536
Views
17
CrossRef citations to date
0
Altmetric
Articles

The protective underlying mechanisms of Schisandrin on SH-SY5Y cell model of Alzheimer’s disease

, , , , , , & show all

References

  • Ba, Q. H., C. J. Cui, L. J. Wen, S. T. Feng, J. C. Zhou, and K. Yang. 2015. Schisandrin B shows neuroprotective effect in 6-OHDA-induced Parkinson’s disease via inhibiting the negative modulation of miR-34a on Nrf2 pathway. Biomed. Pharmacother. 75:165–72. doi:10.1016/j.biopha.2015.07.034.
  • Bradford, M. M. 1976. A rapid and sensitive for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–54. doi:10.1016/0003-2697(76)90527-3.
  • Dawkins, E., and D. H. Small. 2014. Insights into the physiological function of the β-amyloid precursor protein: Beyond Alzheimer’s disease. J. Neurochem. 129:756–69. doi:10.1111/jnc.12675.
  • Golpich, M., E. Amini, F. Hemmati, N. M. Ibrahim, B. Rahmani, Z. Mohamed, A. A. Raymond, L. Dargahi, R. Ghasemi, and A. Ahmadiani. 2015. Glycogen synthase kinase-3 beta (GSK-3β)signaling: Implications for Parkinson’s disease. Pharmacol. Res. 97:16–26. doi:10.1016/j.phrs.2015.03.010.
  • Hermida, M. A., K. J. Dinesh, and N. R. Leslie. 2017. GSK3 and its interactions with the PI3K/AKT/mTOR signalling network. Adv. Biol. Regul. 65:5–15. doi:10.1016/j.jbior.2017.06.003.
  • Jeong, E. J., H. K. Lee, K. Y. Lee, B. J. Jeon, D. H. Kim, J. H. Park, J. H. Song, J. Huh, J. H. Lee, and S. H. Sung. 2013. The effects of lignan-riched extract of Shisandra chinensis on amyloid-b-induced cognitive impairment and neurotoxicity in the cortex and hippocampus of mouse. J. Ethnopharmacol. 146:347–54. doi:10.1016/j.jep.2013.01.003.
  • Jiang, E. P., S. Q. Wang, Z. Wang, C. R. Yu, J. G. Chen, and C. Y. Yu. 2014. Effect of Schisandra chinensis lignans on neuronal apoptosis and p-AKT expression of rats in cerebral ischemia injury model. Zhong Guo Zhong Yao Za Zhi 39:1680–84.
  • Song, J. X., X. A. Lin, R. N. S. Wong, S. C. W. Sze, Y. Tong, P. C. Shaw, and Y. B. Zhang. 2011. Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells. Phytother. Res. 25:435–43. doi:10.1002/ptr.3269.
  • Sowndhararajan, K., P. Deepa, M. Kim, S. J. Park, and S. Kim. 2018. An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis. Biomed. Pharmacother. 97:958–68. doi:10.1016/j.biopha.2017.10.145.
  • Wei, B. B., M. Y. Liu, Z. X. Chen, and M. J. Wei. 2018. Schisandrin ameliorates cognitive impairment and attenuates Aβ deposition in APP/PS1 transgenic mice: Involvement of adjusting neurotransmitters and their metabolite changes in the brain. Acta Pharmacol. Sin. 39:616–25. doi:10.1038/aps.2017.135.
  • Yao, Y., Y. Wang, L. Kong, Y. Chen, and J. Yang. 2019. Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3β signaling pathway in Alzheimer’s disease. Life Sci. 217:16–24. doi:10.1016/j.lfs.2018.11.038.
  • Zhang, J., W. Tong, H. Sun, M. Jiang, Y. Shen, Y. Liu, H. Gu, J. Guo, J. Fang, and L. Jin. 2017. Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage viaPI3K/AKT/GSK3β pathway. Exp. Gerontol. 100:77–86. doi:10.1016/j.exger.2017.10.021.
  • Zhang, L. Q., F. Sa, C. M. Chong, Y. Wang, Z. Y. Zhou, C. C. Chang, S. W. Chan, P. M. Hoi, M. Simon, and Y. Lee. 2015a. Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways. J. Ethnopharmacol. 170:8–15. doi:10.1016/j.jep.2015.04.040.
  • Zhang, M., D. S. Huo, and Z. P. Cai. 2015b. The effect of Schizandrol A-induced DNA methylation on SH-SY5YAβ1-40 altered neuronal cell line: A potential use in Alzheimer’s disease. J. Toxicol. Environ. Health Part A 78:1321–27. doi:10.1080/15287394.2015.1085942.
  • Zhang, W., X. Hou, M. Huang, X. Zeng, X. He, and Y. Liao. 2018b. TDCPP protects cardiomyocytes from H2O2-induced injuries via activating PI3K/Akt/GSK3β signaling pathway. Mol. Cell. Biochem. 453:53–64. doi:10.1007/s11010-018-3431-8.
  • Zhang, Y. H., Z. Y. Zhao, B. J. Wang, Y. Q. Zhang, M. Zhang, and Y. Y. Gao. 2018a. Protective effect of Schisandra chinensis lignans on hypoxia-induced PC12 cells and signal transduction. J. Toxicol. Environ. Health Part A 81:1224–30. doi:10.1080/15287394.2018.1502561.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.