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Original Articles

Failure of methapyrilene to induce tumors in hamsters or guinea pigs

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Pages 653-657 | Received 22 Mar 1983, Accepted 15 Jul 1983, Published online: 19 Oct 2009

References

  • Cardy , R. H. and Lijinsky , W. 1980 . Comparison of the carcinogenic effects of five nitrosamines in guinea pigs . Cancer Res. , 40 : 1879 – 1884 .
  • Lijinsky , W. 1984 . Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats . Food Chem. Toxicol. , in press
  • Lijinsky , W. , Reuber , M. D. and Blackwell , B. N. 1980 . Liver tumors induced in rats by chronic oral administration of the common antihistaminic methapyrilene hydrochloride . Science , 209 : 817 – 819 .
  • Reznik‐Schüller , H. M. and Lijinsky , W. 1982 . Ultrastructural changes in the liver of animals treated with methapyrilene and some analogs . Ecotoxicol. Environ. Safety , 6 : 328 – 335 .

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