Anti-hyperlipidemic effects of Campomanesia xanthocarpa aqueous extract and its modulation on oxidative stress and genomic instability in Wistar rats

References

• Bahadoran, Z., P. Mirmiran, and F. Azizi. 2013. Dietary polyphenols as potential nutraceuticals in management of diabetes: A review. J. Diabetes Metab. Disord. 12:43. doi:10.1186/2251-6581-12-43.
   PubMedGoogle Scholar
• Bahmani, M., M. Mirhoseini, H. Shirzad, M. Sedighi, N. Shahinfard, and M. Rafieian-Kopaei. 2015. A review on promising natural agents effective on hyperlipidemia. J. Evid. Based Complementary Altern. Med. 20:228–38. doi:10.1177/2156587214568457.
   PubMedGoogle Scholar
• Baldissera, M. D., C. F. Souza, T. H. Grando, P. H. Doleski, A. A. Boligon, L. M. Stefani, and S. G. Monteiro. 2017. Hypolipidemic effect of β-caryophyllene to treat hyperlipidemic rats. Naunyn Schmiedebergs Arch. Pharmacol. 390:215–23.
   PubMed Web of Science ®Google Scholar
• Ballvé, A. C., N. C. S. Siqueira, L. A. Mentz, G. A. B. Silva, and K. F. D. José. 1995. Plantas medicinais de uso popular. In Atlas Farmacognóstico. 1st. ed. Canoas: Editora da ULBRA.
   Google Scholar
• Bhurosy, T., and R. Jeewon. 2014. Overweight and obesity epidemic in developing countries: A problem with diet, physical activity, or socioeconomic status? Sci. World J. 2014:964236. doi:10.1155/2014/964236.
   Google Scholar
• Biavatti, M. W., C. Farias, F. Curtius, L. M. Brasil, S. Hort, L. Schuster, S. N. Leite, and S. R. Prado. 2004. Preliminary studies on Campomanesia xanthocarpa (Berg.) and Cuphea carthagenensis (Jacq.) J.F. Macbr. aqueous extract: Weight control and biochemical parameters. J. Ethnopharmacol. 93:385–89. doi:10.1016/j.jep.2004.04.015.
   PubMed Web of Science ®Google Scholar
• Boveris, A., and B. Chance. 1973. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem. J. 134:707–16. doi:10.1042/bj1340707.
   PubMed Web of Science ®Google Scholar
• Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–54. doi:10.1016/0003-2697(76)90527-3.
   PubMed Web of Science ®Google Scholar
• Buege, J. A., and S. D. Aust. 1978. Microsomal lipid peroxidation. Meth. Enzymol. 52:302–10.
   PubMedGoogle Scholar
• Cardozo, C. M. L., A. C. Inada, G. Marcelino, P. S. Figueiredo, D. G. Arakaki, P. A. Hiane, C. A. L. Cardoso, R. C. A. Guimarães, and K. C. Freitas. 2018. Therapeutic potential of Brazilian Cerrado Campomanesia species on metabolic dysfunctions. Molecules. 23 article ID E2336. doi:10.3390/molecules23092336.
   Web of Science ®Google Scholar
• Catapano, A. L., I. Graham, G. De Backer, O. Wiklund, M. J. Chapman, H. Drexel, A. W. Hoes, C. S. Jennings, U. Landmesser, T. R. Pedersen, et al. 2016. ESC scientific document group. 2016 ESC/EAS guidelines for the management of dyslipidaemias. Eur. Heart J. 37:2999–3058. doi:10.1093/eurheartj/ehw272.
   PubMed Web of Science ®Google Scholar
• Chao, P. C., C. C. Hsu, and M. C. Yin. 2009. Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice. Nutr. Metab. (Lond). 6:33. doi:10.1186/1743-7075-6-33.
   PubMed Web of Science ®Google Scholar
• de Oliveira, N. C., M. S. Sarmento, E. A. Nunes, C. M. Porto, D. P. Rosa, S. R. Bona, G. Rodrigues, N. P. Marroni, P. Pereira, J. N. Picada, et al. 2012. Rosmarinic acid as a protective agent against genotoxicity of ethanol in mice. Food Chem. Toxicol. 50:1208–14. doi:10.1016/j.fct.2012.01.028.
   PubMed Web of Science ®Google Scholar
• de Sousa, J. A., L. da Silva Prado, B. L. Alderete, F. B. M. Boaretto, M. C. Allgayer, F. M. Miguel, J. T. de Sousa, N. P. Marroni, M. L. B. Lemes, D. S. Correa, et al. 2019. Toxicological aspects of Campomanesia xanthocarpa Berg. associated with its phytochemical profile. J. Toxicol. Environ. Health Part A 82:62–74. doi:10.1080/15287394.2018.1562392.
   PubMed Web of Science ®Google Scholar
• de Sousa, J. A., P. Pereira, M. D. C. Allgayer, N. P. Marroni, A. de Barros Falcão Ferraz, and J. N. Picada. 2017. Evaluation of DNA damage in Wistar rat tissues with hyperlipidemia induced by tyloxapol. Exp. Mol. Pathol. 103:51–55. doi:10.1016/j.yexmp.2017.06.009.
   PubMed Web of Science ®Google Scholar
• Ference, B. A., and N. Mahajan. 2013. The role of early LDL lowering to prevent the onset of atherosclerotic disease. Curr. Atheroscler. Rep. 15:312. doi:10.1007/s11883-013-0312-1.
   PubMed Web of Science ®Google Scholar
• Gnoni, G. V., G. Paglialonga, and L. Siculella. 2009. Quercetin inhibits fatty acid and triacylglycerol synthesis in rat-liver cells. Eur. J. Clin. Invest. 39:761–68. doi:10.1111/eci.2009.39.issue-9.
   PubMed Web of Science ®Google Scholar
• Govaerts, R., N. Sobral, P. Ashton, F. Barrie, B. K. Holst, L. L. Landrum, K. Matsumoto, F. Fernanda Mazine, E. Nic Lughadha, C. Proença, et al. 2008. World checklist of Myrtaceae: 1-455. London: Kew Publishing, Royal Botanic Gardens, Kew.
   Google Scholar
• Harnafi, H., H. Bouanani Nel, M. Aziz, H. Serghini Caid, N. Ghalim, and S. Amrani. 2007. The hypolipidaemic activity of aqueous Erica multiflora flowers extract in Triton WR-1339 induced hyperlipidaemic rats: A comparison with fenofibrate. J. Ethnopharmacol. 109:156–60. doi:10.1016/j.jep.2006.09.017.
   PubMed Web of Science ®Google Scholar
• Hasani-Ranjbar, S., N. Nayebi, L. Moradi, A. Mehri, B. Larijani, and M. Abdollahi. 2010. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; A systematic review. Curr. Pharm. Design 16:2935–47. doi:10.2174/138161210793176464.
   PubMed Web of Science ®Google Scholar
• Jang, A., P. Srinivasan, N. Y. Lee, H. P. Song, J. W. Lee, M. Lee, and C. Jo. 2008. Comparison of hypolipidemic activity of synthetic gallic acid-linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice. Chem. Biol. Interact. 174:109–17. doi:10.1016/j.cbi.2008.05.018.
   PubMed Web of Science ®Google Scholar
• Klafke, J. Z., A. da Silva, M. Fortes Rossato, M. Trevisan, G. Banderó Walker, C. I. Martins Leal, C. A. Olschowsky Borges, D. Chitolina Schetinger, M. R. Noal Moresco, M. M. Medeiros Frescura Duarte, et al. 2012. Antiplatelet, antithrombotic, and fibrinolytic activities of Campomanesia xanthocarpa. Evid. Based Complement. Alternat. Med. 2012:954748.
   Google Scholar
• Klafke, J. Z., M. A. da Silva, T. F. Panigas, K. C. Belli, M. F. de Oliveira, M. M. Barichello, F. K. Rigo, M. F. Rossato, A. R. Soares Dos Santos, M. G. Pizzolatti, et al. 2010. Effects of Campomanesia xanthocarpa on biochemical, hematological and oxidative stress parameters in hypercholesterolemic patients. J. Ethnopharmacol. 127:299–305. doi:10.1016/j.jep.2009.11.004.
   PubMed Web of Science ®Google Scholar
• Klafke, J. Z., F. G. Porto, A. S. de Almeida, M. M. Parisi, G. E. Hirsch, G. Trevisan, and P. R. Viecili. 2016. Biomarkers of subclinical atherosclerosis and natural products as complementary alternative medicine. Curr. Pharm. 22:372–82. doi:10.2174/1381612822666151112151035.
   PubMed Web of Science ®Google Scholar
• Levine, S., and A. A. Saltzman. 2007. Procedure for inducing sustained hyperlipemia in rats by administration of a surfactant. J. Pharmacol. Toxicol. Meth. 55:224–26. doi:10.1016/j.vascn.2006.05.009.
   PubMedGoogle Scholar
• Li, S. Y., C. Q. Chang, F. Y. Ma, and C. L. Yu. 2009. Modulating effects of chlorogenic acid on lipids and glucose metabolism and expression of hepatic peroxisome proliferator-activated receptor-alpha in golden hamsters fed on high fat diet. Biomed. Environ. Sci. 22:122–29. doi:10.1016/S0895-3988(09)60034-9.
   PubMed Web of Science ®Google Scholar
• Libby, P., and P. Theroux. 2005. Pathophysiology of coronary artery disease. Circulation 111:3481–88. doi:10.1161/CIRCULATIONAHA.105.537878.
   PubMed Web of Science ®Google Scholar
• Mannervik, B., and C. Guthenberg. 1981. Glutathione transferase (human placenta). Meth. Enzymol. 77:231–35.
   PubMedGoogle Scholar
• Mavournin, K. H., D. H. Blakey, M. C. Cimino, M. F. Salamone, and J. A. Heddle. 1990. The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental protection agency gene-tox program. Mutat. Res. 239:29–80. doi:10.1016/0165-1110(90)90030-F.
   PubMed Web of Science ®Google Scholar
• Misra, H. P., and I. Fridovich. 1972. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 247:3170–75.
   PubMed Web of Science ®Google Scholar
• Must, A., J. Spadano, E. H. Coakley, A. E. Field, G. Colditz, and W. H. Dietz. 1999. The disease burden associated with overweight and obesity. J Am Med Assoc 282:1523–29. doi:10.1001/jama.282.16.1523.
   PubMed Web of Science ®Google Scholar
• Otero, J. S., G. E. Hirsch, J. Z. Klafke, F. G. Porto, A. S. de Almeida, S. Nascimento, A. Schmidt, B. da Silva, R. L. D. Pereira, M. Jaskulski, et al. 2017. Inhibitory effect of Campomanesia xanthocarpa in platelet aggregation: Comparison and synergism with acetylsalicylic acid. Thromb. Res. 154:42–49. doi:10.1016/j.thromres.2017.03.020.
   PubMed Web of Science ®Google Scholar
• Otway, S., and D. S. Robinson. 1967. The use of a non-ionic detergent (Triton WR 1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions. J. Physiol. 190:321–32. doi:10.1113/jphysiol.1967.sp008211.
   PubMed Web of Science ®Google Scholar
• Pereira, M. C., R. S. Steffens, A. Jablonski, P. F. Hertz, O. Rios Ade, M. Vizzotto, and S. H. Flôres. 2012. Characterization and antioxidant potential of Brazilian fruits from the Myrtaceae family. J. Agric. Food Chem. 60:3061–67. doi:10.1021/jf205263f.
   PubMed Web of Science ®Google Scholar
• Pereira, P., P. A. de Oliveira, P. Ardenghi, L. Rotta, J. A. Henriques, and J. N. Picada. 2006. Neuropharmacological analysis of caffeic acid in rats. Basic Clin. Pharmacol. Toxicol. 99:374–78. doi:10.1111/j.1742-7843.2006.pto_533.x.
   PubMed Web of Science ®Google Scholar
• Porto, L. C., J. da Silva, A. B. Ferraz, E. M. Ethur, C. D. Porto, N. P. Marroni, and J. N. Picada. 2015. The antidiabetic and antihypercholesterolemic effects of an aqueous extract from pecan shells in Wistar rats. Plant Foods Hum. Nutr. 70:414–19. doi:10.1007/s11130-015-0510-9.
   PubMed Web of Science ®Google Scholar
• Porto, L. C., J. da Silva, K. Sousa, M. L. Ambrozio, A. de Almeida, C. E. Dos Santos, J. F. Dias, M. C. Allgayer, M. S. Dos Santos, P. Pereira, et al. 2016. Evaluation of toxicological effects of an aqueous extract of shells from the pecan nut Carya illinoinensis (Wangenh.) K. Koch and the possible association with its inorganic constituents and major phenolic compounds. Evid. Based Complementary. Altern. Med. 2016:4647830. doi:10.1155/2016/4647830.
   PubMed Web of Science ®Google Scholar
• Priyadarsini, K. I., S. M. Khopde, S. S. Kumar, and H. Mohan. 2002. Free radical studies of ellagic acid, a natural phenolic antioxidant. J. Agric. Food Chem. 50:2200–06. doi:10.1021/jf011275g.
   PubMed Web of Science ®Google Scholar
• Rasouli, M., H. Tahmouri, and M. Mosavi-Mehr. 2016. The long term kinetic of plasma lipids and lipoproteins in tyloxapol injected rats. J. Clin. Diagn. Res. 10:BF01–05. doi:10.7860/JCDR/2016/18890.7993.
   PubMed Web of Science ®Google Scholar
• Rody, H. V. S., D. C. Gontijo, V. P. M. Cielho, M. C. Ventrella, R. M. Padua, L. G. Fietto, and J. P. V. Leite. 2018. Mutagenic activity and chemical composition of phenolic-rich extracts of leaves of two species of Ficus medicinal plants. J. Toxicol. Environ. Health Part A 81:861–73. doi:10.1080/15287394.2018.1498420.
   PubMed Web of Science ®Google Scholar
• Rouhi-Boroujeni, H., E. Heidarian, H. Rouhi-Boroujeni, F. Deris, and M. Rafieian-Kopaei. 2017. Medicinal plants with multiple effects on cardiovascular diseases: A systematic review. Curr. Pharm. Des. 23:999–1015. doi:10.2174/1381612822666161021160524.
   PubMed Web of Science ®Google Scholar
• Salmazzo, G. R., M. H. Verdan, F. Silva, R. M. Cicarelli, J. D. S. Mota, M. J. Salvador, J. E. de Carvalho, and C. A. L. Cardoso. 2019. Chemical composition and antiproliferative, antioxidant and trypanocidal activities of the fruits from Campomanesia xanthocarpa (Mart.) O. Berg (Myrtaceae). Nat. Prod. Res. 15:1–5. doi:10.1080/14786419.2019.1607333.
   Google Scholar
• Sant’Anna, L. S., L. Merlugo, C. S. Ehle, J. Limberger, M. B. Fernandes, M. C. Santos, A. S. L. Mendez, F. R. Paula, and C. M. Moreira. 2017. Chemical composition and hypotensive Effect of Campomanesia xanthocarpa. Evid. Based Complementary. Altern. Med. 2017: article ID 1591762. doi:10.1155/2017/1591762.
   PubMed Web of Science ®Google Scholar
• Sheehan, D., G. Meade, V. M. Foley, and C. A. Dowd. 2001. Structure, function and evolution of glutathione transferases: Implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem. J. 360:1–16. doi:10.1042/bj3600001.
   PubMed Web of Science ®Google Scholar
• Siasos, G., D. Tousoulis, V. Tsigkou, E. Kokkou, E. Oikonomou, M. Vavuranakis, E. K. Basdra, A. G. Papavassiliou, and C. Stefanadis. 2013. Flavonoids in atherosclerosis: An overview of their mechanisms of action. Curr. Med. Chem. 20:2641–60. doi:10.2174/0929867311320210003.
   PubMed Web of Science ®Google Scholar
• Signorelli, S. S., V. Fiore, and G. Malaponte. 2014. Inflammation and peripheral arterial disease: The value of circulating biomarkers (Review). Int. J. Mol. Med. 33:777–83. doi:10.3892/ijmm.2014.1657.
   PubMed Web of Science ®Google Scholar
• Souza-Moreira, T. M., L. E. Salvagnini, E. Santos, V. Y. Silva, R. R. Moreira, H. R. Salgado, and R. C. Pietro. 2011. Antidiarrheal activity of Campomanesia xanthocarpa fruit. J. Med. Food. 14:528–31. doi:10.1089/jmf.2009.0278.
   PubMed Web of Science ®Google Scholar
• Tice, R. R., E. Agurell, D. Anderson, B. Burlinson, A. Hartmann, H. Kobayashi, Y. Miyamae, E. Rojas, J. C. Ryu, and Y. F. Sasaki. 2000. Single cell gel/Comet assay: Guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 35:206–21. doi:10.1002/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J.
   PubMed Web of Science ®Google Scholar
• Tieppo, J., R. Vercelino, A. S. Dias, M. F. Silva Vaz, T. R. Silveira, C. A. Marroni, N. P. Marroni, J. A. Henriques, and J. N. Picada. 2007. Evaluation of the protective effects of quercetin in the hepatopulmonary syndrome. Food Chem. Toxicol. 45:1140–46. doi:10.1016/j.fct.2006.12.020.
   PubMed Web of Science ®Google Scholar
• Tooulia, K. K., P. Theodosis-Nobelos, and E. A. Rekka. 2015. Thiomorpholine derivatives with hypolipidemic and antioxidant activity. Arch. Pharm. 348:629–34. doi:10.1002/ardp.201500147.
   PubMed Web of Science ®Google Scholar
• Usta, C., S. Ozdemir, M. Schiariti, and P. E. Puddu. 2013. The pharmacological use of ellagic acid-rich pomegranate fruit. Int. J. Food Sci. Nutr. 64:907–13. doi:10.3109/09637486.2013.798268.
   PubMed Web of Science ®Google Scholar
• Venkadeswaran, K., A. R. Muralidharan, T. Annadurai, V. V. Ruban, M. Sundararajan, R. Anandhi, P. A. Thomas, and P. Geraldine. 2014. Antihypercholesterolemic and antioxidative potential of an extract of the plant, Piper betle, and its active constituent, eugenol, in Triton WR-1339-induced hypercholesterolemia in experimental rats. Evid. Based Complementary. Altern. Med. 2014:478973. doi:10.1155/2014/478973.
   PubMed Web of Science ®Google Scholar
• Viecili, P. R., D. O. Borges, K. Kirsten, J. Malheiros, E. Viecili, R. D. Melo, G. Trevisan, M. A. da Silva, G. V. Bochi, R. N. Moresco, et al. 2014. Effects of Campomanesia xanthocarpa on inflammatory processes, oxidative stress, endothelial dysfunction and lipid biomarkers in hypercholesterolemic individuals. Atherosclerosis 234:85–92. doi:10.1016/j.atherosclerosis.2014.02.010.
   PubMed Web of Science ®Google Scholar
• Wan, C. W., C. N. Wong, W. K. Pin, M. H. Wong, C. Y. Kwok, R. Y. Chan, P. H. Yu, and S. W. Chan. 2013. Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-α in hypercholesterolemic rats induced with a high-cholesterol diet. Phytother. Res. 27:545–51. doi:10.1002/ptr.4751.
   PubMed Web of Science ®Google Scholar
• Yao, N., R. R. He, X. H. Zeng, X. J. Huang, T. L. Du, J. C. Cui, and K. Hiroshi. 2014. Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice. Chin. J. Integr. Med. 20:31–35. doi:10.1007/s11655-012-1243-3.
   PubMed Web of Science ®Google Scholar
• Zarzecki, M. S., S. M. Araujo, V. C. Bortolotto, M. T. de Paula, C. R. Jesse, and M. Prigol. 2014. Hypolipidemic action of chrysin on Triton WR-1339-induced hyperlipidemia in female C57BL/6 mice. Toxicol. Rep. 1:200–08. doi:10.1016/j.toxrep.2014.02.003.
   PubMedGoogle Scholar