PPAR-γ AND TOLLIP ARE ASSOCIATED WITH TOLL-LIKE RECEPTORS IN COLITIS RATS

REFERENCES

• Hanauer , S. B. Inflammatory bowel disease: Epidemiology, pathogenesis, and therapeutic opportunities . Inflamm. Bowel Dis. 2006 , 12 ( Suppl 1 ), S3 – 9 . Review.
   PubMed Web of Science ®Google Scholar
• Cario , E. ; Podolsky , D. K. Intestinal epithelial TOLLerance versus inTOLLerance of commensals . Mol. Immunol. 2005 , 42 ( 8 ), 887 – 893 .
   PubMed Web of Science ®Google Scholar
• Wang , J. H. ; Doyle , M. ; Manning , B. J. ; Di Wu , Q. ; Blankson , S. ; Redmond , H. P. Induction of bacterial lipoprotein tolerance is associated with suppression of toll-like receptor 2 expression . J. Biol. Chem. 2002 , 277 ( 39 ), 36068 – 36075 .
   PubMed Web of Science ®Google Scholar
• Kumar , H. ; Kawai , T. ; Akira , S. Toll-like receptors and innate immunity . Biochem. Biophys. Res. Commun. 2009 , 388 ( 4 ), 621 – 625 .
   PubMed Web of Science ®Google Scholar
• Cario , E. ; Gerken , G. ; Podolsky , D. K. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function . Gastroenterology 2007 , 132 ( 4 ), 1359 – 1374 .
   PubMed Web of Science ®Google Scholar
• Oshima , N. ; Ishihara , S. ; Rumi , M. A. ; Aziz , M. M. ; Mishima , Y. ; Kadota , C. ; Moriyama , I. ; Ishimura , N. ; Amano , Y. ; Kinoshita , Y. A20 is an early responding negative regulator of toll-like receptor 5 signalling in intestinal epithelial cells during inflammation . Clin. Exp. Immunol. 2010 , 159 ( 2 ), 185 – 198 .
   PubMed Web of Science ®Google Scholar
• Zhang , G. ; Ghosh , S. Negative regulation of toll-like receptor-mediated signaling by tollip . J. Biol. Chem. 2002 , 277 ( 9 ), 7059 – 7065 .
   PubMed Web of Science ®Google Scholar
• Song , Z. ; Yin , J. ; Yao , C. ; Sun , Z. ; Shao , M. ; Zhang , Y. ; Tao , Z. ; Huang , P. ; Tong , C. Variants in the toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population . Crit. Care. 2011 , 15 ( 1 ), R12 .
   PubMedGoogle Scholar
• Fitzpatrick , L. R. ; Meirelles , K. ; Small , J. S. ; Puleo , F. J. ; Koltun , W. A. ; Cooney , R. N. A new model of chronic hapten-induced colitis in young rats . J. Pediatr. Gastroenterol. Nutr. 2010 , 50 ( 3 ), 240 – 250 .
   PubMed Web of Science ®Google Scholar
• Butzner , J. D. ; Parmar , R. ; Bell , C. J. ; Dalal , V. Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat . Gut. 1996 , 38 ( 4 ), 568 – 573 .
   PubMed Web of Science ®Google Scholar
• Akcan , A. ; Muhtaroglu , S. ; Akgun , H. ; Akyildiz , H. ; Kucuk , C. ; Sozuer , E. ; Yurci , A. ; Yilmaz , N. Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis, oxidative damage and apoptosis in rats . World J. Gastroenterol. 2008 , 14 ( 8 ), 1222 – 1230 .
   PubMed Web of Science ®Google Scholar
• Medzhitov , R. ; Preston-Hurlburt , P. ; Janeway , C. A. Jr. A human homologue of the drosophila toll protein signals activation of adaptive immunity. Nature 1997, 388(6640), 394–397.
   PubMed Web of Science ®Google Scholar
• Abreu , M. T. Toll-like receptor signalling in the intestinal epithelium: How bacterial recognition shapes intestinal function . Nat. Rev. Immunol. 2010 , 10 ( 2 ), 131 – 144 .
   PubMed Web of Science ®Google Scholar
• Suzuki , M. ; Hisamatsu , T. ; Podolsky , D. K. Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular toll-like receptor 4-MD-2 complex . Infect. Immun. 2003 , 71 ( 6 ), 3503 – 3511 .
   PubMed Web of Science ®Google Scholar
• Ungaro , R. ; Fukata , M. ; Hsu , D. ; Hernandez , Y. ; Breglio , K. ; Chen , A. ; Xu , R. ; Sotolongo , J. ; Espana , C. ; Zaias , J. ; Elson , G. ; Mayer , L. ; Kosco-Vilbois , M. ; Abreu , M. T. A novel toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis . Amer. J. Physiol. Gastrointest. Liver Physiol. 2009 , 296 ( 6 ), G1167 – 1179 .
   PubMed Web of Science ®Google Scholar
• Didierlaurent , A. ; Brissoni , B. ; Velin , D. ; Aebi , N. ; Tardivel , A. ; Käslin , E. ; Sirard , J. C. ; Angelov , G. ; Tschopp , J. ; Burns , K. Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide . Mol. Cell Biol. 2006 , 26 ( 3 ), 735 – 742 .
   PubMed Web of Science ®Google Scholar
• Nishimura , M. ; Naito , S. Tissue-specific mRNA expression profiles of human toll-like receptors and related genes . Biol. Pharm. Bull. 2005 , 28 ( 5 ), 886 – 892 .
   PubMed Web of Science ®Google Scholar
• Otte , J. M. ; Cario , E. ; Podolsky , D. K. Mechanisms of cross hyporesponsiveness to toll-like receptor bacterial ligands in intestinal epithelial cells . Gastroenterology 2004 , 126 ( 4 ), 1054 – 1070 .
   PubMed Web of Science ®Google Scholar
• Abreu , M. T. ; Arnold , E. T. ; Thomas , L. S. ; Gonsky , R. ; Zhou , Y. ; Hu , B. ; Arditi , M. TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells . J. Biol. Chem. 2002 , 277 ( 23 ), 20431 – 20437 .
   PubMed Web of Science ®Google Scholar
• Shibolet , O. ; Podolsky , D. K. TLRs in the gut. IV. Negative regulation of toll-like receptors and intestinal homeostasis: Addition by subtraction . Amer. J. Physiol. Gastrointest. Liver Physiol. 2007 , 292 ( 6 ), G1469 – 1473 .
   PubMed Web of Science ®Google Scholar
• Steenholdt , C. ; Andresen , L. ; Pedersen , G. ; Hansen , A. ; Brynskov , J. Expression and function of toll-like receptor 8 and tollip in colonic epithelial cells from patients with inflammatory bowel disease . Scand. J. Gastroenterol. 2009 , 44 ( 2 ), 195 – 204 .
   PubMed Web of Science ®Google Scholar
• Capelluto , D. G. Tollip: A multitasking protein in innate immunity and protein trafficking . Microbes Infect. 2011 , 8 ( 1 ), 1 – 8 .
   Google Scholar
• Adachi , M. ; Kurotani , R. ; Morimura , K. ; Shah , Y. ; Sanford , M. ; Madison , B. B. ; Gumucio , D. L. ; Marin , H. E. ; Peters , J. M. ; Young , H. A. ; Gonzalez , F. J. Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease . Gut 2006 , 55 ( 8 ), 1104 – 1113 .
   PubMed Web of Science ®Google Scholar
• Ogawa , S. ; Lozach , J. ; Benner , C. ; Pascual , G. ; Tangirala , R. K. ; Westin , S. ; Hoffmann , A. ; Subramaniam , S. ; David , M. ; Rosenfeld , M. G. ; Glass , C. K. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors . Cell 2005 , 122 ( 5 ), 707 – 721 .
   PubMed Web of Science ®Google Scholar