnati, OH: American Conference of Government Hygienists.
  • Alarie, Y. 1966. Irritating properties of airborne materials to the upper respiratory tract. Archives of Environmental Health 13:433–49.
  • Alarie, Y. 1973. Sensory irritation by airborne chemicals. Critical Reviews in Toxicology 2:299–363. doi:10.3109/10408447309082020.
  • Alarie, Y. 1981. Bioassay for evaluating the potency of airborne sensory irritants and predicting acceptable levels of exposure in man. Food and Cosmetics Toxicology 19:623–26.
  • Alden, C. L. 1986. A review of unique male rat hydrocarbon nephropathy. Toxicologic Pathology 14:109–11. doi:10.1177/019262338601400113.
  • ASTM Standard E981. 2004. Standard test method for estimating sensory irritancy of airborne chemicals. West Conshohocken, PA: ASTM International.
  • ATSDR. 1995. Toxicological profile for JP-4 and JP-7. Atlanta, GA: Agency for Toxic Substances and Disease Registry. http://www.atsdr.cdc.gov/toxprofiles/index.asp.
  • ATSDR. 1998. Toxicological Profile for JP-5 and JP-8. Atlanta, GA: Agency for Toxic Substances and Disease Registry. http://www.atsdr.cdc.gov/toxprofiles/index.asp.
  • ATSDR. 2017. Toxicological profile for JP-5, JP-8, and Jet A fuels. Atlanta, GA: Agency for Toxic Substances and Disease Registry. http://www.atsdr.cdc.gov/toxprofiles/index.asp.
  • AVMA. 2007. AVMA Guidelines on Euthanasia (Formerly Report of the AVMA Panel on Euthanasia). Schaumburg IL: American Veterinary Medical Association.
  • Baetcke, K. P., G. C. Hard, I. S. Rodgers, R. E. McGaughy, and L. M. Tahan. 1991. Alpha-2u-globulin: Association with chemically induced renal toxicity and neoplasia in the male rat. Washington, D.C.: Risk Assessment Forum, U.S. Environmental Protection Agency. EPA/625/3-91/019F.
  • Blakey, S., L. Rye, and C. W. Wilson. 2011. Aviation gas turbine alternative fuels: A review. Proceedings of the Combustion Institute 33:2863–85. doi:10.1016/j.proci.2010.09.011.
  • Borghoff, S. J., B. G. Short, and J. A. Swenberg. 1990. Biochemical mechanisms and pathobiology of alpha 2u-globulin nephropathy. Annual Review of Pharmacology and Toxicology 30:349–67. doi:10.1146/annurev.pa.30.040190.002025.
  • Breglia, R., Q. Bui, D. Burnett, F. Koschier, E. Lapadula, P. Podhasky, C. Schreiner, and R. White. 2014. A 13-week dermal repeat-dose neurotoxicity study of hydrodesulfurized kerosene in rats. International Journal of Toxicology 33:68S–77S. doi:10.1177/1091581813514282.
  • Bruner, R. H., E. R. Kinkead, T. P. O’Neill, C. D. Flemming, D. R. Mattie, C. A. Russell, and H. G. Wall. 1993. The toxicologic and oncogenic potential of JP-4 jet fuel vapors in rats and mice: 12-month intermittent inhalation exposures. Fundamental and Applied Toxicology 20:97–110.
  • Brusick, D. J., and D. W. Matheson. 1978. Mutagen and oncogen study on JP-8. Wright-Patterson AFB, OH: Aerospace Medical Research Laboratory. AMRL-TR-78-20. http://www.dtic.mil/dtic/tr/fulltext/u2/a064948.pdf.
  • Clark, C. R., P. W. Ferguson, M. A. Katchen, M. W. Dennis, and D. K. Craig. 1989. Comparative acute toxicity of shale and petroleum derived distillates. Toxicology and Industrial Health 5:1005–16.
  • Cooper, J. R., and D. R. Mattie. 1996. Developmental toxicity of JP-8 jet fuel in the rat. Journal of Applied Toxicology 16:197–200. doi:10.1002/(SICI)1099-1263(199605)16:3<197::AID-JAT331>3.0.CO;2-J.
  • DoD. 2014. Department of Defense handbook: Aerospace fuels certification. Wright-Patterson AFB, OH: Aeronautical Systems Center. MIL-HDBK-510-1A (USAF). http://everyspec.com/MIL-HDBK/MIL-HDBK-0500-0599/MIL-HDBK-510A_51601/.
  • Draize, J. H. 1959. Dermal toxicity. In U.S. Food and Drug Administration. Appraisal of the safety of chemicals in food, drugs, and cosmetics, 49–51. Austin, TX: The Association of Food and Drug Officials of the United States.
  • EIA. 2017. How much shale (tight) oil is produced in the United States? U.S. Energy Information Administration. Accessed June 22, 2017. https://www.eia.gov/tools/faqs/faq.php?id=847&t=6.
  • ExxonMobil Biomedical Sciences, Inc. 2001. Sensory irritation study in mice. Annandale NJ: Project number: 162951.
  • Fechter, L. D., J. W. Fisher, G. D. Chapman, V. P. Mokashi, P. A. Ortiz, J. E. Reboulet, J. E. Stubbs, A. M. Lear, S. M. McInturf, S. L. Prues, C. A. Gearhart, S. Fulton, and D. R. Mattie. 2012. Subchronic JP-8 jet fuel exposure enhances vulnerability to noise-induced hearing loss in rats. Journal of Toxicology and Environmental Health A 75:299–317. doi:10.1080/15287394.2012.652060.
  • Flamm, W. G., and L. D. Lehman-McKeeman. 1991. The human relevance of the renal tumor-inducing potential of d-limonene in male rats: Implications for risk assessment. Regulatory Toxicology and Pharmacology 13:70–86. doi:10.1016/0273-2300(91)90042-T.
  • Guthrie, O. W., H. Xu, B. A. Wong, S. M. McInturf, J. E. Reboulet, P. A. Ortiz, and D. R. Mattie. 2014. Exposure to low levels of jet-propulsion fuel impairs brainstem encoding of stimulus intensity. Journal of Toxicology and Environmental Health A 77:261–80. doi:10.1080/15287394.2013.862892.
  • Guthrie, O. W., B. A. Wong, S. M. McInturf, J. E. Reboulet, P. A. Ortiz, and D. R. Mattie. 2015. Inhalation of hydrocarbon jet fuel suppress central auditory nervous system function. Journal of Toxicology and Environmental Health A. 78:1154–1169.
  • Hard, G. C., I. S. Rodgers, K. P. Baetcke, W. L. Richards, R. E. McGaughy, and L. R. Valcovic. 1993. Hazard evaluation of chemicals that cause accumulation of alpha 2u-globulin, hyaline droplet nephropathy, and tubule neoplasia in the kidneys of male rats. Environment Health Perspectives 99:313–49.
  • Hinz, J. P., T. R. Sterner, E. W. Tewksbury, B. A. Wong, D. E. Dodd, C. U. Parkinson, D. J. Wagner, and D. R. Mattie. 2012. Human health hazard assessment of FT jet fuel and sensory irritation study in mice. Wright-Patterson AFB, OH: Air Force Research Laboratory, Molecular Bioeffects Branch. AFRL-RH-FS-TR-2012-0013, ADA563441. http://www.dtic.mil/dtic/tr/fulltext/u2/a563441.pdf.
  • Hurley, J. M., D. Wagner, T. R. Sterner, and D. R. Mattie. 2011. Acute dermal irritation study of JP-8 and S-8 in New Zealand white rabbits. Wright-Patterson AFB, OH: Air Force Research Laboratory, Applied Biotechnology Branch. AFRL-RH-WP-TR-2011-0054, ADA546698. http://www.dtic.mil/dtic/tr/fulltext/u2/a546698.pdf.
  • Kim, Y. W., M. J. Kim, B. Y. Chung, D. Y. Bang, S. K. Lim, S. M. Choi, D. S. Lim, M. C. Cho, K. Yoon, H. S. Kim, K. B. Kim, Y. S. Kim, S. J. Kwack, and B.-M. Lee. 2013. Safety evaluation and risk assessment of d-limonene. Journal of Toxicology and Environmental Health B 16:17–38. doi:10.1080/10937404.2013.769418.
  • Kinkead, E. R., S. A. Salins, and R. E. Wolfe. 1992. Acute irritation and sensitization potential of JP-8 jet fuel. Acute Toxicity Data 11:700.
  • Leavens, T. L., and S. J. Borghoff. 2009. Physiologically based pharmacokinetic model of methyl tertiary butyl ether and tertiary butyl alcohol dosimetry in male rats based on binding to alpha2u-globulin. Toxicological Sciences 109:321–35. doi:10.1093/toxsci/kfp049.
  • Leckel, D., and T. Phillips. 2011. Fischer-Tropsch: Extending the biofuels toolbox? Biofuels 2:109–13. doi:10.4155/bfs.10.85.
  • Mattie, D. R., C. L. Alden, T. K. Newell, C. L. Gaworski, and C. D. Flemming. 1991. A 90-day continuous vapor inhalation toxicity study of JP-8 jet fuel followed by 20 or 21 months of recovery in Fischer 344 rats and C57BL/6 mice. Toxicologic Pathology 19:77–87. doi:10.1177/019262339101900201.
  • Mattie, D. R., A. L. Carter, P. R. Eden, J. Z. Hezel, D. A. Dodd, K. Roberts, D. K. Layko, P. W. Ross, N. Edgerton, E. W. Tewksbury, M. Black, G. A. Willson, K. L. Mumy, T. R. Sterner, and B. A. Wong. 2012. Acute, five- and ten-day inhalation study of Hydroprocessed Esters and Fatty Acids-Mixed Fats (HEFA-F) jet fuel. Wright-Patterson AFB, OH: Air Force Research Laboratory, 711th Human Performance Wing, Molecular Bioeffects Branch. AFRL-RH-FS-TR-2012-0029, ADA577536. http://www.dtic.mil/dtic/tr/fulltext/u2/a577536.pdf.
  • Mattie, D. R., J. R. Cooper, T. R. Sterner, B. D. Schimmel, M. Y. V. Bekkedal, T. A. Bausman, and S. M. Young. 2001. Developmental neurobehavioral effects of JP-8 jet fuel on pups from female Sprague-Dawley rats exposed by oral gavage. Wright-Patterson AFB, OH: Air Force Research Laboratory, Applied Toxicology Branch. AFRL-HE-WP-TR-2001-0186, ADA428272. http://www.dtic.mil/dtic/tr/fulltext/u2/a428272.pdf.
  • Mattie, D. R., G. B. Marit, J. R. Cooper, T. R. Sterner, and C. D. Flemming. 2000. Reproductive effects of JP-8 jet fuel on male and female Sprague-Dawley rats after exposure by oral gavage. Wright-Patterson AFB, OH: Air Force Research Laboratory, Human Effectiveness Directorate. AFRL-HE-WP-TR-2000-0067, ADA453146. http://www.dtic.mil/dtic/tr/fulltext/u2/a453146.pdf.
  • Mattie, D. R., and T. R. Sterner. 2011. Past, present and emerging toxicity issues for jet fuel. Toxicology and Applied Pharmacology 254:127–32. doi:10.1016/j.taap.2010.04.022.
  • Mattie, D. R., T. R. Sterner, M. Oppong-Nketiah, T. Becker, B. Wallner, W. Riedel, A. Lutterbach, and D. J. Wagner. 2011c. F-T jet fuel reverse mutation assay and chromosome aberration test. Wright-Patterson AFB, OH: Air Force Research Laboratory, 711 Human Performance Wing, Applied Biotechnology Branch. AFRL-RH-WP-TR-2011-0010, ADA536685. http://www.dtic.mil/dtic/tr/fulltext/u2/a536685.pdf.
  • Mattie, D. R., T. R. Sterner, B. A. Wong, D. E. Dodd, D. K. Layko, P. W. Ross, E. A. Gross, G. A. Willson, J. P. Hinz, and D. J. Wagner. 2011b. 90-day inhalation toxicity study of FT fuel. Wright-Patterson AFB, OH: Air Force Research Laboratory, 711 Human Performance Wing, Human Effectiveness Directorate, Molecular Bioeffects Branch. AFRL-RH-FS-2011-0014, ADA557260. http://www.dtic.mil/dtic/tr/fulltext/u2/a557260.pdf.
  • Mattie, D. R., T. R. Sterner, B. A. Wong, D. E. Dodd, P. W. Ross, E. A. Gross, P. Gao, S. Sharma, X. J. Wang, M. A. Sochaski, G. A. Willson, and D. J. Wagner. 2011a. Acute and short-term inhalation toxicity study of FT fuel. Wright-Patterson AFB, OH: Air Force Research Laboratory, 711 Human Performance Wing, Applied Biotechnology Branch. AFRL-RH-WP-TR-2011-0107; ADA550389. http://www.dtic.mil/dtic/tr/fulltext/u2/a550389.pdf.
  • Morgan, K. T. 1991. Approaches to the identification and recording of nasal lesions in toxicology studies. Toxicologic Pathology 19:337–51.
  • Moses, C. A. 2008. Comparative evaluation of semi-synthetic jet fuels. Dayton, OH: Universal Technology Corporation. vols. AV-2-04a. http://crcao.org/publications/aviation/index.html.
  • Moses, C. A. 2009. Comparative evaluation of semi-synthetic jet fuels. Addendum: Further analysis of hydrocarbons and trace materials to support dxxxx. Dayton, OH: Universal Technology Corporation. vols. AV-2-04a. http://crcao.org/publications/aviation/index.html.
  • Natural Resources Canada. 2014. Energy markets fact book 2014-2015. Ottawa, Ontario: Natural Resources Canada.
  • NRC. 1996a. Permissible exposure levels for selected military fuel vapors. Edited by N. R. C. Committee on Toxicology. National Academy Press. Washington, D.C.: National Research Council of the National Academies of Science, Committee on Toxicology.
  • NRC. 1996b. Guide for the care and use of laboratory animals. National Academy Press, Washington, D.C.: Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council.
  • NRC. 2003. Toxicologic Assessment of Jet-Propulsion Fuel 8. National Academy Press, Washington, D.C.: National Research Council of the National Academies of Science, Committee on Toxicology.
  • NTP. 1986. Toxicology and carcinogenesis studies of marine diesel fuel and JP-5 Navy fuel (CAS NO. 8008-20-6) in B6C3F1 mice (dermal studies). Research Triangle Park, NC: National Toxicology Program. NTP-TR-310, NIH/PUB-86-2566, NTIS PB87-131678.
  • OECD. 1981. OECD guideline for testing of chemicals 412: Repeated dose inhalation toxicity: 28-day or 14-day study. Paris: Organisation for Economic Co-operation and Development.
  • OECD. 1997a. OECD guideline for testing of chemicals 471: Bacterial reverse mutation test. Paris: Organisation for Economic Co-operation and Development.
  • OECD. 1997b. OECD guideline for testing of chemicals 473: In vitro mammalian chromosome aberration test. Paris: Organisation for Economic Co-operation and Development.
  • OECD. 1997c. OECD guideline for testing of chemicals 474: Mammalian erythrocyte micronucleus test. Paris: Organisation for Economic Co-operation and Development.
  • OECD. 2002. OECD guideline for testing of chemicals 404: Acute dermal irritation/corrosion. Paris: Organisation for Economic Co-operation and Development.
  • Riccio, E. S., C. E. Green, and D. R. Mattie. 2010. Evaluation of five jet fuels in the Salmonella-Escherichia coli/microsome plate incorporation assay. Wright-Patterson AFB, OH: Air Force Research Laboratory, 711 Human Performance Wing, Applied Biotechnology Branch. AFRL-RH-WP-TR-2010-0138, ADA536581. http://www.dtic.mil/dtic/tr/fulltext/u2/a536581.pdf.
  • Rohan, J. G., S. M. McInturf, M. K. Miklasevich, C. P. Gut, M. D. Grimm, J. E. Reboulet, W. R. Howard, and K. L. Mumy. 2018. Comparative electrophysiological evaluation of hippocampal function following repeated inhalation exposures to JP-8, Jet A, JP-5, and the synthetic Fischer Tropsch fuel. Journal of Toxicology and Environmental Health A 81:314–32. doi:10.1080/15287394.2018.1437097.
  • Speight, J. G. 2016. Heavy oil and tar sand bitumen. In Introduction to enhanced recovery methods for heavy oil and tar sands., Second ed., 3–48. Amsterdam: Elsevier Inc., Gulf Professional Publishing.
  • Sterner, T. R., J. M. Hurley, J. T. Edwards, L. M. Shafer, and D. R. Mattie. 2014. Acute dermal irritation study of six jet fuels in New Zealand white rabbits: Comparison of four bio-based jet fuels with two petroleum JP-8 fuels. Wright-Patterson AFB OH: Air Force Research Laboratory, Human Effectiveness Directorate, Bioeffects Division, Molecular Bioeffects Branch. AFRL-RH-WP-TR-2014-0046, ADA606443. http://www.dtic.mil/dtic/tr/fulltext/u2/a606443.pdf.
  • Striebich, R. C., L. M. Shafer, R. K. Adams, Z. J. West, M. J. DeWitt, and S. Zabarnick. 2014. Hydrocarbon group-type analysis of petroleum-derived and synthetic fuels using two-dimensional gas chromatography. Energy & Fuels 28:5696–706. doi:10.1021/ef500813x.
  • Sweeney, L. M., S. L. Prues, and J. E. Reboulet. 2013. Subacute effects of inhaled Jet Fuel-A (Jet A) on airway and immune function in female rats. Inhalation Toxicology 25:257–71. doi:10.3109/08958378.2013.780191.
  • U.S. EPA. 1998a. Health effects test guidelines: OPPTS 870.2500 acute dermal irritation. Washington, D.C.: U.S. Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances. EPA 712-C-98-196.
  • U.S. EPA. 1998b. Health effects test guidelines OPPTS 870.1300 acute inhalation toxicity. Washington, D.C.: U.S. Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances. EPA 712-C-98-193.
  • U.S. EPA. 1998c. Health effects test guidelines: OPPTS 870.3465 90-day inhalation toxicity. Washington, D.C.: U.S. Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances. EPA 712-C-98-204.
  • U.S. EPA. 1998d. Health effects test guidelines: OPPTS 870.6200 neurotoxicity screening battery. Washington, D.C.: U.S. Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances. EPA 712-C-98-238.
  • U.S. EPA. 1998e. Health effects test guidelines: OPPTS 870.5100 bacterial reverse mutation test. Washington, D.C.: U.S. Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances. EPA 712-C-98-247.
  • U.S. EPA. 1998f. Health effects test guidelines. OPPTS 870.5375 In vitro mammalian cytogenetics. Washington, D.C.: U.S. Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances. EPA712-C-98-223.
  • U.S. EPA. 1998g. Health effects test guidelines. OPPTS 870.5395 Mammalian erythrocyte micronucleus test. Washington, D.C.: U.S. Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances. EPA712-C-98-226.
  • Vernot, E. H., R. T. Drew, and M. L. Kane. 1990. Acute toxicological evaluation of Jet Fuel A. Acute Toxicity Data 1:29–30.
  • Vijayalaxmi, V., A. D. Kligerman, T. J. Prihoda, and S. E. Ullrich. 2006. Micronucleus studies in the peripheral blood and bone marrow of mice treated with jet fuels, JP-8 and Jet-A. Mutation Research 608:82–87. doi:10.1016/j.mrgentox.2006.05.005.
  • White, K., M. P. Delorme, P. W. Beatty, M. J. Smith, and V. L. Peachee. 2013. Jet fuel kerosene is not immunosuppressive in mice or rats following inhalation for 28 days. Journal of Toxicology and Environmental Health A 76:778–97. doi:10.1080/15287394.2013.819307.
  • Whitman, F. T., and J. P. Hinz. 2001. Sensory irritation study in mice: JP-4, JP-8, JP-8+100. Brooks AFB, TX: AF Institute for Environment, Safety and Occupational Health Risk Analysis. IERA-RS-BR-SR-2001-0005. http://www.dtic.mil/dtic/tr/fulltext/u2/a398112.pdf.
  • Whitman, F. T., and J. P. Hinz. 2004. Sensory irritation study in mice: JP-5, JP-TS, JP-7, DFM, JP-10. Brooks City-Base, TX: Air Force Institute for Operational Health, Risk Analysis Directorate. IOH-RS-BR-SR-2004-0001. http://www.dtic.mil/dtic/tr/fulltext/u2/a432128.pdf.
  • Wolfe, R. E., E. R. Kinkead, M. L. Feldmann, H. F. Leahy, W. W. Jederberg, D. R. Mattie, and K. R. Still. 1996. Acute toxicity evaluation of JP-8 jet fuel and JP-8 jet fuel containing additives. Wright-Patterson AFB, OH: Armstrong Laboratory. AL/OE-TR-1996-0136. http://www.dtic.mil/dtic/tr/fulltext/u2/a318722.pdf.

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