6
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Time‐dependent effects of o‐xylene on rat lung and liver microsomal membrane structure and function

, , &
Pages 469-481 | Received 05 Jan 1994, Accepted 29 Apr 1994, Published online: 19 Oct 2009

References

  • Agency for Toxic Substances and Disease Registry . 1990 . Toxicological Profile for Total Xylenes , U.S. Department of Health and Human Services, Public Health Service .
  • Bligh , E. G. and Dyer , W. J. 1959 . A rapid method for total lipid extraction and purification . Can. J. Bhchem. Physiol. , 37 : 911 – 917 .
  • Burke , M. D. , Thompson , S. , Elcombe , C. R. , Halpert , J. , Haaparanta , T. and Mayer , R. T. 1985 . Ethoxy‐, pentoxy‐, and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P‐450 . Biochem. Pharmacol. , 34 : 3337 – 3345 .
  • Day , B. J. and Carlson , G. P. 1992 . Effect of p‐xylene metabolites, p‐methylbenzyl alcohol and 2,5‐dimethylphenol, on rat hepatic and pulmonary microsomal metabolism . Res. Commun. Chem. Pathol. Pharmacol. , 76 : 117 – 120 .
  • Day , B. J. , DeNicola , D. B. , Marcus , C. B. and Carlson , C. P. 1992 . Effect of p‐xylene inhalation on the bioactivation of bromobenzene in rat lung and liver . Fundam. Appl. Toxicol. , 19 : 50 – 56 .
  • Elovaara , E. 1982 . Dose related effects of m‐xylene inhalation on the xenobiotic metabolism in the rat . Xenobiotica , 12 : 345 – 352 .
  • Elovaara , E. , Collan , Y. , Pfaffli , P. and Vainio , H. 1980 . The combined toxicity of technical grade xylene and ethanol in rat . Xenobiotica , 10 : 435 – 445 .
  • Estabrook , R. W. , Peterson , J. , Baron , J. and Hildebrandt , A. 1972 . “ The spectrophotometric measurement of turbid suspensions of cytochromes associated with drug metabolism ” . In Methods in pharmacology , Edited by: Chingell , C. F. vol. II , 303 – 350 . New York : Meredith .
  • Foy , J. W.‐D. , Silverman , D. M. and Schatz , R. A. 1993 . Effects of m‐xylene inhalation on cytochrome P450 ¡sozymes in rat lung and liver . Toxicologist , 13 : 364
  • Furman , G. M. , Stickney , J. A. and Schatz , R. A. 1989 . Organic solvent toxicity in rat pulmonary micro‐somes: Role of metabolic aldehyde formation in vivo . Toxicologist , 9 : 251
  • Gerarde , H. W. 1959 . Toxicological studies on hydrocarbons. III. The biochemorphology of the phenyl‐alkanes and phenylalkenes . AMA Arch. Ind. Health , 19 : 403 – 418 .
  • Gonzalez , F. J. and Kasper , C. B. 1982 . Cloning of DNA complementary to rat liver NADPH‐cytochrome c (P‐450) oxidoreductase and cytochrome P‐450 mRNAs . J. Biol. Chem. , 257 : 5962 – 5968 .
  • Gordon , L. M. , Sauerheber , R. D. , Esgate , J. A. , Dipple , I. , Marchmont , R. J. and Houslay , M. D. 1980 . The increase in bilayer fluidity of rat liver plasma membrane achieved by the local anesthetic benzyl alcohol affects the activity of intrinsic membrane enzymes . J. Biol. Chem. , 255 : 4519 – 4527 .
  • Guberan , E. , Usel , M. , Raymond , L. , Tissot , R. and Sweetnam , P. M. 1989 . Disability, mortality, and incidence of cancer among Geneva painters and electricians: A historical prospective study . Br. J. Ind. Med. , 45 : 16 – 23 .
  • Gut , J. , Kawato , S. , Cherry , R. J. , Winterhalter , K. H. and Richter , C. 1985 . Lipid peroxidation decreases the rational mobility of cytochrome P‐450 in rat microsomes . Biochim. Biophys. Acta , 817 : 217 – 227 .
  • Hess , H. H. and Derr , J. E. 1975 . Assay of inorganic phosphorous in the 0.1–5 nmol range . Anal. Biochem. , 63 : 607 – 613 .
  • Ioannides , C. and Parke , D. V. 1987 . The cytochromes P‐448—a unique family of enzymes involved in chemical toxicology and carcinogenesis . Biochem. Pharmacol. , 36 : 4197 – 4207 .
  • James , M. O. and Bend , J. R. 1978 . A radiochemical assay for glycine N‐acyltransferase activity: Some properties of the enzyme in rat and rabbit . Biochem. J. , 172 : 285 – 293 .
  • Kaliss , D. and Pressman , D. 1950 . Plasma and blood volumes of mouse organs as determined with radioactive iodoproteins . Proc. Soc. Exp. Biol. Med. , 75 : 16 – 20 .
  • Kelsey , K. T. , Wiencke , J. K. , Little , F. F. , Baker , E. L. and Little , J. B. 1989 . Sister chromatid exchange in painters recently exposed to solvents . Environ. Res. , 50 : 248 – 255 .
  • LeBel , C. P. and Schatz , R. A. 1989 . Toluene‐induced alterations in rat synaptosomal membrane composition and function . J. Biochem. Toxicol. , 3 : 279 – 293 .
  • Lowry , O. H. , Rosebrough , N. J. , Farr , A. L. and Randall , R. J. 1951 . Protein measurement with the Folin phenol reagent . J. Biol. Chem. , 193 : 265 – 275 .
  • Nakajima , T. , Wang , R.‐S. , Elovaara , E. , Park , S. S. , Gelboin , H. V. , Hietanen , E. and Vaino , H. 1990 . Monoclonal antibody‐directed characterization of cytochrome P‐450 isozymes responsible for toluene metabolism in rat liver . Biochem. Pharmacol. , 41 : 395 – 404 .
  • Nebert , D. W. and Gelboin , H. V. 1968 . Substrate induced microsomal arylhydrocarbon hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme . J. Biol. Chem. , 253 : 6242 – 6249 .
  • Ohyashiki , T. , Ohtsuka , T. and Mohri , T. 1986 . A change in the lipid fluidity of the porcine intestinal brush‐border membranes by lipid peroxidation. Studies using pyrene and fluorescent stearic acid derivatives . Biochem. Biophys. Acta , 861 : 311 – 318 .
  • Omura , T. and Sato , R. 1964 . The carbon monoxide binding pigment of liver microsomes. I. Evidence for its hemoprotein nature . J. Biol. Chem. , 239 : 2370 – 2378 .
  • Parandoosh , Z. , Fujita , V. S. , Coon , M. J. and Philpot , R. M. 1987 . Cytochrome P‐450 isozymes 2 and 5 in rabbit lung and liver. Comparison of structure and inducibility . Drug Metab. Dispos. , 15 : 59 – 67 .
  • Park , S.‐H. , Silverman , D. M. and Schatz , R. A. 1993 . Effect of low level (300 ppm) 1 day inhalation of o‐xylene on in vitro BaP metabolism and BaP‐DNA adduct formation . Toxicologist , 12 : 366
  • Patel , J. M. , Wolf , C. T. and Philpot , R. M. 1979 . Interaction of 4‐methylbenzaldehyde with rabbit pulmonary cytochrome P‐450 in the intact animal, microsomes, and purified systems . Biochem. Pharmacol. , 28 : 2031 – 2036 .
  • Pathiratne , A. , Puyear , R. and Brammer , J. D. 1986 . A comparative study of the effects of benzene, toluene and xylenes on their in vitro metabolism and drug metabolizing enzymes in rat liver . Toxicol. Appl. Pharmacol. , 82 : 272 – 280 .
  • Philpot , R. M. and Smith , B. R. 1984 . Role of cytochrome P‐450 and related enzymes in the pulmonary metabolism of xenobiotics . Environ. Health Perspect. , 55 : 359 – 367 .
  • Pyyko , K. 1980 . Effects of methylbenzenes on microsomal enzymes in rat liver, kidney and lung . Biochim. Biophys. Acta , 633 : 1 – 9 .
  • Pyyko , K. 1983 . Time‐course of effects of toluene on microsomal enzymes in rat liver, kidney and lung during and after inhalation exposure . Chem. Biol. Interact. , 44 : 299 – 310 .
  • Pyyko , K. , Paavilainen , S. , Mesta‐Ketela , T. and Laustiola , K. 1987 . The increasing and decreasing effects of aromatic hydrocarbon solvents on pulmonary and hepatic cytochrome P‐450 in the rat . Pharmacol. Toxicol. , 60 : 288 – 293 .
  • Rettie , A. E. , Williams , F. M. , Rawlins , M. D. , Mayert , R. T. and Burke , M. D. 1986 . Major differences between lung, skin and liver in the microsomal metabolism of homologous series of resorufin and coumarin ethers . Biochem. Pharmacol. , 35 : 3495 – 3500 .
  • Roberts , A. E. , Bogdanffy , M. S. , Brown , D. R. and Schatz , R. A. 1986 . Lung metabolism of benzo(a)pyrene in rats treated with p‐xylene and/or ethanol . J. Toxicol. Environ. Health , 18 : 257 – 266 .
  • Roberts , A. E. , LeBel , C. P. , Stickney , J. A. , Silverman , D. M. , Brown , D. R. and Schatz , R. A. 1988 . Changes in rat lung microsomal lipids after p‐xylene: Relationship to inhibition of benzo(a)pyrene metabolism . J. Toxicol. Environ. Health , 25 : 479 – 494 .
  • Rudel , L. L. and Morris , M. D. 1973 . Determination of cholesterol using o‐phthalaldehyde . J. Lipid Res. , 14 : 364 – 366 .
  • Seybert , D. W. 1990 . Lipid regulation on bovine cytochrome P450 11B activity . Arch. Biochem. Biophys. , 279 : 188 – 194 .
  • Shean , K. and Paine , A. J. 1990 . Immunochemical quantitation of cytochrome P450IA and IIB subfamilies in the livers of metyrapone‐treated rats . Biochem. J. , 267 : 715 – 719 .
  • Silverman , D. M. and Schatz , R. A. 1991 . Pulmonary microsomal alterations following short‐term low level inhalation of p‐xylene in rats . Toxicology , 65 : 271 – 281 .
  • Silverman , D. M. , Stickney , J. , Fisher , B. and Schatz , R. A. 1991 . The role of p‐tolualdehyde in p‐xylene induced pulmonary microsomal damage . Toxicologist , 11 : 318
  • Smith , B. R. , Plummer , J. L. , Wolf , C. R. , Philpot , R. M. and Bend , J. R. 1982 . p‐Xylene metabolism by rabbit lung and liver and its relationship to the selective destruction of pulmonary cytochrome P450 . J. Pharmacol. Exp. Ther. , 223 : 736 – 742 .
  • Spector , A. A. 1989 . Polyunsaturated fatty acids and membrane function . Biomembr. Nutr. , 195 : 11 – 20 .
  • Stickney , J. A. , Roberts , A. E. , Silverman , D. M. and Schatz , R. A. 1989 . The effect of m‐xylene on rat lung benzo(a)pyrene metabolism and microsomal membrane lipids: Comparison with p‐xylene . Toxicology , 58 : 155 – 165 .
  • Stickney , J. A. , Silverman , D. M. and Schatz , R. A. 1990 . Role of isozyme specific inhibition of cytochrome P‐450 activity in m‐xylene‐induced alterations in rat lung benzo(a)pyrene metabolism . Toxicologist , 10 : 121
  • Stickney , J. A. , Silverman , D. M. and Schatz , R. A. 1991 . Inhibition of cytochrome P‐450 isozymes by m‐xylene and its metabolite m‐tolualdehyde in rat lung microsomes . Toxicologist , 11 : 317
  • Strobel , H. W. , Lu , A. Y. U. , Heidema , J. and Coon , M. J. 1970 . Phosphatidylcholine requirement in the enzymatic reduction of hemoprotein P‐450 and in fatty acid, hydrocarbon, and drug hydroxylation . J. Biol. Chem. , 245 : 4851 – 4654 .
  • Toftgard , R. and Nilsen , O. G. 1982 . Effects of xylene and xylene isomers on cytochrome P‐450 and in vitro enzymatic activities in rat liver, kidney and lung . Toxicology , 23 : 197 – 212 .
  • Toftgard , R. , Halpert , J. and Gustafsson , J. A. 1982 . Xylene induces a cytochrome P‐450 isozyme in rat liver similar to the major enzyme induced by phenobarbital . Mol. Pharmacol. , 23 : 265 – 271 .
  • Verschoyle , R. D. , Dinsdale , D. and Wolf , C. R. 1992 . Inhibition and induction of cytochrome P450 isozymes in rat lung . J. Pharmacol. Exp. Ther. , 265 : 386 – 391 .
  • Vore , M. , Lu , A. Y. U. , Kuntzman , R. and Conney , A. H. 1974 . Organic solvent extraction of liver microsomal lipid. II. Effect on the metabolism of substrates and binding spectra of cytochrome P‐450 . Mol. Pharmacol. , 10 : 963 – 974 .
  • Ward , P. A. , Till , G. O. , Hatherill , J. R. , Annesley , T. M. and Kunkel , R. G. 1985 . Systemic complement activation, lung injury and products of lipid peroxidation . J. Clin. Invest. , 76 : 517 – 527 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.