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Original Articles

Evaluation of di(2‐ethylhexyl)phthalate‐induced embryotoxicity in rodent whole‐embryo culture

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Pages 361-367 | Received 21 Jan 1994, Accepted 08 Apr 1994, Published online: 20 Oct 2009

References

  • Brown , N. A. and Fabro , S. 1981 . Quantitation of rat embryonic development in vitro: A morphological scoring system . Teratology , 24 : 65 – 78 .
  • Dirven , H. A. A. M. , Van Den Broek , P. H. H. , Arends , A. M. M. , Nordkamp , H. H. , De Lepper , A. J. G. M. , Henderson , P. Th. and Jongeneelen , F. J. 1993a . Metabolites of the plasticizer di(2‐ethylhexyl)phthalate in urine samples of workers in Polyvinylchloride processing industries . Int. Arch. Occup. Environ. Health , 64 : 549 – 554 .
  • Dirven , H. A. A. M. , Van Den Broek , P. H. H. and Jongeneelen , F. J. 1993b . Determination of four metabolites of the plasticizer di(2‐ethylhexyl)phthalate in human urine samples . Int. Arch. Occup. Environ. Health , 64 : 555 – 560 .
  • Field , E. A. , Price , C. J. , Sleet , R. B. , George , J. D. , Marr , M. C. , Myers , C. B. , Schwetz , B. A. and Morrissey , R. E. 1993 . Developmental toxicity evaluation of diethyl and dimethyl phthalate in rats . Teratology , 48 : 33 – 44 .
  • Grafton , T. F. , Bazare , J. J. , Hansen , D. K. and Sheehan , D. M. 1987 . The in vitro embryotoxicity of 5‐fluorouracil in rat embryos . Teratology , 36 : 371 – 377 .
  • Jaeger , R. J. and Rubin , R.J. 1970 . Plasticizers from plastic devices: Extraction, metabolism, and accumulation by biological systems . Science , 170 : 460 – 462 .
  • Labarca , C. and Paigen , K. 1980 . A simple, rapid, and sensitive DNA assay procedure . Anal. Biochem. , 102 : 344 – 352 .
  • Lewandowski , M. , Fernandes , J. and Chen , T. S. 1980 . Assessment of the teratogenic potential of plasma‐soluble extracts of diethylhexyl phthalate plasticized polyvinyl chloride plastics in rats . Toxicol. Appl. Pharmacol. , 54 : 141 – 147 .
  • Lowry , O. H. , Rosebrough , N. J. , Farr , A. L. and Randall , R. J. 1951 . Protein measurement with the Folin phenol reagent . J. Biol. Chem. , 193 : 265 – 275 .
  • Mes , J. , Coffin , D. E. and Campbell , D. S. 1974 . Di‐n‐butyl phthalate and di‐2‐ethylhexyl phthalate in human adipose tissue . Bull. Environ. Contam. Toxicol. , 12 : 721 – 725 .
  • New , D. A. T. 1978 . Whole embryo culture and the study of mammalian embryos during organogenesis . Biol. Rev. , 53 : 81 – 122 .
  • Nikonorow , M. , Mazur , H. and Piekacz , H. 1973 . Effect of orally dministered plasticizers and polyvinyl chloride stabilizers in the rat . Toxicol. Appl. Pharmacol. , 26 : 253 – 259 .
  • Parkhie , M. R. , Webb , M. and Norcross , M. A. 1982 . Dimethoxyethyl phthalate: Embryopathy, teratogenicity, fetal metabolism and the role of zinc in the rat . Environ. Health Perspect. , 45 : 89 – 97 .
  • Peakall , D. B. 1975 . Phthalate esters: Occurrence and biological effects . Residue Res. , 54 : 1 – 41 .
  • Plasterer , M. R. , Bradshaw , W. S. , Booth , G. M. , Carter , M. W. , Schuler , R. L. and Hardin , B. D. 1985 . Developmental toxicity of nine selected compounds following prenatal exposure in the mouse: Naphthalene, p‐nitrophenol, sodium selenite, dimethyl phthalate, ethylenethiourea, and four glycol ether derivatives . J. Toxicol. Environ. Health , 15 : 25 – 38 .
  • Ritter , E. J. , Scott , W. J. Jr. , Randall , J. L. and Ritter , J. M. 1987 . Teratogenicity of di(2‐ethylhexyl) phthalate, 2‐ethylhexanol, 2‐ethylhexanoic acid, and valproic acid, and potentiation by caffeine . Teratology , 35 : 41 – 46 .
  • Ruddick , J. A. , Villeneuve , D. C. , Chu , I. , Nestmann , E. and Miles , D. 1981 . An assessment of the teratogenicity in the rat and mutagenicity In Salmonella of mono‐2‐ethylhexyl phthalate . Bull. Environ. Contam. Toxicol. , 27 : 181 – 186 .
  • Shiota , K. , Chou , M. J. and Nishimura , H. 1980 . Embryotoxic effects of di‐2‐ethylhexyl phthalate (DEHP) and di‐n‐butyl phthalate (DBP) in mice . Environ. Res. , 22 : 245 – 253 .
  • Singh , A. R. , Lawrence , W. H. and Autian , J. 1972 . Teratogenicity of phthalate esters in rats . J. Pharm. Sci. , 61 : 51 – 55 .
  • Singh , A. R. , Lawrence , W. H. and Autian , J. 1975 . Maternal‐fetal transfer of 14C‐di‐2‐ethylhexyl phthalate and 14C‐diethyl phthalate in rats . J. Pharm. Sci. , 64 : 1347 – 1350 .
  • Thomas , J. A. and Thomas , M. J. 1984 . Biological effects of di‐(2‐ethylhexyl)phthalate and other phthalic acid esters . Crit. Rev. Toxicol. , 13 : 283 – 317 .
  • Tomita , M. I. , Nakamura , Y. , Yagi , Y. and Tutikawa , K. 1982 . Teratogenicity/fetotoxicity of DEHP in mice . Environ. Health Perspect. , 45 : 71 – 75 .
  • Tyl , R. W. , Price , C. J. , Marr , M. C. and Kimmel , C. A. 1988 . Developmental toxicity evaluation of dietary di(2‐ethylhexyl)phthalate in Fischer 344 rats and CD‐1 mice . Fundam. Appl. Toxicol. , 10 : 395 – 412 .
  • Yagi , Y. , Nakamura , Y. , Tomita , I. , Tsuchikawa , K. and Shimoi , N. 1980 . Teratogenic potential of di‐and mono‐(2‐ethylhexyl)phthalate in mice . J. Environ. Pathol. Toxicol. , 4 : 533 – 544 .

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