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Part three: Detection of chemical carcinogens

Identification and definition of chemical carcinogens: Review of criteria and research needs

Pages 1029-1057 | Published online: 20 Oct 2009

References

  • Adamo , S. , De Luca , L. M. , Akalovsky , I. and Bhat , P. V. 1979 . Retinoid‐induced adhesion in cultured transformed mouse fibroblasts . J. Natl. Cancer Inst. , 62 : 1473 – 1478 .
  • Ad Hoc Committee on the Evaluation of Low Levels of Environmental Carcinogens . 1971 . “ Evaluation of environmental carcinogens–Report to the Surgeon General ” . In Chemicals and the Future of Man 171 – 198 .
  • Hearings before the Subcommittee on Executive Reorganization and Government Research of the Committee on Government Operations . U.S. Senate, 92nd Congress, 1st Session. Washington, D.C.. Government Printing Office .
  • Autrup , H. , Schwartz , R. D. , Essigmann , J. M. , Smith , L. , Trump , B. F. and Harris , C. C. 1980 . “ Metabolism of aflatoxin B,, benzo[a]pyrene and 1,2‐dimethylhydrazine by cultured rat and human colon ” . In Teratogenesis Carcinogenesis and Mutagenesis in press
  • Becci , P. J. , McDowell , E. M. and Trump , B. F. 1978a . The respiratory epithelium. II. Hamster trachea, bronchus, and bronchioles . J. Natl. Cancer Inst. , 61 : 551 – 561 .
  • Becci , P. J. , McDowell , E. M. and Trump , B. F. 1978b . The respiratory epithelium. IV. Histogenesis of epidermoid metaplasia and carcinoma in situ in the hamster . J. Natl. Cancer Inst. , 61 : 577 – 586 .
  • Becci , P. J. , McDowell , E. M. and Trump , B. F. 1978c . The respiratory epithelium. VI. Histogenesis of lung tumors induced by benzo(a)pyrene‐ferric oxide in the hamster . J. Natl. Cancer Inst. , 61 : 607 – 618 .
  • Berenblum , I. 1941 . The cocarcinogenic action of croton resin . Cancer Res. , 1 : 44 – 48 .
  • Berenblum , I. and Shubik , P. 1947 . A new, qualitative, approach to the study of the stages of chemical carcinogenesis in the mouse's skin . Br. J. Cancer , 1 : 383 – 391 .
  • Chiazze , L. Jr. and Lundin , F. E. , eds. 1980 . Epidemiologic Methods for Occupational and Environmental Health Studies , Washington, D.C. : Society for Occupational and Environmental Health . In press
  • Colburn , N. H. 1978 . “ Chemical transformation of epidermal cell cultures ” . In In Vitro Carcinogenesis. Guide to the Literature Recent Advances and Laboratory Procedures , National Cancer Institute Carcinogenesis Technical Report Series No. 44 Edited by: Saffiotti , U. and Autrup , H. 57 – 64 . 78 – 844 . DHEW Publ. (NIH) .
  • Colburn , N. H. 1980 . “ Tumor promotion and preneoplastic progression ” . In Carcinogenesis, vol. 5 Modifiers of Chemical Carcinogenesis , Edited by: Slaga , T. J. vol. 5 , 33 – 56 . New York : Raven .
  • Colburn , N. H. , Vorder Bruegge , U. V. , Bates , J. and Yuspa , S. H. 1978 . “ Epidermal cell transformation in vitro ” . In Mechanisms of Tumor Promotion and Cocarcinogenesis , Edited by: Slaga , T. J. , Sivak , A. and Boutwell , R. K. 257 – 271 . New York : Raven .
  • De Luca , L. M. 1977 . The direct involvement of vitamin A in glycosyl transfer reactions of mammalian membranes . Vitam. Horm. (N.Y.) , 35 : 1 – 57 .
  • De Luca , L. M. , Adamo , S. , Bhat , P. V. , Sasak , W. , Silverman‐Jones , C. S. , Akalovsky , I. , Frot‐Coutaz , J. P. , Fletcher , T. R. and Chader , G. J. 1979 . Recent developments in studies on biological functions of vitamin A in normal and transformed tissues . Pure Appl. Chem. , 51 : 581 – 591 .
  • Department of Labor, Occupational Safety and Health Administration . 1980 . Identification, classification and regulation of potential occupational carcinogens . Fed. Regist. , 45 (15) : 5002 – 5296 .
  • Farrell , R. L. and Davis , G. W. 1974 . “ Effect of particulate benzo(a)pyrene carrier on carcinogenesis in the respiratory tract of hamsters ” . In Experimental Lung Cancer. Carcinogenesis and Bioassays , Edited by: Karbe , E. and Park , J. F. 186 – 198 . New York : Springer‐Verlag .
  • Fondazione Carlo Erba . Methods for carcinogenesis tests at the cellular level and their evaluation for the assessment of occupational cancer hazards . Proceedings of the Meeting of the Scientific Committee . December 4–6 , Milan.
  • Food and Drug Administration. Advisory Committee on Protocols for Safety Evaluation . 1971 . Panel on carcinogenesis report on cancer testing in the safety evaluation of food additives and pesticides . Toxicol. Appl. Pharmacol. , 20 : 419 – 438 .
  • Harris , C. C. , ed. 1978 . Pathogenesis and Therapy of Lung Cancer , New York : Dekker .
  • Harris , C. C. 1980 . “ Culture of human respiratory tissues and cells. An overview ” . In Cultured Human Tissues and Cells , Edited by: Harris , C. C. , Trump , B. F. and Stoner , G. D. New York : Academic . In press
  • Harris , C. C. , Sporn , M. B. , Kaufman , D. G. , Smith , J. M. , Baker , M. S. and Saffiotti , U. 1972a . Acute ultrastructural effects of benzo[a]pyrene and ferric oxide on the hamster tracheobronchial epithelium . Cancer Res. , 31 : 1977 – 1981 .
  • Harris , C. C. , Sporn , M. B. , Kaufman , D. G. , Smith , J. M. , Jackson , F. and Saffiotti , U. 1972b . Histogenesis of squamous metaplasia in the hamster tracheal epithelium caused by vitamin A deficiency or benzo[a] pyrene‐ferric oxide . J. Natl. Cancer Inst. , 48 : 743 – 761 .
  • Harris , C. C. , Kaufman , D. G. , Sporn , M. B. , Boren , H. , Jackson , F. , Smith , J. M. , Pauley , J. , Dedick , P. and Saffiotti , U. 1973a . Localization of benzo[a] pyrene‐3H and alterations in nuclear chromatin caused by benzo[a] pyrene‐ferric oxide in the hamster respiratory epithelium . Cancer Res. , 33 : 2842 – 2848 .
  • Harris , C. C. , Kaufman , D. G. , Sporn , M. B. and Saffiotti , U. 1973b . Histogenesis of squamous metaplasia and squamous cell carcinoma of the respiratory epithelium in an animal model . Cancer Chemother. Rep. , 4 : 43 – 54 .
  • Harris , C. C. , Kaufman , D. G. , Sporn , M. B. , Smith , J. M. , Jackson , F. and Saffiotti , U. 1973c . Ultrastructural effects of N‐methyl‐nitrosourea on the tracheobronchial epithelium of the Syrian golden hamster . Int. J. Cancer , 12 : 259 – 269 .
  • Harris , C. C. , Kaufman , D. G. , Jackson , F. , Smith , J. M. , Dedick , P. and Saffiotti , U. 1974 . Atypical cilia in the tracheobronchial epithelium of the hamster during respiratory carcinogenesis . J. Pathol. , 114 : 17 – 19 .
  • Harris , C. C. , Autrup , H. , Trump , B. F. and Stoner , G. D. 1978 . “ Carcinogenesis studies in human respiratory epithelium. An experimental model system ” . In Pathogenesis and Therapy of Lung Cancer , Edited by: Harris , C. C. 559 – 607 . New York : Dekker .
  • Hennings , H. , Yuspa , S. H. , Michael , D. and Lichti , U. 1978 . “ Modification of epidermal cell response to 12‐O‐tetradecanoyl‐phorbol‐13‐acetate by serum level, culture temperature and pH ” . In Mechanisms of Tumor Promotion and Cocarcinogenesis , Edited by: Slaga , T. J. , Sivak , A. and Boutwell , R. K. 233 – 243 . New York : Raven .
  • Henry , M. C. and Kaufman , D. G. 1973 . Clearance of benzo[a] pyrene from hamster lungs after administration on coated particles . J. Natl. Cancer Inst. , 51 : 1961 – 1964 .
  • Henry , M. C. , Port , C. D. and Kaufman , D. G. 1974 . “ Role of particles in respiratory carcinogenesis bioassay ” . In Experimental Lung Cancer. Carcinogenesis and Bioassays , Edited by: Karbe , E. and Park , J. F. 173 – 185 . New York : Springer‐Verlag .
  • Hueper , W. C. 1942 . Occupational Tumors and Allied Diseases , Springfield, Ill. : Thomas .
  • Hueper , W. C. and Conway , W. D. 1964 . Chemical Carcinogenesis and Cancers , Springfield, Ill. : Thomas .
  • Interagency Regulatory Liaison Group. Working Group on Risk Assessment . 1979 . Scientific bases for identification of potential carcinogens and estimation of risks . J. Natl. Cancer Inst. , 63 : 241 – 268 .
  • International Agency for Research on Cancer . 1979 . Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Chemical and Industrial Processes Associated with Cancer in Humans , vols. 1–20 , Lyon : International Agency for Research on Cancer . suppl. 1
  • International Union Against Cancer . 1957 . Report of symposium on potential cancer hazards from chemical additives and contaminants to foodstuffs . Acta Unio Int. Contra Cancrum , 13 : 170 – 193 .
  • Kaufman , D. G. , Baker , M. S. , Harris , C. C. , Smith , J. M. , Boren , H. , Sporn , M. B. and Saffiotti , U. 1972 . Coordinated biochemical and morphologic examination of hamster tracheal epithelium . J. Natl. Cancer Inst. , 49 : 783 – 792 .
  • Lynch , H. T. , Frichot , B. C. III and Lynch , J. F. 1977 . Cancer control in xeroderma pigmentosum . Arch. Dermatol. , 113 : 193 – 195 .
  • McDowell , E. M. , Barrett , L. A. , Glavin , F. , Harris , C. C. and Trump , B. F. 1978a . The respiratory epithelium. I. Human bronchus . J. Natl. Cancer Inst. , 61 : 539 – 549 .
  • McDowell , E. M. , McLaughlin , J. S. , Merenyi , D. K. , Kieffer , R. F. , Harris , C. C. and Trump , B. F. 1978b . The respiratory epithelium. V. Histogenesis of lung carcinomas in the human . J. Natl. Cancer Inst. , 61 : 587 – 606 .
  • Montesano , R. , Saffiotti , U. and Shubik , P. 1970 . “ The role of topical and systemic factors in experimental respiratory carcinogenesis ” . In Inhalation Carcinogenesis , AEC Symposium Series No. 18 (CONF‐691001) Edited by: Hanna , M. G. Jr. , Nettesheim , P. and Gilbert , J. R. 353 – 371 .
  • Mottram , J. C. 1944 . A developing factor in experimental blastogenesis . J. Pathol. Bacteriol. , 56 : 181 – 187 .
  • National Cancer Institute . 1979 . The National Cancer Act and Amendments of 1978 , DHEW Publ. (NIH)79–1936 Washington, D.C. : Government Printing Office .
  • Occupational Cancer Task Force . 1979 . Report to the Director National Cancer Institute , DHEW Publ. (NIH) 79–1953 23 – 36 . Washington, D.C. : Government Printing Office . chap. 3
  • Pott , P. 1775 . Chirurgical Observations Relative to the Cataract the Polypus of the Nose the Cancer of the Scrotum the Different Kinds of Ruptures and the Mortification of the Toes and Feet , 63 – 68 . London : Hawes, Clarke and Collins .
  • Regulatory Council . 1979 . Regulation of chemical carcinogens . Fed. Regist. , 44 (202) : 60038 – 60049 .
  • Rice , J M. 1976 . Carcinogenesis: A late effect of irreversible toxic damage during development . Environ. Health Perspect. , 18 : 133 – 139 .
  • Rice , J. M. Problems and perspectives in perinatal carcinogenesis: A summary of the conference . Natl. Cancer Inst. Monogr. Vol. 51 , pp. 271 – 278 .
  • Rice , J. M. , Joshi , S. R. , Shenefelt , R. E. and Wenk , M. L. 1978 . “ Transplacental carcinogenic activity of 7,12‐dimethylbenz[a]anthracene ” . In Polynuclear Aromatic Hydrocarbons , Edited by: Jones , P. W. and Freudenthal , R. I. 413 – 422 . New York : Raven .
  • Rice , J. M. , Sly , D. L. , Palmer , A. E. and London , W. T. 1979 . Transplacental effects of ethylnitrosourea in a nonhuman primate Erythrocebus patas . Natl. Cancer Inst. Monogr. , 51 : 185 – 192 .
  • Russell , B. 1948 . Human Knowledge. The Scope and Limits , New York : Simon & Schuster .
  • Saffiotti , U. 1970 . “ Experimental respiratory tract carcinogenesis and its relation to inhalation exposures ” . In Inhalation Carcinogenesis , AEC Symposium Series No. 18 Edited by: Hanna , M. G. Jr , Nettesheim , P. and Gilbert , J. R. 27 – 54 . (CONF‐691001)
  • Saffiotti , U. 1977a . Carcinogenesis 1957–77: Notes for a historical review . J. Natl. Cancer Inst. , 59 : 617 – 622 .
  • Saffiotti , U. 1977b . Scientific bases of environmental carcinogenesis and cancer prevention: Developing an interdisciplinary science and facing its ethical implications . J. Toxicol. Environ. Health , 2 : 1435 – 1447 .
  • Saffiotti , U. 1980 . Extrapolation from observed carcinogenic effects to estimates of risk for exposed populations . J. Toxicol. Environ. Health , 6 : 1309
  • Saffiotti , U. and Autrup , H. , eds. 1978 . In Vitro Carcinogenesis. Guide to the Literature Recent Advances and Laboratory Procedures , National Cancer Institute Carcinogenesis Technical Report Series No. 44 DHEW Publ. (NIH)78–844 .
  • Saffiotti , U. and Harris , C. C. 1979 . “ Carcinogenesis studies on organ cultures of animal and human respiratory tissues ” . In Carcinogens: Identification and Mechanisms of Action , Edited by: Griffin , A. C. and Shaw , C. R. 65 – 82 . New York : Raven .
  • Saffiotti , U. and Kaufman , D. G. 1975 . Carcinogenesis of laryngeal carcinoma . Laryngoscope , 85 : 454 – 467 .
  • Saffiotti , U. and Shubik , P. 1956 . The effects of low concentrations of carcinogen in epidermal carcinogenesis: A comparison with promoting agents . J. Natl. Cancer Inst. , 16 : 961 – 969 .
  • Saffiotti , U. and Shubik , P. 1963 . Studies on promoting action in skin carcinogenesis . Natl. Cancer Inst. Monogr. , 10 : 489 – 507 .
  • Saffiotti , U. and Wagoner , J. K. 1976 . Occupational carcinogenesis . Ann. N.Y. Acad. Sci. , 271 : 1 – 516 .
  • Saffiotti , U. , Borg , S. A. , Grote , M. I. and Karp , D. B. 1964 . Retention rates of paniculate carcinogens in the lungs. Studies in an experimental model for lung cancer induction . Chicago Med. Sch. Q. ,
  • Saffiotti , U. , Cefis , F. , Kolb , L. H. and Shubik , P. 1965 . Experimental studies of the conditions of exposure to carcinogens for lung cancer induction . J. Air. Pollut. Control Assoc. , 15 : 23 – 25 .
  • Saffiotti , U. , Montesano , R. , Sellakumar , A. R. and Borg , S. A. 1967 . Studies on experimental lung cancer: Inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumors . Cancer , 20 : 857 – 864 .
  • Saffiotti , U. , Cefis , F. and Kolb , L. H. 1968 . A method for the experimental induction of bronchogenic carcinoma . Cancer Res. , 28 : 104 – 124 .
  • Saffiotti , U. , Montesano , R. , Sellakumar , A. R. , Cefis , F. and Kaufman , D. G. 1972a . Respiratory tract carcinogenesis in hamsters induced by different numbers of administrations of benzo[a] pyrene and ferric oxide . Cancer Res. , 32 : 1073 – 1081 .
  • Saffiotti , U. , Montesano , R. , Sellakumar , A. R. and Kaufman , D. G. 1972b . Respiratory tract carcinogenesis induced in hamsters by different dose levels of benzo[a] pyrene and ferric oxide . J. Natl. Cancer Inst. , 49 : 1199 – 1204 .
  • Sellakumar , A. R. , Montesano , R. , Saffiotti , U. and Kaufman , D. G. 1973 . Hamster respiratory carcinogenesis induced by benzo[a] pyrene and different dose levels of ferric oxide . J. Natl. Cancer Inst. , 50 : 507 – 510 .
  • Sontag , J. M. , Page , N. P. and Saffiotti , U. 1976 . Guidelines for Carcinogen Bioassay in Small Rodents , National Cancer Institute Carcinogenesis Technical Report Series No. 1 DHEW Publ. . (NIH)76–801
  • Sporn , M. B. and Newton , D. L. 1979 . Chemoprevention of cancer with retinoids . Fed. Proc. , 38 : 2528 – 2534 .
  • Sporn , M. B. , Dunlop , N. M. , Newton , D. L. and Smith , J. M. 1976 . Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs . Fed. Proc. , 35 : 1332 – 1338 .
  • Sporn , M. B. , Newton , D. L. , Roberts , A. B. , DeLarco , J. E. and Todaro , G. J. 1980 . “ Retinoids and the suppression of the effects of polypeptide transforming factors. A new molecular approach to chemoprevention of cancer ” . In Molecular Actions and Targets for Cancer Chemotherapuetic Agents , Edited by: Sartorelli , A. C. , Bertino , J. R. and Lazo , J. S. New York : Academic . In press
  • Trump , B. F. , McDowell , E. M. , Glavin , F. , Barrett , L. A. , Becci , P. J. , Schurch , W. , Kaiser , H. E. and Harris , C. D. 1978 . The respiratory epithelium. III. Histogenesis of epidermoid metaplasia and carcinoma in situ in the human . J. Natl. Cancer Inst. , 61 : 563 – 575 .
  • Vesselinovitch , S. D. , Rao , K. V. N. , Mihailovich , N. , Rice , J. M. and Lombard , L. S. 1974 . Development of a broad spectrum of tumors by ethylnitrosourea in mice and the modifying role of age, sex and strain . Cancer Res. , 34 : 2530 – 2538 .
  • Vesselinovitch , S. D. , Koka , M. , Rao , K. V. N. , Mihailovich , N. and Rice , J. M. 1977 . Prental multicarcinogenesis by ethylnitrosourea in mice . Cancer Res. , 37 : 1822 – 1828 .
  • Wechsler , W. , Rice , J. M. and Vesselinovitch , S. 1979 . Transplacental and neonatal induction of neurogenic tumors in mice: Comparison with related species and with human pediatric neoplasms . Natl. Cancer Inst. Monogr. , 51 : 219 – 226 .
  • Working Group on Mutagenicity Testing, Subcommittee on Environmental Mutagenesis, U.S. Department of Health, Education and Welfare Committee to Coordinate Toxicology and Related Programs . 1977 . Approaches to determining the mutagenic properties of chemicals: Risk to future generations . J. Environ. Pathol. Toxicol. , 1 : 301 – 352 .
  • Yuspa , S. H. 1978 . “ Mouse epidermal cell cultures as an in vitro model for the study of chemical carcinogenesis ” . In In Vitro Carcinogenesis. Guide to the Literature Recent Advances and Laboratory Procedures , National Cancer Institute Carcinogenesis Technical Report Series No. 44 Edited by: Saffiotti , U. and Autrup , H. 47 – 56 . DHEW Publ. . (NIH)78–844
  • Yuspa , S. H. and Harris , C. C. 1974 . Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro . Exp. Cell Res. , 86 : 95 – 105 .
  • Yuspa , S. H. and Harris , C. C. 1980 . “ Molecular and cellular basis of chemical carcinogenesis ” . In Cancer Epidemiology and Prevention , Edited by: Schottenfeld , D. and Fraumeni , J. Jr . Philadelphia : Saunders . In press
  • Yuspa , S. H. , Morgan , D. L. , Walker , R. J. and Bates , R. R. 1970 . The growth of fetal mouse skin in cell culture and transplantation to F1 mice . J. Invest. Dermatol. , 55 : 379 – 389 .
  • Yuspa , S. H. , Hennings , H. and Saffiotti , U. 1976 . Cutaneous chemical carcinogenesis: Past, present and future . J. Invest. Dermatol. , 67 : 199 – 208 .
  • Yuspa , S. H. , Lichti , U. , Hennings , H. , Ben , T. , Patterson , E. and Slaga , T. J. 1978 . “ Tumor promoter stimulated proliferation in mouse epidermis in vivo and in vitro: Mediation by polyamines and inhibition by the antipromoter steroid fluocinolone acetonide ” . In Mechanisms of Tumor Promotion and Cocarcinogenesis , Edited by: Slaga , T. J. , Sivak , A. and Boutwell , R. K. 221 – 232 . New York : Raven .

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