8
Views
10
CrossRef citations to date
0
Altmetric
Original Articles

Effects of age and obesity on the metabolism of lindane by black a/a, yellow Avy/a, and pseudoagouti Avy/a phenotypes of (ys × vy) f1 hybrid mice

, , , , &
Pages 771-796 | Received 18 May 1985, Accepted 01 Jul 1985, Published online: 20 Oct 2009

References

  • Anderson , V. L. and McLean , R. A. 1974 . Design of Experiments: A Realistic Approach , 16 – 22 . New York : Dekker .
  • Bligh , E. G. and Dyer , W. J. 1959 . A rapid method of total lipid extraction and purification . Can. J. Biochem. Physiol. , 37 : 911 – 917 .
  • Brodie , B. B. , Reid , W. D. , Cho , A. K. , Sipes , G. , Krishna , G. and Gillette , J. R. 1971 . Possible mechanisms of liver necrosis caused by aromatic organic compounds . Proc. Natl. Acad. Sci. U.S.A. , 68 : 160 – 164 .
  • Cameron , G. R. , Thomas , J. C. , Ashmore , J. A. , Buchanan , J. L. , Warren , E. H. and McKenny‐Hughes , A. W. 1937 . The toxicity of certain chlorine derivatives of benzene with special reference to o‐dichlorobenzene . J. Path. Bacteriol. , 44 : 281 – 296 .
  • Chadwick , R. W. and Freal , J. J. 1972 . Comparative acceleration of lindane metabolism to chloro‐phenols by pretreatment of rats with lindane or with DDT and lindane . Food Cosmet. Toxicol. , 10 : 789 – 795 .
  • Chadwick , R. W. , Cranmer , M. F. and Peoples , A. J. 1971 . Comparative stimulation of γ‐HCH metabolism by pretreatment of rats with γ‐HCH, DDT, and DDT + γ‐HCH . Toxicol. Appl. Pharmacol. , 18 : 685 – 695 .
  • Chadwick , R. W. , Linko , R. S. , Freal , J. J. and Robbins , A. L. 1975a . The effect of age and long‐term low‐level DDT exposure on the response to enzyme induction in the rat . Toxicol. Appl. Pharmacol. , 31 : 469 – 480 .
  • Chadwick , R. W. , Chuang , L. T. and Williams , K. 1975b . Dehydrogenation: A previously unre‐ported pathway of lindane metabolism in mammals . Pestic. Biochem. Physiol. , 5 : 575 – 586 .
  • Chadwick , R. W. , Simmons , W. S. , Bryden , C. C. , Chuang , L. T. , Key , L. M. and Chadwick , C. J. 1977 . Effect of dietary lipid and dimethyl sulfoxide on lindane metabolism . Toxicol. Appl. Pharmacol. , 39 : 391 – 410 .
  • Chadwick , R. W. , Copeland , M. F. and Chadwick , C. J. 1978a . Enhanced pesticide metabolism, a previously unreported effect of dietary fibre in mammals . Food Cosmet. Toxicol. , 16 : 217 – 225 .
  • Chadwick , R. W. , Freal , J. J. , Sovocool , G. W. , Bryden , C. C. and Copeland , M. F. 1978b . The identification of three previously unreported lindane metabolites from mammals . Chemosphere , 8 : 633 – 640 .
  • Chadwick , R. W. , Copeland , M. F. , Mole , M. L. , Nesnow , S. and Cooke , N. 1981 . Comparative effect of pretreatment with phenobarbital, Aroclor 1254, and β‐naphthoflavone on the metabolism of lindane . Pestic. Biochem. Physiol. , 15 : 120 – 136 .
  • Chen , J. C. , Ove , P. and Lansing , A. 1973 . In vitro synthesis of microsomal protein and albumin in young and old rats . Biochim. Biophys. Acta , 312 : 598 – 607 .
  • Dallner , G. and Ernster , L. 1968 . Subfractionation and composition of microsomal membranes: A review . J. Histochem. Cytochem. , 16 : 611 – 632 .
  • Den Tonkelaar , E. M. and Van Esch , G. J. 1974 . No effect levels of organochlorine pesticides based on induction of microsomal liver enzymes in short‐term toxicity experiments . Toxicology , 2 : 371 – 380 .
  • Didenko , G. G. , Chernov , O. V. and Gupalovich , T. D. 1973 . Investigation of the possible carcinogenic action of the gamma isomer of hexachlorocyclohexane . Gig. Sanit. , 38 : 98 – 99 .
  • Duncan , D. B. 1955 . Multiple range and multiple F tests . Biometrics , 11 : 1 – 42 .
  • Fewster , M. E. , Burns , B. J. and Mead , J. F. 1969 . Quantitative densitometric thin‐layer chromatography of lipids using copper acetate reagent . J. Chromatogr. , 43 : 120 – 126 .
  • Fitzhugh , O. C. , Nelson , A. A. and Frawley , J. P. 1950 . The chronic toxicities of technical benzene hexachloride and its alpha, beta, and gamma isomers . J. Pharmacol. Exp. Ther. , 100 : 59 – 66 .
  • Frith , C. H. , Highman , B. , Burger , G. and Sheldon , W. D. 1983 . Spontaneous lesions in BALB/c and C57BL/6 mice . Lab. Anim. Sci. , 33 : 273 – 286 .
  • Goto , M. , Hattori , M. and Miyagawa , T. 1972 . Ecological chemistry. Toxicity of alpha‐benzene hexachloride in mice . Chemosphere , 1 : 153 – 154 .
  • Hanada , M. , Yutani , C. and Miyaji , T. 1973 . Induction of hepatoma in mice by benzene hexachloride . Gann , 64 : 511 – 513 .
  • Hanson , S. W. F. and Olley , J. 1963 . Application of the Bligh and Dyer method of lipid extraction to tissue homogenates . Biochem. J. , 89 : 101p – 102p .
  • Herbst , M. , Weisse , I. and Koellmer , H. 1975 . A contribution to the question of the possible hepatocarcinogenic effects of lindane . Toxicology , 4 : 91 – 96 .
  • Heston , W. E. and Vlahakis , G. 1961 . Influence of the Ay gene on mammary gland tumors, hepatomas and normal growth in mice . J. Natl. Cancer Inst. , 26 : 969 – 983 .
  • Heston , W. E. and Vlahakis , G. 1966 . Factors in the causation of spontaneous hepatomas in mice . J. Natl. Cancer Inst. , 37 : 839 – 843 .
  • Heston , W. E. and Vlahakis , G. 1968 . C3H‐Avy—A high hepatoma and high mammary tumor strain of mice . J. Natl. Cancer Inst. , 40 : 1161 – 1166 .
  • Ito , N. , Nagasaki , H. , Masayuki , A. , Sugihara , S. and Makiura , S. 1973 . Histologic and ultrastructural studies on the hepatocarcinogenicity of benzene hexachloride in mice . J. Natl. Cancer Inst. , 51 : 817 – 822 .
  • Ito , N. , Nagasaki , H. , Aoe , H. , Sugihara , S. , Muyata , Y. , Arai , M. and Shirai , T. 1975 . Development of hepatocellular carcinomas in rats treated with benzene hexachloride . J. Natl. Cancer Inst. , 54 : 801 – 805 .
  • Jollow , D. J. , Mitchell , J. R. , Zampaglione , N. and Gillette , J. R. 1974 . Bromobenzene‐induced liver necrosis. Protective role of glutathione and evidence for 3,4‐bromobenzene oxide as the hepatic metabolite . Pharmacology , 11 : 151 – 169 .
  • Kasik , J. E. 1971 . Absorption, metabolism and excretion of toxic substances . J. Occup. Med. , 13 : 8 – 13 .
  • Kato , R. and Takanaka , A. 1968a . Metabolism of drugs in old rats. I. Activities of NADPH‐linked electron transport and drug metabolizing enzyme systems in liver microsomes of old rats . Jp. J. Pharmacol. , 18 : 381 – 388 .
  • Kato , R. and Takanaka , A. 1968b . Metabolism of drugs in old rats. II. Metabolism in vivo and effect of drugs in old rats . Jp. J. Pharmacol. , 18 : 389 – 396 .
  • Kitchin , K. T. and Ebron , M. T. 1983 . Maternal hepatic and embryonic effects of 1,2,4‐trichloro‐benzene in the rat . Environ. Res. , 31 : 362 – 373 .
  • Kohli , J. , Jones , D. and Safe , S. 1976 . The metabolism of higher chlorinated benzene isomers . Can. J. Biochem. , 54 : 203 – 208 .
  • Kolmodin‐Hedman , B. , Alexanderson , B. and Sjoqvist , F. 1971 . Effect of exposure to lindane on drug metabolism: Decreased hexobarbital sleeping‐times and increased antipyrine disappearance rate in rats . Toxicol. Appl. Pharmacol. , 20 : 299 – 307 .
  • Kurihara , N. , Tanaka , K. and Nakajima , M. 1979 . “ Anaerobic metabolism of lindane and related compounds by liver microsomes ” . In Advances in Pesticide Science , Edited by: Geissbuhler , H. 557 – 561 . New York : Pergamon . Part 3
  • Kurihara , N. , Yamakawa , K. , Fujita , T. and Nakajima , M. 1980 . Anaerobic degradation of tetra‐, penta‐, and hexachlorocyclohexene isomers by rat liver microsomal P‐450 . J. Pestic. Sci. , 5 : 93 – 100 .
  • Lyon , M. F. 1981 . “ Rules for nomenclature of inbred strains ” . In Genetic Variants and Strains of the Laboratory Mouse , Edited by: Green , M. C. 368 – 372 . New York : Fisher‐Verlag .
  • Mikol , Y. B. , Roux , F. , Decloitre , F. and Fournier , E. P. 1980 . Liver‐enzyme induction in lindane‐and captan‐treated rats . Food Cosmet. Toxicol. , 18 : 377 – 382 .
  • Miller , E. C. and Miller , J. A. 1974 . “ Biochemical mechanisms of chemical carcinogenesis ” . In The Molecular Biology of Cancer , Edited by: Busch , H. 377 New York : Academic .
  • Nagasaki , H. , Tomii , S. , Mega , T. , Marugami , M. and Ito , N. 1972 . Hepatocarcinogenic effect of alpha, beta, gamma, and delta isomers of BHC in mice . Gann , 63 : 393
  • National Cancer Institute . 1977 . A bioassay for possible carcinogenicity of lindane . Fed. Reg. , 42 (218) : 58791
  • Oesch , F. , Jerina , D. M. , Daly , J. W. and Rice , J. M. 1973 . Induction, activation and inhibition of epoxide hydrase: An anomalous prevention of chlorobenzene‐induced hepatotoxicity by an inhibitor of epoxide hydrase . Chem. Biol. Interact. , 6 : 189 – 202 .
  • Op Den Kamp , J. A. F. , Van Iterson , W. and Van Deenen , L. L. M. 1967 . Phospholipids and morphology of protoplasts of Bacillus megaterium . Biochim. Biophys. Acta , 135 : 862 – 884 .
  • Ortega , P. , Hayes , W. J. and Durham , W. F. 1957 . Pathologic changes in the liver of rats after feeding low levels of various insecticides . A.M.A. Arch. Pathol. , 64 : 614 – 622 .
  • Ove , P. , Obenrader , M. and Lansing , A. 1972 . Synthesis and degradation of liver proteins in young and old rats . Biochim. Biophys. Acta , 277 : 211 – 221 .
  • Papahadjopoulos , D. , Cowden , M. and Kimelberg , H. 1973 . Role of cholesterol in membranes. Effects of phospholipid‐protein interactions, membrane permeability and enzyme activity . Biochim. Biophys. Acta , 330 : 8 – 26 .
  • Reid , W. D. and Krishna , G. 1973 . Centrilobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons . Exp. Mol. Pathol. , 18 : 80 – 99 .
  • Reuber , M. D. 1979 . Carcinogenicity of lindane . Environ. Res. , 19 : 460 – 481 .
  • Rikans , L. E. 1984 . Influence of aging on the susceptibility of rats to hepatotoxic injury . Toxicol. Appl. Pharmacol. , 73 : 243 – 249 .
  • Rikans , L. E. and Notley , B. A. 1982 . Age‐related changes in hepatic microsomal drug metabolism are substrate selective . J. Pharmacol. Exp. Ther. , 220 : 574 – 578 .
  • Roberts , D. W. , Wolff , G. L. and Campbell , W. L. 1984 . Differential effects of the mottled yellow and pseudoagouti phenotypes on immunocompetence in Avy/a mice . Proc. Natl. Acad. Sci. U.S.A. , 81 : 2152 – 2156 .
  • Robinson , J. R. , Felton , J. S. , Levitt , R. C. , Thorgeirsson , S. S. and Nebert , D. W. 1975 . Relationship between “aromatic hydrocarbon responsiveness”; and the survival times in mice treated with various drugs and environmental compounds . Mol. Pharmacol. , 11 : 850 – 865 .
  • SAS Institute Statistical Analysis System . 1982 . SAS User's Guide: Statistics , Cary, N.C. : SAS Institute, Inc. .
  • Schmucker , D. L. and Wang , R. L. 1980 . Age‐related changes in liver drug‐metabolizing enzymes . Exp. Gerontol. , 15 : 321 – 329 .
  • Thorgeirsson , S. S. and Wirth , P. J. 1979 . Genetic aspects of metabolic processing of chemical substances . J. Toxicol. Environ. Health , 5 : 83 – 87 .
  • Thorpe , E. and Walker , A. I. T. 1973 . The toxicology of dieldrin (HEOD). II. Comparative long‐term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, β‐BHC, and γ‐BHC . Food Cosmet. Toxicol. , 11 : 433 – 442 .
  • Vaino , H. 1973 . On the topography and synthesis of drug‐metabolizing enzymes in hepatic endo‐plasmic reticulum , 1 – 46 . Finland : University of Turku . M.D. dissertation
  • Williams , R. T. 1978 . Species variations in the pathways of drug metabolism . Environ. Health Perspect. , 22 : 133 – 138 .
  • Wolff , G. L. 1963 . Growth of inbred yellow (Avy/a) and non‐yellow (aa) mice in parabiosis . Genetics , 48 : 1041 – 1058 .
  • Wolff , G. L. 1971 . Genetic modification of homeostatic regulation in the mouse . Am. Nat. , 105 : 241 – 252 .
  • Wolff , G. L. 1978 . Influence of maternal phenotype on metabolic differentiation of agouti locus mutants in the mouse . Genetics , 88 : 529 – 539 .
  • Wolff , G. L. Maternal influence on phenotypic differentiation on a mutant mouse susceptible to neoplasia and obesity . Proc. 4th International Conference on Environmental Mutagens . June 24–28 , Stockholm, Sweden.
  • Wolff , G. L. and Pitot , H. C. 1972 . Variation of hepatic malic enzyme capacity with hepatoma susceptibility in mice of different genotypes . Cancer Res. , 32 : 1861 – 1863 .
  • Wolff , G. L. and Suber , R. L. 1983 . Influence of lindane and yellow (Avyla) phenotype on hepatic glutathione S‐transferase activity in mice . Toxicologist , 3 : 77
  • Yen , T. T. , Allan , J. A. , Yu , P. , Acton , M. A. and Pearson , D. V. 1976 . Triacylglycerol contents and in vivo lipogenesis of oblob, db/db and Avy/a mice . Biochim. Biophys. Acta , 441 : 213 – 220 .
  • Zampaglione , N. , Jollow , D. J. , Mitchell , J. R. , Stripp , B. and Hamrick , M. 1973 . Role of detoxifying enzymes in bromobenzene‐induced liver necrosis . J. Pharmacol. Exp. Ther. , 187 : 218 – 227 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.