In vitro exposure to the next-generation plasticizer diisononyl cyclohexane-1,2-dicarboxylate (DINCH): cytotoxicity and genotoxicity assessment in human cells

References

• Andrady, A. L., and M. A. Neal. 2009. Applications and societal benefits of plastics. Philos. Trans. R Soc. Lond. B Biol. Sci. 364:1977–84. doi:10.1098/rstb.2008.0304.
   PubMed Web of Science ®Google Scholar
• ANSES Report, 2015. Avis de l’Anses nº2015-RE-0003 relatif à une analyse de la meilleure option de gestion dos risques (RMOA) pour le DINCH® (1,2-cyclohexanedicarboxylic acid, diisononyl ester, n° CAS 166412-78-8). Accessed July 23, 2018. https://www.anses.fr/fr/system/files/REACH2015re0003.pdf.
   Google Scholar
• Apel, P., J. Angerer, M. Wilhelm, and M. Kolossa-Gehring. 2017. New HBM values for emerging substances, inventory of reference and HBM values in force, and working principles of the German human biomonitoring commission. Int. J. Hyg. Environ. Health. 220:152–66. doi:10.1016/j.ijheh.2016.09.007.
   PubMed Web of Science ®Google Scholar
• Bhat, V. S., J. L. Durham, G. L. Ball, and J. C. English. 2014. Derivation of an oral reference dose (RfD) for the non-phthalate alternative plasticizer 1,2-cyclohexane dicarboxylic acid, di-isononyl ester (DINCH). J. Toxicol. Environ. Health B 17:63–94. doi:10.1080/10937404.2013.876288.
   PubMed Web of Science ®Google Scholar
• Boisvert, A., S. Jones, L. Issop, H. C. Erythropel, V. Papadopoulos, and M. Culty. 2016. In vitro functional screening as a means to identify new plasticizers devoid of reproductive toxicity. Environ. Res. 150:496–512. doi:10.1016/j.envres.2016.06.033.
   PubMed Web of Science ®Google Scholar
• Bui, T. T., G. Giovanoulis, A. P. Cousins, J. Magner, I. T. Cousins, and C. A. Wit. 2016. Human exposure, hazard and risk of alternative plasticizers to phthalate esters. Sci. Total Environ. 541:451–67. doi:10.1016/j.scitotenv.2015.09.036.
   PubMed Web of Science ®Google Scholar
• Cadet, J., and K. J. A. Davies. 2017. Oxidative DNA damage and repair: An introduction. Free Radicals Biol. 107:2–12. doi:10.1016/j.freeradbiomed.2017.03.030.
   PubMed Web of Science ®Google Scholar
• CDC 2018. Centers for disease control and prevention, biomonitoring summary of Di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) CAS No. 166412-78-8. Accessed August 26.https://www.cdc.gov/biomonitoring/DINCH_BiomonitoringSummary.html
   Google Scholar
• Collins, A., G. Koppen, V. Valdiglesias, M. Dusinska, M. Kruszewski, P. Møller, E. Rojas, A. Dhawan, I. Benzie, E. Coskun, et al. 2014. The comet assay as a tool for human biomonitoring studies: The ComNet project. Mutat. Res. 759:27–39. doi:10.1016/j.mrrev.2013.10.001.
   PubMed Web of Science ®Google Scholar
• Correia-Sá, L., A. Schütze, S. Norberto, C. Calhau, V. F. Domingues, and H. M. Koch. 2017. Exposure of Portuguese children to the novel non-phthalate plasticizer di-(iso-nonyl)- cyclohexane-1,2-dicarboxylate (DINCH). Environ Int 102:79–86. doi:10.1016/j.envint.2017.02.001.
   PubMed Web of Science ®Google Scholar
• Dizdaroglu, M. 2012. Oxidatively induced DNA damage: Mechanisms, repair and disease. Cancer Lett. 327:26–47. doi:10.1016/j.canlet.2012.01.016.
   PubMed Web of Science ®Google Scholar
• ECHA 2016. Analysis of the most appropriate risk management option (RMOA), EC Number 431-890-2, 1,2-Cyclohexanedicarboxylic acid, diisononyl ester (DINCH®), MSCA-FR, France, January 2016. Accessed May 22. https://www.echa.europa.eu/documents/10162/fc77bffd- e7ec-4846-b080-11de2564e582.
   Google Scholar
• ECHA. 2018. Annnex III Inventory. Accessed May 22. https://echa.europa.eu/information-on- chemicals/annex-iii-inventory/-/dislist/details/AIII-100.121.507.
   Google Scholar
• ECPI 2009. European Plasticizer Consumption – Trends. European Council for Plasticizers and Intermediates. Accessed September 21. http://www.ccaia.org.cn/meetdown/download/2013pvc/2013_NScholz_Ordos_ final(2).pdf
   Google Scholar
• ECPI 2014. European Council for Plasticizers and Intermediates. Accessed September 21. http://www.plasticizers.org/en_GB/plasticizers.
   Google Scholar
• EFSA 2006. Opinion of the Scientific Panel on food additives, flavorings, processing aids and materials in contact with food (AFC) on a request related to a 12th list of substances for food contact materials Question N° EFSA-Q-2004-073, EFSA-Q-2006-024, EFSA-Q- 2005-238a, EFSA-Q-2005-238b, EFSA-Q-2005-238c, EFSA-Q-2006-012, EFSA-Q-2006-027. The EFSA Journal 395-401, 1-221. Accessed May 24. http://www.efsa.europa.eu/en/scdocs/doc/395.pdf.
   Google Scholar
• Eljezi, T., P. Pinta, F. Nativel, D. Richard, J. Pinguet, O. Roy, V. Sautou, G. Grimandi, and E. Moreau. 2019. In vitro cytotoxic effects of secondary metabolites of DEHP and its alternative plasticizers DINCH and DINP on a L929 cell line. Int. J. Hyg. Environ. Health. 222:583–89. doi:10.1016/j.ijheh.2019.03.005.
   PubMed Web of Science ®Google Scholar
• Eljezi, T., P. Pinta, D. Richard, J. Pinguet, J.-M. Chezal, M.-C. Chagnon, V. Sautou, G. Grimandi, and E. Moreau. 2017. In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line. Chemosphere 173:452–59. doi:10.1016/j.chemosphere.2017.01.026.
   PubMed Web of Science ®Google Scholar
• Engel, A., T. Buhrke, S. Kasper, A. C. Behr, A. Braeuning, S. Jessel, A. Seidel, W. Völkel, and A. Lampen. 2018. The urinary metabolites of DINCH® have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ. Toxicol. Lett. 287:83–91. doi:10.1016/j.toxlet.2018.02.006.
   PubMed Web of Science ®Google Scholar
• Eriksen, M., L. C. M. Lebreton, H. S. Carson, M. Thiel, C. J. Moore, J. C. Borerro, F. Galgani, P. G. Ryan, and J. Reisser. 2014. Plastic pollution in the world’s oceans: More than 5 trillion plastic pieces weighing over 250,000 tons afloat at sea. PLoS ONE 9:e111913. doi:10.1371/journal.pone.0111913.
   PubMed Web of Science ®Google Scholar
• Fenech, M. 2007. Cytokinesis-block micronucleus cytome assay. Nat Protoc 2:1084–104. doi:10.1038/nprot.2007.77.
   PubMed Web of Science ®Google Scholar
• Franco, R., O. Schoneveld, A. G. Georgakilas, and M. I. Panayiotidis. 2008. Oxidative stress, DNA methylation and carcinogenesis. Cancer Lett. 266:6–11. doi:10.1016/j.canlet.2008.02.026.
   PubMed Web of Science ®Google Scholar
• Fromme, H., A. Schütze, T. Lahrz, M. Kraft, L. Fembacher, S. Siewering, R. Burkardt, S. Dietrich, H. M. Koch, and W. Völkel. 2016. Non-phthalate plasticizers in German daycare centers and human biomonitoring of DINCH metabolites in children attending the centers (LUPE 3). Int. J. Hyg. Environ. Health. 219:33–39. doi:10.1016/j.ijheh.2015.08.002.
   PubMed Web of Science ®Google Scholar
• Giovanoulis, G., A. Alves, E. Papadopoulou, A. P. Cousins, A. Schütze, H. M. Koch, L. S. Haug, A. Covaci, J. Magnér, and S. Voorspoels. 2016. Evaluation of exposure to phthalate esters and DINCH in urine and nails from a Norwegian study population. Environ. Res. 151:80–90. doi:10.1016/j.envres.2016.07.025.
   PubMed Web of Science ®Google Scholar
• Hewitt, N. J., and P. Hewitt. 2004. Phase I and II enzyme characterization of two sources of HepG2 cell lines. Xenobiotica 34:243–56. doi:10.1080/00498250310001657568.
   PubMed Web of Science ®Google Scholar
• Koch, H. M., A. Schütze, C. Pälmke, J. Angerer, and T. Brüning. 2013. Metabolism of the plasticizer and phthalate substitute diisononyl-xyxlohexane-1,2-dicarboxylate (DINCH®) in humans after single oral doses. Arch. Toxicol. 87:799–806. doi:10.1007/s00204-012-0990-4.
   PubMed Web of Science ®Google Scholar
• Kryston, T. B., A. B. Georgiv, P. Pissis, and A. G. Georgakilas. 2011. Role of oxidative stress and DNA damage in human carciogenesis. Mutat. Res. 711:193–201. doi:10.106/j.mrfmmm.210.12.016.
   PubMed Web of Science ®Google Scholar
• Louro, H., M. Pinhão, J. Santos, A. Tavares, N. Vital, and M. J. Silva. 2016. Evaluation of the cytotoxic and genotoxic effects of benchmark multi-walled carbon nanotubes in relation to their physicochemical properties. Toxicol. Lett. 262:123–34. doi:10.1016/j.toxlet.2016.09.016.
   PubMed Web of Science ®Google Scholar
• Lowell Centre for Sustainable Production 2011. Phthalates and their alternatives: Health and environmental concerns, technical briefing, University of Massachusetts Lowell. http://www.sustainableproduction.org/publ.alternatives.php.
   Google Scholar
• Nardelli, T. C., H. C. Erythropel, and B. Robaire. 2015. Toxicogenomic screening of replacements for di(2-ethylhexyl) phthalate (DEHP) using the immortalized TM4 Sertoli cell line. PLoS ONE 10:e0138421. doi:10.1371/journal.pone.0138421.
   PubMed Web of Science ®Google Scholar
• NICNAS- National Industrial Chemicals Notification and Assessment Scheme, 2012. (NICNAS), public report: 1,2-Cyclohexanedicarboxylic acid, 1,2-diisononyl ester (‘Hexamoll DINCH’). File No: EX/170 (STD/1259) February 2012. accessed May 22. http://www.nicnas.gov.au/PUBLICATIONS/CAR/NEW/EX/EXFULLR/EX0000FR/ex170f r.pdf.
   Google Scholar
• OECD- Organisation for Economic Co-operation and Development, 2016. OECD guidelines for the testing of chemicals: In Vitro mammalian cell micronucleus test (No. 487, 2016). Accessed June 20. http://www.oecd.org/env/ehs/testing/TG487%20Oct%202012%20updated%2029oct.pdf.
   Google Scholar
• SCENIHR, 2016. Scientific committee on emerging and newly-identified health risks, SCENIHR, opinion on the safety of medical devices containing DEHP-plasticized PVC or other plasticizers on neonates and other groups possibly at risk (2015 Update). Revision February 2016. European Comission, Health and Consumer Protection, Directorate-Generale, Brussels. Accessed August 7. https://ec.europa.eu/health/scientific_committees/emerging/docs/scenihr_o_047.pdf.
   Google Scholar
• Schütze, A., M. Kolossa-Gehring, P. Apel, T. Brüning, and H. M. Koch. 2014. Entering markets and bodies: Increasing levels of the novel plasticizer Hexamoll®DINCH® in 24h urine samples from the German environmental specimen bank. Int. J. Hyg. Environ. Health. 217:421–26. doi:10.1016/j.ijheh.2013.08.004.
   PubMed Web of Science ®Google Scholar
• Schütze, A., R. Otter, H. Modick, A. Langsch, T. Brüning, and H. M. Koch. 2016. Additional oxidized and alkyl chain breakdown metabolites of the plasticizer DINCH in urine after oral dosage to human volunteers. Arch. Toxicol. 1:179–88. doi:10.1007/s00204-016-1688-9.
   Google Scholar
• Schütze, A., C. Pälmke, J. Angerer, T. Weiss, T. Brüning, and H. M. Koch. 2012. Quantification of biomarkers of environmental exposure to di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) in urine via HPLC–MS/MS. J. Chromatogr B. 895–896:123–30. doi:10.1016/j.jchromb.2012.03.030.
   PubMed Web of Science ®Google Scholar
• Sheikh, I. A., and M. A. Beg. 2019. Structural characterization of potential endocrine disrupting activity of alternate plasticizers di-(2ethylhexyl)adipate (DEHA) acetyly tributyl citrate (ATBC) and 2,2,4-trimethyl-1,3-pentanediol diisobutryrate (TPIB) with human sex hormone-binding globulin. Reprod. Toxicol. 83:46–53. doi:10.1016/j.reprotox.2018.11.003.
   PubMedGoogle Scholar
• Shih, C. L., P. M. Liao, J. Y. Hsu, Y. N. Chung, V. G. Zgoda, and P. C. Liao. 2018. Exposure marker discovery of di(isononyl)cyclohexane-1,2-dicarboxylate using two mass spectrometry-based metabolite profiling data processing methods. Environ.L Sci. Pollut. Res. 5:11999–2011. doi:10.1007/s11356-018-1484-6.
   Google Scholar
• Van Vliet, E. D. S., E. M. Reitano, J. S. Chhabra, G. P. Bergen, and R. M. Whyatt. 2011. A review of alternatives to di (2-ethylhexyl) phthalate containing medical devices in the neonatal intensive care unit. J. Perinatol. 31:551–60. doi:10.1038/jp.2010.208.
   PubMed Web of Science ®Google Scholar