19
Views
23
CrossRef citations to date
0
Altmetric
Original Articles

Acute and genetic toxicity of 1‐nitropyrene and its fate after single oral doses to rats

, , , &
Pages 373-384 | Received 31 Oct 1981, Accepted 26 Feb 1982, Published online: 19 Oct 2009

References

  • Allen , J. W. and Lott , S. A. 1976 . In vivo BrdU‐33258 Hoechst analysis of DNA replication kinetics and sister chromatid formation in mouse somatic and meiotic cells . Chromosoma , 58 : 325 – 340 .
  • Allen , J. W. , Shuler , C. F. , Mendes , R. W. and Lott , S. A. 1977 . A simplified technique for in vivo analysis of sister‐chromatid exchanges using 5‐bromodeoxyuridine tablets . Cytogenet. Cell Genet. , 18 : 231 – 237 .
  • Batzinger , R. P. , Bueding , E. , Reddy , B. S. and Weisburger , J. H. 1978 . Formation of a mutagenic drug metabolite by intestinal microorganisms . Cancer Res. , 38 : 608 – 612 .
  • Bavin , P. M. G. and Dewar , M. J. S. 1956 . Electrophilic substitution. I. Preliminary investigations . J. Chew. Soc. , 1956 : 164 – 169 .
  • Carrano , A. V. Sister chromatid exchange: Relevance to gene mutation, DNA repair and human population studies . Proc. 4th Radiat. Biol. Cent. Int. Symp. Sept. 28–29 , Kyoto, Japan.
  • Clark , C. R. and Vigil , C. L. 1980 . Influence of rat lung and liver homogenates on the mutagenicity of diesel exhaust paniculate extracts . Toxicol. Appl. Pharmacol. , 56 : 110 – 115 .
  • Cuddihy , R. G. , Seiler , F. A. , Griffith , W. C. , Scott , B. R. and McClellan , R. O. 1980 . Potential Health and Environmental Effects of Diesel Light Duty Vehicles , Rep. LMF‐82 UC‐48 Albuquerque, N.M. : Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute .
  • Deichmann , W. B. and LeBlanc , T. J. 1943 . Determination of the approximate lethal dose with about six animals . J. Ind. Hyg. Toxicol. , 25 : 415 – 417 .
  • Dewar , M. J. S. and Mole , T. 1956 . Palladized charcoal as a catalyst for the reduction of aromatic nitro‐compounds by hydrazine hydrate . J. Chem. Soc. , 1956 : 2556 – 2557 .
  • Glazko , A. J. , Wolf , L. M. , Dill , W. A. and Bratton , A. C. 1949 . Biochemical studies on chloramphenicol (Chloromycetin). II. Tissue distribution and excretion studies . J. Pharmacol. Exp. Ther. , 96 : 445 – 459 .
  • Gruswold , D. P. Jr. , Casey , A. E. , Weisburger , E. K. and Weisburger , J. H. 1968 . The carcinogenicity of multiple intragastric doses of aromatic and heterocyclic nitro or amine derivatives in young female Sprague‐Dawley rats . Cancer Res. , 28 : 924
  • Henderson , T. R. , Royer , R. E. and Clark , C. R. MS/MS characterization of diesei emissions . Proc. 29th Annu. Conf. Am. Soc. Mass Spectrom. in press
  • Hsie , A. W. , Couch , D. B. , O'Neill , J. P. , San Sebastian , J. R. , Brimmer , P. A. , Machanoff , R. , Riddle , J. C , Li , A. P. , Fuscoe , J. C. , Forbes , N. and Hsie , M. H. 1979 . “ Utilization of a quantitative mammalian cell mutation system, CHO/HGPRT, in experimental mutagenesis and genetic toxicology ” . In Strategies for Short‐Term Testing for Mutagens/Carcinogens , Edited by: Butterworth , B. E. 39 – 54 . West Palm Beach, Fla. : CRC Press .
  • Huisingh , J. , Bradow , R. , Jungers , R. , Claston , L. , Zweidinger , R. , Tejeda , G. , Bumgarner , J. , Duffield , F. , Waters , M. , Simon , V. F. , Hare , C , Rodriguez , C. and Snow , L. 1978 . “ Application of a bioassay to characterization of diesel particle emissions ” . In Applications of Short‐Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures , Edited by: Waters , M. D. , Nesnow , S. , Huisingh , J. L. , Sandu , S. S. and Claston , L. 1 – 32 . Research Triangle Park, N.C. : Health Effects Research Laboratory . EPA 600/9–78–027
  • Kaplan , S. 1981 . Carbon‐13 chemical shift assignments of the nitration products of pyrene . Org. Magn. Reson. , 15 : 197 – 199 .
  • King , C. M. , Wang , C. Y. and Warmer , P. O. 1980 . Evidence for the presence of nitro aromatics in airborne particulates . Proc. Am. Assoc. Cancer Res. , 21 : 83
  • Klassen , C. D. 1975 . Biliary excretion of xenobiotics . Crit. Rev. Toxicol. , 4 : 1 – 29 .
  • Kubitscheck , H. E. and Williams , D. M. 1980 . Mutagenicity of fly ash from a fluidized‐bed combustor during start‐up and steady state operating conditions . Mutat. Res. , 77 : 287 – 291 .
  • Li , A. P. 1981 . Simplification of the CHO/HGPRT mutation assay through the growth of Chinese hamster ovary cells as unattached cuftures . Mutat. Res. , 85 : 165 – 175 .
  • Li , A. P. , Brooks , A. L. and Royer , R. E. 1980 . Cytotoxicity and mutagenicity of diesel exhaust soot extracts . Environ. Mutag. , 2 : 273
  • Marshall , T. C. and Dorough , H. W. 1979 . Biliary excretion of carbamate insecticides in the rat . Pestic. Biochem. Physiol. , 11 : 56 – 63 .
  • Mermelstein , R. , Kiriazides , D. K. , Butler , M. , McCoy , E. A. and Rosenkranz , H. S. 1981 . The extraordinary mutagenicity of nitropyrene in bacteria . Mutat. Res. , 89 : 187 – 196 .
  • Miller , J. A. 1970 . Carcinogenesis by chemicals: An overview . Cancer Res. , 30 : 559 – 576 .
  • Mulder , G. J. and Hagedoorn , A. H. 1974 . UDP glucuronyltransferase and phenol sulfotransferase in vivo and in vitro: Conjugation of harmol and harmold . Biochem. Pharmacol. , 23 : 2101 – 2109 .
  • O'Neill , J. P. , Brimer , P. A. , Machanoff , R. , Hirsh , G. P. and Hsie , A. W. 1977 . A quantitative assay of mutation induction at the hypoxanthineguanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): Development and definition of the system . Mutat. Res. , 45 : 91 – 101 .
  • Pederson , T. C. and Siak , J. Characterization of direct acting mutagens in diesel exhaust particles by thin layer chromatography . Presented at the 5th International Symposium on Polynuclear Aromatic Hydrocarbons . Oct. 28–30 1980 , Columbus, Ohio.
  • Pitts , J. N. Jr. , van Canwenberghe , K. A. , Grosjean , D. , Schmid , J. P. , Fitz , D. R. , Belser , W. L. Jr. , Knudson , G. B. and Hynds , P. M. 1978 . Atmospheric reactions of polycyclic aromatic hydrocarbons: Facile formation of mutagenic nitro derivatives . Science , 202 : 515 – 519 .
  • Poirier , L. A. and Weisburger , J. H. 1974 . Enzymatic reduction of carcinogenic aromatic nitro compounds by rat and mouse liver fractions . Biochem. Pharmacol. , 23 : 661 – 669 .
  • Rickert , D. E. , Long , R. M. , Krakowka , S. and Dent , J. G. 1981 . Metabolism and excretion of 2,4‐[14C]dinitrotoluene in conventional and oxenic Fischer 344 rats . Toxicol. Appl. Pharmacol. , 59 : 574 – 579 .
  • Rosenkranz , H. S. , McCoy , E. C. , Sanders , D. R. , Butler , M. , Kiriazides , D. K. , Mermelstein , R. and Wilson , J. C. 1980 . Nitroyprenes: Isolation, identification and reduction of mutagenic impurities in carbon black and toners . Science , 209 : 1039 – 1043 .
  • Rosenkranz , H. S. , McCoy , E. C. , Mermelstein , R. and Speck , W. T. 1981 . A cautionary note on the use of nitroreductase‐deficient strains of Salmonella typhimurium for the detection of nitroarenes as mutagens in complex mixtures including diesel exhausts . Mutat. Res. , 91 : 103 – 105 .
  • Scheline , R. R. 1973 . Metabolism of foreign compounds by gastrointestinal microorganisms . Pharmacol. Rev. , 25 : 451 – 523 .
  • Schuetzl , D. , Prater , T. , Riley , T. , Durisin , A. and Salmeen , K. Analysis of nitrated derivatives of PAH and determinations of their contribution to Ames assay mutagenicity for diesel particulate extracts . Presented at the 5th International Symposium on Polynuclear Aromatic Hydrocarbons . Oct. 28–30 1980 , Columbus, Ohio.
  • Stedka , D. G. and Wolff , S. 1976 . Sister chromatid exchange as an assay for genetic damage induced by mutagen‐carcinogens. I. In vivo test for compounds requiring metabolic activation . Mutat. Res. , 41 : 333 – 342 .
  • Wheeler , L. , Soderberg , F. and Goldman , P. 1975 . The relationship between nitro group reduction and the intestinal microflora . J. Pharmacol. Exp. Ther. , 194 : 135 – 144 .
  • Wolff , S. 1977 . Sister chromatid exchange . Am. Rev. Genet. , 11 : 183 – 201 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.