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Original Articles

Lung retention and binding of [14c]‐1‐nitropyrene when inhaledby f344 rats as a pure aerosol or adsorbed to carbon black particles

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Pages 309-325 | Received 25 Mar 1988, Accepted 13 Sep 1988, Published online: 20 Oct 2009

References

  • Bond , J. A. , Sun , J. D. , Medinsky , M. A. , Jones , R. K. and Yeh , H. C. 1986a . Deposition, metabolism and excretion of 14C‐1‐nitropyrene coated on diesel exhaust particles as influenced by exposure concentration . Toxicol. Appl. Pharmacol. , 85 : 102 – 117 .
  • Bond , J. A. , Sun , J. D. , Mitchell , C. E. , Dutcher , J. S. , Wolff , R. K. and McClellan , R. O. 1986b . “ Biological fate of inhaled organic compounds associated with particulate matter ” . In Aerosols , Edited by: Lee , S. D. , Schneider , T. , Grant , L. D. and Verker , P. J. 579 – 592 . Chelsea, Mich. : Lewis .
  • Cheng , Y. S. , Yeh , H. C. , Mauderly , J. L. and Mokler , B. V. 1984 . Characterization of diesel exhaust in a chronic inhalation study . Am. Ind. Hyg. Assoc. J. , 45 : 547 – 555 .
  • Creasia , D. A. , Poggenburg , J. K. and Nettesheim , P. 1976 . Elution of benzo(a)pyrene from carbon particles in the respiratory tract of mice . J. Toxicol. Environ. Health , 1 : 967 – 975 .
  • Dixon , W. J. , ed. 1983 . BMDP Statistical Software , Berkeley : University of California Press .
  • El‐Bayoumy , K. , Hecht , S. S. , Sackl , T. and Stoner , G. D. 1984 . Tumorigenicity and metabolism of 1‐nitropyrene in A/J mice . Carcinogenesis , 5 : 2449 – 2452 .
  • Falk , H. L. , Kotin , P. and Markul , I. 1958 . The disappearance of carcinogens from soot in human lungs . Cancer , 11 : 482 – 489 .
  • Farrell , R. L. and Davis , G. W. 1974 . “ Effect of particulate benzo(a)pyrene carrier on carcinogenesis in the respiratory tract of hamsters ” . In Experimental Lung Cancer: Carcinogenesis and Bioas‐say , Edited by: Karbe , R. and Park , J. F. 186 – 198 . New York : Springer‐Verlag .
  • Gallant , A. R. 1975 . Nonlinear regression . Am. Statistician , 29 : 73 – 81 .
  • Hanson , R. L. , Henderson , T. R. , Hobbs , C. H. , Clark , C. R. , Carpenter , R. L. and Dutcher , J. S. 1983 . Detection of nitroaromatic compounds on coal combustion particles . J. Toxicol. Environ. Health , 11 : 971 – 980 .
  • Harris , C. C. 1985 . Future directions in the use of DNA adducts as internal dosimeters for monitoring human exposure to environmental mutagens and carcinogens . Environ. Health Perspect. , 62 : 185 – 191 .
  • Henderson , T. R. , Royer , R. E. , Clark , C. R. , Harvey , T. M. and Hunt , D. F. 1982 . MS/MS analysis of diesel emissions and fuels treated with NO2 . J. Appl. Toxicol. , 2 : 231 – 237 .
  • Henry , M. C. and Kaufman , D. C. 1973 . Clearance of benzo(a)pyrene from hamster lungs after administration on coated particles . J. Natl. Cancer Inst. , 51 : 1961 – 1964 .
  • Hirose , M. , Lee , M. S. , Wang , C. Y. and King , C. M. 1984 . Induction of rat mammary gland tumors by 1‐nitropyrene, a recently recognized environmental mutagen . Cancer Res. , 44 : 1158 – 1162 .
  • Jackson , M. A. , King , L. C. , Ball , L. M. , Ghayourmanesh , S. , Jeffrey , A. M. and Lewtas , J. 1985 . Nitropyrene: DNA binding and adduct formation in respiratory tissues . Environ. Health Perspect. , 68 : 203 – 207 .
  • King , L. C. , Loud , K. , Tejada , S. B. , Kohahn , M. J. and Lewtas , J. 1983 . Evaluation of the release of mutagens and 1‐nitropyrene from diesel particles in the presence of lung macrophages in1 culture . Environ. Mutagen. , 5 : 577 – 588 .
  • Maeda , T. , Izumi , K. , Otsuka , H. , Manabe , Y. , Kinouchi , T. and Ohnishi , Y. 1986 . Induction of squamous cell carcinoma in the rat lung by 1,6‐dinitropyrene . JNCl , 76 : 693 – 701 .
  • Mauderly , J. L. 1986 . Respiration of F344 rats in nose‐only inhalation exposure tubes . J. Appl. Toxicol. , 6 : 25 – 30 .
  • Mitchell , C. E. 1985 . Effect of aryl hydrocarbon hydroxylase induction on the in vivo covalent binding of 1‐intropyrene, benzo(a)pyrene 2‐aminoanthracene, and phenanthridone to mouse lung deoxyribonucleic acid . Biochem. Pharmacol. , 34 : 545 – 551 .
  • Moon , R. C. Health Effects Institute Annual Conference . February 16–19 , Pacific Grove, Calif.
  • Morrow , P. E. 1973 . Alveolar clearance of aerosols . Arch. Int. Med. , 131 : 101 – 108 .
  • Morrow , P. E. 1986 . The setting of particulate exposure levels for chronic inhalation toxicity studies . J. Am. Coll. Toxicol. , 5 : 533 – 544 .
  • Nau , C. A. , Neal , J. , Stemridge , V. A. and Cooley , R. N. 1962 . Physiological effects of carbon black . Arch. Environ. Health , 4 : 415 – 431 .
  • Ohgaki , H. , Hasegawa , H. , Kato , T. , Negishi , C. , Sato , S. and Sugimura , T . 1985 . Absence of carcinogenicity of 1‐nitropyrene, correction of previous results, and new demonstration of carcinogenicity of 1,6‐dinitropyrene in rats . Cancer Lett. , 25 : 239 – 245 .
  • Pyleve , L. N. , Roe , F. J. C. and Warwick , G. P. 1969 . Elimination of radioactivity after intratracheal installation of 3,4‐benzopyrene in hamsters . Br. J. Cancer , 23 : 103 – 115 .
  • Raabe , O. G. , Bennick , J. E. , Light , M. E. , Hobbs , C. H. , Thomas , R. L. and Tillery , M. I. 1973 . An improved apparatus for acute inhalation exposure of rodents to radioactive aerosols . Toxicol. Appl. Pharmacol. , 26 : 264 – 273 .
  • Riley , T. , Prater , T. , Schuetzel , D. , Harvy , T. M. and Hunt , D. The analysis of nitrated polynuclear aromatic hydrocarbons in diesel exhaust particulates by mass spectrometry/mass spectrometry techniques . Abstracts of the 29th Annual Conference on Mass Spectrometry and Applied Topics . May 24–29 , pp. 636 – 637 . Minneapolis, Minn 1981
  • Rivin , D. and Atkins , J. H. 1987 . Sorption of bioactive materials on carbon . Carbon , 25 : 135 – 145 .
  • Rosenkranz , H. S. 1982 . Direct acting mutagens in diesel exhausts: Magnitude of the problem . Mutat. Res. , 101 : 1 – 10 .
  • Rothenberg , S. J. , Kittelson , D. B. , Cheng , Y. S. and McClellan , R. O. 1985 . Adsorption of nitrogen and xylene by light‐duty diesel exhaust samples . Aerosol Sci. Technol. , 4 : 383 – 400 .
  • Saffiotti , U. , Borg , S. A. , Grote , M. I. and Karp , D. B. 1964 . Retention rates of particulate carcinogens in lungs . Chicago Med. School Q. , 24 : 10 – 17 .
  • Saffiotti , U. , Cefin , F. , Kolb , L. H. and Shubik , P. 1965 . Experimental studies of the conditions of exposure to carcinogens for lung cancer induction . J. Air Pollut. Control Assoc. , 15 : 23 – 25 .
  • Salmeen , I. A. , Durisin , A. M. , Prater , T. J. , Riley , T. and Schuetzle , D. Contribution of 1‐nitropyrene to direct acting Ames assay of mutagenicities of diesel particulate extracts . Presented at E.P.A. Symposium on Diesel Emissions . October 1981 , Raleigh, N.C.
  • Schuetzle , D. 1983 . Sampling of vehicle emissions for chemical analysis and biological testing . Environ. Health Perspect. , 47 : 65 – 80 .
  • Smith , R. G. and Musch , D. C. 1982 . Occupational exposure to carbon black: A particulate sampling study . Am. Ind. Hyg. Assoc. J. , 43 : 925 – 930 .
  • Sun , J. D. and Dent , J. G. 1980 . A new method for measuring covalent binding of chemicals to cellular macromolecules . Chem. Biol. Interact. , 32 : 41 – 61 .
  • Sun , J. D. , Wolff , R. K. and Kanapilly , G. M. 1982 . Deposition, retention and biological fate of inhaled benzo(a)pyrene adsorbed onto ultrafine particles and as a pure aerosol . Toxicol. Appl. Pharmacol. , 65 : 231 – 244 .
  • Sun , J. D. , Wolff , T. K. , Aberman , H. M. and McClellan , R. O. 1983 . Inhalation of 1‐nitropyrene associated with ultrafine insoluble particles or as a pure aerosol: A comparison of deposition and biological fate . Toxicol. Appl. Pharmacol. , 69 : 185 – 198 .
  • Sun , J. D. , Wolff , R. K. , Kanapilly , G. M. and McClellan , R. O. 1984 . Lung retention and metabolic fate of inhaled benzo(a)pyrene associated with diesel exhaust particles . Toxicol. Appl. Pharmacol. , 73 : 48 – 59 .
  • Sun , J. D. , Wolff , R. K. , Maio , S. M. and Barr , E. G. 1989 . The influence of adsorption to carbon black particles on the retention and metabolic activation of benzo(a)pyrene in rat lungs following inhalation exposure or intratracheal instillation . Inhalation Toxicol. , 1 : 79 – 94 .
  • Tokiwa , H. , Otofuji , T. , Horikama , K. , Kitamori , S. , Otsuka , H. , Manabe , Y , Kinouchi , T. and Ohnishi , Y. 1984 . 1,6‐Dinitropyrene: Mutagenicity in Salmonella and carcinogenicity in BALB/C mice . JNCI , 73 : 1359 – 1363 .
  • Tu , K. W. , Kanapilly , G. M. and Mitchell , C. E. 1981 . Generation and characterization of condensation aerosols of benzo(a)pyrene . J. Toxicol. Environ. Health , 7 : 353 – 362 .
  • Vostal , J. J. , White , H. J. , Strom , K. A. , Siak , J. S. , Chen , K. C. and Dziedzic , D. 1982 . “ Response of the pulmonary defense system to diesel particulate exposure ” . In Toxicological Effects of Emissions from Diesel Engines , Edited by: Lewtas , J. 201 – 221 . New York : Elsevier Biomedical .
  • White , C. M. , ed. 1985 . Nitrated Polycyctic Aromatic Hydrocarbons, 1985 , Heidelberg : Hüthig .
  • Wolff , R. K. , Henderson , R. F. , Snipes , M. B. , Sun , J. D. , Bond , J. A. , Mitchell , C. E. , Mauderly , J. L. and McClellan , R. O. 1986 . “ Lung retention of diesel soot and associated organic compounds ” . In Carcinogenic and Mutagenic Effects of Diesel Engine Exhaust , Edited by: Ishinishi , N. , Koizumi , A. , McClellan , R. O. and Stöber , W. 199 – 211 . Amsterdam : Elsevier .
  • Wolff , R. K. , Henderson , R. F. , Eidson , A. R. , Pickrell , J. A. , Rothenberg , S. J. and Hahn , R F. 1988 . Toxicity of gallium oxide particles following a 4‐week inhalation exposure . J. Appl. Toxicol. , 8 : 191 – 199 .

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