15
Views
9
CrossRef citations to date
0
Altmetric
Original Articles

Dietary protein and chronic toxicity of 1,2‐dimethylhydrazine fed to mice

, , , , , , , , & show all
Pages 383-413 | Received 05 Apr 1990, Accepted 02 Oct 1990, Published online: 20 Oct 2009

References

  • Amara , I. A. and Koch , G. G. 1979 . “ Categorical Data Programs: FROG ” . University of North Carolina Department of Biostatistics . Unpublished computer software documentation
  • American Institute of Nutrition (Anonymous) . 1977 . Report of the American Institute of Nutrition Ad Hoc Committee on Standards for Nutritional Studies . J. Nutr. , 107 : 1340 – 1348 .
  • American Institute of Nutrition (Anonymous) . 1980 . Second report of the Ad Hoc Committee on Standards for Nutritional Studies . J. Nutr. , 110 : 1726
  • Armstrong , B. and Doll , R. 1975 . Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices . Int. J. Cancer , 15 : 617 – 631 .
  • Ball , C. R. and Williams , W. L. 1965 . Spontaneous and dietary‐induced cardiovascular lesions in DBA mice . Anat. Rec. , 152 : 199 – 209 .
  • Ball , C. R. , Williams , W. L. and Collum , J. M. 1963 . Cardiovascular lesions in Swiss mice fed a high fat‐low protein diet with and without betaine supplementation . Anat. Rec. , 145 : 49 – 59 .
  • Bedell , M. A. , Lewis , J. C. , Billings , K. C. and Swanberg , J. A. 1982 . Cell specificity in hepatocarcinogenesis: preferential accumulation of 6‐methylguanine in target cell DNA during continuous exposure of rats to 1,2‐dimethylhydrazine . Cancer Res. , 42 : 3079 – 3083 .
  • Bruce , W. R. 1987 . Recent hypothesis for the origin of colon cancer . Cancer Res. , 47 : 4237 – 4242 .
  • Burdette , W. J. 1973 . Special rat strains provide model for adenocarcinoma of the large intestine . Comp. Pathol. Bull. , 5 : 1 – 4 .
  • Burek , J. D. , Mollelo , J. A. and Warner , S. D. 1982 . “ Selected non‐neoplastic diseases ” . In The Mouse in Biomedical Research , Edited by: Foster , H. L. , Small , J. D. and Fox , J. O. vol. II , 429 New York : Academic Press .
  • Clinton , S. K. , Destree , R. J. , Anderson , D. B. , Truex , C. R. , Imrey , P. B. and Visek , W. J. 1979 . 1,2‐ Dimethylhydrazine induced gastrointestinal cancer in rats fed beef or soybean protein . Nutr. Rep. Int. , 20 : 335 – 342 .
  • Clinton , S. K. and Visek , W. J. 1986 . “ The macronutrients in experimental carcinogenesis of the breast, colon, and pancreas ” . In Dietary Fat and Cancer , Edited by: Ip , C. , Birt , D. , Rogers , A. and Mettlin , C. 377 – 402 . New York : Alan R. Liss .
  • DeLong , D. M. and Goodnight , J. H. 1985 . “ Probit ” . In SAS Users Guide: Statistics, Version , 5 Edition , Cary, N.C. : SAS Institute, Inc .
  • Druckery , H. 1970 . “ Production of colonic carcinomas by 1,2‐dialkylhydrazines and azoxyalkanes ” . In Carcinoma of Colon and Antecedent Epithelium , Edited by: Burdett , W. J. 267 – 279 . Springfield, Il. : Charles C Thomas .
  • Druckery , H. , Preussman , R. , Matzkies , F. and Ivankovic , S. 1967 . Selektive erzeugung von darmkrebs bei ratten durch, 1,2‐dimethylhydrazin . Naturwissenschaften , 54 : 285 – 286 .
  • Eaton , G. J. , Custer , R. P. , Johnson , F. N. and Stabenow , K. T. 1978 . Dystrophic cardiac calcinosis in mice . Am. J. Pathol. , 90 : 173 – 186 .
  • Everitt , J. I. , Olson , L. M. , Magnum , J. B. and Visek , W. J. 1988 . High mortality with severe dystrophic cardiac calcinosis in C3H/OUJ mice fed high fat purified diets . Vet. Pathol. , 25 : 113 – 118 .
  • Fiala , E. S. 1977 . Investigations into the metabolism and mode of action of the colon carcinogens 1,2‐dimethylhydrazine and azoxymethane . Cancer , 40 : 2436 – 2445 .
  • Finney , D. J. 1978 . Statistical Method in Biological Assay , London : Charles Griffin .
  • Fukunishi , R. , Terashi , S. , Watanabe , K. and Kawaji , K. 1972 . High yield of hepatic tumors in rats by cycasin . Gann , 63 : 575 – 578 .
  • Fullerton , R. R. and Greenman , D. L. 1985 . Myocardial damage in mice associated with semipurified diet . Toxicologist , 5 : 102
  • Goodnight , J. H. , Sall , J. P. and Sarle , W. S. 1985 . “ GLM ” . In SAS Users Guide: Statistics, Version , 5 Edition , Cary, N.C. : SAS Institute, Inc .
  • Gregor , O. , Toman , R. and Prusova , F. 1969 . Gastrointestinal cancer and nutrition . Gut , 10 : 1031 – 1034 .
  • Gregor , O. , Toman , R. and Prusova , F. 1971 . Relation of gastrointestinal cancer mortality to cancer mortality in general . Scand. J. Gastroenterol. Suppl. , 9 : 79 – 85 .
  • 1972 . Guide for the Care and Use of Laboratory Animals , U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health Publication 8253 .
  • Haase , P. , Cowen , D. M. , Knowles , J. C. and Cooper , E. H. 1973 . Evaluation of dimethylhydrazine‐induced tumors in mice as a model system for colorectal cancer . Br. J. Cancer , 28 : 530 – 543 .
  • Hawks , A. , Hicks , R. M. , Holsman , J. W. and Magee , P. N. 1974 . Morphological and biochemical effects of 1,2‐dimethylhydrazine and 1‐methylhydrazine in rats and mice . Br. J. Cancer , 30 : 429 – 439 .
  • Hawks , A. and Magee , P. N. 1974 . The alkylation of nucleic acids of rat and mouse in vivo by the carcinogen 1,2‐dimethylhydrazine . Br. J. Cancer , 30 : 440 – 447 .
  • Highman , B. and Daft , F. S. 1951 . Calcified lesions in C3H mice given purified low protein diets . Arch. Pathol. , 52 : 221 – 229 .
  • Hunziker , J. 1975 . A new feeder system for quantitating actual toxicant consumption by mice during feeding studies . Lab. Anim. Sci. , 25 : 84 – 87 .
  • Jacobs , L. R. 1968 . Relationship between dietary fiber and cancer: Metabolic, physiologic, and cellular mechanisms . Proc. Soc. Exp. Biol. Med. , 183 : 299 – 310 .
  • Jenson , O. M. 1986 . “ The epidemiology of large bowel cancer ” . In Diet, Nutrition and Cancer: A Critical Evaluation , Edited by: Reddy , B. S. and Cohen , L. A. 27 – 46 . Boca Raton, Fla. : CRC Press .
  • Kari , F. W. , Johnston , J. P. , Truex , C. R. and Visek , W. J. 1983 . Effect of dietary protein concentration on yield of mutagenic metabolites from 1,2‐dimethylhydrazine in mice . Cancer Res. , 43 : 3674 – 3679 .
  • Krigel , R. L. and Friedman‐Kien , A. E. 1985 . “ Kaposi's sarcoma in AIDS ” . In AIDS. Etiology, Diagnosis, Treatment, and Prevention , Edited by: DeVita , V. T. , Hellman , S. and Rosenberg , S. A. 185 – 211 . Philadelphia : Lippincott .
  • Kolonel , L. N. and LeMarchanel , L. 1986 . “ The epidemiology of colon cancer and dietary fat ” . In Dietary Fat and Cancer , Edited by: Ip , C. , Birt , D. , Rogers , A. and Mettlin , C. 69 – 92 . New York : Alan R. Liss .
  • Landis , R. J. , Cooper , M. M. , Kennedy , T. and Koch , G. C. 1978 . A computer program for testing average partial association in three‐way contingency tables (PARCAT) . Comp. Prog. Biomed. , 9 : 223 – 246 .
  • Laqueur , G. L. 1965 . The induction of intestinal neoplasms in rats with the glycoside cycasin and its aglycone . Virchows. Arch. A (Pathol. Anat. Histol.) , 340 : 151 – 163 .
  • Laqueur , G. L. 1970 . “ Contribution of intestinal microflora to carcinogenesis ” . In Carcinoma of the Colon and Antecedent Epithelium , Edited by: Burdette , W. J. 305 – 313 . Springfield, Ill : Charles C Thomas .
  • Laqueur , G. L. , McDaniel , E. G. and Matsumoto , H. 1967 . Tumor induction in germ free rats with methylazoxymethanol (MAM) and synthetic MAM acetate . J. Natl. Cancer Inst. , 39 : 335 – 371 .
  • Laqueur , G. L. , Mickelsen , O. , Whiting , M. and Kurland , L. T. 1963 . Carcinogenic properties of nuts from Cycas circinalis indigenous to Guam . J. Natl. Cancer Inst. , 31 : 919 – 951 .
  • Laqueur , G. L. and Spatz , M. 1968 . Toxicology of cycasin . Cancer Res. , 28 : 2262 – 2267 .
  • Lewis , J. G. and Swenberg , J A. 1983 . The kinetics of DNA alkylation, repair and replication in hepatocytes, Kupffer cells, and sinusoidal endothelial cells in rat liver during continuous exposure to 1,2‐dimethylhydrazine . Carcinogenesis , 4 : 529 – 536 .
  • Martin , M. S. , Martin , F. , Michels , R. , Bistien , H. , Justrabo , E. , Bardes , M. and Viry , B. 1973 . An experimental model for cancer of the colon and rectum: intestinal carcinoma induced in the rat by 1,2‐dimethylhydrazine . Digestion , 8 : 22 – 34 .
  • Maskens , A. P. 1979 . Significance of the karyorrhectic index in 1,2‐dimethylhydrazine carcinogenesis . Cancer Lett. , 8 : 77 – 86 .
  • Moon , R. C. and Fricks , C. M. 1977 . Influence of gonadal hormones and age on 1,2‐ dimethylhydrazine‐induced colon carcinogenesis . Cancer , 40 : 2502 – 2508 .
  • Nelson , J. B. 1967 . “ Respiratory infections of rats and mice with emphasis on indigenous mycoplasms ” . In Pathology of Laboratory Rats and Mice , Edited by: Cotchin , E. and Roe , F. J. D. 259 – 294 . Oxford : Blackwell Scientific Publications .
  • Newberne , P. M. and Nauss , K. M. 1986 . “ Dietary fat and colon cancer: variable results in animal models ” . In Dietary Fat and Cancer , Edited by: Ip , C. , Birt , D. , Rogers , A. and Mettlin , C. 311 – 330 . New York : Alan R. Liss .
  • Pegg , A. E. and Hawks , A. 1971 . Increased transfer ribonucleic acid methylase activity in tumors induced in the mouse colon by administration of 1,2‐dimethylhydrazine . Biochem. J. , 122 : 121 – 123 .
  • Reddy , B. S. 1986 . “ Amount and type of dietary fat and colon cancer: animal model studies ” . In Dietary fat and Cancer , Edited by: Ip , C. , Birt , D. , Rogers , A. and Mettlin , C. 295 – 310 . New York : Alan R. Liss .
  • Sieber , S. M. , Correa , P. , Dalgard , D. W. , Mclntire , K. R. and Adamson , R. H. 1980 . Carcinogenicity and hepatotoxicity of cycasin and its aglycone methylazoxymethanol acetate in nonhuman primates . JNCI , 65 : 177 – 189 .
  • Teague , C. A. , Gavin , J. B. and Herdson , P. B. 1981 . The response of three inbred strains of rat to the carcinogen, 1,2‐dimethylhydrazine . Pathology , 13 : 473 – 485 .
  • Topping , D. C. and Visek , W. J. 1976 . Nitrogen intake and tumorigenesis in rats injected with 1,2‐dimethylhydrazine . J. Nutr. , 106 : 1583 – 1587 .
  • Toth , B. 1972 . Tumorogenesis studies with 1,2‐dimethylhydrazine‐dihydrochloride, hydrazine sulfate and isonicohnic acid in golden hamsters . Cancer Res. , 32 : 804 – 807 .
  • Toth , B. 1977 . The large bowel carcinogenic effects of hydrazines and related compounds occurring in nature and in the environment . Cancer , 40 (5 Suppl.) : 2427 – 2431 .
  • Toth , B. and Patil , K. 1982 . A carcinogenicity dose response study by continuous administration of 1,2‐dimethylhydrazine‐dihydrochloride in mice . Anticancer Res. , 2 : 365 – 368 .
  • Toth , B. , Malick , L. and Shimizu , H. 1976 . Production of intestinal and other tumors by 1,2‐ dimethylhydrazine‐dihydrochloride in mice. I. Light and transmission electron microscopic study of colonic neoplasms . Am. J. Pathol. , 84 : 69 – 86 .
  • Toth , B. and Wilson , R. B. 1971 . Blood vessel tumorigenesis by 1,2‐dimethylhydrazine‐ dihydrochloride (symmetrical)—gross, light and electron microscopic descriptions . Am. J. Pathol. , 64 : 585 – 600 .
  • Turusov , V. S. , Lanko , N. S. , Krutovskikh , V. A. and Parfenov , Y. D. 1982 . Strain differences in susceptibility of female mice to 1,2‐dimethylhydrazine . Carcinogenesis , 3 : 603 – 608 .
  • Ward , J. M. , Goodman , D. G. , Squire , R. A. , Chu , K. C. and Linhart , M. S. 1979 . Neoplastic and nonneoplastic lesions in aging (C57BL/6N × C3H/HeN)F1 (B6C3F1) mice . J. Natl. Can. Inst. , 63 : 849 – 854 .
  • Witkin , L. B. 1956 . Acute toxicity of hydrazine and some of its methylated derivatives . AMA Arch. Ind. Health , 13 : 34 – 36 .
  • Williams , W. L. and Oliver , R. I. 1961 . The relation of dietary fat to hepatic lipidosis and myocardial damage in mice . Anat. Rec. , 141 : 97 – 107 .
  • Zedeck , M. S. 1984 . “ Hydrazine derivatives, azo and azoxy compounds, and methylazoxymethanol and cycasin ” . In Chemical Carcinogens , 2nd ed. , Edited by: Searle , C. E. 915 – 944 . Washington, D.C. : American Chemical Society . Monograph 182
  • Zedeck , M. S. , Sternberg , S. S. , Poynter , R. W. and McGowan , J. 1970 . Biochemical and pathological effects of methylazoxymethanol acetate, a potent carcinogen . Cancer Res. , 30 : 801 – 812 .
  • Zedeck , M. S. , Sternberg , S. S. , Yataganas , X. and McGowan , Y. 1974 . Early changes induced in rat liver by methylazoxymethanol acetate: mitotic abnormalities and polyploidy . J. Natl. Cancer Inst. , 53 : 719 – 724 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.