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Articles

Dissociation predicts treatment response in eye-movement desensitization and reprocessing for posttraumatic stress disorder

, MD, PhD, , MD, PhD & , MD, PhD
Pages 112-130 | Received 29 Aug 2014, Accepted 26 Mar 2015, Published online: 14 Dec 2015

References

  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.
  • Asmundson, G. J., Stapleton, J. A., & Taylor, S. (2004). Are avoidance and numbing distinct PTSD symptom clusters? Journal of Traumatic Stress, 17, 467–475. doi:10.1007/s10960-004-5795-7
  • Beck, A. T., Steer, R. A., & Carbin, M. G. (1988). Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation. Clinical Psychology Review, 8(1), 77–100. doi:10.1016/0272-735 8(88)90050-5
  • Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561–571. doi:10.1001/archpsyc.1961.01710120031004
  • Bernstein, E. M., & Putnam, F. W. (1986). Development, reliability, and validity of a dissociation scale. Journal of Nervous and Mental Disorders, 174, 727–735.
  • Bisson, J. I., Roberts, N. P., Andrew, M., Cooper, R., & Lewis, C. (2013). Psychological therapies for chronic post-traumatic stress disorder (PTSD) in adults. Cochrane Database and Systemic Review, 12, CD003388.
  • Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., & Keane, T. M. (1995). The development of a clinician-administered PTSD scale. Journal of Traumatic Stress, 8(1), 75–90. doi:10.1002/jts.2490080106
  • Bradley, R., Greene, J., Russ, E., Dutra, L., & Westen, D. (2005). A multidimensional meta-analysis of psychotherapy for PTSD. American Journal of Psychiatry, 162(2), 214–227. doi:10.1176/appi.ajp.162.2.214
  • Brady, K. T., Dansky, B. S., Back, S. E., Foa, E. B., & Carroll, K. M. (2001). Exposure therapy in the treatment of PTSD among cocaine-dependent individuals: Preliminary findings. Journal of Substance Abuse and Treatment, 21(1), 47–54. doi:10.1016/S0740-5472(01)00182-9
  • Brady, K. T., Killeen, T. K., Brewerton, T., & Lucerini, S. (2000). Comorbidity of psychiatric disorders and posttraumatic stress disorder. Journal of Clinical Psychiatry, 61(Suppl. 7), 22–32.
  • Brand, B. L., McNary, S. W., Myrick, A. C., Classen, C. C., Lanius, R., Loewenstein, R. J., … Putnam, F. W. (2013). A longitudinal naturalistic study of patients with dissociative disorders treated by community clinicians. Psychological Trauma: Theory, Research, Practice, and Policy, 5(4), 301–308. doi:10.1037/a0027654
  • Breslau, N., Davis, G. C., Andreski, P., & Peterson, E. (1991). Traumatic events and posttraumatic stress disorder in an urban population of young adults. Archives of General Psychiatry, 48(3), 216–222. doi:10.1001/archpsyc.1991.01810270028003
  • Briere, J., Kaltman, S., & Green, B. L. (2008). Accumulated childhood trauma and symptom complexity. Journal of Traumatic Stress, 21(2), 223–226. doi:10.1002/jts.20317
  • Carlson, E. B., & Putnam, F. W. (1993). An update on the Dissociative Experiences Scale. Dissociation, 6(1), 16–23.
  • Chapman, C., Mills, K., Slade, T., McFarlane, A. C., Bryant, R. A., Creamer, M., … Teesson, M. (2012). Remission from post-traumatic stress disorder in the general population. Psychological Medicine, 42, 1695–1703. doi:10.1017/S0033291711002856
  • Cloitre, M., Courtois, C. A., Charuvastra, A., Carapezza, R., Stolbach, B. C., & Green, B. L. (2011). Treatment of complex PTSD: Results of the ISTSS expert clinician survey on best practices. Journal of Traumatic Stress, 24, 615–627. doi:10.1002/jts.20697
  • Cloitre, M., Petkova, E., Wang, J., & Lu Lassell, F. (2012). An examination of the influence of a sequential treatment on the course and impact of dissociation among women with PTSD related to childhood abuse. Depression and Anxiety, 29, 709–717. doi:10.1002/da.21920
  • Cloitre, M., Stolbach, B. C., Herman, J. L., van der Kolk, B., Pynoos, R., Wang, J., & Petkova, E. (2009). A developmental approach to complex PTSD: Childhood and adult cumulative trauma as predictors of symptom complexity. Journal of Traumatic Stress, 22, 399–408. doi:10.1002/jts.20444
  • Connor, K. M., Hidalgo, R. B., Crockett, B., Malik, M., Katz, R. J., & Davidson, J. R. (2001). Predictors of treatment response in patients with posttraumatic stress disorder. Progress in Neuropsychopharmacology and Biological Psychiatry, 25(2), 337–345. doi:10.1016/S0278-5846(00)00163-9
  • Dadic-Hero, E., Toric, I., Ruzic, K., Medved, P., & Graovac, M. (2009). Comorbidity—A troublesome factor in PTSD treatment. Psychiatria Danubina, 21, 420–424.
  • Davidson, J. R., Rothbaum, B. O., van der Kolk, B. A., Sikes, C. R., & Farfel, G. M. (2001). Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder. Archives of General Psychiatry, 58, 485–492. doi:10.1001/archpsyc.58.5.485
  • Feeny, N. C., Zoellner, L. A., & Foa, E. B. (2002). Treatment outcome for chronic PTSD among female assault victims with borderline personality characteristics: A preliminary examination. Journal of Personality Disorder, 16(1), 30–40. doi:10.1521/pedi.16.1.30.22555
  • First, M. B., Spitzer, R. L., Miriam, G., Williams, J. B. W. (1996). Structured Clinical Interview for DSM–IV–TR Axis I Disorders, Clinician Version (SCID-CV). Washington, D.C.: American Psychiatric Press, Inc.
  • Foa, E. B., & Kozak, M. J. (1986). Emotional processing of fear: Exposure to corrective information. Psychological Bulletin, 99(1), 20–35. doi:10.1037/0033-2909.99.1.20
  • Foa, E. B., Riggs, D. S., Massie, E. D., & Yarczower, M. (1995). The impact of fear activation and anger on the efficacy of exposure treatment for posttraumatic stress disorder. Behavior Therapy, 26, 487–499. doi:10.1016/S0005-7894(05)80096-6
  • Forbes, D., Creamer, M., Hawthorne, G., Allen, N., & McHugh, T. (2003). Comorbidity as a predictor of symptom change after treatment in combat-related posttraumatic stress disorder. Journal of Nervous and Mental Disorders, 191(2), 93–99.
  • Forbes, D., Parslow, R., Creamer, M., Allen, N., McHugh, T., & Hopwood, M. (2008). Mechanisms of anger and treatment outcome in combat veterans with posttraumatic stress disorder. Journal of Traumatic Stress, 21(2), 142–149. doi:10.1002/jts.20315
  • Ford, J. D., Grasso, D., Greene, C., Levine, J., Spinazzola, J., & van der Kolk, B. (2013). Clinical significance of a proposed developmental trauma disorder diagnosis: Results of an international survey of clinicians. Journal of Clinical Psychiatry, 74, 841–849. doi:10.4088/JCP.12m08030
  • Gerger, H., Munder, T., & Barth, J. (2014). Specific and nonspecific psychological interventions for PTSD symptoms: A meta-analysis with problem complexity as a moderator. Journal of Clinical Psychology, 70, 601–615. doi:10.1002/jclp.22059
  • Hagenaars, M. A., van Minnen, A., & Hoogduin, K. A. (2010). The impact of dissociation and depression on the efficacy of prolonged exposure treatment for PTSD. Behaviour Research and Therapy, 48, 19–27. doi:10.1016/j.brat.2009.09.001
  • Halvorsen, J. O., Stenmark, H., Neuner, F., & Nordahl, H. M. (2014). Does dissociation moderate treatment outcomes of narrative exposure therapy for PTSD? A secondary analysis from a randomized controlled clinical trial. Behaviour Research and Therapy, 57, 21–28. doi:10.1016/j.brat.2014.03.010
  • Hembree, E. A., Street, G. P., Riggs, D. S., & Foa, E. B. (2004). Do assault-related variables predict response to cognitive behavioral treatment for PTSD? Journal of Consulting and Clinical Psychology, 72, 531–534. doi:10.1037/0022-006X.72.3.531
  • Holmes, E. A., Brown, R. J., Mansell, W., Fearon, R., Hunter, E., Frasquilho, F., & Oakley, D. A. (2005). Are there two qualitatively distinct forms of dissociation? A review and some clinical implications. Clinical Psychology Review, 25(1), 1–23. doi:10.1016/j.cpr.2004.08.006
  • Ipser, J. C., & Stein, D. J. (2012). Evidence-based pharmacotherapy of post-traumatic stress disorder (PTSD). International Journal of Neuropsychopharmacology, 15, 825–840. doi:10.1146/annurev-med-051812-145438
  • Karadag, F., Sar, V., Tamar-Gurol, D., Evren, C., Karagoz, M., & Erkiran, M. (2005). Dissociative disorders among inpatients with drug or alcohol dependency. Journal of Clinical Psychiatry, 66, 1247–1253.
  • Karatzias, A., Power, K., McGoldrick, T., Brown, K., Buchanan, R., Sharp, D., & Swanson, V. (2007). Predicting treatment outcome on three measures for post-traumatic stress disorder. European Archives of Psychiatry and Clinical Neuroscience, 257(1), 40–46. doi:10.1007/s00406-006-0682-2
  • Kessler, R. C. (2000). Posttraumatic stress disorder: The burden to the individual and to society. Journal of Clinical Psychiatry, 61(Suppl. 5), 4–12; discussion, 13–14.
  • Kleindienst, N., Limberger, M. F., Ebner-Priemer, U. W., Keibel-Mauchnik, J., Dyer, A., Berger, M., … Bohus, M. (2011). Dissociation predicts poor response to dialectical behavioral therapy in female patients with borderline personality disorder. Journal of Personality Disorder, 25, 432–447. doi:10.1521/pedi.2011.25.4.432
  • Labbate, L. A., Sonne, S. C., Randal, C. L., Anton, R. F., & Brady, K. T. (2004). Does comorbid anxiety or depression affect clinical outcomes in patients with post-traumatic stress disorder and alcohol use disorders? Comprehensive Psychiatry, 45(4), 304–310. doi:10.1016/j.comppsych.2004.03.015
  • Lanius, R. A., Brand, B., Vermetten, E., Frewen, P. A., & Spiegel, D. (2012). The dissociative subtype of posttraumatic stress disorder: Rationale, clinical and neurobiological evidence, and implications. Depression and Anxiety, 29, 701–708. doi:10.1002/da.21889
  • Lanius, R. A., Hopper, J. W., & Menon, R. S. (2003). Individual differences in a husband and wife who developed PTSD after a motor vehicle accident: A functional MRI case study. American Journal of Psychiatry, 160, 667–669. doi:10.1176/appi.ajp.160.4.667
  • Lee, C. W., & Cuijpers, P. (2014). What does the data say about the importance of eye movement in EMDR? Journal of Behavior Therapy and Experimental Psychiatry, 45(1), 226–228. doi:10.1016/j.jbtep.2013.10.002
  • Lin, Y. N. (2002). The application of cognitive-behavioral therapy to counseling Chinese. American Journal of Psychotherapy, 56(1), 46–58.
  • Maaranen, P., Tanskanen, A., Honkalampi, K., Haatainen, K., Hintikka, J., & Viinamaki, H. (2005). Factors associated with pathological dissociation in the general population. Australian and New Zealand Journal of Psychiatry, 39(5), 387–394. doi:10.1080/j.1440-1614.2005.01586
  • Malta, L. S., Wyka, K. E., Giosan, C., Jayasinghe, N., & Difede, J. (2009). Numbing symptoms as predictors of unremitting posttraumatic stress disorder. Journal of Anxiety Disorders, 23(2), 223–229. doi:10.1016/j.janxdis.2008.07.004
  • Muller, M., Vandeleur, C., Rodgers, S., Rossler, W., Castelao, E., Preisig, M., & Ajdacic-Gross, V. (2014). Factors associated with comorbidity patterns in full and partial PTSD: Findings from the PsyCoLaus study. Comprehensive Psychiatry, 55, 837–848. doi:10.1016/j.comppsych.2014.01.009
  • Nijdam, M. J., Gersons, B. P., Reitsma, J. B., de Jongh, A., & Olff, M. (2012). Brief eclectic psychotherapy v. eye movement desensitisation and reprocessing therapy for post-traumatic stress disorder: Randomised controlled trial. British Journal of Psychiatry, 200(3), 224–231. doi:10.1192/bjp.bp.111.099234
  • Price, M., Kearns, M., Houry, D., & Rothbaum, B. O. (2014). Emergency department predictors of posttraumatic stress reduction for trauma-exposed individuals with and without an early intervention. Journal of Consulting and Clinical Psychology, 82(2), 336–341. doi:10.1037/a0035537
  • Resick, P. A., Suvak, M. K., Johnides, B. D., Mitchell, K. S., & Iverson, K. M. (2012). The impact of dissociation on PTSD treatment with cognitive processing therapy. Depression and Anxiety, 29, 718–730. doi:10.1002/da.21938
  • Richardson, J. D., Elhai, J. D., & Sarreen, J. (2011). Predictors of treatment response in Canadian combat and peacekeeping veterans with military-related posttraumatic stress disorder. Journal of Nervous and Mental Disease, 199, 639–645. doi:10.1097/NMD.0b013e318229ce7b
  • Ronconi, J. M., Shiner, B., & Watts, B. V. (2014). Inclusion and exclusion criteria in randomized controlled trials of psychotherapy for PTSD. Journal of Psychiatric Practice, 20(1), 25–37. doi:10.1097/01.pra.0000442936.23457.5b
  • Sar, V., & Ross, C. (2006). Dissociative disorders as a confounding factor in psychiatric research. Psychiatric Clinics of North America, 29(1), 129–144. doi:10.1016/j.psc.2005.10.008
  • Schottenbauer, M. A., Glass, C. R., Arnkoff, D. B., Tendick, V., & Gray, S. H. (2008). Nonresponse and dropout rates in outcome studies on PTSD: Review and methodological considerations. Psychiatry, 71(2), 134–168. doi:10.1521/psyc.2008.71.2.134
  • Shadish, W. R., Jr., & Sweeney, R. B. (1991). Mediators and moderators in meta-analysis: There’s a reason we don’t let dodo birds tell us which psychotherapies should have prizes. Journal of Consulting and Clinical Psychology, 59, 883–893. doi:10.1037/0022-006X.59.6.883
  • Shalev, A. Y., Bonne, O., & Eth, S. (1996). Treatment of posttraumatic stress disorder: A review. Psychosomatic Medicine, 58(2), 165–182.
  • Shapiro, F. (2001). Eye movement desensitization and reprocessing (EMDR): Basic principles, protocols, and procedures (2nd ed.). New York, NY: Guilford Press.
  • Shin, L. M., Davis, F. C., Vanelzakker, M. B., Dahlgren, M. K., & Dubois, S. J. (2013). Neuroimaging predictors of treatment response in anxiety disorders. Biology of Mood and Anxiety Disorders, 3(1), 15. doi:10.1186/2045-5380-3-15
  • Spinazzola, J., Blaustein, M., & van der Kolk, B. A. (2005). Posttraumatic stress disorder treatment outcome research: The study of unrepresentative samples? Journal of Traumatic Stress, 18, 425–436. doi:10.1002/jts.20050
  • Spitzer, C., Barnow, S., Freyberger, H. J., & Grabe, H. J. (2007). Dissociation predicts symptom-related treatment outcome in short-term inpatient psychotherapy. Australian and New Zealand Journal of Psychiatry, 41, 682–687. doi:10.1080/00048670701449146
  • Stein, D. J., Koenen, K. C., Friedman, M. J., Hill, E., McLaughlin, K. A., Petukhova, M., … Kessler, R. C. (2013). Dissociation in posttraumatic stress disorder: Evidence from the World Mental Health Surveys. Biological Psychiatry, 73(4), 302–312. doi:10.1016/j.biopsych.2012.08.022
  • Steuwe, C., Lanius, R. A., & Frewen, P. A. (2012). Evidence for a dissociative subtype of PTSD by latent profile and confirmatory factor analyses in a civilian sample. Depression and Anxiety, 29, 689–700. doi:10.1002/da.21944
  • Taylor, S., Fedoroff, I. C., Koch, W. J., Thordarson, D. S., Fecteau, G., & Nicki, R. M. (2001). Posttraumatic stress disorder arising after road traffic collisions: Patterns of response to cognitive-behavior therapy. Journal of Consulting and Clinical Psychology, 69, 541–551. doi:10.1037/0022-006X.69.3.541
  • van der Kolk, B. A., Spinazzola, J., Blaustein, M. E., Hopper, J. W., Hopper, E. K., Korn, D. L., & Simpson, W. B. (2007). A randomized clinical trial of eye movement desensitization and reprocessing (EMDR), fluoxetine, and pill placebo in the treatment of posttraumatic stress disorder: Treatment effects and long-term maintenance. Journal of Clinical Psychiatry, 68(1), 37–46.
  • van IJzendoorn, M. H., & Schuengel, C. (1996). The measurement of dissociation in normal and clinical populations: Meta-analytic validation of the Dissociative Experiences Scale (DES). Clinical Psychology Review, 16(5), 365–382.
  • van Minnen, A., Arntz, A., & Keijsers, G. P. J. (2002). Prolonged exposure in patients with chronic PTSD: Predictors of treatment outcome and dropout. Behaviour Research and Therapy, 40, 439–457.
  • van Minnen, A., Hendriks, L., & Olff, M. (2010). When do trauma experts choose exposure therapy for PTSD patients? A controlled study of therapist and patient factors. Behaviour Research and Therapy, 48, 312–320. doi:10.1016/j.brat.2009.12.003
  • Watts, B. V., Shiner, B., Zubkoff, L., Carpenter-Song, E., Ronconi, J. M., & Coldwell, C. M. (2014). Implementation of evidence-based psychotherapies for posttraumatic stress disorder in VA specialty clinics. Psychiatric Services, 65, 648–653. doi:10.1176/appi.ps.201300176
  • Weathers, F. W., Keane, T. M., & Davidson, J. R. (2001). Clinician-Administered PTSD Scale: A review of the first ten years of research. Depression and Anxiety, 13(3), 132–156.
  • Weiss, D., & Marmar, C. (1997). The Impact of Events Scale-Revised. In J. Wilson & T. Kean (Eds.), Assessing psychological trauma and PTSD (pp. 399–411). New York, NY: Guilford Press.
  • Yehuda, R., Daskalakis, N. P., Desarnaud, F., Makotkine, I., Lehrner, A. L., Koch, E., … Bierer, L. M. (2013). Epigenetic biomarkers as predictors and correlates of symptom improvement following psychotherapy in combat veterans with PTSD. Frontiers in Psychiatry, 4, 118. doi:10.3389/fpsyt.2013.00118

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