25
Views
24
CrossRef citations to date
0
Altmetric
Original Articles

Teratogenic evaluation of epichlorohydrin in the mouse and rat and glycidol in the mouse

, &
Pages 87-96 | Received 23 Mar 1981, Accepted 15 Jun 1981, Published online: 20 Oct 2009

References

  • Cooper , E. R. A. , Jones , A. R. and Jackson , H. 1974 . Effects of a‐chlorohydrin and related compounds on the reproductive organs and fertility of the male rat . J. Reprod. Fertil. , 38 : 379 – 386 .
  • Elmore , J. D. , Wong , J. L. , Laumbach , A. D. and Streips , U. N. 1976 . Vinyl chloride mutagenicity via the metabolites chlorooxirane and chloroacetaldehyde monomer hydrate . Biochim. Biophys. Acta , 442 : 405 – 419 .
  • Epstein , S. S. , Arnold , E. , Andrea , J. , Bass , W. and Bishop , Y. 1972 . Detection of chemical mutagens by the dominant lethal assay in the mouse . Toxicol. Appl. Pharmacol. , 23 : 288 – 325 .
  • Ericson , R. J. and Youngdale , G. A. 1970 . Antifertility intermediate . Nature (Lond.) , 226 : 386
  • Hahn , J. D. 1970 . Post‐testicular antifertility effects of epichlorohydrin and 2,3‐epoxypropanol . Nature (Lond.) , 226 : 87
  • HEW . 1976 . Criteria for a Recommended Standard … Occupational Exposure to Epichlorohydrin, HEW Publ. (NIOSH) 76–206 , Washington, D.C. : Government Printing Office .
  • Hine , C. H. and Rowe , V. K. 1962 . “ Epoxy compounds ” . In Industrial Hygiene and Toxicology , 2d ed. , Edited by: Patty , F. A. vol. 2 , 1593 – 1635 . New York : Interscience .
  • Hine , C. H. , Kodama , J. K. , Wellington , J. S. , Dunlap , M. K. and Anderson , H. H. 1956 . The toxicology of glycidol and some glycidyl ethers . Arch. Ind. Health , 14 : 250 – 264 .
  • Jackson , H. , Campbell , I. S. C. and Jones , A. R. 1970 . 1s glycidol an active intermediate in the antifertility action of α‐chlorohydrin in male rats? . Nature (Lond.) , 226 : 86 – 87 .
  • Jonckheere , A. R. 1954 . A distribution‐free k‐sample test against ordered alternatives . Biometrika , 41 : 133 – 145 .
  • Jones , A. R. , Davies , P. , Edwards , K. and Jackson , H. 1969 . Antifertility effects and metabolism of α and epi‐chlorohydrins in the rat . Nature (Lond.) , 224 : 83
  • Jones , P. and Jackson , H. 1974 . Actions of antifertility chemicals on Xenopus laevis spermatozoa in vitro . J. Reprod. Fertil. , 38 : 347 – 357 .
  • Kolmark , G. and Giles , N. H. 1955 . Comparative studies on monoepoxides as inducers of reverse mutations in . Neurospora. Genetics , 40 : 890 – 902 .
  • Kucerova , M. , Polivkova , Z. , Sram , R. and Matousek , V. 1976 . Mutagenic effect of epichlorohydrin. I. Testing on human lymphocytes in vitro in comparison with TEPA . Mutat. Res. , 34 : 271 – 278 .
  • Kucerova , M. , Zhurkov , V. S. , Polivkova , Z. and Ivanova , J. E. 1977 . Mutagenic effect of epichlorohydrin. II. Analysis of chromosomal aberrations in lymphocytes of persons occupationally exposed to epichlorohydrin . Mutat. Res. , 48 : 355 – 360 .
  • McCann , J. and Ames , B. N. 1976 . Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals: Discussion . Proc. Natl. Acad. Sci. U.S.A. , 73 : 950 – 954 .
  • McCann , J. , Choi , E. , Yamasaki , E. and Ames , B. N. 1975 . Detection of carcinogens as mutagens in the Salmonellal/microsome test: Assay of 300 chemicals . Proc. Natl. Acad. Sci. U.S.A. , 72 : 5135 – 5139 .
  • NIOSH/OSHA . 1975 . Draft Technical Standards for 2‐Butoxy Ethanol N‐Butyl Glycidyl Ether, Cyclohexane, Dipropylene Glycol Methyl Ether, Ethyl Ether, Glycidol , PB Rept. ISS PB‐267220, Set F, pt. 1 64 – 75 . Springfield, Va. : National Technical Information Service .
  • Siegel , S. 1956 . Nonparametric Statistics for the Behavioral Sciences , 75 – 83 . 116 – 127 . New York : McGraw‐Hill .
  • Staples , R. E. 1974 . Detection of visceral alterations in mammalian fetuses . Teratology , 9 : A37 – A38 . (abstract)
  • Staples , R. E. and Schnell , V. L. 1964 . Refinements in rapid clearing technic in the KOH‐Alizarin Red S method for fetal bone . Stain Technol. , 39 : 62 – 63 .
  • Strauss , B. and Okubo , S. 1960 . Protein synthesis and the induction of mutations in Escherichia coli by alkylating agents . J. Bacteriol. , 79 : 464 – 473 .
  • Van Duuren , B. L. 1969 . Carcinogenic epoxides, lactones, and halo‐ethers and their mode of action . Ann. N.Y. Acad. Sci. , 163 : 633 – 651 .
  • Voogd , C. E. 1973 . Mutagenic action of epoxy compounds and several alcohols . Mutat. Res. , 21 : 52 – 53 . (abstract)
  • Wade , M. , Moyer , J. and Hine , C. 1976 . The mutagenicity of epoxides . Fed. Proc. , 25 : 504 (abstract)
  • Wilson , J. G. 1965 . “ Methods for administering agents and detecting malformations in experimental animals ” . In Teratology, Principles and Techniques , Edited by: Wilson , J. G. and Warkany , J. 262 – 277 . Chicago, Ill : Univ. of Chicago Press .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.