1
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Adrenal mediation of ethanol's inhibition of benzo[a]pyrene metabolism

, &
Pages 799-810 | Received 20 Oct 1983, Accepted 07 Dec 1983, Published online: 20 Oct 2009

References

  • Bogdanffy , M. S. , Krull , I. S. and Brown , D. R. 1982 . Alteration of benzo(a)pyrene metabolism by acute ethanol or corticosterone . Res. Commun. Chem. Pathol. Pharmacol. , 37 (3) : 375 – 384 .
  • Bonnichsen , R. K. and Theorell , H. 1951 . An enzymatic method for the microdetermination of ethanol . Scand. J. Clin. Lab. Invest. , 3 : 58 – 62 .
  • Brown , D. R. , Chung , H. and Bogdanffy , M. S. 1983 . “ Acute ethanol and stress alteration of chemical toxicity ” . In Safety Evaluation and Regulation of Chemicals , Edited by: Homburger , F. 183 – 190 . Basel : Karger .
  • Brown , D. , Ning , J. , Bogdanffy , M. , Krull , I. , Kuttab , S. and Shargel , L. 1982 . Alcohol‐stress inhibition of mixed function oxidase metabolism in the rat . Toxicologist , 2 (1) : 442
  • Capel , I. D. , Jenner , M. , Pinnock , M. H. and Williams , D. C. 1978 . The effect of chronic alcohol intake upon the hepatic microsomal carcinogen‐activating system . Oncology , 35 : 168 – 170 .
  • Chung , H. and Brown , D. R. 1976a . Alcohol‐hexobarbital interaction in rats under acute stress . Life Sci. , 18 : 123 – 128 .
  • Chung , H. and Brown , D. R. 1976b . Mechanism of the effect of acute ethanol on hexobarbital metabolism . Biochem. Pharmacol. , 25 : 1613 – 1616 .
  • Conney , A. H. 1982 . Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture . Cancer Res. , 42 : 4875 – 4917 .
  • Gelboin , H. V. 1980 . Benzo(a)pyrene metabolism, activation, and carcinogenesis: Role and regulation of mixed‐function oxidases and related enzymes . Physiol. Rev. , 60 : 1107 – 1166 .
  • Gelboin , H. V. , West , D. , Gozukara , E. , Natori , S. , Nagao , M. and Sugimura , T. 1981 . Maackiain acetate specifically inhibits different forms of aryl hydrocarbon hydroxylase in rat and man . Nature (Lond.) , 291 (5817) : 659 – 661 .
  • Goujon , F. M. , Nebert , D. W. and Geilen , H. E. 1972 . Genetic expression of aryl hydrocarbon hydroxylase inducation. IV. Interation of various compounds with different forms of cytochrome P‐450 and the effect on benzo(a)pyrene metabolism in vitro . Mol. Pharmacol. , 8 : 667 – 680 .
  • Guaza , C. , Torrellas , A. and Borrell , S. 1983 . Adrenocortical response to acute and chronic ethanol administration in rats . Psychopharmacology , 79 : 173 – 176 .
  • Kinoshita , N. , Shears , B. and Gelboin , H. V. 1973 . K‐Region and non‐K‐region metabolism of ben‐zo(a)pyrene by rat liver microsomes . Cancer Res. , 33 : 1937 – 1944 .
  • Kremers , P. , Pasleau , F. and Gielen , J. E. 1978 . Is steroid‐16a‐hydroxylase supported by more than one monooxygenase? . Biochem. Biophys. Res. Commun. , 84 (3) : 706 – 712 .
  • Levin , W. , Wood , A. W. , Wislocki , P. G. , Chang , R. L. , Kapitulnik , J. , Mah , H. D. , Yagi , H. , Jerina , D. M. and Conney , A. H. 1978 . “ Mutagenicity and carcinogenicity of benzo(a)pyrene and benzo‐(a)pyrene derivatives ” . In Polycyclic Aromatic Hydrocarbons and Cancer , 189 – 202 . New York : Academic .
  • Lieber , C. S. , Seitz , H. K. , Garro , A. J. and Worner , T. 1979 . Alcohol‐related diseases and carcinogenesis . Cancer Res. , 39 : 2863 – 3886 .
  • Liu , S. ‐J. , Ramsey , R. K. and Fallon , H. J. 1975 . Effects of ethanol on hepatic microsomal drug‐metabolizing enzymes in the rat . Biochem. Pharmacol. , 24 : 369 – 378 .
  • Lowry , O. H. , Rosenbough , N. J. , Farr , A. L. and Randall , R. J. 1951 . Protein measurement with the Folin phenol reagent . J. Biol. Chem. , 193 : 265 – 275 .
  • Morgenstern , R. , DePierre , J. W. , Lind , C. , Guthenberg , C. , Mannervik , B. and Ernster , L. 1981 . Benzo(a)pyrene quinones can be generated by lipid peroxidation and are conjugated with glu‐tathione by glutathione S‐transferase B from rat liver . Biochem. Biophys. Res. Commun. , 99 (2) : 682 – 690 .
  • Nebert , D. W. and Gelboin , H. V. 1969 . The in vivo in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states . Arch. Biochem. Biophys. , 134 : 76 – 89 .
  • Nesnow , S. , Huisingh , J. , Bergman , H. , Easterling , R. , Inmon , H. , King , L. , Morris , M. , Williams , K. , Hyatt , B. , Montgomery , L. and Cudak , C. 1980 . Carcinogen metabolism in rat liver cell culture . Ann. N. Y. Acad. Sci. , 239 : 247 – 263 .
  • Omura , T. and Sato , R. 1964 . The carbon monoxide‐binding pigment of liver microsomes I. Evidence for its hemoprotein nature . J. Biol. Chem. , 239 (7) : 2370 – 2378 .
  • Pasleau , F. , Kremers , P. and Gielen , J. E. 1981 . Competition between various steroids for cytochrome P‐450 dependant rat liver monooxygenases . Chem.‐Biol. Interact. , 34 : 279 – 286 .
  • Pelkonen , O. 1977 . Differential inhibition of aryl hydrocarbon hydroxylase in human foetal liver, adrenal gland, and placenta . Acta Pharmacol. Toxicol. , 41 : 306 – 316 .
  • Pelkonen , O. and Nebert , D. W. 1982 . Metabolism of polycyclic aromatic hydrocarbons: Etiologic role in carcinogenisis . Pharmacol. Rev. , 34 (2) : 189 – 222 .
  • Pennington , S. N. , Smith , C. G. and Tappsott , B. 1978 . Effect of an acute dose of ethanol on rat liver microsomal mixed function oxidase components and membrane lipid composition . Alcoholism: Exp. Res. , 2 : 311 – 316 .
  • Pickett , C. B. , Jeter , T. L. , Morin , J. and Lu , A. Y. H. 1981 . Electroimmunochemical quantitation of cytochrome P‐450, cytochrome P‐448, and epoxide hydrolase in rat liver microsomes . J. Biol. Chem. , 256 (16) : 8815 – 8820 .
  • Poland , R. E. , Weichsel , M. E. and Rubin , R. T. 1981 . Neonatal dexamethasone administration. I. Temporary delay of development of the circadian serum corticosterone rhythm in rats . Endocrinology , 108 (3) : 1049 – 1054 .
  • Reinke , L. , McManus , P. , Kauffman , F. C. and Thurman , R. G. 1982 . Benzo(a)pyrene phenol production by perfused rat liver and its inhibition by ethanol . Cancer R es. , 42 : 1681 – 1685 .
  • Riihimaki , V. , Savolainen , K. , Pfaffli , P. , Pekari , K. , Sippel , H. W. and Laine , A. 1982 . Metabolic interaction between m‐xylene and ethanol . Arch. Toxicol. , 49 : 253 – 263 .
  • Rubin , E. , Bacchin , P. , Gang , H. and Leiber , C. S. 1970a . Induction and inhibition of hepatic microsomal and mitochondrial enzymes by ethanol . Lab. Invest. , 22 : 569 – 580 .
  • Rubin , E. , Gang , H. , Misra , P. S. and Lieber , C. S. 1970b . Inhibition of drug metabolism by ethanol intoxication . Am. J. Med. , 49 : 801 – 806 .
  • Ryan , D. D. , Thomas , P. E. , Korzeniowski , D. and Levin , W. 1979 . Preparation and characterization of highly purified forms of liver microsomal cytochrome P‐450 from rats treated with poly‐chlorinated biphenyls, phdenobarbital and 3‐methylcholanthrene . J. Biol. Chem. , 254 (4) : 1365 – 1374 .
  • Valenzuela , A. , Fernandez , N. , Fernandez , V. , Ugarta , G. , Videla , L. A. , Guerra , R. and Villaneueva , A. 1980 . Effect of acute ethanol ingestion on lipid peroxidation and on the activity of the enzymes related to peroxide metabolism in rat liver . FEBS Lett. , 111 (1) : 11 – 13 .
  • Vigny , P. , Ginot , Y. M. , Kindts , M. , Cooper , C. S. , Grover , P. L. and Sims , P. 1980 . Fluorescence spectral evidence that benzo(a)pyrene is activated by metabolism in mouse skin to a diol‐epoxide and a phenol‐epoxide . Carcinogenesis , 1 : 945 – 950 .
  • Wislocki , P. G. , Miwa , G. T. and Lu , A. Y. H. 1980 . “ Reactions catalyzed by the cytochrome P‐450 system ” . In Enzymatic Basis of Detoxication , Edited by: Jakoby , W. B. vol. 1 , 135 – 182 . New York : Academic .
  • Wong , L. T. , Whitehouse , L. W. , Solomonraj , G. and Paul , S. J. 1980 . Effect of a concomitant single dose of ethanol on the hepatotoxicity and metabolism of acetaminophen in mice . Toxicology , 17 : 297 – 309 .
  • Wydner , E. L. , Mushinski , M. H. and Spivak , J. C. 1977 . Tobacco and alcohol consumption in relation to the development of multiple primary cancers . Cancer , 40 (4) : 1872 – 1878 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.