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Articles

Genotoxic effects induced by beta-myrcene following metabolism by liver HepG2/C3A human cells

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References

  • Bakkali, F., S. Averbeck, D. Averbeck, and M. Idaomar. 2008. Biological effects of essential oils – A review. Food Chem. Toxicol. 46:446–75. doi:10.1016/j.fct.2007.09.106.
  • Behr, A., and L. Johnen. 2009. Myrcene as a natural base chemical in sustainable chemistry: A critical review. ChemSusChem 2:1072–95. doi:10.1002/cssc.v2:12.
  • Collins, A. R., A. A. Oscoz, G. Brunborg, I. Gaivão, L. Giovannelli, M. Kruszewski, C. C. Smith, and R. Stetina. 2008. The comet assay: Topical issues. Mutagenesis 23:143–51. doi:10.1093/mutage/gem051.
  • Crespo, R., S. M. Villegas, M. C. Abba, M. G. Bravo, and M. P. Polo. 2013. Transcriptional and posttranscriptional inhibition of HMGCR and PC biosynthesis by geraniol in 2 Hep-G2 cell proliferation linked pathways. Biochem. Cell Biol. 91:131–39. doi:10.1139/bcb-2012-0076.
  • Delgado, I. F., A. C. Nogueira, C. A. Souza, A. M. Costa, L. H. Figueiredo, A. P. Mattos, I. Chahoud, and F. J. Paumgartten. 1993. Peri- and postnatal developmental toxicity of beta-myrcene in the rat. Food Chem. Toxicol. 31:623–28. doi:10.1016/0278-6915(93)90044-Y.
  • Fahlbusch, K. G., F. J. Hammerschmidt, J. Panten, W. Pickenhagen, D. Schatkowski, K. Bauer, D. Garbe, and H. Surburg. 2002. Flavors and fragrances. In Ullmann’s encyclopedia of industrial chemistry. Ullmann’s encyclopedia of industrial chemistry. Weinheim: Wiley-VCH. http://dx.doi.org/10.1002/14356007.a11_141
  • Fenech, M. 2000. The in vitro micronucleus technique. Mutat. Res. 455:81–95.
  • Fenech, M., and J. W. Crott. 2002. Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes evidence for breakage-fusion-bridge cycles in the cytokinesis block micronucleus assay. Mutat. Res. 504:131–36. doi:10.1016/S0027-5107(02)00086-6.
  • Fotakis, G., and J. A. Timbrell. 2006. In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol. Lett. 160:171–77. doi:10.1016/j.toxlet.2005.07.001.
  • Hartmann, A., and G. Speit. 1997. The contribution of cytotoxicity to DNA-effects in the single cell gel test (comet assay). Toxicol. Lett. 90:183–88.
  • Hewitt, N. J., and P. Hewitt. 2004. Phase I and II enzyme characterization of two sources of HepG2 cell lines. Xenobiotica 34:243–56. doi:10.1080/00498250310001657568.
  • Inui, T., F. Tsuchiya, M. Ishimaru, K. Oka, and H. Komura. 2013. Different beers with different hops. Relevant compounds for their aroma characteristics. J. Agric. Food Chem. 61:4758–64. doi:10.1021/jf3053737.
  • Kim, Y. W., M. J. Kim, B. Y. Chung, D. Y. Bang, S. K. Lim, S. M. Choi, D. S. Lim, M. C. Cho, K. Yoon, H. S. Kim, et al. 2013. Safety evaluation and risk assessment of d-Limonene. J. Toxicol. Environ. Health B 16:17–38. doi:10.1080/10937404.2013.769418.
  • Kirsch-Volders, M., G. Plas, A. Elhajouji, M. Lukamowicz, L. Gonzalez, K. V. Loock, and I. Decordier. 2011. The in vitro MN assay in 2011: Origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance. Arch. Toxicol. 85:873–99. doi:10.1007/s00204-011-0691-4.
  • Lachenmeier, K., F. Musshoff, B. Madea, and D. W. Lachenmeier. 2006. Application of experimental design to optimise solid-phase microextraction of orange juice flavour. Electron J. Environ. Agric. Food Chem. 5:1380–88.
  • Lee, S., Y. R. Park, S. H. Kim, E. J. Park, M. J. Kang, I. So, J. N. Chun, and J. H. Jeon. 2016. Geraniol suppresses prostate cancer growth through down-regulation of E2F8. Cancer Med. 5:2899–908. doi:10.1002/cam4.864.
  • Malich, G., B. Markovic, and C. Winder. 1997. The sensitivity and specificity of the MTS tetrazolium assay for detecting the in vitro cytotoxicity of 20 chemicals using human cell lines. Toxicology 124:179–92.
  • Martin, D. M., J. Gershenzon, and J. Bohlmann. 2003. Induction of volatile terpene biosynthesis and diurnal emission by methyl jasmonate in foliage of Norway spruce. Plant Physiol. 13:1586–99. doi:10.1104/pp.103.021196.
  • Mitic-Culafic, D., B. Zegura, B. Nikolic, B. Vukovic-Gacic, J. Knezevic-Vukcevic, and M. Filipic. 2009. Protective effect of linalool, myrcene and eucalyptol against t-butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells. Food Chem. Toxicol. 47:260–66. doi:10.1016/j.fct.2008.11.015.
  • Mohamed-Hanaa, A. R., Y. I. Sallam, A. S. El-Leithy, and S. E. Aly. 2012. Lemongrass (Cymbopogon citratus) essential oil as affected by drying methods. Ann. Agric. Sci. 57:113–16. doi:10.1016/j.aoas.2012.08.004.
  • Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65:55–63. doi:10.1016/0022-1759(83)90303-4.
  • Murata, S., R. Shiragami, C. Kosugi, T. Tezuka, M. Yamazaki, A. Hirano, Y. Yoshimura, M. Suzuki, K. Shuto, N. Ohkohchi, et al. 2013. Antitumor effect of 1,8-cineole against colon cancer. Oncol. Rep. 30:2647–52. doi:10.3892/or.2013.2763.
  • National Toxicology Program (NTP). 2010. NTP technical report on the toxicology and carcinogenesis studies of beta-myrcene (CAS No. 123-35-3) in F344/N rats and B6C3F1 mice (Gavage studies). Natl. Toxicol. Program Tech. Rep. Ser. 557: 1–163.
  • NTP (National Toxicology Program). 1990. Toxicology and carcinogenesis studies of d-limonene (CAS No. 5989-27-5) in F344/N rats and B6C3F1 mice (Gavage studies). Natl. Toxicol. Program Tech. Rep. Ser. 347: 1–165.
  • OECD TG 487. 2014. Guidelines for the testing of chemicals. In vitro mammalian cell micronucleus test. OECD Publishing,  http://dx.doi.org/10.1787/9789264264861-en
  • OECD TG 489. 2014. Guidelines for the testing of chemicals. In vivo mammalian alkaline comet assay. OECD Publishing, http://dx.doi.org/10.1787/9789264264885-en
  • Paumgartten, F. J., R. R. De-Carvalho, C. A. Souza, K. Madi, and I. Chahoud. 1998. Study of the effects of beta-myrcene on rat fertility and general reproductive performance. Braz. J. Med. Biol. Res. 31:955–65.
  • Pichersky, E. 2006. Biosynthesis of plant volatiles: Nature’s diversity and ingenuity. Science 311:808–11.
  • Pículo, F., C. G. Macedo, S. F. Andrade, and E. L. Maistro. 2011. In vivo genotoxicity assessment of nerolidol. J. Appl. Toxicol. 31:633–39. doi:10.1002/jat.1607.
  • Queiroz, T. B., G. F. Santos, S. C. Ventura, C. A. Hiruma-Lima, I. O. M. Gaivão, and E. L. Maistro. 2017. Cytotoxic and genotoxic potential of geraniol in peripheral blood mononuclear cells and human hepatoma cell line (HepG2). Genet. Mol. Res. 16:gmr16039777. doi:10.4238/gmr16039744.
  • Ruiz-Cabello, M. L., M. Puerto, S. Maisanaba, R. Guzmán-Guillén, S. Pichardo, and A. M. Cameán. 2018. Use of micronucleus and comet assay to evaluate the genotoxicity of oregano essential oil (Origanum vulgare l. Virens) in rats orally exposed for 90 days. J. Toxicol. Environ. Health A 81:525–33. doi:10.1080/15287394.2018.1447522.
  • Sobral, M. V., A. L. Xavier, T. C. Lima, and D. P. Sousa. 2014. Antitumor activity of monoterpenes found in essential oils. Sci. World J. 2014:953451. doi:10.1155/2014/953451.
  • Souza, A. C. S., L. K. Silva, T. B. Queiroz, E. S. Marques, C. A. Hiruma-Lima, I. O. M. Gaivão, and E. L. Maistro. 2019. Citral presents cytotoxic and genotoxic effects in human cultured cells. Drug Chem. Toxicol. (in press).
  • Takabe, K., T. Katagiri, J. Tanaka, T. Fujita, S. Watanabe, and K. Suga. 1989. Addition of dialkylamines to myrcene: N,n-diethylgeranylamine. Org. Synth. 67:44. doi:10.15227/orgsyn.067.0044.
  • Tice, R. R., E. Agurell, D. Anderson, B. Burlison, A. Hartmann, H. Kobayashi, Y. Miyamae, E. Rojas, J.-C. Ryu, and Y. F. Sasaki. 2000. Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 35:206–21.
  • Usta, J., S. Kreydiyyeh, K. Knio, P. Barnabe, Y. Bou-Moughlabay, and S. Dagher. 2009. Linalool decreases HepG2 viability by inhibiting mitochondrial complexes I and II, increasing reactive oxygen species and decreasing ATP and GSH levels. Chem. Biol. Interact. 180:39–46. doi:10.1016/j.cbi.2009.02.012.
  • Vázquez-Araújo, L., R. Rodríguez-Solana, S. M. Cortés-Diéguez, and J. M. Domínguez. 2013. Use of hydrodistillation and headspace solid-phase microextraction to characterize the volatile composition of different hop cultivars. J. Sci. Food Agric. 93:2568–74. doi:10.1002/jsfa.2013.93.issue-10.
  • Vieira, A., R. Heidor, M. T. Cardozo, C. Scolastici, E. Purgatto, T. M. Shiga, L. F. Barbisan, T. P. Ong, and F. S. Moreno. 2011. Efficacy of geraniol but not of B-ionone or their combination for the chemoprevention of rat colon carcinogenesis. Braz. J. Med. Biol. Res. 44:538–45.
  • Zwenger, S., and C. Basu. 2008. Plant terpenoids: Applications and future potentials. Biotechnol. Mol. Biol. Rev. 3:1–7.

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