Protein‐bound pyrroles in rat hair following subchronic intraperitoneal injections of 2,5‐hexanedione

References

• Abou‐Donia , M. B. , Makkawy , H. M. and Graham , D. G. 1982 . The relative neurotoxicities of n‐hexane, methyl n‐butyl ketone, 2,5‐hexanediol, and 2,5‐hexanedione following oral or intraperitoneal administration in hens . Toxicol. Appl. Pharmacol. , 62 : 369 – 389 .
   PubMed Web of Science ®Google Scholar
• Abou‐Donia , M. B. , Lapadula , D. M. , Campbell , G. M. and Abdo , K. M. 1985a . The joint neurotoxic action of inhaled methyl butyl ketone vapor and dermally applied O‐ethyl O‐4‐nitrophenyl phenyl‐phosphonothioate in hens: Potentiating effect . Toxicol. Appl. Pharmacol. , 79 : 69 – 82 .
   PubMed Web of Science ®Google Scholar
• Abou‐Donia , M. B. , Makkawy , M. H. and Campbell , G. M. 1985b . The pattern of neurotoxicity produced by dermal application of n‐hexane, methyl n‐butyl ketone, 2,5‐hexanediol, and 2,5‐hexanedione alone and in combination with O‐ethyl O‐4‐nitrophenyl phenylphosphonothioate in hens . J. Toxicol. Environ. Health , 16 : 85 – 100 .
   PubMed Web of Science ®Google Scholar
• Abou‐Donia , M. B. , Hu , Z. , Lapadula , D. M. and Gupta , R. P. 1991 . Mechanisms of joint neurotoxicity of n‐hexane, methyl isobutyl ketone, and O‐ethyl O‐4‐nitrophenyl phenylphosphonothioate (EPN) in hens . J. Pharmacol. Exp. Ther. , 257 : 282 – 289 .
   PubMedGoogle Scholar
• DeCaprio , A. P. 1986 . Mechanisms of in vitro pyrrole adduct autoxidation in 2,5‐hexanedione‐treated protein . Mol. Pharmacol. , 30 : 452 – 458 .
   PubMed Web of Science ®Google Scholar
• DeCaprio , A. P. , Jackowski , S.J. and Regan , K. A. 1987 . Mechanism of formation and quantification of imines, pyrroles, and stable nonpyrrole adducts in 2,5‐hexanedione‐treated protein . Mol. Pharmacol. , 32 : 542 – 548 .
   PubMed Web of Science ®Google Scholar
• DeCaprio , A. P. and O'Neill , E. A. 1985 . Alterations in rat axonal cytoskeletal proteins induced by in vitro and in vivo 2,5‐hexanedione exposure . Toxicol. Appl. Pharmacol. , 78 : 235 – 247 .
   PubMed Web of Science ®Google Scholar
• DeCaprio , A. P. , Olajos , E. J. and Weber , P. 1982 . Covalent binding of a neurotoxic n‐hexane metabolite: Conversion of primary amines to substituted pyrrole adducts by 2,5‐hexanedione . Toxicol. Appl. Pharmacol. , 65 : 440 – 450 .
   PubMed Web of Science ®Google Scholar
• DeCaprio , A. P. , Strominger , N. L. and Weber , P. 1983 . Neurotoxicity and protein binding of 2,5‐hexanedione in the hen . Toxicol. Appl. Pharmacol. , 68 : 297 – 307 .
   PubMedGoogle Scholar
• Ebling , F. J. G. , Hale , P. A. and Randall , V. A. 1991 . “ Hormones and hair growth ” . In Physiology, biochemistry, and molecular biology of the skin , Edited by: Goldsmith , L. A. 660 – 696 . New York : Oxford University Press .
   Google Scholar
• Gibson , K. D. , Neuberger , A. and Scott , J. J. 1955 . The purification and properties of y‐aminolaevulinic acid dehydrase . Biochem. J. , 61 : 618 – 629 .
   PubMed Web of Science ®Google Scholar
• Gillespie , J. M. 1991 . “ The structural proteins of hair: Isolation, characterization, and regulation of biosynthesis ” . In Physiology, biochemistry, and molecular biology of the skin , Edited by: Goldsmith , L. A. 625 – 659 . New York : Oxford University Press .
   Google Scholar
• Graham , D. G. , Anthony , D. C. , Boeketheide , K. , Maschmann , N. A. , Richards , R. G. , Wolfram , J. W. and Shaw , B. R. 1982 . Studies on the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivation of lysyl residues leads to protein crosslinking . Toxicol. Appl. Pharmacol. , 64 : 415 – 422 .
   PubMed Web of Science ®Google Scholar
• Johnson , D. J. , Lack , L. and Abou‐Donia , M. B. 1994 . “ Hair as a target tissue for developing a biological marker for precursors to 2,5‐hexanedione ” . In Biomarkers of human exposure to pesticides , ACS Symposium Series 542 Edited by: Saleh , M. A. , Blancato , J. N. and Nauman , C. H. 125 – 132 . Washington, D.C. : American Chemical Society .
   Google Scholar
• Kessler , W. , Heilmaier , H. , Kreuzer , P. , Shen , J. H. , Filser , M. and Filser , J. G. 1990 . Spectrophoto‐metric determination of pyrrole‐like substances in urine of rat and man: an assay for the evaluation of 2,5‐hexanedione formed from n‐hexane . Arch. Toxicol. , 64 : 242 – 246 .
   PubMed Web of Science ®Google Scholar
• Lapadula , D. M. , Irwin , R. D. , Suwita , E. and Abou‐Donia , M. B. 1986 . Crosslinking of neurofilament proteins of rat spinal cord in vivo after administration of 2,5‐hexanedione . J. Neurochem. , 46 : 1843 – 1850 .
   PubMed Web of Science ®Google Scholar
• Lapadula , D. M. , Suwita , E. and Abou‐Donia , M. B. 1988 . Evidence for multiple mechanisms responsible for 2,5‐hexanedione induced neuropathy . Brain Res. , 458 : 123 – 131 .
   PubMedGoogle Scholar
• Lapadula , D. M. , Habig , C. , Gupta , R. P. and Abou‐Donia , M. B. 1991 . Induction of cytochrome P‐450 isozymes by simultaneous inhalation exposure of hens to n‐hexane and methyl isobutyl ketone (MiBK) . Biochem. Pharmacol. , 41 : 877 – 883 .
   PubMed Web of Science ®Google Scholar
• Montagna , W. and Parakkal , P. R. 1974 . “ The pilary apparatus ” . In The structure and function of skin , 172 – 258 . New York : Academic Press .
   Google Scholar
• Spencer , P. S. , Schaumburg , H. H. , Raleigh , R. L. and Terhaar , C. J. 1975 . Nervous system degeneration produced by the industrial solvent methyl n‐butyl ketone . Arch. Neurol. , 32 : 219 – 222 .
   PubMed Web of Science ®Google Scholar