Some practical problems arising from use of the gamma multihit model for risk estimation

References

• Armitage , P. and Doll , R. 1961 . “ Stochastic models for carcinogenesis ” . In Proceedings of the Fourth Berkeley Symposium on Mathematical Statistics and Probability, No. 4 , Edited by: Lecam , L.M. and Neyman , J. 19 – 38 . Berkeley, Calif. : Univ. of California Press .
   Google Scholar
• Crump , K.S. 1981 . An improved procedure for low‐dose carcinogenic risk assessment from animal data . J. Environ. Pathol. Toxicol. , in press
   PubMedGoogle Scholar
• Crump , K.S. , Hoel , O.G. , Langley , C.H. and Peto , R. 1976 . Fundamental carcinogenic processes and their implications for low dose risk assessment . Cancer Res. , 36 : 2973 – 2979 .
   PubMed Web of Science ®Google Scholar
• Haseman , J.K. and Kupper , L.L. 1979 . Analysis of dichotomous response data from certain toxi‐cological experiments . Biometrics , 35 : 281 – 293 .
   PubMed Web of Science ®Google Scholar
• Hoel , D.G. 1980 . The incorporation of background in dose response models . Fed. Proc. , 39 : 73 – 75 .
   PubMedGoogle Scholar
• Rai , K. and Van Ryzin , J. 1979 . “ Risk assessment of toxic environmental substances using a generalized multi‐hit dose response model ” . In Energy and Health , Edited by: Breslow , N. and Whitte‐more , A. 99 – 117 . Philadelphia, Pa. : Slam .
   Google Scholar
• Rai , K. and Van Ryzin , J. 1981 . A generalized multi‐hit dose response model for low‐dose extrapolation . Biometrics , in press
   PubMed Web of Science ®Google Scholar
• Scientific Committee of the Food Safety Council . 1978 . Proposed system for food safety assessment . Food Cosmet. Toxicol. Suppl. 2 , 16 : 1 – 136 .
   PubMedGoogle Scholar
• Van Ryzin , J. and Rai , K. 1980 . “ The use of quantal response data to make predictions ” . In The Scientific Basis of Toxicity Assessment , Edited by: Witschi , H. 273 – 290 . Amsterdam : Elsevier‐North Holland Biomedical .
   Google Scholar