References
- Ames , B. N. , McCann , J. and Yamasaki , E. 1975 . Methods for detecting carcinogens and mutagens with the Salmonella/mammalian‐microsome mutagenicity test . Mutat. Res. , 31 : 347 – 364 .
- Beatty , P. W. , Mueller , R. L. , Page , A. C. and Cingell , R. 1985 . Factors affecting the in vitro metabolism of 1,2‐dibromo‐3‐chloropropane (DBCP) by rat hepatic microsomes . Toxicologist , 5 : 203 (abstr. 809)
- Dunnett , C. W. 1964 . New tables for multiple comparisons with a control . Biometrics , 20 : 482 – 491 .
- Edwards , K. , Jackson , H. and Jones , A. R. 1970 . Studies with alkylating esters—11. A chemical interpretation through metabolic studies of the anti‐fertility effects of ethylene dimethane‐sulphonate and ethylene dibromide . Biochem. Pharmacol. , 19 : 1783 – 1789 .
- Elfarra , A. A. and Anders , M. W. 1984a . Renal processing of glutathione conjugates. Role in nephrotoxicity . Biochem. Pharmacol. , 33 : 3729 – 3732 .
- Elfarra , A. A. and Anders , M. W. 1984b . Nephrotoxicity of S‐1,2‐dichlorovinyl‐glutathione (DCVG) . Pharmacologist , 26 : 239 (abstr.)
- Elfarra , A. A. , Baggs , R. B. and Anders , M. W. Structure‐nephrotoxicity relationships of S‐(2‐ chloroethyl)‐DL‐cysteine and analogs: Role for an episulfonium ion . J. Pharmacol. Exp. Ther. , 233 512 – 516 .
- Ellman , G. L. 1959 . Tissue sulfhydryl groups . Arch. Biochem. Biophys. , 82 : 70 – 77 .
- Gornall , A. G. , Bardawill , C. J. and David , M. M. 1949 . Determination of serum proteins by means of the biuret reaction . J. Biol. Chem. , 177 : 751 – 766 .
- Hughey , R. P. , Rankin , B. B. , Elce , J. S. and Curthoys , N. P. 1978 . Specificity of a particulate rat renal peptidase and its localization along with other enzymes of mercapturic acid synthesis . Arch. Biochem. Biophys. , 186 : 211 – 217 .
- Inskeep , P. B. and Guengerich , P. 1984 . Glutathione‐mediated binding of dibromoalkanes to DNA: Specificity of rat glutathione‐5‐transferases and dibromoalkane structure . Carcinogenesis , 5 : 805 – 808 .
- Jones , A. R. , Fakhouri , G. and Gadiel , P. 1979 . The metabolism of the soil fumigant, 1,2‐dibromo‐3‐chloropropane in the rat . Experientia , 35 : 1432 – 1434 .
- Kato , Y. , Sato , K. , Maki , S. , Matano , C. and Goto , S. 1979 . Metabolic fate of 1,2‐dibromo‐3‐chloro‐propane (DBCP) in rats . J. Pestic. Sci. , 4 : 195 – 203 .
- Kato , Y. , Sato , K. , Harada , T. , Maki , S. , Matano , O. and Goto , S. 1980a . Correlation between macromolecular binding of DBCP‐metabolite and pathogenicity of necrosis . J. Pestic. Sci. , 5 : 81 – 88 .
- Kato , Y. , Sato , K. , Matano , O. and Goto , S. 1980b . Alkylation of cellular macromolecules by reactive metabolic intermediates of DBCP . J. Pestic. Sci. , 5 : 45 – 53 .
- Kluwe , W. M. 1981a . Acute toxicity of 1,2‐dibromo‐3‐chloropropane in the F344 male rat. I. Dose‐response relationships and differences in routes of exposure . Toxicol. Appl. Pharmacol. , 59 : 71 – 83 .
- Kluwe , W. M. 1981b . Acute toxicity of 1,2‐dibromo‐3‐chloropropane in the F344 male rat. II. Development and repair of the renal, epididymal, testicular, and hepatic lesions . Toxicol. Appl. Pharmacol. , 59 : 84 – 95 .
- Kluwe , W. M. , McNish , R. and Hook , J. B. 1981 . Acute nephrotoxicities and hepatotoxicities of 1,2‐dibromo‐3‐chloropropane and 1,2‐dibromoethane in male and female rats . Toxicol. Lett. , 8 : 317 – 321 .
- Kluwe , W. M. , Creenwell , A. and Harrington , F. 1982 . Relationship of tissue nonprotein sulfhy‐dryls to the acute toxic effects of 1,2‐dibromo‐3‐chloropropane . J. Pharmacol. Exp. Ther. , 220 : 399 – 405 .
- MacFarland , R. T. , Gandolfi , A. J. and Sipes , I. G. 1984 . Extra‐hepatic GSH‐dependent metabolism of 1,2‐dibromoethane (DBE) and 1,2‐dibromo‐3‐chloro‐propane (DBCP) in the rat and mouse . Drug Chem. Toxicol. , 7 : 213 – 227 .
- Mannervik , B. 1985 . The isoenzymes of glutathione transferase . Adv. Enzymol. , 57 : 357 – 417 .
- Marsden , P. J. and Casida , J. E. 1982 . 2‐Haloacrylic acids as indicators of mutagenic 2‐haloacrolein intermediates in mammalian metabolism of selected promutagens and carcinogens . J. Agric. Food Chem. , 30 : 627 – 631 .
- Miller , G. E. and Kulkarni , A. P. 1983 . 1,2‐Dibromo‐3‐chloropropane as a substrate for hepatic, renal, and testicular glutathione S‐transferases in the rat . Toxicologist , 3 : 104 (abstr. 416)
- National Cancer Institute/National Toxicology Program . 1982a . Carcinogenesis bioassay of 1,2‐di‐bromo‐3‐chloropropane (CAS No. 96–12–8) in F344 rats and B6C3F1 mice (inhalation study) , Research Triangle Park, N.C. : National Toxicology Program . TR 206
- National Cancer Institute/National Toxicology Program . 1982b . Carcinogenesis bioassay of 1,2‐dibromoethane (CAS No. 106–93–4) in F344 rats and B6C3F1 mice (inhalation study) , Research Triangle Park, N.C. : National Toxicology Program . TR 210
- Neter , J. and Wasserman , W. 1974 . Applied Linear Statistical Models. Regression, Analysis of Variance, and Experimental Designs , 419 – 491 . Homewood, Ill. : Irwin .
- Omura , T. and Sato , R. 1964 . The carbon monoxide‐binding pigment of liver microsomes. I. Evidence for its hemoprotein nature . J. Biol. Chem. , 239 : 2370 – 2378 .
- Ozawa , N. and Guengerich , F. P. 1983 . Evidence for formation of an S‐[2‐(N7‐guanyl)ethyl]gluta‐thione adduct in glutathione‐mediated binding of the carcinogen 1,2‐dibromoethane to DNA . Proc. Natl. Acad. Sci. USA , 80 : 5266 – 5270 .
- Rosen , J. D. , Segall , Y. and Casida , J. E. 1980 . Mutagenic potency of haloacroleins and related compounds . Mutat. Res. , 78 : 113 – 119 .
- Stevens , J. and Jakoby , W. B. 1983 . Cysteine conjugate beta‐lyase . Mol. Pharmacol. , 23 : 761 – 765 .
- Stolzenberg , S. J. and Hine , C. H. 1979 . Mutagenicity of halogenated and oxygenated three‐carbon compounds . J. Toxicol. Environ. Health , 5 : 1149 – 1158 .
- Sundheimer , D. W. , White , R. D. , Brendel , K. and Sipes , I. G. 1982 . The bioactivation of 1,2‐dibromoethane in rat hepatocytes: Covalent binding to nucleic acids . Carcinogenesis , 3 : 1129 – 1133 .
- Torkelson , T. R. , Sadek , S. E. and Rowe , V. K. 1961 . Toxicologic investigations of 1,2‐dibromo‐3‐chloropropane . Toxicol. Appl. Pharmacol. , 3 : 545 – 559 .
- U.S. Environmental Protection Agency . 1977 . Rebuttable presumption against registration and continued registration of pesticide products containing dibromochloropropane (DBCP) . Fed. Reg. , 42 : 48026 – 48031 .
- U.S. Occupational Safety and Health Administration . 1977 . Occupational exposure to 1,2‐di‐bromo‐3‐chloropropane (DBCP). Emergency temporary standard, hearing . Fed. Reg. , 42 : 45536 – 45549 .
- van Bladeren , P. J. , Breimer , D. D. , Rotteveel‐Smijs , G. M. T. , de Jong , R. A. W. , Bluijs , W. , van der Gen , A. and Mohn , G. R. 1980 . The role of glutathione conjugation in the mutagenicity of 1,2‐dibromoethane . Biochem. Pharmacol. , 29 : 2975 – 2982 .
- van Bladeren , P. J. , Breimer , D. D. , Rotteveel‐Smijs , G. M. T. , de Knijff , P. , Mohn , G. R. , van Meeteren‐Walchli , B. , Buifs , W. and van der Gen , A. 1981 . The relationship between the structure of vicinal dihalogen compounds and their mutagenic activation via conjugation to gluthione . Carcinogenesis , 2 : 499 – 505 .
- Whorton , D. , Milby , T. H. , Krauss , R. M. and Stubbs , H. A. 1979 . Testicular function in DBCP exposed pesticide workers . J. Occup. Med. , 21 : 161 – 166 .