Use of quinones in brain‐tumor therapy: Preliminary results of preclinical laboratory investigations

References

• AliOsman , F. , Giblin , J. and Rosenblum , M. L. Development of clonal and macromolecular synthesis assays for bone marrow CFU‐GM to measure myelotoxicity of selected chemotherapeutic agents . Proc. V Conf. Brain Tumor Res. 1983 , Asilomar, Calif.. Abstract 2
   Google Scholar
• Cosby , L. A. , Pardini , R. S. , Biagini , R. E. , Lambert , T. L. , Lin , A. J. , Huang , Y.‐M. , Hwang , K. M. and Sartorelli , A. C. 1976 . Mode of action of the bioreductive alkylating agent 2,3‐bis (chloromethyl)‐1,4‐naphthoquinone . Cancer Res. , 36 : 4023 – 4031 .
   PubMedGoogle Scholar
• Engel , L. W. , Young , N. A. , Tralka , T. S. , Lippman , M. E. , O'Brien , S. J. and Joyce , M. J. 1978 . Establishment and characterization of a new continuous cell line derived from human breast carcinomas . Cancer Res. , 38 : 3352 – 3364 .
   PubMed Web of Science ®Google Scholar
• Ernster , L. 1967 . DT‐Diaphorase . Methods Enzymol. , 10 : 309 – 317 .
   Google Scholar
• Favaudon , V. 1982 . On the mechanism of reductive activation in the mode of action of some anticancer drugs . Biochimie , 64 : 457 – 475 .
   PubMed Web of Science ®Google Scholar
• Hollander , P. M. and Ernster , L. 1975 . Studies on the reaction mechanism of DT diaphorase action of dead‐end inhibitors and effects of phospholipids . Arch. Biochem. Biophys. , 169 : 560 – 567 .
   Google Scholar
• Leighton , J. 1951 . A sponge matrix method for tissue culture. Formation of organized aggregates of cells in vitro. . J. Natl. Cancer Inst. , 12 : 545 – 560 .
   PubMed Web of Science ®Google Scholar
• Lin , A. J. and Sartorelli , A. 1976 . Potential bioreductive alkylating agents. VI. Determination of the relationship between oxidation‐reduction potential and antineoplastic activity . Biochem. Pharmacol. , 25 : 206 – 207 .
   PubMed Web of Science ®Google Scholar
• Lin , T.‐S. , Antonini , I. , Cosby , L. A. and Sartorelli , A. C. 1984 . 2,3‐Dimethyl‐1,4‐naphthoquinone derivatives as bioreductive alkylating agents with cross‐linking potential . J. Med. Chem. , 27 : 813 – 815 .
   PubMedGoogle Scholar
• Lind , C. , Hochstein , P. and Ernster , L. 1982 . DT‐diaphorase as a quinone reductase: A cellular control device against semiquinone and superoxide radical formation . Arch. Biochem. Biophys. , 216 : 178 – 185 .
   PubMed Web of Science ®Google Scholar
• Miller , G. L. 1959 . Protein determination for large numbers of samples. . Anal. Chem. , 31 : 964
   Web of Science ®Google Scholar
• Moore , H. W. 1977 . Bioactivation as a model for drug design. Bioreductive alkylation . Science , 197 : 527 – 532 .
   PubMed Web of Science ®Google Scholar
• Rosenblum , M. L. , Vasquez , D. A. , Hoshino , T. and Wilson , C. B. 1978 . Development of a clon‐ogenic cell assay for human brain tumors . Cancer , 41 : 2305 – 2314 .
   PubMed Web of Science ®Google Scholar
• Smith , M. T. 1985 . Quinones as mutagens, carcinogens and anticancer agents: Introduction and overview . J. Toxicol. Environ. Health, , 16 : 665 – 672 .
   PubMed Web of Science ®Google Scholar
• Stenflo , J. , Fernlund , P. , Egan , W. and Roepstorff , P. 1974 . Vitamin K dependent modification of glutamic acid residues in prothrombin . Proc. Natl. Acad. Sci. U.S.A. , 71 : 2730 – 2733 .
   PubMed Web of Science ®Google Scholar
• Talcott , R. E. , Rosenblum , M. and Levin , V. A. 1983 . Possible role of DT‐diaphorase in the bioactivation of antitumor quinones . Biochem. Biophys. Res. Commun. , 111 : 346 – 351 .
   Google Scholar
• Thor , H. , Smith , M. T. , Hartzell , P. , Bellomo , G. , Jewell , S. A. and Orrenius , S. 1982 . The metabolism of menadione (2‐methyl‐1,4‐naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells . J. Biol. Chem. , 257 : 12419 – 12425 .
   PubMed Web of Science ®Google Scholar