51
Views
95
CrossRef citations to date
0
Altmetric
Session III. Genetic and molecular markers—susceptibility

Regiospecific expression of cytochrome P‐450s and microsomal epoxide hydrolase in human brain tissue

&
Pages 317-335 | Published online: 19 Oct 2009

References

  • Bhambre , S. , Anandatheerthavarada , H. K. , Shankar , S. K. and Ravindranath , V. 1992 . Microsomal cytochrome P450 in human brain regions . Biochem. Pharmacol. , 44 : 1223 – 1225 .
  • Calne , D. B. , McGeer , E. , Eisen , A. and Spencer , P. 1986 . Alzheimer's disease, Parkinson's disease and motor neuron disease: Abiotropic interaction between aging and environment? . Lancet , 11 : 1067 – 1070 .
  • Chomczynski , P. and Sacchi , N. 1987 . Single‐step method of RNA isolation by acid guanidinium thio‐cyanate‐phenol‐chloroform extraction . Anal. Biochem. , 162 : 156 – 159 .
  • Crespi , C. I. , Penman , B. W. , Gelboin , H. V. and Gonzalez , F. J. 1991 . A tobacco smoke‐derived nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6 . Carcinogenesis , 12 : 1197 – 1201 .
  • deWaziers , I. , Cugnenc , P. H. , Yang , C. S. , Leroux , J. P. and Beaune , P. H. 1990 . Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extra‐hepatic tissues . J. Pharmacol. Exp. Ther. , 253 : 387 – 394 .
  • Dey , A. , Westphal , H. and Nebert , D. W. 1989 . Cell‐specific induction of mouse Cyplal mRNA during development . Proc. Natl. Acad. Sci. USA , 86 : 7446 – 7450 .
  • Dislerath , L. M. and Guengerich , F. P. 1987 . “ Enzymology of human cytochromes P‐450 ” . In Mammalian Cytochrome P‐450 , Edited by: Guengerich , F. P. 1 – 54 . Boca Raton, Fla. : CRC Press .
  • Ghersi‐Egea , J. F. , Walther , B. , Perrin , R. , Minn , A. and Siest , G. 1987 . Inducibility of rat drug‐metabolizing enzymes . Bur. J. Drug Metab. Pharmacokinet. , 12 : 263 – 265 .
  • Ghersti‐Egea , J. , Minn , A. and Siest , G. 1988 . A new aspect of the protective functions of the blood‐brain barrier: Activities of four drug‐metabolizing enzymes in isolated rat brain microvessels . Life Sci. , 42 : 2515 – 2523 .
  • Goldstein , J. A. and Linko , P. 1984 . Differential induction of two 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin‐inducible forms of cytochrome P‐450 in extrahepatic versus hepatic tissues . Mol. Pharmacol. , 20 : 185 – 191 .
  • Gonzalez , F. J. 1989 . The molecular biology of cytochrome P450s . Pharmacol. Rev. , 40 : 243 – 288 .
  • Gram , T. E. , Okine , L. K. and Gram , R. A. 1986 . The metabolism of xenobiotics by certain extrahepatic organs and its relation to toxicity . Annu. Rev. Pharmacol. Toxicol. , 26 : 259 – 291 .
  • Guengerich , F. P. 1988 . Roles of cytochrome P‐450 enzymes in chemical carcinogenesis and cancer chemotherapy . Cancer Res. , 48 : 2946 – 2954 .
  • Guengerich , F. P. and Mason , P. S. 1979 . Immunological comparison of hepatic and extrahepatic cytochromes. P‐450 . Mol. Pharmacol. , 15 : 154 – 164 .
  • Guengerich , P. F. and Turvy , C. G. 1991 . Comparison of levels of several human microsomal cytochrome P‐450 enzymes and epoxide hydrolase in normal and disease states using immuno‐chemical analysis of surgical liver samples . J. Pharmacol. Exp. Ther. , 256 : 1189 – 1194 .
  • Guengerich , P. F. , Martin , M. V. , Beaune , P. H. , Kremers , P. , Wolff , T. and Waxman , D. J. 1986a . Characterization of rat and human liver microsomal cytochrome P‐450 forms involved in nifedi‐pine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism . J. Biol. Chem. , 261 : 5051 – 5060 .
  • Guengerich , P. , Muller‐Enoch , D. and Blair , I. A. 1986b . Oxidation of quinidine by human liver cytochrome P‐450 . Mol. Pharmacol. , 30 : 287 – 295 .
  • Hansson , T. , Tindberg , N. , Ingelman‐Sundberg , M. and Kohler , C. 1990 . Regional distribution of ethanol‐inducible cytochrome P450 IIE1 in the rat central nervous system . Neuroscience , 34 : 451 – 463 .
  • Ikeya , K. , Jaiswal , A. K. , Owens , R. A. , Jones , J. E. , Nebert , D. W. and Kimura , S. 1989 . Human CYP1A2: Sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression . Mol. Endocrinol. , 3 : 1399 – 1406 .
  • Jaiswal , A. K. , Gonzalez , F. J. and Nebert , D. W. 1985 . Human P1–450 gene differences in benzo[alpyrene metabolism . Nucleic Acids Res. , 13 : 4503 – 4519 .
  • Jayyosi , Z. , Cooper , K. O. and Thomas , P. E. 1992 . Brain cytochrome P450 and testosterone metabolism by rat brain subcellular fractions: Presence of cytochrome P450 3A immunoreactive protein in rat brain mitochondria . Arch. Biochem. Biophys. , 298 : 265 – 270 .
  • Johansson , I. and Ingelman‐Sundberg , M. 1985 . Carbon tetrachloride‐induced lipid peroxidation dependent on an ethanol‐inducible form of rabbit liver microsomal cytochrome P‐450 . FEBS Lett. , 183 : 265 – 269 .
  • Kamataki , T. , Maeda , K. , Yamazoe , Y. , Matsuda , N. , Ishii , K. and Kato , R. 1983 . A high‐spin form of cytochrome P‐450 highly purified from polychlorinated biphenyl‐treated rats . Mol. Pharmacol. , 24 : 146 – 155 .
  • Kapitulnik , J. , Gelboin , H. V. , Guengerich , F. P. and Jacobowitz , D. M. 1987 . Immunohistochemical localization of cytochrome P‐450 in rat brain . Neuroscience , 20 : 829 – 833 .
  • Kimura , S. , Gonzalez , F. J. and Nebert , D. W. 1986 . Tissue‐specific expression of the mouse dioxin‐inducible P,450 and P3450 genes: Differential transcriptional activation and mRNA stability in liver and extrahepatic tissues . Mol. Cell. Biol. , 6 : 1471 – 1477 .
  • Kitada , M. , Taneda , M. , Ohi , H. , Komori , M. , Itahashi , K. , Nagao , M. and Kamataki , T. 1989 . Mutagenic activation of aflatoxin B1 by P‐450 HFLa in human fetal livers . Mutat. Res. , 227 : 53 – 58 .
  • Kohler , C. , Eriksson , L. G. , Hansson , T. , Warner , M. and Gustafsson , J. 1988 . Immunohistochemical localization of cytochrome P‐450 in the rat brain . Neurosci. Lett. , 84 : 109 – 114 .
  • Koop , D. R. and Casazza , J. P. 1985 . Identification of ethanol‐inducible P‐450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes . J. Biol. Chem. , 260 : 13607 – 13612 .
  • Koop , D. R. , Orlandi , C. L. and Schnier , G. G. 1988 . Ethanol‐inducible P450 isozyme 3a is a benzene hydroxylase . FASEB J. , 2 : A1012
  • Kronbach , T. , Fisher , V. and Meyer , U. A. 1988 . Cyclosporine metabolism in human liver: identification of a cytochrome P‐450III gene family and the major cyclosporine‐metabolizing enzyme explains interactions of cyclosporine with other drugs . Clin. Pharmacol. Ther. , 43 : 630 – 635 .
  • McDonnell , W. M. , Scheiman , J. M. and Traber , P. G. 1992 . Induction of cytochrome P450IA genes (CYP1 A) by omeprazple in the human alimentary tract . Castroenterology , 103 : 1509 – 1516 .
  • Morgan , E. T. , Koop , D. R. and Coon , M. J. 1982 . Catalytic activity of cytochrome P‐450 isozyme 3a isolated from liver microsomes of ethanol‐treated rabbits: oxidation of alcohols . J. Biol. Chem. , 257 : 13951 – 13957 .
  • Morgan , E. T. , Koop , D. R. and Coon , M. J. 1983 . Comparison of six rabbit liver cytochrome P‐450 isozymes in formation of a reactive metabolite of acetaminophen . Biochem. Biophys. Res. Commun. , 112 : 8 – 13 .
  • Niznik , H. B. , Tyndale , R. F. , Sallee , F. R. , Gonzalez , F. J. , Hardwick , J. P. , Inaba , T. and Kalow , W. 1990 . The dopamine transporter and cytochrome P450IIDI (debrisoquine 4‐hydroxylase) in brain: Resolution and identification of two distinct [3H]GBR‐12935 binding proteins . Arch. Biochem. Biophys. , 276 : 424 – 432 .
  • Oesch , F. , Glatt , H. and Schmassmann , H. 1977 . The apparent ubiquity of epoxide hydratase in rat organs . Biochem. Pharmacol. , 26 : 603 – 607 .
  • Omiecinski , C. J. , Redlich , C. A. and Costa , P. 1990a . Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction . Cancer Res. , 50 : 4315 – 4321 .
  • Omiecinski , C. J. , Hassett , C. and Costa , P. 1990b . Developmental expression and in situ localization of the phenobarbital‐inducible rat hepatic mRNAs for cytochromes CYP2B1, CPY2B2, CYP2C6, and CYP3A1 . Mol. Pharmacol. , 38 : 462 – 470 .
  • Pelkonen , O. and Nebert , D. W. 1982 . Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis . Pharmacol. Rev. , 34 : 189 – 222 .
  • Perrin , R. , Minn , A. , Ghersi‐Egea , J. F. , Grassiot , M. C. and Siest , G. 1990 . Distribution of acytochrome P450 activities towards alkoxyresorufin derivatives in rat brain regions, subcellular fractions and isolated cerebral microvessels . Biochem. Pharmacol. , 40 : 2145 – 2151 .
  • Preston‐Martin , S. , Yu , M. C. , Benton , B. and Henderson , B. E. 1982 . N‐Nitroso compounds and childhood brain tumors: A case‐control study . Cancer Res. , 42 : 5240 – 5245 .
  • Ravindranath , V. and Anandatheerthavarada , H. K. 1989a . High activity of cytochrome P‐450 linked aminopyrine N‐demethylase in mouse brain microsomes and associated sex‐related difference . Biochem. J. , 261 : 769 – 773 .
  • Ravindranath , V. , Anandatheerthavarada , H. K. and Shankar , S. K. 1989b . Xenobiotic metabolism in human brain—Presence of cytochrome P‐450 and associated mono‐oxygenases . Brain Res. , 496 : 331 – 335 .
  • Ravindranath , V. , Anandatheerthavarada , H. K. and Shankar , S. K. 1990 . NADPH cytochrome P‐450 reductase in rat, mouse and human brain . Biochem. Pharmacol. , 39 : 1013 – 1018 .
  • Seidegard , J. and DePierre , J. 1983 . Microsomal epoxide hydrolase properties, regulation and function . Biochem. Biophys. Acta , 695 : 251 – 270 .
  • Sugita , O. , Miyairi , S. , Sassa , S. and Kappas , A. 1987 . Partial purification of cytochrome P450 from rat brain and demonstration of estradiol hydroxylation . Biochem. Biophys. Res. Commun. , 147 : 1245 – 1250 .
  • Terelius , Y. , Norsten‐Hoog , C. , Cronholm , T. and Ingelman‐Sunberg , M. 1991 . Acetaldehyde as a substrate for ethanol‐inducible cytochrome P450 (CYP2E1) . Biochem. Biophys. Res. Commun. , 179 : 689 – 694 .
  • Warner , M. , Kohler , C. , Hansson , T. and Gustafsson , J. 1988 . Regional distribution of cytochrome P‐450 in the rat brain: spectral quantitation and contribution of P‐450b,e and P‐450c,d . J. Neurochem. , 50 : 1057 – 1065 .
  • Watkins , P. B. , Wrighton , S. A. , Schuetz , E. G. , Molowa , D. T. and Guzelian , P. S. 1987 . Identification of glucocorticoid‐inducible cytochromes P‐450 in the intestinal mucosa of rats and man . J. Clin. Invest. , 80 : 1029 – 1036 .
  • Waxman , D. J. , Attisano , C. , Geungerich , F. P. and Lapenson , D. P. 1988 . Human liver microsomal steroid metabolism: Identification of the major steroid hormone 6 β‐hydroxylase cytochrome P‐450 enzyme . Arch. Biochem. Biophys. , 263 : 424 – 436 .
  • Wood , A. W. , Levin , W. , Lu , A. Y. H. , Yagi , H. , Hernandez , O. , Jerina , D. M. and Conney , A. H. 1976 . Metabolism of benzo[a]pyrene and benzo[a]pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes . J. Biol. Chem. , 251 : 4882 – 4890 .
  • Yang , S. K. , McCourt , D. W. , Leutz , J. C. and Gelboin , H. V. 1977 . Benzo[a]pyrene diol epoxides: Mechanism of enzymatic formation and optically active intermediates . Science , 196 : 1199 – 1201 .
  • Yang , C. S. , Tu , Y. Y. , Koop , D. R. and Coon , M. J. 1985 . Metabolism of nitrosamines by purified rabbit liver cytochrome P‐450 isozymes . Cancer Res. , 45 : 1140 – 1145 .
  • Yoo , J. S. H. , Guengerich , P. F. and Yang , C. S. 1988 . Metabolism of N‐nitrosodialkylamines by human liver microsomes . Cancer Res. , 88 : 1499 – 1504 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.