Long‐term effects of single and combined doses of DDT and PCB on drug‐metabolizing enzymes in rat liver

References

• Aitio , A. and Vainio , H. 1976 . UDPglucuronosyltransferase and mixed‐function oxidase activity in microsomes prepared by differential centrifugation and calcium aggregation . Acta Pharmacol. Toxicol. , 39 : 555 – 561 .
   PubMedGoogle Scholar
• Alvares , A. P. , Bickers , D. R. and Kappas , A. 1973 . Polychlorinated biphenyls: A new type of inducer of cytochrome P‐448 in the liver . Proc. Natl. Acad. Sci. U.S.A. , 70 : 1321 – 1325 .
   PubMed Web of Science ®Google Scholar
• Bickers , D. R. , Kappas , A. and Alvares , A. P. 1973 . Differences in inducibility of cutaneous and hepatic drug metabolizing enzymes and cytochrome P‐450 by polychlorinated biphenyls and 1,1,1‐trichloro‐2,2‐bis(p‐chlorophenyl)ethane (DDT) . J. Pharmacol. Exp. Ther. , 188 : 300 – 309 .
   Web of Science ®Google Scholar
• Bowes , G. W. , Mulvihill , M. J. , Simoneit , B. R. T. , Burlingame , A. L. and Risebrough , R. W. 1975 . Identification of chlorinated dibenzofurans in American polychlorinated biphenyls . Nature (Lond) , 256 : 305 – 307 .
   PubMed Web of Science ®Google Scholar
• Bruckner , J. V. , Khanna , K. L. and Kornish , H. H. 1973 . Biological responses of rat to polychlorinated biphenyls . Toxicol. Appl. Pharmacol. , 24 : 434 – 448 .
   PubMed Web of Science ®Google Scholar
• Bruckner , J. V. , Khanna , K. L. and Cornish , H. H. 1974 . Polychlorinated biphenyl induced alteration of biologic parameters in the rat . Toxicol. Appl. Pharmacol. , 28 : 189 – 199 .
   PubMed Web of Science ®Google Scholar
• Burse , V. W. , Moseman , R. F. , Sovocool , G. W. and Villanueva , E. C. 1976 . PCB metabolism in rats following prolonged exposure to Aroclor 1242 and Aroclor 1016 . Bull. Environ. Contam. Toxicol. , 15 : 122 – 128 .
   PubMed Web of Science ®Google Scholar
• Conney , A. H. 1967 . Pharmacological implications of microsomal enzyme induction . Pharmacol. Rev. , 19 : 317 – 366 .
   PubMed Web of Science ®Google Scholar
• Curley , A. , Burse , V. W. , Jennings , R. W. , Villanueva , E. C. and Kimbrough , R. D. 1975 . Evidence of tetrachlorodibenzofuran (TCDF) in Aroclor 1254 and the urine of rats following dietary exposure to Aroclor 1254R . Bull. Environ. Contam. Toxicol. , 14 : 153 – 158 .
   PubMed Web of Science ®Google Scholar
• Ecobichon , D. J. and Comeau , A. M. 1974 . Comparative effects of commercial Aroclors on rat liver enzyme activities . Chem. Biol. Interact. , 9 : 341 – 350 .
   PubMed Web of Science ®Google Scholar
• Ecobichon , D. J. and Comeau , A. M. 1975 . Isomerically pure chlorobiphenyl congeners and function in the rat: Influence of position and degree of chlorination . Toxicol. Appl. Pharmacol. , 33 : 94 – 105 .
   PubMed Web of Science ®Google Scholar
• Goldstein , J. A. , Hickman , P. , Burse , V. W. and Bergman , H. 1975 . A comparative study of two polychlorinated biphenyl mixtures (Aroclors 1242 and 1016) containing 42% chlorine on induction of hepatic porphyria and drug‐metabolizing enzymes . Toxicol. Appl. Pharmacol. , 32 : 461 – 473 .
   PubMed Web of Science ®Google Scholar
• Hänninen , O. 1968 . On the metabolic regulation in the glucuronic acid pathway in the rat tissues . Ann. Acad. Sci. Fenn. Ser. A II , 142 : 1 – 96 .
   Google Scholar
• Hart , L. G. and Fouts , J. E. 1963 . Effects of acute and chronic DDT administration on microsomal drug metabolism in the rat . Proc. Soc. Exp. Biol. Med. , 114 : 288 – 292 .
   Web of Science ®Google Scholar
• Jensen , S. and Sundström , G. 1974 . Structures and levels of most chlorobiphenyls in two technical PCB products and human adipose tissue . Ambio , 3 : 70 – 76 .
   Google Scholar
• Johnstone , G. J. , Ecobichon , D. J. and Hutzinger , O. 1974 . The influence of pure polychlorinated biphenyl compounds on hepatic function in the rat . Toxicol. Appl. Pharmacol. , 28 : 66 – 81 .
   PubMed Web of Science ®Google Scholar
• Marniemi , J. and Parkki , M. G. 1975 . Radiochemical assay of glutathione S‐epoxide transferase and its enhancement by phenobarbital in rat liver in vivo . Biochem. Pharmacol. , 24 : 1569 – 1572 .
   Web of Science ®Google Scholar
• Matthews , H. B. and Anderson , M. W. 1975 . Effect of chlorination on the distribution and excretion of polychlorinated biphenyls . Drug Metab. Dispos. , 3 : 371 – 380 .
   PubMed Web of Science ®Google Scholar
• Nebert , D. W. and Gelboin , H. V. 1968 . Substrate inducible microsomal aryl hydroxylase. I. Assay and properties of induced enzyme . J. Biol. Chem. , 243 : 6242 – 6249 .
   PubMed Web of Science ®Google Scholar
• Oesch , F. 1973 . Mammalian epoxide hydrases: Inducible enzyme catalyzing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds . Xenobiotica , 3 : 305 – 340 .
   PubMed Web of Science ®Google Scholar
• Oesch , F. , Jerina , D. M. and Daly , J. 1971 . A radiometric assay for hepatic epoxide hydrase activity with (7–3H) styrene oxide . Biochim. Biophys. Acta , 227 : 685 – 691 .
   PubMed Web of Science ®Google Scholar
• Omura , T. and Sato , R. 1964 . The carbon‐monoxide binding pigment of liver microsomes. II. Solubilization, purification and properties . J. Biol. Chem. , 239 : 2379 – 2385 .
   PubMed Web of Science ®Google Scholar
• Parkki , M. G. 1976 . Effects of Silymarin on carbon tetrachloride, paracetamol and bromobenzene caused deterioration of detoxifying enzymes . Acta Physiol. Scand. Suppl. , 440 : 218
   Google Scholar
• Parkki , M. G. , Marniemi , J. and Vainio , H. 1976 . Action of styrene and its metabolites styrene oxide and styrene glycol on activities of xenobiotic biotransformation enzymes in rat liver in vivo . Toxicol. Appl. Pharmacol. , 38 : 59 – 70 .
   PubMed Web of Science ®Google Scholar
• Phillips , A. H. and Langdon , R. G. 1962 . Hepatic triphosphopyridine nucleotide‐cytochrome c‐reductase: Isolation, characterization and kinetic studies . J. Biol. Chem. , 237 : 2652 – 2660 .
   PubMed Web of Science ®Google Scholar
• Poland , A. and Glover , E. 1976 . Stereospecific, high affinity binding of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin by hepatic cytosol . J. Biol. Chem. , 251 : 4936 – 4946 .
   PubMed Web of Science ®Google Scholar
• Risebrough , R. W. , Rieche , P. , Herman , S. G. , Peakall , D. B. and Kirven , M. N. 1968 . Polychlorinated biphenyls in the global ecosystem . Nature (Lond) , 220 : 1098 – 1102 .
   PubMed Web of Science ®Google Scholar
• Vainio , H. 1973 . “ On the topology and synthesis of drug‐metabolizing enzymes in hepatic endoplasmic reticulum ” . 1 – 46 . Turku : Academic dissertation .
   Google Scholar
• Vainio , H. 1974a . Enhancement of hepatic microsomal drug oxidation and glucuronidation in rat by 1,1,1‐trichloro‐2,2‐bis(p‐chlorophenyl)ethane (DDT) . Chem. Biol. Interact. , 2 : 7 – 14 .
   Google Scholar
• Vainio , H. 1974b . Enhancement of microsomal drug oxidation and glucuronidation in rat liver by an environmental chemical, polychlorinated biphenyl . Chem. Biol. Interact. , 2 : 379 – 387 .
   Google Scholar
• Vainio , H. and Aitio , A. 1974 . Enhancement of microsomal drug hydroxylation and glucuronidation in rat liver by phenobarbital and 3‐methylcholanthrene in combination . Acta Pharmacol. Toxicol. , 34 : 130 – 140 .
   PubMedGoogle Scholar
• Vainio , H. and Aitio , A. 1975 . Influence of hematin, carbon tetrachloride and SKF 525‐A administration on the enhancement of microsomal monooxygenase and UDPglucuronosyl‐transferase by 3,4‐benzpyrene in rat liver . Acta Pharmacol. Toxicol. , 37 : 23 – 32 .
   PubMedGoogle Scholar
• Vainio , H. and Parkki , M. G. 1974 . Protection of microsomal drug biotransformation enzymes against carbon tetrachloride by diethyldithiocarbamate in rat liver . Res. Commun. Chem. Pathol. Pharmacol. , 9 : 511 – 522 .
   PubMedGoogle Scholar
• Vainio , H. and Parkki , M. G. 1976 . Enhancement of microsomal monooxygenase, epoxide hydrase and UDPglucuronosyltransferase by aldrin, dieldrin and isosafrole administrations in rat liver . Toxicology , 5 : 279 – 286 .
   PubMed Web of Science ®Google Scholar
• Vainio , H. , Aitio , A. and Hänninen , O. 1974 . Action of transcription and translation inhibitors on the enhancement of drug hydroxylation and glucuronidation by 3‐methylcholanthrene and phenobarbital . Int. J. Biochem. , 5 : 193 – 200 .
   Google Scholar
• Vos , J. G. , Koeman , J. H. , Van ver Maas , H. L. , Ten Noever De Brauw , M. C. and De Vos , R. H. 1970 . Identification and toxicological evaluation of chlorinated dibenzofuran and chlorinated naphthalene in two commercial polychlorinated biphenyls . Food Cosmet. Toxicol. , 8 : 625 – 633 .
   PubMedGoogle Scholar
• Webb , R. G. and McCall , A. C. 1972 . Identities of polychlorinated biphenyl isomers in Aroclors . J. Assoc. Off. Anal. Chem. , 55 : 746 – 752 .
   PubMedGoogle Scholar