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Part two: Carcinogenesis at the molecular level

Alkylation of DNA and carcinogenicity of N‐nitroso compounds

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Pages 1001-1008 | Published online: 20 Oct 2009

References

  • Abbott , P. J. and Saffhill , R. 1977 . DNA synthesis with methylated poly(dA‐dT) templates: Possible role of O4‐methylthymine as a promutagenic base . Nucleic Acids Res. , 4 : 761 – 769 .
  • Coulondre , C. and Miller , J. H. 1977 . Genetic studies of the lac repressor. IV. Mutagenic specificity in the lacl gene of Escherichia coli . J. Mol. Biol. , 117 : 577 – 606 .
  • Craddock , V. M. 1976 . “ Cell proliferation and experimental liver cancer ” . In Liver Cell Cancer , Edited by: Cameron , H. M. , Linsell , D. A. and Warwick , G. P. 153 – 201 . Amsterdam : Elsevier/North‐Holland Biomedical .
  • Druckrey , H. 1973 . Specific carcinogenic and teratogenic effects of “indirect” alkylating methyl and ethyl compounds and their dependency on stages of oncogenic developments . Xenobiotica , 3 : 271 – 303 .
  • Druckrey , H. , Preussmann , R. , Ivankovic , S. and Schmähl , D. 1967 . Organotrope carcinogene Wirkungen bei 65 verschiedenen N‐nitroso‐Verbindungen an BD‐Ratten . Z. Krebsforsch. , 69 : 103 – 201 .
  • Gerchman , L. L. and Ludlum , D. B. 1973 . the properties of O6‐methylguanine in templates for RNA polymerase . Biochim. Biophys. Acta , 308 : 310 – 316 .
  • Goth , R. and Rajewsky , M. F. 1974 . Persistence of O6‐ethylguanine in rat‐brain DNA: Correlation with nervous system‐specific carcinogenesis by ethylnitrosourea . Proc. Nati. Acad. Sci. U.S.A. , 71 : 59 – 62 .
  • IARC . 1978 . Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, vol. 17 Some N‐Nitroso Compounds , vol. 17 , Lyon : International Agency for Research on Cancer .
  • Karran , P. , Lindahl , T. and Griffin , B. 1979 . Adaptive response to alkylating agents involves alteration in situ of O6‐methylguanine residues in DNA . Nature (Lond.) , 280 : 76 – 77 .
  • Kleihues , P. and Margison , G. P. 1976 . Exhaustion and recovery of repair excision of O6‐methylguanine from rat liver DNA . Nature (Lond.) , 259 : 153 – 155 .
  • Kroeger‐Koepke , M. B. and Michejda , C. J. 1979 . Evidence for several demethylase enzymes in the oxidation of dimethylnitrosamine and phenylmethylnitrosamine by rat liver fractions . Cancer Res. , 39 : 1587 – 1591 .
  • Lawley , P. D. 1976 . “ Carcinogenesis by alkylating agents ” . In Chemical Carcinogens , Edited by: Searle , C. E. 83 – 244 . Washington, D.C. : American Chemical Society .
  • Loveless , A. 1969 . Possible relevance of O6‐alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides . Nature (Lond.) , 233 : 206 – 207 .
  • Loveless , A. and Hampton , C. L. 1969 . Inactivation and mutation of coliphage T2 by N‐methyl‐ and N‐ethyl‐N‐nitrosourea . Mutat. Res. , 7 : 1 – 12 .
  • Magee , P. N. and Barnes , J. M. 1967 . Carcinogenic nitroso compounds . Adv. Cancer Res. , 10 : 163 – 246 .
  • Magee , P. N. , Montesano , R. and Preussmann , R. 1976 . “ N‐Nitroso compounds and related carcinogens ” . In Chemical Carcinogens , Edited by: Searle , C. E. 491 – 625 . Washington, D.C. : American Chemical Society .
  • Margison , G. P. and O'Connor , P. 1979 . “ Nucleic acid modification by N‐nitroso compounds ” . In Chemical Carcinogens and DNA , Edited by: Grover , P. L. 111 – 159 . Baltimore : CRC Press .
  • Margison , G. P. and Saffhill , R. 1979 . “ Carcinogenicity of alkylating agents ” . In Advances in Medical Oncology‐Research and Education vol. 1 Carcinogenesis , Edited by: Margison , G. P. vol. 1 , 229 – 239 . Oxford : Pergamon .
  • Margison , G. P. , Margison , J. M. and Montesano , R. 1976 . Methylated purines in deoxyribonucleic acid of various Syrian golden hamster tissues after administration of a hepatocarcinogenic dose of dimethylnitrosamine . Biochem. J. , 157 : 627 – 634 .
  • Margison , G. P. , Curtin , N. J. , Snell , K. and Craig , A. W. 1979a . Effect of chronic N,N‐diethylnitrosamine on the excision of O6‐ethylguanine from rat liver DNA . Br. J. Cancer , 40 : 809 – 813 .
  • Margison , G. P. , Margison , J. M. and Montesano , R. 1979b . Persistence of methylated bases in ribonucleic acid of Syrian golden hamster liver after administration of dimethylnitrosamine . Biochem. J. , 177 : 967 – 973 .
  • Milstein , S. and Guttenplan , J. B. 1979 . Near quantitative production of molecular nitrogen from metabolism of dimethylnitrosamine . Biochem. Biophys. Res. Commun. , 87 : 337 – 342 .
  • Montesano , R. and Bartsch , H. 1976 . Mutagenic and carcinogenic N‐nitroso compounds: Possible environmental hazards . Mutat. Res. , 32 : 179 – 228 .
  • Montesano , R. , Brésil , H. and Margison , G. P. 1979 . Increased excision of O6‐methylguanine from rat liver DNA after chronic administration of dimethylnitrosamine . Cancer Res. , 39 : 1798 – 1802 .
  • Montesano , R. , Brésil , H. , Planche‐Martel , G. , Margison , G. P. and Pegg , A. E. 1980 . The effect of chronic treatment of rats with dimethylnitrosamine on the removal of O6‐methylguanine from DNA . Cancer Res. , 40 : 452 – 458 .
  • Pegg , A. E. 1977 . Formation and metabolism of alkylated nucleosides: Possible role in carcinogenesis by nitroso compounds and alkylating agents . Adv. Cancer Res. , 25 : 195 – 269 .
  • Pegg , A. E. 1978 . Enzymatic removal of O6‐methylguanine from DNA by mammalian cell extracts . Biochem. Biophys. Res. Commun. , 84 : 166 – 173 .
  • Pegg , A. E. 1980a . Formation and subsequent repair of alkylation lesions in tissues of rodents treated with nitrosamines . Arch. Toxicol. , in press
  • Pegg , A. E. 1980b . “ Metabolism of N‐nitrosodimethylamine ” . In Molecular and Cellular Aspects of Carcinogen Screening Tests , IARC Sci. Publ. 27 Edited by: Montesano , R. , Bartsch , H. and Tomatis , L. 3 – 22 . Lyon : International Agency for Research on Cancer .
  • Pegg , A. E. and Hui , G. 1978 . Formation and subsequent removal of O6‐methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine . Biochem. J. , 173 : 739 – 748 .
  • Robins , P. and Cairns , J. 1979 . Quantitation of the adaptive response to alkylating agents . Nature (Lond.) , 280 : 74 – 76 .
  • Singer , B. 1979 . N‐Nitroso alkylating agents: Formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis . J. Natl. Cancer Inst. , 62 : 1329 – 1339 .
  • Stumpf , R. , Margison , G. P. , Montesano , R. and Pegg , A. E. 1979 . Formation and loss of alkylated purines from DNA of hamster liver after administration of dimethylnitrosamine . Cancer Res. , 39 : 50 – 54 .
  • Swann , P. F. and Magee , P. N. 1968 . Nitrosamine induced carcinogenesis. The alkylation of nucleic acids of the rat by N‐methyl‐N‐nitrosourea, dimethylnitrosamine, diethylsulphate and methyl methanesulphonate . Biochem. J. , 110 : 39 – 47 .
  • Swann , P. F. and Magee , P. N. 1971 . Nitrosamine‐induced carcinogenesis. The alkylation of N‐7 of guanine of nucleic acids of the rat by diethylnitrosamine, N‐ethyl‐N‐nitrosourea and ethyl methanesulphonate . Biochem. J. , 125 : 841 – 847 .
  • Tomatis , L. and Cefis , F. 1967 . The effects of multiple and single administration of dimethylnitrosamine to hamsters . Tumori , 53 : 447 – 452 .
  • Vogel , E. and Natarajan , A. T. 1979 . The relation between reaction kinetics and mutagenic action of monofunctional alkylating agents in higher eukaryotic systems. I. Recessive lethal mutations and translocations in . Drosophila. Mutat. Res. , 62 : 55 – 100 .

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