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Research Article

Age, gender, and 11 comorbidities as risk factors associated with COVID-19 mortality: A retrospective cohort including 1.8 million individuals

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References

  • Ahmadian, E., S. M. Hosseiniyan Khatibi, S. Razi Soofiyani, S. Abediazar, M. M. Shoja, M. Ardalan, and S. Zununi Vahed. 2021. Covid-19 and kidney injury: Pathophysiology and molecular mechanisms. Rev. Med. Virol. 31 (3):e2176. doi:10.1002/rmv.2176.
  • Asselah, T., D. Durantel, E. Pasmant, G. Lau, and R. F. Schinazi. 2021. COVID-19: Discovery, diagnostics and drug development. J. Hepatol. 74 (1):168–84. doi:10.1016/j.jhep.2020.09.031.
  • Atkins, J. L., J. A. H. Masoli, J. Delgado, L. C. Pilling, C. L. Kuo, G. A. Kuchel, and D. Melzer. 2020. Preexisting comorbidities predicting COVID-19 and mortality in the UK biobank community cohort. J. Gerontol. A Biol. Sci. Med. Sci. 75 (11):2224–30. doi:10.1093/gerona/glaa183.
  • Bajaj, V., N. Gadi, A. P. Spihlman, S. C. Wu, C. H. Choi, and V. R. Moulton. 2021. Aging, immunity, and COVID-19: How age influences the host immune response to Coronavirus infections? Front Physiol. 11:4. doi:10.3389/fphys.2020.571416.
  • Balboa-Castillo, T., O. Andrade-Mayorga, G. N. Marzuca-Nassr, G. Morales Illanes, M. Ortiz, I. Schiferlli, N. Aguilar-Farias, Á. Soto, and J. Sapunar. 2021. Pre-existing conditions in Latin America and factors associated with adverse outcomes of COVID-19: A review. Medwave 21 (4):e8180–8180. doi:10.5867/medwave.2021.04.8180.
  • Barek, M. A., M. A. Aziz, and M. S. Islam. 2020. Impact of age, sex, comorbidities and clinical symptoms on the severity of COVID-19 cases: A meta-analysis with 55 studies and 10014 cases. Heliyon 6 (12):e05684. doi:10.1016/j.heliyon.2020.e05684.
  • Berghäll, E., M. Hultström, R. Frithiof, M. Lipcsey, and V. Hahn-Strömberg. 2022. The evolution of blood cell phenotypes, intracellular and plasma cytokines and morphological changes in critically ill COVID-19 patients. Biomedicines 10 (5):934. doi:10.3390/biomedicines10050934.
  • Bergman, J., M. Ballin, A. Nordström, and P. Nordström. 2021. Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: A nationwide study. Eur. J. Epidemiol. 36 (3):287–98. doi:10.1007/s10654-021-00732-w.
  • Beyerstedt, S., E. B. Casaro, and B. Rangel É. 2021. COVID-19: Angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. Eur. J. Clin. Microbiol. Infect. Dis. 40 (5):905–19. doi:10.1007/s10096-020-04138-6.
  • Chen, Y., S. L. Klein, B. T. Garibaldi, H. Li, C. Wu, N. M. Osevala, T. Li, J. B. Margolick, G. Pawelec, and S. X. Leng. 2021. Aging in COVID-19: Vulnerability, immunity and intervention. Ageing Res. Rev. 65:101205. doi:10.1016/j.arr.2020.101205.
  • Cruz, J. C., C. K. Martins, and A. K. Neto. 2021. Risk factors for COVID-19 mortality in hospitalised children and adolescents in Brazil. The Lancet Child & Adolescent Health 5 (10):e39–e40. doi:10.1016/S2352-4642(21)00265-0.
  • de Lucena, T. M. C., A. F. da Silva Santos, B. R. de Lima, M. E. de Albuquerque Borborema, and J. de Azevêdo Silva. 2020. Mechanism of inflammatory response in associated comorbidities in COVID-19. Diabetes Metab. Syndrome 14 (4):597–600. doi:10.1016/j.dsx.2020.05.025.
  • de Souza, F. S. H., N. S. Hojo-Souza, B. D. O. Batista, C. M. da Silva, D. L. Guidoni, and F. Di Gennaro. 2021. On the analysis of mortality risk factors for hospitalized COVID-19 patients: A data-driven study using the major Brazilian database. PLos One 16 (3):e0248580. doi:10.1371/journal.pone.0248580.
  • Dennis, A., M. Wamil, J. Alberts, J. Oben, D. J. Cuthbertson, D. Wootton, M. Crooks, M. Gabbay, M. Brady, L. Hishmeh, et al. 2021. Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: A prospective, community-based study. BMJ Open. 11(3):e048391. doi:10.1136/bmjopen-2020-048391.
  • Dessie, Z. G., and T. Zewotir. 2021. Mortality-related risk factors of COVID-19: A systematic review and meta-analysis of 42 studies and 423,117 patients. BMC Infect. Dis. 21 (1):855. doi:10.1186/s12879-021-06536-3.
  • Gallo, G., V. Calvez, and C. Savoia. 2022. Hypertension and COVID-19: Current evidence and perspectives. High Blood Press Cardiovasc Prev. 29 (2):115–23. doi:10.1007/s40292-022-00506-9.
  • Gao, Y. D., M. Ding, X. Dong, J. J. Zhang, A. K. Azkur, D. Azkur, H. Gan, Y. L. Sun, W. Fu, W. Li, et al. 2021. Risk factors for severe and critically ill COVID-19 patients: A review. Allergy 76(2):428–55. doi:10.1111/all.14657.
  • Guan, W.-J., W.-H. Liang, Y. Zhao, H.-R. Liang, Z.-S. Chen, Y.-M. Li, X.-Q. Liu, R.-C. Chen, C.-L. Tang, T. Wang et al. 2020. Comorbidity and its impact on 1590 patients with Covid-19 in China: A nationwide analysis. Eur. Respir. J. 55(5):1–14. doi:10.1183/13993003.00547-2020.
  • Haitao, T., J. V. Vermunt, J. Abeykoon, R. Ghamrawi, M. Gunaratne, M. Jayachandran, K. Narang, S. Parashuram, S. Suvakov, and V. D. Garovic. 2020. COVID-19 and sex differences: Mechanisms and biomarkers. Mayo Clin. Proc. 95 (10):2189–203. doi:10.1016/j.mayocp.2020.07.024.
  • Hales, C. M., C. D. Fryar, M. D. Carroll, D. S. Freedman, and C. L. Ogden. 2018. Trends in obesity and severe obesity prevalence in US youth and adults by sex and age, 2007-2008 to 2015-2016. J. Am. Med. Assoc. 319 (16):1723–25. doi:10.1001/jama.2018.3060.
  • Harrison, S. L., E. Fazio-Eynullayeva, D. A. Lane, P. Underhill, and G. Y. H. Lip. 2020. Comorbidities associated with mortality in 31,461 adults with COVID-19 in the United States: A federated electronic medical record analysis. PLoS Med. 17 (9):e1003321. doi:10.1371/journal.pmed.1003321.
  • Hasanvand, A. 2022. COVID-19 and the role of cytokines in this disease. Inflammopharmacology 30 (3):789–98. doi:10.1007/s10787-022-00992-2.
  • Hu, B., S. Huang, and L. Yin. 2021. The cytokine storm and COVID-19. J. Med. Virol. 93 (1):250–56. doi:10.1002/jmv.26232.
  • Jordan, R. E., P. Adab, and K. K. Cheng. 2020. Covid-19: Risk factors for severe disease and death. Br Med J 368:m1198. doi:10.1136/bmj.m1198.
  • Kifer, D., D. Bugada, J. Villar-Garcia, I. Gudelj, C. Menni, C. Sudre, F. Vučković, I. Ugrina, L. F. Lorini, M. Posso, et al. 2021. Effects of environmental factors on severity and mortality of COVID-19. Front Med. 7:607786. doi:10.3389/fmed.2020.607786.
  • Kim, J. S., J. Y. Lee, J. W. Yang, K. H. Lee, M. Effenberger, W. Szpirt, A. Kronbichler, and J. I. Shin. 2021. Immunopathogenesis and treatment of cytokine storm in COVID-19. Theranostics 11 (1):316–29. doi:10.7150/thno.49713.
  • Krewski, D., P. Saunders-Hastings, P. Larkin, M. Westphal, M. G. Tyshenko, W. Leiss, M. Dusseault, M. Jerrett, and D. Coyle. 2022. Principles of risk decision-making. J. Toxicol. Environ. Health B 25 (5):250–78. doi:10.1080/10937404.2022.2107591.
  • Lai, C. C., T. P. Shih, W. C. Ko, H. J. Tang, and P. R. Hsueh. 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int. J. Antimicrob. Agents 55 (3):105924. doi:10.1016/j.ijantimicag.2020.105924.
  • Lee, P. I., Y. L. Hu, P. Y. Chen, Y. C. Huang, and P. R. Hsueh. 2020. Are children less susceptible to COVID-19? J. Microbiol. Immunol. Infect. 53 (3):371–72. doi:10.1016/j.jmii.2020.02.011.
  • Liu, Y., Y. Li, D. Xu, J. Zhang, and Z. Peng. 2021. Severe COVID-19: Immunosuppression or hyperinflammation? Shock 56 (2):188–99. doi:10.1097/SHK.0000000000001724.
  • Luo, X. H., Y. Zhu, J. Mao, and R. C. Du. 2021. T cell immunobiology and cytokine storm of COVID-19. Scand. J. Immunol. 93 (3):e12989. doi:10.1111/sji.12989.
  • Macedo, M. C. F., I. M. Pinheiro, C. J. L. Carvalho, H. C. J. R. Fraga, I. P. C. Araujo, S. S. Montes, O. A. C. Araujo, L. A. Alves, H. Saba, M. L. V. Araújo, et al. 2020. Correlation between hospitalized patients’ demographics, symptoms, comorbidities, and COVID-19 pandemic in Bahia, Brazil. PLos One. 15:e0243966. doi:10.1371/journal.pone.0243966.
  • Mohamed, M. S., T. C. Moulin, and H. B. Schiöth. 2021. Sex differences in COVID-19: The role of androgens in disease severity and progression. Endocrine 71 (1):3–8. doi:10.1007/s12020-020-02536-6.
  • Moore, K. M., and M. S. Suthar. 2021. Comprehensive analysis of COVID-19 during pregnancy. Biochem. Biophys. Res. Commun. 538:180–86. doi:10.1016/j.bbrc.2020.12.064.
  • Muralidar, S., S. V. Ambi, S. Sekaran, and U. M. Krishnan. 2020. The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2. Biochimie. 179:85–100. doi:10.1016/j.biochi.2020.09.018.
  • Mustafa, N. M., and L. A. Selim. 2020. Characterisation of COVID-19 pandemic in paediatric age group: A systematic review and meta-analysis. J. Clin. Virol. 128:104395. doi:10.1016/j.jcv.2020.104395.
  • National Institutes of Health. 2023. NIH style guide: Age. https://www.nih.gov/nih-style-guide/age#:~:text=Adults%2018%20years%20or%20older.
  • Olak, A. S., W. S. Santos, A. M. Susuki, H. Pott-Junior, A. V. Skalny, A. A. Tinkov, M. Aschner, J. P. P. Pinese, M. R. Urbano, and M. M. B. Paoliello. 2022. Meteorological parameters and cases of COVID-19 in Brazilian cities: An observational study. J. Toxicol. Environ. Health Part A 85 (1):14–28. doi:10.1080/15287394.2021.1969304.
  • Olak, A. S., A. M. Susuki, M. Kanashiro, M. M. B. Paoliello, M. Aschner, and M. R. Urbano. 2021. Risk factors associated with COVID-19-induced death in patients hospitalized in intensive care units (ICUs) in a city in Southern Brazil. Toxicol Rep. 8:1565–68. doi:10.1016/j.toxrep.2021.07.020.
  • Oliveira, E. A., E. A. Colosimo, A. C. S. E Silva, R. H. Mak, D. B. Martelli, L. R. Silva, H. Martelli-Júnior, and M. C. L. Oliveira. 2021. Clinical characteristics and risk factors for death among hospitalised children and adolescents with COVID-19 in Brazil: An analysis of a nationwide database. Lancet Child Adolescent Health 5 (8):559–68. doi:10.1016/S2352-4642(21)00134-6.
  • Parohan, M., S. Yaghoubi, A. Seraji, M. H. Javanbakht, P. Sarraf, and M. Djalali. 2020. Risk factors for mortality in patients with Coronavirus disease 2019 (COVID-19) infection: A systematic review and meta-analysis of observational studies. Aging Male 23 (5):1416–24. doi:10.1080/13685538.2020.1774748.
  • Passarelli-Araujo, H., H. Passarelli-Araujo, R. R. Pescim, A. S. Olak, A. M. Susuki, M. F. A. I. Tomimatsu, C. J. Volce, M. A. Z. Neves, F. F. Silva, S. G. Narciso, et al. 2023. Probabilistic survival modeling in health research: An assessment using cohort data from hospitalized patients with COVID-19 in a Latin American city. J. Toxicol. Environ. Health A 86(7):217–29. doi:10.1080/15287394.2023.2181249.
  • Peckham, H., N. M. de Gruijter, C. Raine, A. Radziszewska, C. Ciurtin, L. R. Wedderburn, E. C. Rosser, K. Webb, and C. T. Deakin. 2020. Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission. Nat. Commun. 11 (1):6317. doi:10.1038/s41467-020-19741-6.
  • Pérez-López, F. R., M. Tajada, R. Savirón-Cornudella, M. Sánchez-Prieto, P. Chedraui, and E. Terán. 2020. Coronavirus disease 2019 and gender-related mortality in European countries: A meta-analysis. Maturitas. 141:59–62. doi:10.1016/j.maturitas.2020.06.017.
  • Poblador-Plou, B., J. Carmona-Pírez, I. Ioakeim-Skoufa, A. Poncel-Falcó, K. Bliek-Bueno, M. Cano-Del Pozo, L. A. Gimeno-Feliú, F. González-Rubio, M. Aza-Pascual-Salcedo, A. C. Bandrés-Liso, et al. 2020. Baseline chronic comorbidity and mortality in laboratory-confirmed COVID-19 cases: Results from the PRECOVID study in Spain. Int. J. Environ. Res. 17(14):5171. doi:10.3390/ijerph17145171.
  • Polverino, F., D. A. Stern, G. Ruocco, E. Balestro, M. Bassetti, M. Candelli, B. Cirillo, M. Contoli, A. Corsico, F. D’Amico, et al. 2020. Comorbidities, cardiovascular therapies, and COVID-19 mortality: A nationwide, Italian observational study (ItaliCO). Front Cardiovasc. Med. 7:585866. doi:10.3389/fcvm.2020.585866.
  • Rapp, J. L., W. Lieberman-Cribbin, S. Tuminello, and E. Taioli. 2021. Male sex, severe obesity, older age, and chronic kidney disease are associated with COVID-19 severity and mortality in New York City. Chest. 159 (1):112–15. doi:10.1016/j.chest.2020.08.2065.
  • Russell, C. D., N. I. Lone, and J. K. Baillie. 2023. Comorbidities, multimorbidity and COVID-19. Nat. Med. 29 (2):334–43. doi:10.1038/s41591-022-02156-9.
  • Shah, P., J. Owens, J. Franklin, A. Mehta, W. Heymann, W. Sewell, J. Hill, K. Barfield, and R. Doshi. 2020. Demographics, comorbidities and outcomes in hospitalized Covid-19 patients in rural southwest Georgia. Ann. Med. 52 (7):354–60. doi:10.1080/07853890.2020.1791356.
  • Viveiros, A., J. Rasmuson, J. Vu, S. L. Mulvagh, C. Y. Y. Yip, C. M. Norris, and G. Y. Oudit. 2021. Sex differences in COVID-19: Candidate pathways, genetics of ACE2, and sex hormones. Am. J. Physiol. 320 (1):H296–H304. doi:10.1152/ajpheart.00755.2020.
  • von Elm, E., D. G. Altman, M. Egger, S. J. Pocock, P. C. Gøtzsche, and J. P. Vandenbroucke. 2014. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies. Int. J. Surg. 12 (12):1495–99. doi:10.1016/j.ijsu.2014.07.013.
  • Wu, C., X. Chen, Y. Cai, J. Xia, X. Zhou, S. Xu, H. Huang, L. Zhang, X. Zhou, C. Du, et al. 2020. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. J. Am. Med. Assoc. Intern. Med. 180(7):934–43. doi:10.1001/jamainternmed.2020.0994.
  • Zhang, H., J. M. Penninger, Y. Li, N. Zhong, and A. S. Slutsky. 2020. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: Molecular mechanisms and potential therapeutic target. Intensive Care Med 46 (4):586–90. doi:10.1007/s00134-020-05985-9.
  • Zhou, Y., J. Chi, W. Lv, and Y. Wang. 2021. Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (Covid-19). Diabetes Metab. Res. Rev. 37 (2):e3377. doi:10.1002/dmrr.3377.
  • Zimmermann, P., and N. Curtis. 2020. Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections. Arch. Dis. Child. 106 (5):1–11. doi:10.1136/archdischild-2020-320338.

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