Mutagenicity and mutagenic specificity of metronidazole and niridazole in neurospora crassa

References

• Brockman , H. E. and de Serres , F. J. 1963 . Induction of ad‐3 mutants of Neurospora crassa by 2‐aminopurine . Genetics , 48 : 597 – 604 .
   PubMed Web of Science ®Google Scholar
• Brockman , H. E. and Goben , W. 1965 . Mutagenicity of a monofunctional alkylating agent derivative of acridine in Neurosporo . Science , 147 : 750 – 751 .
   PubMed Web of Science ®Google Scholar
• Brusick , D. J. 1969 . Revision of acridine mustard‐induced ad‐3 mutants of Neurospora crassa . Mutat. Res. , 8 : 247 – 254 .
   PubMedGoogle Scholar
• de Serres , F. J. 1964a . Mutagenesis and chromosome structure . J. Cell. Comp. Physiol. , 64 (Suppl. 1) : 33 – 42 .
   PubMedGoogle Scholar
• de Serres , F. J. 1964b . Genetic analysis of the structure of the ad‐3 region of Neurosporo crassa by means of irreparable recessive lethal mutations . Genetics , 50 : 21 – 30 .
   PubMed Web of Science ®Google Scholar
• de Serres , F. J. 1968 . Genetic analysis of the extent and type of functional inactivation in irreparable recessive lethal mutations in the ad‐3 region of Neurospora crassa . Genetics , 58 : 69 – 77 .
   PubMed Web of Science ®Google Scholar
• de Serres , F. J. and Brockman , H. E. 1968 . Homology tests on presumed multilocus deletions in the ad‐3 region of Neurospora crassa induced by the acridine mustard ICR‐170 . Genetics , 58 : 79 – 83 .
   PubMed Web of Science ®Google Scholar
• de Serres , F. J. and Mailing , H. V. 1971 . “ Measurement of recessive lethal damage over entire genomes and at two specific loci in the ad‐3 region of a two‐component heterokaryon of Neurospora crassa ” . In Chemical Mutagens: Principles and Methods for Their Detection , Edited by: Hollaender , A. vol. 2 , 311 – 342 . New York : Plenum .
   Google Scholar
• de Serres , F. J. and Webber , B. B. 1963 . Recessive lethal mutations resulting from deletion of closely linked loci in balanced heterokaryons of Neurospora crassa . Neurospora Newslett. , 3 : 3 – 5 .
   Google Scholar
• de Serres , F. J. , Brockman , H. E. , Barnett , W. E. and K⊘lmark , H. G. 1971 . Mutagen specificity in Neurospora crassa . Mutat. Res. , 12 : 129 – 142 .
   PubMedGoogle Scholar
• Feller , D. R. , Monta , M. and Gillette , J. R. 1971 . Enzymatic reduction of niridazole by rat liver microsomes . Biochem. Pharmacol. , 20 : 203 – 215 .
   PubMed Web of Science ®Google Scholar
• Horowitz , N. H. and Beadle , G. W. 1943 . A microbiological method for the determination of choline by use of a mutant of Neurospora . J. Biol. Chem. , 150 : 325 – 333 .
   Google Scholar
• Legator , M. S. , Connor , T. H. and Stockel , M. 1975 . Detection of mutagenic activity of metronidazole and niridazole in body fluids of humans and mice with Salmonella typhimurium . Science , 188 : 1118 – 1119 .
   PubMedGoogle Scholar
• Mailing , H. V. 1967 . The mutagenicity of acridine mustard (ICR‐170) and the structurally related compounds in Neurospora . Mutat. Res. , 4 : 265 – 274 .
   PubMedGoogle Scholar
• Mailing , H. V. and de Serres , F. J. 1968a . Correlation between base‐pair transition and complementation pattern in nitrous acid‐induced ad‐3B mutants of Neurospora crassa . Mutat. Res. , 5 : 359 – 371 .
   PubMedGoogle Scholar
• Mailing , H. V. and de Serres , F. J. 1968b . Identification of genetic alterations induced by ethyl methanesulfonate in Neurospora crassa . Mutat. Res. , 6 : 181 – 193 .
   PubMedGoogle Scholar
• McCalla , D. R. , Voutsinos , D. and Olive , P. L. 1975 . Mutagen screening with bacteria: Niridazole and nitrofurans . Mutat. Res. , 31 : 31 – 37 .
   PubMed Web of Science ®Google Scholar
• McCann , J. , Spingarn , N. E. , Kobori , J. and Ames , B. N. 1975 . Detection of carcinogens as mutagens: Bacterial tester strains with R factor plasmids . Proc. Natl. Acad. Science U.S.A. , 72 : 979 – 983 .
   PubMed Web of Science ®Google Scholar
• Mintz , M. 1974 . Controversial drug okayed for tests . Washington Post , June 30
   Google Scholar
• Morita , M. , Feller , D. R. and Gillette , J. R. 1971 . Reduction of niridazole by rat liver xanthine oxidase . Biochem. Pharmacol. , 20 : 217 – 226 .
   PubMed Web of Science ®Google Scholar
• Ong , T. 1970 . Characterization of ICR‐177‐induced ad‐3 mutants of Neurospora crassa . Mutat. Res. , 9 : 183 – 191 .
   PubMedGoogle Scholar
• Ong , T. and de Serres , F. J. 1975 . Mutagenic evaluation of antischistosomal drugs and their derivatives in Neurospora crassa . J. Toxicol. Environ. Health , 1 : 271 – 279 .
   PubMed Web of Science ®Google Scholar
• Ong , T. , Matter , B. E. and de Serres , F. J. 1975 . Genetic characterization of adenine‐3 mutants induced by 4‐nitroquinoline 1‐oxide and 4‐hydroxyamino‐quinoline 1‐oxide in Neurospora crassa . Cancer Res. , 35 : 291 – 295 .
   PubMed Web of Science ®Google Scholar
• Rosenkranz , H. S. and Speck , W. T. 1975 . Mutagenicity of metronidazole: Activation by mammalian liver microsomes . Biochem. Biophys. Res. Commun. , 66 : 520 – 525 .
   PubMed Web of Science ®Google Scholar
• Rustía , M. and Shubik , P. 1972 . Induction of lung tumors and malignant lymphomas in mice by metronidazole . J. Natl. Cancer Inst. , 48 : 721 – 729 .
   PubMed Web of Science ®Google Scholar
• Shahin , M. M. 1975 . Genetic activity of niridazole in yeast . Mutat. Res. , 30 : 191 – 198 .
   PubMedGoogle Scholar
• Voogd , C. E. , van der Stel , J. J. and Jacobs , J. J. J. A. A. 1974 . The mutagenic action of nitroimidazoles. 1. Metronidazole, niridazole, dimetridazole, and ronidazole . Mutat. Res. , 26 : 483 – 490 .
   PubMed Web of Science ®Google Scholar