4
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Covalent binding of 1,1,1,2‐tetrachloroethane to nucleic acids as evidence of genotoxic activity

, , , , , , , & show all
Pages 485-495 | Received 26 Feb 1988, Accepted 26 Sep 1988, Published online: 15 Oct 2009

References

  • Arfellini , G. , Bartoli , S. , Colacci , A. , Mazzullo , M. , Galli , M. C. , Prodi , G. and Grilli , S. 1984 . In vivo in vitro binding of 1,2‐dibromoethane and 1,2‐dichloroethane to macromolecules in rat and mouse organs . J. Cancer Res. Clin. Oncol. , 108 : 204 – 213 .
  • Bolt , H. M. 1984 . “ Metabolism of genotoxic agents: Halogenated compounds ” . In Monitoring Human Exposure to Carcinogenic and Mutagenic Agents , Edited by: Berlin , A. , Draper , M. , Hemminki , K. and Vainio , H. 63 – 71 . Lyon : International Agency for Research on Cancer . IARC Scientific Publications no. 59
  • Colacci , A. , Mazzullo , M. , Arfellini , G. , Prodi , G. and Grilli , S. 1985a . In vitro microsome‐ and cytosol‐mediated binding of 1,2‐dichloroethane and 1,2‐dibromoethane with DNA . Cell. Biol. Toxicol. , 1 : 45 – 55 .
  • Colacci , A. , Arfellini , G. , Mazzullo , M. , Prodi , G. and Grilli , S. 1985b . Genotoxicity of 1,1‐dichloroethane . Res. Commun. Chem. Pathol. Pharmacol. , 49 : 243 – 255 .
  • Colacci , A. , Grilli , S. , Lattanzi , G. , Prodi , G. , Turina , M. P. , Cantelli Forti , G. and Mazzullo , M. 1987 . The covalent binding of 1,1,2,2‐tetrachloroethane to macromolecules of rat and mouse organs . Teratogen. Carcinogen. Mutagen. , 7 : 465 – 474 .
  • Henschler , D. 1985 . “ Specific covalent binding and genotoxicity ” . In Environmental Carcinogens Selected Methods of Analysis vol. 7 Volatile Halogenated Hydrocarbons , Edited by: Fishbein , L. and O'Neill , I. K. vol. 7 , 21 – 44 . Lyon : International Agency for Research on Cancer . IARC Scientific Publications no. 68
  • IARC . 1986 . “ Pentachloroethane ” . In Some Halogenated Hydrocarbons and Pesticide Exposure , IARC Monogr. Eval. Carcinogen. Risk Chem. Hum. Vol. 41 , 99 – 111 . Lyon : International Agency for Research on Cancer .
  • Inskeep , P. B. , Koga , N. , Charik , S. J. and Guengerich , F. P. 1986 . Covalent binding of 1,2‐dihaloalkanes to DNA and stability of the major DNA adduct, S‐[2(N7‐guanyl)ethyl]glutathione . Cancer Res. , 46 : 2839 – 2844 .
  • Laib , R. J. 1986 . “ The role of cyclic base adducts in vinylchloride‐induced carcinogenesis: Studies on nucleic acid alkylation in vivo ” . In The Role of Cyclic Nucleic Acid Adducts in Carcinogenesis and Mutagenesis , Edited by: Singer , B. and Bartsch , H. 101 – 108 . Lyon : International Agency for Research on Cancer . IARC Scientific Publications no. 70
  • Lattanzi , G. , Colacci , A. , Grilli , S. , Mazzullo , M. , Prodi , G. and Turina , M. P. 1988 . Binding of hexachloroethane to biological macromolecules from rat and mouse organs . J. Toxicol. Environ. Health , 24 : 403 – 411 .
  • Loew , G. H. , Rebagliati , M. and Poulsen , M. 1984 . Metabolism and relative carcinogenic potency of chloroethanes: A quantum chemical structure‐activity study . Cancer Biochem. Biophys. , 7 : 109 – 132 .
  • Lutz , W. K. 1979 . In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis . Mutat. Res. , 65 : 289 – 356 .
  • Lutz , W. K. 1986 . Quantitative evaluation of DNA binding data for risk estimation and for classification of direct and indirect carcinogens . J. Cancer Res. Clin. Oncol. , 112 : 85 – 91 .
  • Mazzullo , M. , Colacci , A. , Grilli , S. , Prodi , G. and Arfellini , G. 1986 . 1,1,2‐Trichloroethane: Evidence of genotoxicity from short‐term tests . Jpn. J. Cancer Res. (Gann) , 77 : 532 – 539 .
  • Nastainczyk , W. , Ahr , H. J. and Ullrich , V. 1982 . The reductive metabolism of halogenated alkanes by liver microsomal cytochrome P‐450 . Biochem. Pharmacol. , 31 : 391 – 396 .
  • National Cancer Institute . 1978 . “ Bioassay of 1,1,1,2‐tetrachloroethane for possible carcinogenicity ” . Technical Report Series No. 68 Washington, D.C. : U.S. Government Printing Office . U.S. Department of Health, Education, & Welfare, DHEW publication no. (NIOSH) 78–827, CAS no. 78–34–5 NCI‐CG‐TR‐27
  • National Toxicology Program . 1983 . “ Carcinogenesis studies of 1,1,1,2‐tetrachloroethane ” . Research Triangle Park, N.C. : National Toxicology Program . (CAS no. 630–20–6) in F344/N rats and B6C3F1 mice (gavage study)
  • Story , D. L. , Meierhenry , E. F. , Tyson , C. A. and Milman , H. A. 1986 . Differences in rat liver enzyme‐altered foci produced by chlorinated aliphatics and phenobarbital . Toxicol. Ind. Health , 2 : 351 – 362 .
  • Swenson , D. H. and Lawley , P. D. 1978 . Alkylation of deoxyribonucleic acid by carcinogens dimethyl sulphate, ethyl methanesulphonate, N‐ethyl‐N‐nitrosourea, and N‐methyl‐N‐nitrosourea . Biochem. J. , 171 : 575 – 587 .
  • Thompson , J. A. , Ho , B. and Mastovich , S. L. 1984 . Reductive metabolism of 1,1,1,2‐tetrachloroethane and related chloroethanes by rat liver microsomes . Chem. Biol. Interact. , 51 : 321 – 333 .
  • Thompson , J. A. , Ho , B. and Mastovich , S. L. 1985 . Dynamic headspace analysis of volatile metabolites from the reductive dehalogenation of trichloro‐ and tetrachloroethanes by hepatic microsomes . Anal. Biochem. , 145 : 376 – 384 .
  • Town , C. and Leibman , K. C. 1979 . In vitro dechlorination of polychlorinated ethanes by rat ho‐mogenates . Fed. Proc. , 38 : 538
  • Turina , M. P. , Colacci , A. , Grilli , S. , Mazzullo , M. , Prodi , G. and Lattanzi , G. 1986 . Short‐term tests of genotoxicity for 1,1,1‐trichloroethane . Res. Commun. Chem. Pathol. Pharmacol. , 52 : 305 – 320 .
  • Turina , M. P. , Colacci , A. , Grilli , S. , Mazzullo , M. , Prodi , G. , Lattanzi , G. , Bonora , B. , Bartoli , S. and Guidotti , L. 1988 . Metabolic activation and covalent binding to nucleic acids of pentachloroethane as short‐term test of genotoxicity . Res. Commun. Chem. Pathol. Pharmacol. , in press

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.