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Research Article

21-Day dermal exposure to aircraft engine oils: effects on esterase activities in brain and liver tissues, blood, plasma, and clinical chemistry parameters for Sprague Dawley rats

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References

  • Aardema, H., J. H. Meertens, J. J. Ligtenberg, O. M. Peters-Polman, J. E. Tulleken, and J. G. Zijlstra. 2008. Organophosphorus pesticide poisoning: Cases and developments. Neth. J. Med. 66:149–53.
  • Aldridge, W. N. 1954. Tricresyl phosphates and cholinesterase. Biochem. J. 56:185–89. doi:10.1042/bj0560185.
  • Arun, M., and V. Palimar. 2008. Neurological manifestations in organophosphorus toxicity. J. Indian Acad. Forensic Med. 30:29–31.
  • Aurbek, N., H. Thiermann, F. Eyer, P. Eyer, and F. Worek. 2009. Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: A kinetic analysis. Toxicology 259:133–39. doi:10.1016/j.tox.2009.02.014.
  • Banks, C. N., and P. J. Lein. 2012. A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation. Neurotoxicology 33:575–84. doi:10.1016/j.neuro.2012.02.002.
  • Banks, W. A. 2015. The blood-brain barrier in neuroimmunology: Tales of separation and assimilation. Brain Behav. Immun. 44 (1–8):1–8. doi:10.1016/j.bbi.2014.08.007.
  • Barna-Lloyd, T., J. R. Szabo, and N. L. Davis, 1990. Chlorpyrifos-methyl (Reldan R) rat subchronic dietary toxicity and recovery study. Unpublished Report TXT: K-046193-026 from Dow Chemical, Texas, USA. Submitted to WHO by Dow Elanco, Indianapolis, USA.
  • Barrett, D. S., and F. W. Oehme. 1994. The effect of a single oral dose of tri-o-cresyl phosphate on neurotoxic esterase and acetylcholinesterase activities in the central nervous system, erythrocytes and plasma. Vet. Human Toxicol. 36:1–4.
  • Berben, L., S. M. Sereika, and S. Engberg. 2012. Effect size estimation: Methods and examples. Int. J. Nurs. Stud. 49:1039–47. doi:10.1016/j.ijnurstu.2012.01.015.
  • Berríos, V. O., N. M. Boukli, J. W. Rodriguez, P. D. Negraes, T. T. Schwindt, C. A. Trujillo, S. L. Oliveira, L. A. Cubano, P. A. Ferchmin, V. A. Eterović, et al. 2015. Paraoxon and pyridostigmine interfere with neural stem cell differentiation. Neurochem. Res. 40:2091–101. doi:10.1007/s11064-015-1548-7.
  • Binukumar, B. K., A. Bal, and K. D. Gill. 2011. Chronic dichlorvos exposure: Microglial activation, proinflammatory cytokines and damage to nigrostriatal dopaminergic system. Neuromol. Med 13:251–65. doi:10.1007/s12017-011-8156-8.
  • Bird, S. B., R. J. Gaspari, and E. W. Dickson. 2003. Early death due to severe organophosphate poisoning is a centrally mediated process. Appl. Environ. Microbiol. 10:295–98.
  • Bondy, H. F., E. J. Field, A. N. Worden, and J. P. Hughes. 1960. A study on the acute toxicity of the tri-aryl phosphates used as plasticizers. Occup. Environ. Med. 17:190–200. doi:10.1136/oem.17.3.190.
  • Buchanan, D., A. Pilkington, C. Sewell, S. N. Tannahill, M. W. Kidd, B. Cherrie, and J. F. Hurley. 2001. Estimation of cumulative exposure to organophosphate sheep dips in a study of chronic neurological health effects among United Kingdom sheep dippers. Occup. Environ. Med. 58:694–701. doi:10.1136/oem.58.11.694.
  • Carletti, E., J. P. Colletier, L. M. Schopfer, G. Santoni, P. Massoni, O. Rockridge, F. Nachon, and M. Weik. 2013. Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry. Chem. Res. Toxicol. 26:280–89. doi:10.1021/tx3004505.
  • Carletti, E., L. M. Schopfer, J. P. Colletier, M. T. Froment, F. Nachon, M. Weik, O. Lockridge, and P. Masson. 2011. Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: Mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis. Chem. Res. Toxicol. 24:797–808. doi:10.1021/tx100447k.
  • Centers, P. W 1992. Potential neurotoxin formation in thermally degraded synthetic ester turbine lubricants. Arch. Toxicol. 66: 679–80. doi:10.1007/bf01981509
  • Chen, J. X., Y. J. Sun, P. Wang, D. X. Long, W. Li, L. Li, and Y. J. Wu. 2013. Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth. Toxicology 310:92–97. doi:10.1016/j.tox.2013.05.012.
  • Cohen, J. 1988. Statistical Power Analysis for the Behavioral Sciences. Second ed. Mahwah, N.J: Lawrence Erlbaum Associates.
  • Costa, L. G. 2006. Current issues in organophosphate toxicology. Clin. Chim. Acta 366:1–3. doi:10.1016/j.cca.2005.10.008.
  • Costa, L. G. 2018. Organophosphorus compounds at 80: Some Old and new issues. Toxicol. Sci. 162:24–35. doi:10.1093/toxsci/kfx266.
  • CRL, 2006. Clinical Laboratory Parameters for Crl: CD(SD) rats. Charles River Laboratories,
  • Damodaran, T. V., K. H. Jones, A. G. Patel, and M. B. Abou-Donia. 2003. Sarin (nerve agent GB)-induced differential expression of mRNA coding for the acetylcholinesterase gene in the rat central nervous system. Biochem. Pharmacol. 65:2041–47. doi:10.1016/s0006-2952(03)00160-6.
  • Das, A., M. Dikshit, and C. Nath. 2001. Profile of acetylcholinesterase in brain areas of male and female rats of adult and old age. Life Sci. 68:1545–55. doi:10.1016/s0024-3205(01)00950-x.
  • Davies, R., G. Ahmed, and T. Freer. 2000a. Chronic exposure to organophosphates: Background and clinical picture. Adv. Psychiatr. Treat. 6:187–92. doi:10.1192/apt.6.3.187.
  • Davies, R., G. Ahmed, and T. Freer. 2000b. Psychiatric aspects of chronic exposure to organophosphates: Diagnosis and management. Adv. Psychiatr. Treat. 6:356–61. doi:10.1192/apt.6.5.356.
  • De Bleecker, J. L., J. L. De Reuck, and J. L. Willems. 1992. Neurological aspects of organophosphate poisoning. Clin. Neurol. Neurosurg. 94:93–103. doi:10.1016/0303-8467(92)90065-b.
  • Denola, G., P. J. Hanhela, and W. Mazurek. 2011. Determination of tricresyl phosphate air contamination in aircraft. Ann. Occup. Hyg. 55:710–22. doi:10.1093/annhyg/mer040.
  • Devi, M., and M. Fingerman. 1995. Inhibition of acetylcholinesterase activity in the central nervous system of the red swamp crayfish, Procambarus clarkii, by mercury, cadmium, and lead. Bull. Environ. Contam. Toxicol. 55:746–50. doi:10.1007/BF00203762.
  • Dickson, E. W., S. B. Bird, R. J. Gaspari, E. W. Boyer, and C. F. Ferris. 2003. Diazepam inhibits organophosphate-induced central respiratory depression. Appl. Environ. Microbiol. 10:1303–06. doi:10.1197/s1069-6563(03)00533-5.
  • Duarte, D. J., J. M. M. Rutten, M. van den Berge, and R. H. S. Westerink. 2017. In vitro neurotoxic hazard characterization of different tricresyl phosphate (TCP) isomers and mixtures. Neurotoxicology 59:222–30. doi:10.1016/j.neuro.2016.02.001.
  • Durham, W. F., H. R. Wolfe, and J. W. Elliott. 1972. Absorption and excretion of parathion by spraymen Arch.. Environ. Health 24:381–87. doi:10.1080/00039896.1972.10666113.
  • Earl, C. J., and R. H. S. Thompson. 1952. Cholinesterase levels in the nervous system of in tri-ortho-cresyl phosphate poisoning. Br. J. Pharmacol. 7:685–94. doi:10.1111/j.1476-5381.1952.tb00738.x.
  • Ecobichon, D. J. 1994. Organophosphorus ester insecticides. In Pesticides and Neurological Diseases, ed. D. J. Echobion and R. M. Joy. Boca Raton: CRC Press, FL, pp. 171–249.
  • Eddleston, M., and D. N. Bateman. 2012. Pesticides. Medicine 40:147–50. doi:10.1016/j.mpmed.2011.12.029.
  • Edwards, J. A., and S. Brimijoin. 1983. Effects of hypophysectomy on acetylcholinesterase and butyrylcholinesterase in the rat. Biochem. Pharmacol. 32:1183–89. doi:10.1016/0006-2952(83)90269-1.
  • Ellman, G. L. K. D., K. D. Courtney, V. Andres, and R. M. Featherstone. 1961. A new and rapid colorometric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:88–90. doi:10.1016/0006-2952(61)90145-9.
  • EPA, 1998. Health effects test guidelines. OPPTS 870.3200 21-28 day dermal toxicity. United States Environmental Protection Agency, EPA 712-C-98-201.
  • Fenske, R. A., F. M. Farahat, K. Galvin, E. K. Fenske, and J. R. Olson. 2012. Contributions of inhalation and dermal exposure to chlorpyrifos dose in Egyptian cotton field workers. Int. J. Occup. Environ. Health 18:198–209. doi:10.1179/1077352512Z.00000000030.
  • Ferchmin, P. A., D. Pérez, B. L. Cuadrado, M. Carrasco, A. H. Martins, and V. A. Eterović. 2015. Neuroprotection against diisopropylfluorophosphate in acute hippocampal slices. Neurochem. Res. 40:2143–51. doi:10.1007/s11064-015-1729-4.
  • Flora, S. J. S., M. Mittal, and A. Mehta. 2008. Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Indian. J. Med. Res. 128:501–23.
  • Garfitt, S., and K. Jones. 2002. Exposure to the organophosphate diazinon: Data from a human volunteer study with oral and dermal doses. Toxicol. Lett. 134:105–13. doi:10.1016/s0378-4274(02)00178-9.
  • Giacobini, E., and G. Pepeu. 2018. Sex and gender differences in the brain cholinergic system and in the response to therapy of Alzheimer Disease with cholinesterase inhibitors. Curr. Alzheimer Res. 15:1077–84. doi:10.2174/1567205015666180613111504.
  • Girish, T., G. S. Kishore, and K. Kanav. 2010. Evaluation of incidence, clinical characteristics and management in organophosphorous poisoning patients in a tertiary care hospital. J. Toxicol. Environ. Health 2:73–76.
  • Glusker, J., A. Katz, and C. Bock. 1999. Metal ions in biological systems. Rigaku J 16:381–412.
  • Gu, Z., and J. L. Yakel. 2011. Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticity. Neuron 71:155–65. doi:10.1016/j.neuron.2011.04.026.
  • Hardos, J. E., L. W. Whitehead, I. Han, D. K. Ott, and D. K. Waller. 2016. Depression prevalence and exposure to organophosphate esters in aircraft maintenance workers. Aerosp. Med. Human Perform. 87:712–17. doi:10.3357/AMHP.4561.2016.
  • Hardos, J. E., M. Rubenstein, and S. Pfahler, 2019. Organophosphate skin exposure and biological burden of aircraft maintainers. Air Force Research Laboratory, 711 Human Performance Wing, U.S. Air Force School of Aerospace Medicine, Occupational & Environmental Health Department, Wright-Patterson Air Force Base, OH, AFRL-SA-WP-TR-2019-0013.
  • Hardos, J. E., M. Rubenstein, S. Pfahler, and T. Sleight. 2020. Cholinesterase inhibition and exposure to organophosphate esters in aircraft maintenance workers. Aerosp. Med. Human Perform. 91:710714. doi:10.3357/AMHP.5439.2020.
  • Hausherr, V., C. van Thriel, A. Krug, M. Leist, and N. Schobel. 2014. Impairment of glutamine signaling in mouse central nervous system neurons in vitro by tri-ortho-cresyl phosphate at noncytotoxic concentrations. Toxicol. Sci. 142:274–84. doi:10.1093/toxsci/kfu174.
  • Hausherr, V., N. Schobel, J. Liebing, and C. van Thriel. 2017. Assessment of neurotoxic effects of tri-cresyl phosphates (TCPs) and cresyl saligenin phosphate (CBDP) using a combination of in vitro techniques. Neurotoxicology 59:210–21. doi:10.1016/j.neuro.2016.06.005.
  • He, F. 1999. Biological monitoring of exposure to pesticides: Current issue. Toxicol. Lett. 108:277–83. doi:10.1016/s0378-4274(99)00099-5.
  • Hernández, A., M. A. Gómez, G. Pena, F. Gil, L. Rodrigo, E. Villanueva, and A. Pla. 2004. Effect of long-term exposure to pesticides on plasma esterases from plastic greenhouse workers. J. Toxicol. Environ. Health A 67:1095. doi:10.1080/15287390490452371.
  • Hernández, A. F., O. López, L. Rodrigo, F. Gil, G. Pena, J. L. Serrano, T. Parrón, J. C. Alvarez, J. A. Lorente, and A. Pla. 2005. Changes in erythrocyte enzymes in humans long-term exposed to pesticides: Influence of several markers of individual susceptibility. Toxicol. Lett. 159:13–21. doi:10.1016/j.toxlet.2005.04.008.
  • Howard, A. S., R. Bucelli, D. A. Jett, D. Bruun, D. Yang, and P. J. Lein. 2005. Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures. Toxicol. Appl. Pharmacol. 207:112–24. doi:10.1016/j.taap.2004.12.008.
  • Indu, T. H., D. Raja, B. Manjunatha, and S. Ponnusankar. 2016. Can galantamine act as an antidote for organophosphate poisoning? A review. Indian J. Pharm. Sci. 78:428–35. doi:10.4172/pharmaceutical-sciences.1000136.
  • Jamal, G. A., S. Hansen, A. Pilkington, D. Buchanan, R. A. Gillham, M. Abdel-Azis, P. O. Julu, S. F. Al-Rawas, F. Hurley, and J. P. Ballantyne. 2002. A clinical neurological, neuro-physiological, and neuropsychological study of sheep farmers and dippers exposed to organophosphate pesticides. Occup. Environ. Med. 59:434–41. doi:10.1136/oem.59.7.434.
  • Jameson, R. R., F. J. Seidler, and T. A. Slotkin. 2007. Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: Chlorpyrifos, chlorpyrifos oxon, and diazinon. Environ. Health Perspect. 115:65–70. doi:10.1289/ehp.9487.
  • Kalman, D. A., K. J. Voorhees, D. Osborn, and I. N. Einhorn. 1985. Production of a bicyclophosphate neurotoxic agent during pyrolysis of synthetic lubricant oil. J Fire Sci 3:322–29. doi:10.1177/073490418500300503.
  • Kamanyire, R., and L. Karalliedde. 2004. Organophosphate toxicity and occupational exposure. Occup. Med. 54:69–75. doi:10.1093/occmed/kqh018.
  • Kamel, F., and J. A. Hoppin. 2004. Association of pesticide exposure with neurologic dysfunction and disease. Environ. Health Perspect. 112:950–58. doi:10.1289/ehp.7135.
  • Lee, Y. S., J. A. Lewis, D. L. Ippolito, N. Hussainzada, P. J. Lein, and D. A. Jackson. 2016. Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides. Toxicology 340:53–62. doi:10.1016/j.tox.2016.01.001.
  • Leon-S, F. E., G. Pradilla, and E. Vesga. 1996. Neurological effects of organophosphate pesticides. Br. Med. J. 313:690–91. doi:10.1136/bmj.313.7058.690c.
  • Lionetto, M. G., R. Caricato, A. Calisi, M. E. Giordano, and T. Schettino. 2013. Acetylcholinesterase as a biomarker in environmental and occupational medicine: New insights and future perspectives. Biomed Res. Int. 2013:321213. doi:10.1155/2013/321213.
  • Liyasova, M. S., L. M. Schopfer, and O. Lockridge. 2012. Cresyl saligenin phosphate, an organophosphorus toxicant, makes covalent adducts with histidine, lysine, and tyrosine residues of human serum albumin. Chem. Res. Toxicol. 25:1752–61. doi:10.1021/tx300215g.
  • Lotti, M. 2001. Clinical toxicology of anticholinesterase agents in humans. In Handbook of Pesticide Toxicology, ed. R. I. Krieger, 1043–85. second ed. Academic Press, San Diego.
  • Ma, Z., F. E. Jacobsen, and D. P. Giedroc. 2009. Metal transporters and metal sensors: How coordination chemistry controls bacterial metal homeostasis. Chem. Rev. 109:4644–81. doi:10.1021/cr900077w.
  • Mackerer, C. R., M. L. Barth, A. J. Krueger, B. Chawla, and T. A. Roy. 1999. Comparison of neurotoxic effects and potential risks from oral administration or ingestion of tricresyl phosphate and jet engine oil containing tricresyl phosphate. J. Toxicol. Environ. Health A 57:293–328. doi:10.1080/009841099157638.
  • Maroni, M., C. Colosio, A. Ferioli, and A. Fait. 2000. Biological monitoring of pesticide exposure: A review. Introduction. Toxicology 143:5–118. doi:10.1016/s0300-483x(99)00152-3.
  • Marsillach, J., L. G. Costa, and C. E. Furlong. 2013. Protein adducts as biomakers of exposure to organophosphorus compounds. Toxicology 307:46–54. doi:10.1016/j.tox.2012.12.007.
  • Masson, P., and O. Lockridge. 2009. Butyrylcholinesterase for protection from organophosphorus poisons; catalytic complexities and hysteretic behavior. Arch. Biochem. Biophys. 494:107–20. doi:10.1016/j.abb.2009.12.005.
  • McEwen, B. S., and T. A. Milner. 2017. Understanding the broad influence of sex hormones and sex differences in the brain. J. Neurosci. Res. 95:24–39. doi:10.1002/jnr.23809.
  • Meneguz, A., G. M. Bisso, and H. Michalek. 1992. Age-related changes in acetylcholinesterase and its molecular forms in various brain areas of rats. Neurochem. Res. 17:785–90. doi:10.1007/bf00969013.
  • Mense, S. M., A. Sengupta, C. Lan, M. Zhou, G. Bentsman, and D. J. Volsky. 2006. The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes. Toxicol. Sci. 93:125–35. doi:10.1093/toxsci/kfl046.
  • Mok, M. S., and J. N. C. Kew. 2006. Excitation of rat hippocampal interneurons via modulation of endogenous agonist activity at the a7 nicotinic Ach receptor. J. Physiol. 574:699–710. doi:10.1113/jphysiol.2006.104794.
  • Mourad, T. A. 2005. Adverse impact of insecticides on the health of Palestinian farm workers in the Gaza Strip: A hematologic biomarker study. Int. J. Occup. Environ. Health 11:144–49. doi:10.1179/oeh.2005.11.2.144.
  • Mwila, K., M. H. Burton, J. S. Van Dyk, and B. I. Pletschke. 2013. The effect of mixtures of organophosphate and carbamate pesticides on acetylcholinesterase and application of chemometrics to identify pesticides in mixtures. Environ. Monit. Assess. 185:2315–27. doi:10.1007/s10661-012-2711-0.
  • Namba, T. 1971. Cholinesterase inhibition by organophosphorus compounds and its clinical effects. Bull. World Health Organ. 44:289–307.
  • Neal, R. 1972. A comparison of the in vitro metabolism of parathion in the lung and liver of the rabbit. Toxicol. Appl. Pharmacol. 23:123–30. doi:10.1016/0041-008x(72)90211-6.
  • Nemcsók, J., A. Németh, Z. Buzás, and L. Boross. 1984. Effects of copper, zinc and paraquat on acetylcholinesterase activity in carp (Cyprinus carpio L.). Aquat. Toxicol. 5:23–31. doi:10.1016/0166-445X(84)90029-8.
  • Neupane, D., E. Jørs, and L. Brandt. 2014. Pesticide use, erythrocyte acetylcholinesterase level and self-reported acute intoxication symptoms among vegetable farmers in Nepal: A cross-sectional study. Environ. Health 13:98. doi:10.1186/1476-069X-13-98.
  • Ng, V., D. Koh, A. Wee, and S. E. Chia. 2009. Salivary acetylcholinesterase as a biomarker for organophosphate exposure. Occup. Med. 59:120–22. doi:10.1093/occmed/kqn164.
  • Nigg, H. N., and J. B. Knaak. 2000. Blood cholinesterases as human biomarkers of organophosphorus pesticide exposure. Rev. Environ. Contam. Toxicol. 163:29–111. doi:10.1007/978-1-4757-6429-1_2.
  • NRC. 2011. Guide for the care and use of laboratory animals. 8th ed. Washington, DC: National Academy Press.
  • Oh, M. M., W. W. Wu, J. M. Power, and J. F. Disterhoft. 2006. Galantamine increases excitability of CA1 hippocampal pyramidal neurons. Neuroscience 137:113–23. doi:10.1016/j.neuroscience.2005.08.063.
  • Owasoyo, J. O., O. Adeyemo, and C. A. Iramain. 1980. Acetylcholinesterase activity in seven brain areas and adenohypophysis during the estrous cycle. Neurosci. Lett. 19:289–92. doi:10.1016/0304-3940(80)90275-X.
  • Paudyal, B. P. 2008. Organophosphorous poisoning. J. Nepal. Med. Assoc. 47:251–58. doi:10.31729/jnma.170.
  • Perwitasari, D. A., D. Prasasti, W. Supadmi, S. A. D. Jaikishin, and I. A. Wiraagni. 2017. Impact of organophosphate exposure on farmers’ health in Kulon Progo, Yogyakarta: Perspectives of physical, emotional and social health. SAGA Open Med 5:2050312117719092. doi:10.1177/2050312117719092.
  • Pizzurro, D. M., K. Dao, and L. G. Costa. 2014a. Astrocytes protect against diazinon- and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathione. Toxicology 318:59–68. doi:10.1016/j.tox.2014.01.010.
  • Pizzurro, D. M., K. Dao, and L. G. Costa. 2014b. Diazinon and diazoxon impair the ability of astrocytes to foster neurite outgrowth in primary hippocampal neurons. Toxicol. Appl. Pharmacol. 274:372–82. doi:10.1016/j.taap.2013.11.023.
  • Pradhan, S. N. 1980. Central neurotransmitters and aging. Life Sci. 26:1643–56. doi:10.1016/0024-3205(80)90172-1.
  • Prasad, D. R. M. M. 2014. Reduced levels of serum potassium and plasma cholinesterase in acute organophosphate poisoning: Possible predictive markers. Asia Pac. J. Med. Toxicol. 3:68–72.
  • Prasad, D. R. M. M., P. S. Jirli, M. Mahesh, and S. Mamatha. 2013. Relevance of plasma cholinesterase to clinical findings in acute organophosphorous poisoning. Asia Pac. J. Med. Toxicol. 2:23–27.
  • Prohanka, M. 2013. Butyrylcholinesterase as a biochemical marker. Bratisl. Lek. Listy. 114:726–34. doi:10.4149/bll_2013_153.
  • Ramsden, J. 2013. On the proportion of ortho isomers in the tricresyl phosphates contained in jet oil. J Biophys Physics Chem 13:69–72. doi:10.4024/03RA13L.jbpc.13.02.
  • Rani, P. J. A., and C. Panneerselvam. 2001. Protective efficacy of L-carnitine on acetylcholinesterase activity in aged rat brain. J. Gerontol. A. Biol. Sci. Med. Sci. 56:B140–B141. doi:10.1093/gerona/56.3.b140.
  • Ray, D. E. 1998. Chronic effects of low level exposure to anticholinesterases–a mechanistic review. Toxicol. Lett. 102-103:527–33. doi:10.1016/s0378-4274(98)00260-4.
  • Ray, D. E., and P. G. Richards. 2001. The potential for toxic effects of chronic, low-dose exposure to organophosphates. Toxicol. Lett. 120:343–51. doi:10.1016/s0378-4274(01)00266-1.
  • Remor, A. P., C. C. Totti, D. A. Moreira, G. P. Dutra, V. D. Heuser, and J. M. Boeira. 2009. Occupational exposure of farm workers to pesticides: Biochemical parameters and evaluation of genotoxicity. Environ. Int. 35:273–78. doi:10.1016/j.envint.2008.06.011.
  • Richards, P., M. Johnson, D. Ray, and C. Walker. 1999. Novel protein targets for organophosphorus compounds. Chem. Biol. Interact. 119-120:503–11. doi:10.1016/s0009-2797(99)00064-2.
  • Rocha, E. S., M. D. Santos, S. R. Chebabo, Y. Aracava, and E. X. Alburquerque. 1999. Low concentrations of the organophosphate VX affect spontaneous and evoked transmitter release from hippocampal neurons: Toxicological relevance of cholinesterase-independent actions. Toxicol. Appl. Pharmacol. 159:31–40. doi:10.1006/taap.1999.8733.
  • Rohlman, D. S., A. A. Ismail, G. A. Rasoul, M. R. Bonner, O. Hendy, and K. Mara. 2016. A 10-month prospective study of organophosphorus pesticide exposure and neurobehavioral performance among adolescents in Egypt. Cortex 74:383–95. doi:10.1016/j.cortex.2015.09.011.
  • Rohlman, D. S., W. K. Anger, and P. J. Lein. 2011. Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure. Neurotoxicology 32:268–76. doi:10.1016/j.neuro.2010.12.008.
  • Rosenstock, L., M. Keifer, W. E. Daniell, R. McConnell, and K. Claypoole. 1991. Chronic central nervous system effects of acute organophosphate pesticide intoxication. The Pesticide Health Effects Study Group. Lancet 338:223–27. doi:10.1016/0140-6736(91)90356-t.
  • Rubey, W. A., R. C. Striebich, J. Bush, P. W. Centers, and R. L. Wright. 1996. Neurotoxin formation from pilot-scale incineration of synthetic ester turbine lubricants with a triaryl phosphate additive. Arch. Toxicol. 70:508–09. doi:10.1007/s002040050306.
  • Salmon, A., C. Erb, E. Meshorer, D. Ginzberg, Y. Adani, I. Rabinovitz, G. Amitai, and H. Soreq. 2005. Muscarinic modulations of neuronal anticholinesterase responses. Chem. Biol. Interact. 157-158:105–13. doi:10.1016/j.cbi.2005.10.015.
  • Schäfer, T., and M. A. Schwarz. 2019. The meaningfulness of effect sizes in psychological research: Differences between sub-disciplines and the impact of potential biases. Front. Psychol. 10:813. doi:10.3389/fpsyg.2019.00813.
  • Schindler, B. K., S. Koslitz, T. Weiss, H. C. Broding, T. Brüning, and J. Bünger. 2014. Exposure of aircraft maintenance technicians to organophosphates from hydraulic fluids and turbine oils: A pilot study. Int. J. Hyg. Environ. Health 217:34–37. doi:10.1016/j.ijheh.2013.03.005.
  • Selmi, S., K. Rtibi, D. Grami, H. Sebai, and L. Marzouki. 2018. Malathion, an organophosphate insecticide, provokes metabolic, histopathologic and molecular disorders in liver and kidney in prepubertal male mice. Toxicol Rep 5:189–95. doi:10.1016/j.toxrep.2017.12.021.
  • Sibomana, I., and D. R. Mattie. 2020. Sub-chronic dermal exposure to aircraft engine oils impacts the reproductive organ weights and alters hematological profiles of Sprague Dawley rats. CRTOX 1:12–24. doi:10.1016/j.crtox.2020.02.001.
  • Sibomana, I., N. A. Good, P. T. Hellman, L. Rosado, and D. R. Mattie. 2019. Acute dermal toxicity study of new, used and laboratory aged aircraft engine oils. Toxicol Rep 6:1246–52. doi:10.1016/j.toxrep.2019.11.010.
  • Singh, R., N. Gautam, A. Mishra, and R. Gupta. 2011. Heavy metals and living systems: An overview. Indian. J. Pharmacol. 43:246–53. doi:10.4103/0253-7613.81505.
  • Singh, S., and N. Sharma. 2000. Neurological syndromes following organophosphate poisoning. Neurol. India 48:308–13.
  • Šišková, K., M. Dubničková, Ľ. Pašková, D. Rajdl, Z. Ďuračková, J. Muchová, I. Pauliková, and J. Racek. 2017. Betaine increases the butyrylcholinesterase activity in rat plasma. Physiol Res 65:101–08. doi:10.33549/physiolres.933028.
  • Slotkin, T. A., and F. J. Seidler. 2010. Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: Effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. Brain Res. 1353:36–52. doi:10.1016/j.brainres.2010.07.073.
  • Solbu, K., H. L. Daae, S. Thorud, D. G. Ellingsen, E. Lundanes, and P. Molander. 2010. Exposure to airborne organophosphate originating from hydraulic and turbine oils among aviation technicians and loaders. J. Environ. Monit. 12:2259–68. doi:10.1039/c0em00273a.
  • Speed, H. E., C. A. Blaiss, A. Kim, M. E. Haws, N. R. Melvin, and M. Jennings. 2012. Delayed reduction of hippocampal synaptic transmission and spines following exposure to repeated subclinical doses of organophosphorus pesticide in adult mice. Toxicol. Sci. 125:196–208. doi:10.1093/toxsci/kfr253.
  • Steenland, K. 1996. Chronic neurological effects of organophosphate pesticides. Br. Med. J. 312:1312–13. doi:10.1136/bmj.312.7042.1312.
  • Tilton, F. A., T. K. Bammler, and E. P. Gallagher. 2011. Swimming impairment and acetylcholinesterase inhibition in zebrafish exposed to copper or chlorpyrifos separately, or as mixtures. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 153:9–16. doi:10.1016/j.cbpc.2010.07.008.
  • Tomokuni, K., and T. Hasegawa. 1985. Diazinon concentrations and blood cholinesterase activities in rats exposed to diazinon. Toxicol. Lett. 25:7–10. doi:10.1016/0378-4274(85)90093-1.
  • von Osten, R., J., . C. Epomex, R. Tinoco-Ojanguren, A. M. V. M. Soares, and L. Guilhermino. 2004. Effect of pesticide exposure on acetylcholinesterase activity in subsistence farmers from Campeche, Mexico. Arch. Environ. Health 59:418–25. doi:10.3200/AEOH.59.8.418-425.
  • Voorhees, J. R., D. S. Rohlman, P. J. Lein, and A. A. Pieper. 2017. Neurotoxicity in preclinical models of occupational exposure to organophosphorus compounds. Front. Neurosci. 10:590. doi:10.3389/fnins.2016.00590.
  • Winder, C., and J. C. Balouet. 2002. The toxicity of commercial jet oils. Environ. Res. 89:146–64. doi:10.1006/enrs.2002.4346.
  • Wood, S. J., and J. E. H. Tattersall. 2001. An improved brain slice model of nerve agent-induced seizure activity. J. Appl. Toxicol. 21 (Suppl 1):S83–S86. doi:10.1002/jat.817.
  • Wright, R. L. 1996. Formation of the neurotoxin TMPP from TMPE-phosphate formulations. Tribol. T. 39:827–34. doi:10.1080/10402009608983601.
  • Yang, D., A. Howard, D. Bruun, M. Ajua-Alemanj, C. Pickart, and P. J. Lein. 2008. Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Toxicol. Appl. Pharmacol. 228:32–41. doi:10.1016/j.taap.2007.11.005.
  • Yousefpour, M., F. Bahrami, B. Shahsavan Behboodi, A. Khoshbaten, and A. Asgari. 2006. Paraoxon-induced ultrastructural growth changes of rat cultured hippocampal cells in neurobasal/B27. Toxicology 217:221–27. doi:10.1016/j.tox.2005.09.018.

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