A Recent Update on Drug Delivery Systems for Pain Management

References

• Merskey HE. Classification of chronic pain: Descriptions of chronic pain syndromés and definitions of pain terms. Pain. 1986; Suppl 3:226.
   Google Scholar
• Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006;10(4):287–333. doi:10.1016/j.ejpain.2005.06.009.
   PubMed Web of Science ®Google Scholar
• Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139(2):267–84. doi:10.1016/j.cell.2009.09.028.
   PubMed Web of Science ®Google Scholar
• Yan Y-y, Li C-y, Zhou L, Ao L-y, Fang W-r, Li Y-m. Research progress of mechanisms and drug therapy for neuropathic pain. Life Sci. 2017;190:68–77. doi:10.1016/j.lfs.2017.09.033.
   PubMed Web of Science ®Google Scholar
• Perl ER. Pain and nociception. In: Terjung R, ed. Comprehensive Physiology. 2011: 915–75.
   Google Scholar
• Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150(3699):971–9. doi:10.1126/science.150.3699.971.
   PubMed Web of Science ®Google Scholar
• Millan MJ. The induction of pain: an integrative review. Prog Neurobiol. 1999;57(1):1–164. doi:10.1016/S0301-0082(98)00048-3.
   PubMed Web of Science ®Google Scholar
• Dworkin RH, Grzesiak RC. Chronic pain. In: Stricker G, Gold JR, eds. Comprehensive Handbook of Psychotherapy Integration. Boston, MA: Springer US; 1993:365–84.
   Google Scholar
• Carr DB, Goudas LC. Acute pain. The Lancet. 1999;353(9169):2051–8. doi:10.1016/S0140-6736(99)03313-9.
   PubMed Web of Science ®Google Scholar
• Gangadharan V, Kuner R. Pain hypersensitivity mechanisms at a glance. Dis Model Mech. 2013;6(4):889–95. doi:10.1242/dmm.011502.
   PubMed Web of Science ®Google Scholar
• Nahin RL. Estimates of pain prevalence and severity in adults: United States, 2012. J Pain. 2015;16(8):769–80. doi:10.1016/j.jpain.2015.05.002.
   PubMed Web of Science ®Google Scholar
• Livshits G, Malkin I, Freidin MB, Xia Y, Gao F, Wang J, Spector TD, MacGregor A, Bell JT, Williams FMK. Genome-wide methylation analysis of a large population sample shows neurological pathways involvement in chronic widespread musculoskeletal pain. Pain. 2017;158(6):1053–62. doi:10.1097/j.pain.0000000000000880.
   PubMed Web of Science ®Google Scholar
• Atkinson TJ, Fudin J. Nonsteroidal antiinflammatory drugs for acute and chronic pain. Phys Med Rehabil Clin N Am. 2020;31(2):219–31. doi:10.1016/j.pmr.2020.01.002.
   PubMed Web of Science ®Google Scholar
• Wongrakpanich S, Wongrakpanich A, Melhado K, Rangaswami J. A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly. Aging Dis. 2018;9(1):143–50. doi:10.14336/AD.2017.0306.
   PubMed Web of Science ®Google Scholar
• Bach-Rojecky L, Vađunec D, Žunić K, Kurija J, Šipicki S, Gregg R, Mikula I, Primorac D. Continuing war on pain: a personalized approach to the therapy with nonsteroidal anti-inflammatory drugs and opioids. Per Med. 2019;16(2):171–84. doi:10.2217/pme-2018-0116.
   PubMed Web of Science ®Google Scholar
• Yaksh TL, Wallace MS. Opioids, analgesia, and pain management. In: Goodman and Gilman’s the Pharmacological Basis of Therapeutics. New York: McGraw-Hill Medical; 2011: 481–526.
   Google Scholar
• Cohen B, Ruth LJ, Preuss CV. Opioid analgesics. StatPearls [Internet]. StatPearls Publishing; 2020.
   Google Scholar
• Crockett SD, Greer KB, Heidelbaugh JJ, Falck-Ytter Y, Hanson BJ, Sultan S. American Gastroenterological Association Institute Guideline on the Medical Management of Opioid-Induced Constipation. Gastroenterology. 2019;156(1):218–26. doi:10.1053/j.gastro.2018.07.016.
   PubMed Web of Science ®Google Scholar
• Calcaterra S, Glanz J, Binswanger IA. National trends in pharmaceutical opioid related overdose deaths ­compared to other substance related overdose deaths: 1999–2009. Drug Alcohol Depend. 2013;131(3):263–70. doi:10.1016/j.drugalcdep.2012.11.018.
   PubMed Web of Science ®Google Scholar
• Hesselink JMK. Cr845 (D), a kappa receptors agonist in phase III By CARA therapeutics: a case of ‘spin’ in scientific writing? J Pharmacol Clin Res. 2017;2(3):555588.
   Google Scholar
• Singla N, Minkowitz H, Soergel D, Burt D, Subach RA, Salamea M, Fossler M, Skobieranda F. A randomized, Phase IIb study investigating oliceridine (TRV130), a novel µ-receptor G-protein pathway selective (μ-GPS) modulator, for the management of moderate to severe acute pain following abdominoplasty. JPR. 2017;10:2413–24. doi:10.2147/JPR.S137952.
   Google Scholar
• Miyazaki T, Choi IY, Rubas W, Anand NK, Ali C, Evans J, Gursahani H, Hennessy M, Kim G, McWeeney D, et al. NKTR-181: a novel mu-opioid analgesic with inherently low abuse potential. J Pharmacol Exp Ther. 2017;363(1):104–13. doi:10.1124/jpet.117.243030.
   PubMed Web of Science ®Google Scholar
• Gillman P. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. 2007;151(6):737–48. doi:10.1038/sj.bjp.0707253.
   PubMed Web of Science ®Google Scholar
• Ross ELJN. The evolving role of antiepileptic drugs in treating neuropathic pain. Neurology. 2000;55(5 Suppl 1):S41–S6. discussion S54.
   PubMed Web of Science ®Google Scholar
• Cording M, Moore RA, Derry S, Wiffen PJ. Pregabalin for pain in fibromyalgia in adults. Cochrane Database Syst Rev. 2015;(7).
   PubMedGoogle Scholar
• Scholz A. Mechanisms of (local) anaesthetics on voltage-gated sodium and other ion channels . Br J Anaesth. 2002;89(1):52–61. doi:10.1093/bja/aef163.
   PubMed Web of Science ®Google Scholar
• Teasell RW, Mehta S, Aubut J-AL, Foulon B, Wolfe DL, Hsieh JTC, Townson AF, Short C. Short C spinal cord injury rehabilitation evidence research team. A systematic review of pharmacologic treatments of pain after spinal cord injury. Arch Phys Med Rehabil. 2010;91(5):816–31. doi:10.1016/j.apmr.2010.01.022.
   PubMed Web of Science ®Google Scholar
• Flores MP, de Castro APCR, Nascimento JS. Topical analgesics. Braz J Anesthesiol. 2012;62(2):244–52. doi:10.1016/S0034-7094(12)70122-8.
   Google Scholar
• Svendsen KB, Jensen TS, Bach FW. Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial. BMJ. 2004;329(7460):253. doi:10.1136/bmj.38149.566979.AE.
   PubMed Web of Science ®Google Scholar
• Portenoy RK, Ganae-Motan ED, Allende S, Yanagihara R, Shaiova L, Weinstein S, McQuade R, Wright S, Fallon MT. Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial. J Pain. 2012;13(5):438–49. doi:10.1016/j.jpain.2012.01.003.
   PubMed Web of Science ®Google Scholar
• Skrabek RQ, Galimova L, Ethans K, Perry D. Nabilone for the treatment of pain in fibromyalgia. J Pain. 2008;9(2):164–73. doi:10.1016/j.jpain.2007.09.002.
   PubMed Web of Science ®Google Scholar
• Hill KP. Medical marijuana for treatment of chronic pain and other medical and psychiatric problems: a clinical review. JAMA. 2015;313(24):2474–83. doi:10.1001/jama.2015.6199.
   PubMed Web of Science ®Google Scholar
• Park J, Park HJ. Botulinum toxin for the treatment of neuropathic pain. Toxins (Basel). 2017;9(9):260. doi:10.3390/toxins9090260.
   PubMed Web of Science ®Google Scholar
• Meng G, Wu N, Zhang C, Su R-B, Lu X-Q, Liu Y, Yun L-H, Zheng J-Q, Li J. Analgesic activity of ZC88, a novel N-type voltage-dependent calcium channel blocker, and its modulation of morphine analgesia, tolerance and dependence. Eur J Pharmacol. 2008;586(1-3):130–8. doi:10.1016/j.ejphar.2008.02.066.
   PubMed Web of Science ®Google Scholar
• Morisset V, Derjean D, Rugiero F, Owen D, Giblin G, Walls C, et al. CNV2197944: A novel potent and selective CaV2. 2 state-dependent blocker for evaluation in chronic pain. Neuroscience. 2011:12–6.
   Google Scholar
• Zhu CZ, Vortherms TA, Zhang M, Xu J, Swensen AM, Niforatos W, Neelands T, Milicic I, Lewis LG, Zhong C, et al. Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca2+ channel blocker that reduces nociception in rat preclinical pain models. J Pain. 2014;15(4):387.e1–e14. doi:10.1016/j.jpain.2013.12.002.
   Google Scholar
• Matthews EA, Bee LA, Stephens GJ, Dickenson AH. The Cav2. 3 calcium channel antagonist SNX‐482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. Eur J Neurosci. 2007;25(12):3561–9. doi:10.1111/j.1460-9568.2007.05605.x.
   PubMed Web of Science ®Google Scholar
• Chen J, Jin T, Zhang H. Nanotechnology in chronic pain relief. Front Bioeng Biotechnol. 2020;8(682).
   Google Scholar
• Papaleontiou M, Henderson J, Charles R, Turner BJ, Moore AA, Olkhovskaya Y, Amanfo L. Outcomes associated with opioid use in the treatment of chronic noncancer pain in older adults: a systematic review and meta‐analysis. J Am Geriatr Soc. 2010;58(7):1353–69. doi:10.1111/j.1532-5415.2010.02920.x.
   PubMed Web of Science ®Google Scholar
• Ricardo BM, Rajive AM, Nalini SM. Opioid ­complications and side effects. Pain Physician. 2008;11:S105–S20.
   PubMed Web of Science ®Google Scholar
• Beiranvand S, Eatemadi A, Karimi A. New updates pertaining to drug delivery of local anesthetics in particular bupivacaine using lipid nanoparticles. Nanoscale Res Lett. 2016;11(1):307. doi:10.1186/s11671-016-1520-8.
   PubMedGoogle Scholar
• Trelle S, Reichenbach S, Wandel S, Hildebrand P, Tschannen B, Villiger PM, Egger M, Jüni P. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ. 2011;342:c7086. doi:10.1136/bmj.c7086.
   PubMed Web of Science ®Google Scholar
• Huscher D, Thiele K, Gromnica-Ihle E, Hein G, Demary W, Dreher R, Zink A, Buttgereit F. Dose-related patterns of glucocorticoid-induced side effects. Ann Rheum Dis. 2009;68(7):1119–24. doi:10.1136/ard.2008.092163.
   PubMed Web of Science ®Google Scholar
• Patel H, Panchal DR, Patel U, Brahmbhatt T, Suthar M. Matrix type drug delivery system: a review. J Pharm Sci Biosci Res. 2011;1(3):143–51.
   Google Scholar
• Yang W-W, Pierstorff E. Reservoir-based polymer drug delivery systems. J Lab Autom. 2012;17(1):50–8. doi:10.1177/2211068211428189.
   PubMedGoogle Scholar
• Lengyel M, Kállai-Szabó N, Antal V, Laki AJ, Antal I. Microparticles, microspheres, and microcapsules for advanced drug delivery. Sci Pharm. 2019;87(3):20. doi:10.3390/scipharm87030020.
   Web of Science ®Google Scholar
• Charifson PS, Walters WP. Acidic and basic drugs in medicinal chemistry: a perspective. J Med Chem. 2014;57(23):9701–17. doi:10.1021/jm501000a.
   PubMed Web of Science ®Google Scholar
• Manallack DT, Prankerd RJ, Yuriev E, Oprea TI, Chalmers DK. The significance of acid/base properties in drug discovery. Chem Soc Rev. 2013;42(2):485–96. doi:10.1039/c2cs35348b.
   PubMed Web of Science ®Google Scholar
• Wen H, Jung H, Li X. Drug delivery approaches in addressing clinical pharmacology-related issues: opportunities and challenges. Aaps J. 2015;17(6):1327–40. doi:10.1208/s12248-015-9814-9.
   PubMed Web of Science ®Google Scholar
• Overholser BR, Foster DR. Opioid pharmacokinetic drug-drug interactions. Am J Manag Care. 2011;17(Suppl 11):S276–S87.
   PubMedGoogle Scholar
• Meier R, Thommes M, Rasenack N, Krumme M, Moll KP, Kleinebudde P. Simplified formulations with high drug loads for continuous twin-screw granulation. Int J Pharm. 2015;496(1):12–23. doi:10.1016/j.ijpharm.2015.05.060.
   PubMedGoogle Scholar
• Tian Y, Jacobs E, Jones DS, McCoy CP, Wu H, Andrews GP. The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion platform. Int J Pharm. 2020;586:119545. doi:10.1016/j.ijpharm.2020.119545.
   PubMedGoogle Scholar
• Dasgupta N, Funk MJ, Proescholdbell S, Hirsch A, Ribisl KM, Marshall S. Cohort study of the impact of high-dose opioid analgesics on overdose mortality. Pain Med. 2016;17(1):85–98. doi:10.1111/pme.12907.
   PubMed Web of Science ®Google Scholar
• Volans G, Monaghan J, Colbridge M. Ibuprofen overdose. Int J Clin Pract Suppl. 2003;(135):54–60.
   PubMedGoogle Scholar
• Sobczak Ł, Goryński K. Pharmacological aspects of over-the-counter opioid drugs misuse. Molecules. 2020;25(17):3905. doi:10.3390/molecules25173905.
   Web of Science ®Google Scholar
• Mirza AZ, Siddiqui FA. Nanomedicine and drug delivery: a mini review. Int Nano Lett. 2014;4(1):94. doi:10.1007/s40089-014-0094-7.
   Google Scholar
• Kabanov AV, Lemieux P, Vinogradov S, Alakhov V. Pluronic® block copolymers: novel functional molecules for gene therapy. Adv Drug Del Rev. 2002;54(2):223–33. doi:10.1016/S0169-409X(02)00018-2.
   PubMed Web of Science ®Google Scholar
• Elzoghby AO, Vranic BZ, Samy WM, Elgindy NA. Swellable floating tablet based on spray-dried casein nanoparticles: near-infrared spectral characterization and floating matrix evaluation. Int J Pharm. 2015;491(1-2):113–22. doi:10.1016/j.ijpharm.2015.06.015.
   PubMedGoogle Scholar
• Chen L-H, Cheng L-C, Doyle PS. Nanoemulsion-loaded capsules for controlled delivery of lipophilic active ingredients. Adv Sci (Weinh)). 2020;7(20):2001677. doi:10.1002/advs.202001677.
   PubMedGoogle Scholar
• Möschwitzer J, Achleitner G, Pomper H, Müller RH. Development of an intravenously injectable chemically stable aqueous omeprazole formulation using nanosuspension technology. Eur J Pharm Biopharm. 2004;58(3):615–9. doi:10.1016/j.ejpb.2004.03.022.
   PubMed Web of Science ®Google Scholar
• Patiño-Herrera R, Louvier-Hernández JF, Escamilla-Silva EM, Chaumel J, Escobedo AGP, Pérez E. Prolonged release of metformin by SiO2 nanoparticles pellets for type II diabetes control. Eur J Pharm Sci. 2019;131:1–8. doi:10.1016/j.ejps.2019.02.003.
   PubMed Web of Science ®Google Scholar
• de Carvalho SM, Noronha CM, da Rosa CG, Sganzerla WG, Bellettini IC, Nunes MR, Bertoldi FC, Manique Barreto PL. PVA antioxidant nanocomposite films functionalized with alpha-tocopherol loaded solid lipid nanoparticles. Colloids Surf Physicochem Eng Aspects. 2019;581:123793. doi:10.1016/j.colsurfa.2019.123793.
   Web of Science ®Google Scholar
• Garg T, Rath G, Goyal AK. Biomaterials-based nanofiber scaffold: targeted and controlled carrier for cell and drug delivery. J Drug Target. 2015;23(3):202–21. doi:10.3109/1061186X.2014.992899.
   PubMed Web of Science ®Google Scholar
• Sharifi F, Sooriyarachchi AC, Altural H, Montazami R, Rylander MN, Hashemi N. Fiber based approaches as medicine delivery systems. ACS Biomater Sci Eng. 2016;2(9):1411–31. doi:10.1021/acsbiomaterials.6b00281.
   PubMed Web of Science ®Google Scholar
• Kowalewski T, Błoński S, Barral S. Experiments and modelling of electrospinning process. Bull Pol Acad Sci Tech Sci. 2005;385–94.
   Google Scholar
• KenryLim CT. Nanofiber technology: current status and emerging developments. Prog Polym Sci. 2017;70:1–17. doi:10.1016/j.progpolymsci.2017.03.002.
   Web of Science ®Google Scholar
• Taghavi S, Larson R. Regularized thin-fiber model for nanofiber formation by centrifugal spinning. Phys Rev E. 2014;89(2):023011.
   Web of Science ®Google Scholar
• Mahalingam S, Edirisinghe M. Forming of polymer nanofibers by a pressurised gyration process. Macromol Rapid Commun. 2013;34(14):1134–9. doi:10.1002/marc.201300339.
   PubMed Web of Science ®Google Scholar
• Ikegame M, Tajima K, Aida T. Template synthesis of polypyrrole nanofibers insulated within one-dimensional silicate channels: hexagonal versus lamellar for recombination of polarons into bipolarons . Angew Chem Int Ed Engl. 2003;42(19):2154–7. doi:10.1002/anie.200250800.
   PubMed Web of Science ®Google Scholar
• Polat Y, Calisir M, Gungor M, Sagirli MN, Atakan R, Akgul Y, et al. Solution blown nanofibrous air filters modified with glass microparticles. J Ind Text. 2019;0(0):1–14.
   Google Scholar
• Tseng Y-Y, Liu S-J. Nanofibers used for the delivery of analgesics. Nanomedicine (Lond)). 2015;10(11):1785–800. doi:10.2217/nnm.15.23.
   PubMed Web of Science ®Google Scholar
• He Y, Qin L, Fang Y, Dan Z, Shen Y, Tan G, Huang Y, Ma C. Electrospun PLGA nanomembrane: A novel formulation of extended-release bupivacaine delivery reducing postoperative pain. Mater Des. 2020; 193:108768. doi:10.1016/j.matdes.2020.108768.
   Web of Science ®Google Scholar
• Kao C-W, Lee D, Wu M-H, Chen J-K, He H-L, Liu S-J. Lidocaine/ketorolac-loaded biodegradable nanofibrous anti-adhesive membranes that offer sustained pain ­relief for surgical wounds. Int J Nanomedicine. 2017;12:5893–901. doi:10.2147/IJN.S140825.
   PubMed Web of Science ®Google Scholar
• Kao C-W, Tseng Y-Y, Liu K-S, Liu Y-W, Chen J-C, He H-L, Kau Y-C, Liu S-J. Anesthetics and human epidermal growth factor incorporated into anti-adhesive nanofibers provide sustained pain relief and promote healing of surgical wounds. Int J Nanomedicine. 2019;14:4007–16. doi:10.2147/IJN.S202402.
   PubMed Web of Science ®Google Scholar
• Godakanda VU, Li H, Alquezar L, Zhao L, Zhu L-M, de Silva R, de Silva KMN, Williams GR. Tunable drug release from blend poly(vinyl pyrrolidone)-ethyl cellulose nanofibers . Int J Pharm. 2019;562:172–9. doi:10.1016/j.ijpharm.2019.03.035.
   PubMedGoogle Scholar
• Vatankhah E. Rosmarinic acid-loaded electrospun nanofibers: In vitro release kinetic study and bioactivity assessment. Eng Life Sci. 2018;18(10):732–42. doi:10.1002/elsc.201800046.
   PubMed Web of Science ®Google Scholar
• Bhagwan J, Kumar N, Sharma Y. Chapter 13 - Fabrication, Characterization, and Optimization of MnxOy Nanofibers for Improved Supercapacitive Properties. In: Beeran Pottathara Y, Thomas S, Kalarikkal N, Grohens Y, Kokol V, eds. Nanomaterials Synthesis. Elsevier; 2019: 451–81.
   Google Scholar
• Kumar B, Smita K, Cumbal L, Debut A. Green synthesis of silver nanoparticles using Andean blackberry fruit extract. Saudi J Biol Sci. 2017;24(1):45–50. doi:10.1016/j.sjbs.2015.09.006.
   PubMed Web of Science ®Google Scholar
• Singh R, Lillard JW.Jr. Nanoparticle-based targeted drug delivery. Exp Mol Pathol. 2009;86(3):215–23. doi:10.1016/j.yexmp.2008.12.004.
   PubMed Web of Science ®Google Scholar
• Öztürk AA, Kıyan HT. Treatment of oxidative stress-induced pain and inflammation with dexketoprofen trometamol loaded different molecular weight chitosan nanoparticles: Formulation, characterization and anti-inflammatory activity by using in vivo HET-CAM assay. Microvasc Res. 2020;128:103961. doi:10.1016/j.mvr.2019.103961.
   PubMed Web of Science ®Google Scholar
• Javia A, Thakkar H. Intranasal delivery of tapentadol hydrochloride–loaded chitosan nanoparticles: formulation, characterisation and its in vivo evaluation. J Microencapsul. 2017;34(7):644–58. doi:10.1080/02652048.2017.1375038.
   PubMed Web of Science ®Google Scholar
• Shukla R, Handa M, Vasdev N, Singh DP, Kesharwani P. Chapter 15 - Nanomedicine in pain management. In: Kesharwani P, Taurin S, Greish K, eds. Theory and Applications of Nonparenteral Nanomedicines. Academic Press; 2021: 355–82.
   Google Scholar
• Assali M, Shawahna R, Dayyeh S, Shareef M, Alhimony I-A. Dexamethasone-diclofenac loaded polylactide nanoparticles: Preparation, release and anti-inflammatory activity. Eur J Pharm Sci. 2018;122:179–84. doi:10.1016/j.ejps.2018.07.012.
   PubMed Web of Science ®Google Scholar
• Nagavarma B, Yadav HK, Ayaz A, Vasudha L, Shivakumar H. Different techniques for preparation of polymeric nanoparticles-a review. Asian J Pharm Clin Res. 2012;5(3):16–23.
   Google Scholar
• Zhou J, Patel TR, Sirianni RW, Strohbehn G, Zheng M-Q, Duong N, Schafbauer T, Huttner AJ, Huang Y, Carson RE, et al. Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma. Proc Natl Acad Sci U S A. 2013;110(29):11751–6. doi:10.1073/pnas.1304504110.
   PubMed Web of Science ®Google Scholar
• Chung Y-I, Kim JC, Kim YH, Tae G, Lee S-Y, Kim K, Kwon IC. The effect of surface functionalization of PLGA nanoparticles by heparin- or chitosan-conjugated Pluronic on tumor targeting . J Control Release. 2010;143(3):374–82. doi:10.1016/j.jconrel.2010.01.017.
   PubMed Web of Science ®Google Scholar
• Acharya G, Lee CH, Lee Y. Optimization of cardiovascular stent against restenosis: factorial design-based statistical analysis of polymer coating conditions. PLoS One. 2012;7(8):e43100. doi:10.1371/journal.pone.0043100.
   PubMed Web of Science ®Google Scholar
• Wang T, Hurwitz O, Shimada SG, Tian D, Dai F, Zhou J, Ma C, LaMotte RH. Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice. Neurosci Lett. 2018;668:154–8. doi:10.1016/j.neulet.2018.01.031.
   PubMed Web of Science ®Google Scholar
• Baskaran M, Baskaran P, Arulsamy N, Thyagarajan B. Preparation and evaluation of PLGA-coated capsaicin magnetic nanoparticles. Pharm Res. 2017;34(6):1255–63. doi:10.1007/s11095-017-2142-2.
   PubMed Web of Science ®Google Scholar
• Berrocoso E, Rey-Brea R, Fernández-Arévalo M, Micó JA, Martín-Banderas L. Single oral dose of cannabinoid derivate loaded PLGA nanocarriers relieves neuropathic pain for eleven days. Nanomed Nanotechnol Biol Med. 2017;13(8):2623–32. doi:10.1016/j.nano.2017.07.010.
   PubMed Web of Science ®Google Scholar
• Tobío M, Sánchez A, Vila A, Soriano I, Evora C, Vila-Jato JL, Alonso MJ. The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration. Colloids Surf B Biointerfaces. 2000;18(3-4):315–23. doi:10.1016/S0927-7765(99)00157-5.
   PubMed Web of Science ®Google Scholar
• Owens IID, Peppas NA. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm. 2006;307(1):93–102. doi:10.1016/j.ijpharm.2005.10.010.
   PubMed Web of Science ®Google Scholar
• Dave V, Srivastava P, Sharma S, Bajaj J, Tak K. PEGylated PLA-Phospholipon 90G complex hybrid nanoparticles loaded with etoricoxib for effective treatment pain relief potential. Int J Polymeric Mater Polymeric Biomater. 2020;69(10):640–52. doi:10.1080/00914037.2019.1596914.
   Web of Science ®Google Scholar
• Katara R, Sachdeva S, Majumdar DK. Design, characterization, and evaluation of aceclofenac-loaded Eudragit RS 100 nanoparticulate system for ocular delivery. Pharm Dev Technol. 2019;24(3):368–79. doi:10.1080/10837450.2018.1486424.
   PubMed Web of Science ®Google Scholar
• Öztürk AA, Yenilmez E, Arslan R, Şenel B, Yazan Y. Dexketoprofen trometamol-loaded Kollidon® SR and Eudragit® RS 100 polymeric nanoparticles: formulation and in vitro-in vivo evaluation. Lat Am J Pharm. 2017;36(11):2153–65.
   Web of Science ®Google Scholar
• El-Habashy SE, Allam AN, El-Kamel AH. Ethyl cellulose nanoparticles as a platform to decrease ulcerogenic potential of piroxicam: formulation and in vitro/in vivo evaluation. Int J Nanomedicine. 2016;11:2369–80. doi:10.2147/IJN.S93354.
   PubMed Web of Science ®Google Scholar
• Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MDP, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S, et al. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnology. 2018;16(1):71. doi:10.1186/s12951-018-0392-8.
   PubMed Web of Science ®Google Scholar
• Mahmoudvand H, Khaksarian M, Ebrahimi K, Shiravand S, Jahanbakhsh S, Niazi M, Nadri S. Antinociceptive effects of green synthesized copper nanoparticles alone or in combination with morphine. Ann Med Surg. 2020;51:31–6. doi:10.1016/j.amsu.2019.12.006.
   PubMed Web of Science ®Google Scholar
• An H, Song Z, Li P, Wang G, Ma B, Wang X. Development of biofabricated gold nanoparticles for the treatment of alleviated arthritis pain. Appl Nanosci. 2020;10(2):617–22. doi:10.1007/s13204-019-01135-w.
   Web of Science ®Google Scholar
• Wu P-C, Hsiao H-T, Lin Y-C, Shieh D-B, Liu Y-C. The analgesia efficiency of ultrasmall magnetic iron oxide nanoparticles in mice chronic inflammatory pain model. Nanomedicine. 2017;13(6):1975–81. doi:10.1016/j.nano.2017.05.005.
   PubMed Web of Science ®Google Scholar
• De JW, Borm PJA. Drug delivery and nanoparticles: applications and hazards. Int J Nanomedicine. 2008;3(2):133–49.
   PubMed Web of Science ®Google Scholar
• Sánchez-López E, Guerra M, Dias-Ferreira J, Lopez-Machado A, Ettcheto M, Cano A, Espina M, Camins A, Garcia ML, Souto EB. Current applications of nanoemulsions in cancer therapeutics. Nanomaterials. 2019;9(6):821. doi:10.3390/nano9060821.
   Web of Science ®Google Scholar
• Nigam K, Gabrani R, Dang S. Nano-emulsion from capsaicin: formulation and characterization. Mater Today. 2019;18:869–78. doi:10.1016/j.matpr.2019.06.517.
   Google Scholar
• Koroleva M, Nagovitsina T, Yurtov E. Nanoemulsions stabilized by non-ionic surfactants: stability and degradation mechanisms. Phys Chem Chem Phys. 2018;20(15):10369–77. doi:10.1039/c7cp07626f.
   PubMed Web of Science ®Google Scholar
• Azmi NAN, Elgharbawy AA, Motlagh SR, Samsudin N, Salleh HM. Nanoemulsions: factory for food, pharmaceutical and cosmetics. Processes. 2019;7(9):617. doi:10.3390/pr7090617.
   Web of Science ®Google Scholar
• Azizi M, Esmaeili F, Partoazar A, Ejtemaei Mehr S, Amani A. Efficacy of nano-and microemulsion-based topical gels in delivery of ibuprofen: an in vivo study. J Microencapsul. 2017;34(2):195–202. doi:10.1080/02652048.2017.1316324.
   PubMed Web of Science ®Google Scholar
• Jacob S, Nair AB, Shah J. Emerging role of nanosuspensions in drug delivery systems. Biomater Res. 2020;24(1):3. doi:10.1186/s40824-020-0184-8.
   PubMedGoogle Scholar
• Rabinow BE. Nanosuspensions in drug delivery. Nat Rev Drug Discov. 2004;3(9):785–96. doi:10.1038/nrd1494.
   PubMed Web of Science ®Google Scholar
• Shegokar R, Müller RH. Nanocrystals: industrially feasible multifunctional formulation technology for poorly soluble actives. Int J Pharm. 2010;399(1-2):129–39. doi:10.1016/j.ijpharm.2010.07.044.
   PubMed Web of Science ®Google Scholar
• Müller RH, Jacobs C, Kayser O. Nanosuspensions as particulate drug formulations in therapy: rationale for development and what we can expect for the future. Adv Drug Del Rev. 2001;47(1):3–19. doi:10.1016/S0169-409X(00)00118-6.
   PubMed Web of Science ®Google Scholar
• Oktay AN, Tamer SI, Han S, Uludag O, Celebi N. Preparation and in vitro/in vivo evaluation of flurbiprofen nanosuspension-based gel for dermal application. Eur J Pharm Sci. 2020; 155:105548. doi:10.1016/j.ejps.2020.105548.
   PubMed Web of Science ®Google Scholar
• Donnelly RF, Larrañeta E. Microarray patches: potentially useful delivery systems for long-acting nanosuspensions. Drug Discov Today. 2018;23(5):1026–33. doi:10.1016/j.drudis.2017.10.013.
   PubMed Web of Science ®Google Scholar
• Müller RH, Radtke M, Wissing SA. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Del Rev. 2002;54:S131–S55. doi:10.1016/S0169-409X(02)00118-7.
   PubMed Web of Science ®Google Scholar
• Wissing SA, Müller RH. The influence of solid lipid nanoparticles on skin hydration and viscoelasticity–in vivo study. Eur J Pharm Biopharm. 2003;56(1):67–72. doi:10.1016/S0939-6411(03)00040-7.
   PubMed Web of Science ®Google Scholar
• Akbari J, Saeedi M, Morteza-Semnani K, Rostamkalaei SS, Asadi M, Asare-Addo K, Nokhodchi A. The design of naproxen solid lipid nanoparticles to target skin layers. Colloids Surf B Biointerfaces. 2016;145:626–33. doi:10.1016/j.colsurfb.2016.05.064.
   PubMed Web of Science ®Google Scholar
• Kaur A, Goindi S, Katare OP. Formulation, characterisation and in vivo evaluation of lipid-based nanocarrier for topical delivery of diflunisal. J Microencapsul. 2016;33(5):475–86. doi:10.1080/02652048.2016.1216189.
   PubMed Web of Science ®Google Scholar
• Yoon G, Park JW, Yoon I-S. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery. Int J Pharm Investig. 2013;43(5):353–62. doi:10.1007/s40005-013-0087-y.
   Google Scholar
• Ghasemiyeh P, Mohammadi-Samani S. Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages. Res Pharm Sci. 2018;13(4):288–303. doi:10.4103/1735-5362.235156.
   PubMed Web of Science ®Google Scholar
• Makwana V, Jain R, Patel K, Nivsarkar M, Joshi A. Solid lipid nanoparticles (SLN) of Efavirenz as lymph targeting drug delivery system: Elucidation of mechanism of uptake using chylomicron flow blocking approach. Int J Pharm. 2015;495(1):439–46. doi:10.1016/j.ijpharm.2015.09.014.
   PubMedGoogle Scholar
• Pople PV, Singh KK. Development and evaluation of colloidal modified nanolipid carrier: application to topical delivery of tacrolimus. Eur J Pharm Biopharm. 2011;79(1):82–94. doi:10.1016/j.ejpb.2011.02.016.
   PubMed Web of Science ®Google Scholar
• Pople PV, Singh KK. Development and evaluation of colloidal modified nanolipid carrier: Application to topical delivery of tacrolimus, Part II–In vivo assessment, drug targeting, efficacy, and safety in treatment for atopic dermatitis. Eur J Pharm Biopharm. 2013;84(1):72–83. doi:10.1016/j.ejpb.2012.11.026.
   PubMed Web of Science ®Google Scholar
• Lopes-de-Araújo J, Neves AR, Gouveia VM, Moura CC, Nunes C, Reis S. Oxaprozin-loaded lipid nanoparticles towards overcoming NSAIDs side-effects. Pharm Res. 2016;33(2):301–14. doi:10.1007/s11095-015-1788-x.
   PubMed Web of Science ®Google Scholar
• Tambe S, Jain D, Agarwal Y, Amin P. Hot-melt extrusion: highlighting recent advances in pharmaceutical applications. J Drug Deliv Sci Technol. 2021; 63:102452. doi:10.1016/j.jddst.2021.102452.
   Web of Science ®Google Scholar
• Rincón M, Calpena AC, Clares B, Espina M, Garduño-Ramírez ML, Rodríguez-Lagunas MJ, García ML, Abrego G. Skin-controlled release lipid nanosystems of pranoprofen for the treatment of local inflammation and pain. Nanomedicine (Lond). 2018;13(19):2397–413. doi:10.2217/nnm-2018-0195.
   PubMed Web of Science ®Google Scholar
• Kang Q, Liu J, Zhao Y, Liu X, Liu X-Y, Wang Y-J, Mo N-L, Wu Q. Transdermal delivery system of nanostructured lipid carriers loaded with Celastrol and Indomethacin: optimization, characterization and efficacy evaluation for rheumatoid arthritis. Artif Cells Nanomed Biotechnol. 2018;46(sup3):S585–S97. doi:10.1080/21691401.2018.1503599.
   PubMed Web of Science ®Google Scholar
• Yue Y, Zhao D, Yin Q. Hyaluronic acid modified nanostructured lipid carriers for transdermal bupivacaine delivery: In vitro and in vivo anesthesia evaluation. Biomed Pharmacother. 2018;98:813–20. doi:10.1016/j.biopha.2017.12.103.
   PubMed Web of Science ®Google Scholar
• Otarola JJ, Solis AKC, Farias ME, Garrido M, Correa NM, Molina PG. Piroxicam-loaded nanostructured lipid carriers gel: design and characterization by square wave voltammetry. Colloids Surf Physicochem Eng Aspects. 2020;606:125396. doi:10.1016/j.colsurfa.2020.125396.
   Web of Science ®Google Scholar
• Garg NK, Sharma G, Singh B, Nirbhavane P, Tyagi RK, Shukla R, Katare OP. Quality by Design (QbD)-enabled development of aceclofenac loaded-nano structured lipid carriers (NLCs): An improved dermatokinetic profile for inflammatory disorder (s). Int J Pharm. 2017;517(1-2):413–31. doi:10.1016/j.ijpharm.2016.12.010.
   PubMed Web of Science ®Google Scholar
• Bawazeer S, El-Telbany DFA, Al-Sawahli MM, Zayed G, Keed AAA, Abdelaziz AE, Abdel-Naby DH. Effect of nanostructured lipid carriers on transdermal delivery of tenoxicam in irradiated rats. Drug Deliv. 2020;27(1):1218–30. doi:10.1080/10717544.2020.1803448.
   PubMed Web of Science ®Google Scholar
• Nguyen CN, Nguyen TTT, Nguyen HT, Tran TH. Nanostructured lipid carriers to enhance transdermal delivery and efficacy of diclofenac. Drug Deliv Transl Res. 2017;7(5):664–73. doi:10.1007/s13346-017-0415-2.
   PubMed Web of Science ®Google Scholar
• Mishra RK, Ahmad A, Kumar A, Vyawahare A, Raza SS, Khan R. Lipid-based nanocarrier-mediated targeted delivery of celecoxib attenuate severity of ulcerative colitis. Mater Sci Eng, C. 2020; 116:111103. doi:10.1016/j.msec.2020.111103.
   PubMed Web of Science ®Google Scholar
• Eleraky NE, M, Omar M, A, Mahmoud H, A, Abou-Taleb H. Nanostructured Lipid Carriers to Mediate Brain Delivery of Temazepam: Design and In Vivo Study. Pharmaceutics. 2020;12(5):451.
   Web of Science ®Google Scholar
• Da Silva GH, de Morais Ribeiro LN, Guilherme VA, de Castro SR, Breitkreitz MC, de Paula E. Bupivacaine (S75: R25) loaded in nanostructured lipid carriers: factorial design, HPLC quantification method and physicochemical stability study. CDD. 2018;15(3):388–96. doi:10.2174/1567201814666170726101113.
   PubMed Web of Science ®Google Scholar
• Sinhmar GK, Shah NN, Chokshi NV, Khatri HN, Patel MM. Process, optimization, and characterization of budesonide-loaded nanostructured lipid carriers for the treatment of inflammatory bowel disease. Drug Dev Ind Pharm. 2018;44(7):1078–89. doi:10.1080/03639045.2018.1434194.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Yue Y, Chang M. Local anaesthetic pain relief therapy: in vitro and in vivo evaluation of a nanotechnological formulation co-loaded with ropivacaine and dexamethasone. Biomed Pharmacother. 2017;96:443–9. doi:10.1016/j.biopha.2017.09.124.
   PubMed Web of Science ®Google Scholar
• Rincón M, Calpena A, Fabrega M-J, Garduño-Ramírez M, Espina M, Rodríguez-Lagunas M, García M, Abrego G. Development of pranoprofen loaded nanostructured lipid carriers to improve its release and therapeutic efficacy in skin inflammatory disorders. Nanomaterials. 2018;8(12):1022. doi:10.3390/nano8121022.
   Web of Science ®Google Scholar
• Gao S, Tian B, Han J, Zhang J, Shi Y, Lv Q, Li K. Enhanced transdermal delivery of lornoxicam by nanostructured lipid carrier gels modified with polyarginine peptide for treatment of carrageenan-induced rat paw edema. IJN. 2019;14:6135–50. doi:10.2147/IJN.S205295.
   Google Scholar
• Wang X-R, Gao S-Q, Niu X-Q, Li L-J, Ying X-Y, Hu Z-J, Gao J-Q. Capsaicin-loaded nanolipoidal carriers for topical application: design, characterization, and in vitro/in vivo evaluation. Int J Nanomed. 2017;12:3881–98. doi:10.2147/IJN.S131901.
   PubMed Web of Science ®Google Scholar
• Sütő B, Berkó S, Kozma G, Kukovecz Á, Budai-Szűcs M, Erős G, Kemény L, Sztojkov-Ivanov A, Gáspár R, Csányi E, et al. Development of ibuprofen-loaded nanostructured lipid carrier-based gels: characterization and investigation of in vitro and in vivo penetration through the skin. Int J Nanomed. 2016;11:1201–12. doi:10.2147/IJN.S99198.
   PubMed Web of Science ®Google Scholar
• Chauhan I, Yasir M, Verma M, Singh AP. Nanostructured lipid carriers: a groundbreaking approach for transdermal drug delivery. Adv Pharm Bull. 2020;10(2):150–65. doi:10.34172/apb.2020.021.
   PubMed Web of Science ®Google Scholar
• Jaiswal P, Gidwani B, Vyas A. Nanostructured lipid carriers and their current application in targeted drug delivery. Artif Cells Nanomed Biotechnol. 2016;44(1):27–40. doi:10.3109/21691401.2014.909822.
   PubMed Web of Science ®Google Scholar
• Sardana V, Burzynski J, Zalzal P. Safety and efficacy of topical ketoprofen in transfersome gel in knee osteoarthritis: a systematic review. Musculoskeletal Care. 2017;15(2):114–21. doi:10.1002/msc.1163.
   PubMed Web of Science ®Google Scholar
• Bnyan R. Novel lipid-based vesicles for sustained buccal delivery of a local anaesthetic for oral pain relief [Doctoral dissertation]. Liverpool L2 2QP, United Kingdom: Liverpool John Moores University; 2020.
   Google Scholar
• Tawfeek HM, Abdellatif AA, Abdel-Aleem JA, Hassan YA, Fathalla D. Transfersomal gel nanocarriers for enhancement the permeation of lornoxicam. J Drug Deliv Sci Technol. 2020;56:101540. doi:10.1016/j.jddst.2020.101540.
   Web of Science ®Google Scholar
• Dudhipala N, Phasha Mohammed R, Adel Ali Youssef A, Banala N. Effect of lipid and edge activator concentration on development of aceclofenac-loaded transfersomes gel for transdermal application: in vitro and ex vivo skin permeation. Drug Dev Ind Pharm. 2020;46(8):1334–44. doi:10.1080/03639045.2020.1788069.
   PubMed Web of Science ®Google Scholar
• Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O’Neill F, Roberts M. Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic. J Pharm Pharmacol. 2019;71(10):1508–19. doi:10.1111/jphp.13149.
   PubMed Web of Science ®Google Scholar
• Negi P, Aggarwal M, Sharma G, Rathore C, Sharma G, Singh B, Katare OP. Niosome-based hydrogel of resveratrol for topical applications: an effective therapy for pain related disorder (s). Biomed Pharmacother. 2017;88:480–7. doi:10.1016/j.biopha.2017.01.083.
   PubMed Web of Science ®Google Scholar
• Marzoli F, Marianecci C, Rinaldi F, Passeri D, Rossi M, Minosi P, Carafa M, Pieretti S. Long-lasting, antinociceptive effects of pH-sensitive niosomes loaded with ibuprofen in acute and chronic models of pain. Pharmaceutics. 2019;11(2):62. doi:10.3390/pharmaceutics11020062.
   Web of Science ®Google Scholar
• Rinaldi F, Del Favero E, Rondelli V, Pieretti S, Bogni A, Ponti J, Rossi F, Di Marzio L, Paolino D, Marianecci C, et al. pH-sensitive niosomes: effects on cytotoxicity and on inflammation and pain in murine models. J Enzyme Inhib Med Chem. 2017;32(1):538–46. doi:10.1080/14756366.2016.1268607.
   PubMed Web of Science ®Google Scholar
• Paradkar M, Vaghela S. Thiocolchicoside niosomal gel formulation for the pain management of rheumatoid arthritis through topical drug delivery. DDL. 2018;8(2):159–68. doi:10.2174/2210303108666180216151234.
   Google Scholar
• Madni A, Rahim MA, Mahmood MA, Jabar A, Rehman M, Shah H, Khan A, Tahir N, Shah A. Enhancement of dissolution and skin permeability of pentazocine by proniosomes and niosomal gel. AAPS PharmSciTech. 2018;19(4):1544–53. doi:10.1208/s12249-018-0967-6.
   PubMed Web of Science ®Google Scholar
• Ibrahim MM, Shehata TM. Tramadol HCl encapsulated niosomes for extended analgesic effect following oral administration. J Drug Deliv Sci Technol. 2018;46:14–8. doi:10.1016/j.jddst.2018.04.011.
   Web of Science ®Google Scholar
• Ravalika V, Sailaja AK. Formulation and evaluation of etoricoxib niosomes by thin film hydration technique and ether injection method. Nano BioMed Eng. 2017;9(3):242–8. doi:10.5101/nbe.v9i3.p242-248.
   Google Scholar
• Duangjit S, Nimcharoenwan T, Chomya N, Locharoenrat N, Ngawhirunpat T. Design and development of optimal invasomes for transdermal drug delivery using computer program. Asian J Pharm Sci. 2016;11(1):52–3. doi:10.1016/j.ajps.2015.10.039.
   Google Scholar
• Dreier J, Sørensen JA, Brewer JR. Superresolution and fluorescence dynamics evidence reveal that intact liposomes do not cross the human skin barrier. PLoS One. 2016;11(1):e0146514. doi:10.1371/journal.pone.0146514.
   PubMed Web of Science ®Google Scholar
• Brewer J, Bloksgaard M, Kubiak J, Sørensen JA, Bagatolli LA. Spatially resolved two-color diffusion measurements in human skin applied to transdermal liposome penetration. J Invest Dermatol. 2013;133(5):1260–8. doi:10.1038/jid.2012.461.
   PubMed Web of Science ®Google Scholar
• Gabizon AA, Shmeeda H, Zalipsky S. Pros and cons of the liposome platform in cancer drug targeting. J Liposome Res. 2006;16(3):175–83. doi:10.1080/08982100600848769.
   PubMed Web of Science ®Google Scholar
• Daraee H, Etemadi A, Kouhi M, Alimirzalu S, Akbarzadeh A. Application of liposomes in medicine and drug delivery. Artif Cells Nanomed Biotechnol. 2016;44(1):381–91. doi:10.3109/21691401.2014.953633.
   PubMed Web of Science ®Google Scholar
• Cevc G, Gebauer D. Hydration-driven transport of deformable lipid vesicles through fine pores and the skin barrier. Biophys J. 2003;84(2 Pt 1):1010–24. doi:10.1016/S0006-3495(03)74917-0.
   PubMed Web of Science ®Google Scholar
• Zhang J, Zhu S, Tan Q, Cheng D, Dai Q, Yang Z, Zhang L, Li F, Zuo Y, Dai W, et al. Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief. Theranostics. 2020;10(11):4885–99. doi:10.7150/thno.43932.
   PubMed Web of Science ®Google Scholar
• Nagayasu A, Uchiyama K, Kiwada H. The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugs. Adv Drug Del Rev. 1999;40(1-2):75–87. doi:10.1016/S0169-409X(99)00041-1.
   PubMed Web of Science ®Google Scholar
• Goh JZ, Tang SN, Chiong HS, Yong YK, Zuraini A, Hakim MN. Evaluation of antinociceptive activity of nanoliposome-encapsulated and free-form diclofenac in rats and mice. Int J Nanomedicine. 2015;10(297)
   Google Scholar
• Rose JS, Neal JM, Kopacz DJ. Extended-duration analgesia: update on microspheres and liposomes. Reg Anesth Pain Med. 2005;30(3):275–85. doi:10.1097/00115550-200505000-00010.
   PubMed Web of Science ®Google Scholar
• Xiong S, George S, Yu H, Damoiseaux R, France B, Ng KW, Loo JS-C. Size influences the cytotoxicity of poly (lactic-co-glycolic acid)(PLGA) and titanium dioxide (TiO 2) nanoparticles. Arch Toxicol. 2013;87(6):1075–86. doi:10.1007/s00204-012-0938-8.
   PubMed Web of Science ®Google Scholar
• Nel A, Xia T, Meng H, Wang X, Lin S, Ji Z, Zhang H. Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening. Acc Chem Res. 2013;46(3):607–21. doi:10.1021/ar300022h.
   PubMed Web of Science ®Google Scholar
• Magdolenova Z, Collins A, Kumar A, Dhawan A, Stone V, Dusinska M. Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles. Nanotoxicology. 2014;8(3):233–78. doi:10.3109/17435390.2013.773464.
   PubMed Web of Science ®Google Scholar
• Tekade RK, Maheshwari R, Soni N, Tekade M, Chougule MB. Chapter 1 - Nanotechnology for the Development of Nanomedicine. In: Mishra V, Kesharwani P, Mohd Amin MCI, Iyer A, eds. Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes. Academic Press; 2017: 3–61.
   Google Scholar
• Liu K-S, Chen W-H, Lee C-H, Su Y-F, Liu S-J. Extended pain relief achieved by analgesic-eluting biodegradable nanofibers in the Nuss procedure: In vitro and in vivo studies. Int J Nanomedicine. 2018;13:8355. doi:10.2147/IJN.S189505.
   PubMed Web of Science ®Google Scholar
• Reda RI, Wen MM, El-Kamel AH. Ketoprofen-loaded eudragit electrospun nanofibers for the treatment of oral mucositis. Int J Nanomedicine. 2017;12:2335. doi:10.2147/IJN.S131253.
   PubMed Web of Science ®Google Scholar
• Abid S, Hussain T, Nazir A, Zahir A, Khenoussi N. Acetaminophen loaded nanofibers as a potential contact layer for pain management in Burn wounds. Mater Res Express. 2018;5(8):085017. doi:10.1088/2053-1591/aad2eb.
   Web of Science ®Google Scholar
• Abid S, Hussain T, Nazir A, Zahir A, Khenoussi N. A novel double-layered polymeric nanofiber-based dressing with controlled drug delivery for pain management in burn wounds. Polym Bull. 2019;76(12):6387–411. doi:10.1007/s00289-019-02727-w.
   Web of Science ®Google Scholar
• Lee F-Y, Lee D, Lee T-C, Chen J-K, Wu R-C, Liu K-C, Liu S-J. Fabrication of multi-layered lidocaine and epinephrine-eluting PLGA/collagen nanofibers: in vitro and in vivo study. Polymers. 2017;9(12):416. doi:10.3390/polym9090416.
   Google Scholar
• Chou Y-C, Cheng Y-S, Hsu Y-H, Yu Y-H, Liu S-J. Biodegradable nanofiber-membrane for sustainable release of lidocaine at the femoral fracture site as a periosteal block: In vitro and in vivo studies in a rabbit model. Colloids Surf B Biointerfaces. 2016;140:332–41. doi:10.1016/j.colsurfb.2016.01.011.
   PubMed Web of Science ®Google Scholar
• Nigam K, Kaur A, Tyagi A, Manda K, Gabrani R, Dang S. Baclofen-loaded poly (d, l-lactide-co-glycolic acid) nanoparticles for neuropathic pain management: in vitro and in vivo evaluation. Rejuvenation Res. 2019;22(3):235–45. doi:10.1089/rej.2018.2119.
   PubMed Web of Science ®Google Scholar
• vKim SR, Ho MJ, Kim SH, Cho HR, Kim HS, Choi YS, Choi YW, Kang MJ. Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection. DDDT. 2016;10:3779–87. doi:10.2147/DDDT.S118145.
   PubMed Web of Science ®Google Scholar
• Nigam K, Kaur A, Tyagi A, Nematullah M, Khan F, Gabrani R, et al. Nose-to-brain delivery of lamotrigine-loaded PLGA nanoparticles. Drug Dev Transl Res. 2019;9(5):879–90. doi:10.1007/s13346-019-00622-5.
   PubMed Web of Science ®Google Scholar
• Kovaliov M, Li S, Korkmaz E, Cohen-Karni D, Tomycz N, Ozdoganlar OB, Averick S. Extended-release of opioids using fentanyl-based polymeric nanoparticles for enhanced pain management. RSC Adv. 2017;7(76):47904–12. doi:10.1039/C7RA08450A.
   Web of Science ®Google Scholar
• Kassick AJ, Allen HN, Yerneni SS, Pary F, Kovaliov M, Cheng C, et al. Covalent poly (lactic acid) nanoparticles for the sustained delivery of naloxone. ACS Appl Bio Mater. 2019;2(8):3418–28. doi:10.1021/acsabm.9b00380.
   PubMedGoogle Scholar
• Wang Z, Huang H, Yang S, Huang S, Guo J, Tang Q, et al. Long-term effect of ropivacaine nanoparticles for sciatic nerve block on postoperative pain in rats. Int J Nanomedicine. 2016;11(2081).
   Google Scholar
• Pawar V, Srivastava R, editors. Layered assembly of chitosan nanoparticles and alginate gel for management of post-surgical pain and infection. 2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO). 2016. Sendai, Japan: IEEE. doi:10.1109/NANO.2016.7751388.
   Google Scholar
• Moradkhani MR, Karimi A. Effect of Artemisia aucheri. L and bupivacaine encapsulated nanoparticles on nociceptive pain. Drug Res. 2019;69(07):401–5. doi:10.1055/a-0825-6487.
   Google Scholar
• Catanzano O, Docking R, Schofield P, Boateng J. Advanced multi-targeted composite biomaterial dressing for pain and infection control in chronic leg ulcers. Carbohydr Polym. 2017;172:40–8. doi:10.1016/j.carbpol.2017.05.040.
   PubMed Web of Science ®Google Scholar
• Janjic JM, Vasudeva K, Saleem M, Stevens A, Liu L, Patel S, et al. Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in rat. J Neuroimmunol. 2018;318:72–9. doi:10.1016/j.jneuroim.2018.02.010.
   PubMed Web of Science ®Google Scholar
• Quintans-Júnior LJ, Brito RG, Quintans JS, Santos PL, Camargo ZT, Barreto PA, et al. Nanoemulsion thermoreversible pluronic F127-based hydrogel containing Hyptis pectinata (Lamiaceae) leaf essential oil produced a lasting anti-hyperalgesic effect in chronic noninflammatory widespread pain in mice. Mol Neurobiol. 2018;55(2):1665–75. doi:10.1007/s12035-017-0438-1.
   PubMed Web of Science ®Google Scholar
• Ye L, Miao M, Li S, Hao K. Nanosuspensions of a new compound, ER-β005, for enhanced oral bioavailability and improved analgesic efficacy. Int J Pharm. 2017;531(1):246–56. doi:10.1016/j.ijpharm.2017.08.103.
   PubMedGoogle Scholar
• Jeong SC, Kim DS, Jin SG, Youn YS, Oh KT, Li DX, et al. Development of a novel celecoxib-loaded nanosuspension using a wet media milling process. Die Pharmazie. 2018;73(9):498–502.
   PubMed Web of Science ®Google Scholar
• Shomorony A, Santamaria CM, Zhao C, Rwei AY, Mehta M, Zurakowski D, et al. Prolonged duration local anesthesia by combined delivery of capsaicin-and tetrodotoxin-loaded liposomes. Anesth Analg. 2019;129(3):709–17.
   PubMed Web of Science ®Google Scholar
• Zhao X, Sun Y, Li Z. Topical anesthesia therapy using lidocaine-loaded nanostructured lipid carriers: tocopheryl polyethylene glycol 1000 succinate-modified transdermal delivery system. Drug Des Devel Ther. 2018;12:4231–40. doi:10.2147/DDDT.S187177.
   PubMed Web of Science ®Google Scholar
• Bahrami MA, Farhadian N, Karimi M, Forouzan A, Masoumi K. Improvement of pain relief of fentanyl citrate drug encapsulated in nanostructured lipid carrier: drug formulation, parameter optimization, in vitro and in vivo studies. Drug Des Devel Ther. 2020;14:2033–45. doi:10.2147/DDDT.S235474.
   PubMed Web of Science ®Google Scholar
• Ribeiro LNM, Franz-Montan M, Breitkreitz MC, Alcântara ACS, Castro SR, Guilherme VA, et al. Nanostructured lipid carriers as robust systems for topical lidocaine-prilocaine release in dentistry. Eur J Pharm Sci. 2016;93:192–202. doi:10.1016/j.ejps.2016.08.030.
   PubMed Web of Science ®Google Scholar
• de M. Barbosa R, Ribeiro L, Casadei B, da Silva C, Queiróz V, Duran N, de Araújo D, Severino P, de Paula E. Solid lipid nanoparticles for dibucaine sustained release. Pharmaceutics. 2018;10(4):231. doi:10.3390/pharmaceutics10040231.
   PubMed Web of Science ®Google Scholar
• Abbasnia M, Vatanara AR, Mahjub R. Preparation, statistical optimization and in vitro characterization of solid lipid nanoparticles as a potential vehicle for transdermal delivery of tramadol hydrochloride as a hydrophilic compound. Nanomed Res J. 2020;5(2):120–31.
   Google Scholar
• Anantaworasakul P, Chaiyana W, Michniak-Kohn BB, Rungseevijitprapa W, Ampasavate C. Enhanced transdermal delivery of concentrated capsaicin from chili extract-loaded lipid nanoparticles with reduced skin irritation. Pharmaceutics. 2020;12(5):463. doi:10.3390/pharmaceutics12050463.
   PubMed Web of Science ®Google Scholar
• Yang Q, Forrest L. Drug delivery to the lymphatic system. In: Wang B, Hu L, Siahaan TJ, eds. Drug Delivery: Principles and Applications. 2nd ed. Hoboken, New Jersey: John Wiley & Sons, Inc.; 2016: 503–48.
   Google Scholar
• Desai T, Shea LD. Advances in islet encapsulation technologies. Nat Rev Drug Discov. 2017;16(5):338–50. doi:10.1038/nrd.2016.232.
   PubMed Web of Science ®Google Scholar
• de Araújo DR, da Silva DC, Barbosa RM, Franz-Montan M, Cereda CMS, Padula C, Santi P, de Paula E. Strategies for delivering local anesthetics to the skin: focus on liposomes, solid lipid nanoparticles, hydrogels and patches. Expert Opin Drug Deliv. 2013;10(11):1551–63. doi:10.1517/17425247.2013.828031.
   PubMed Web of Science ®Google Scholar
• Grillo R, de Melo NF, de Araújo DR, de Paula E, Rosa AH, Fraceto LF. Polymeric alginate nanoparticles containing the local anesthetic bupivacaine. J Drug Target. 2010;18(9):688–99. doi:10.3109/10611861003649738.
   PubMed Web of Science ®Google Scholar
• Ma P, Li T, Xing H, Wang S, Sun Y, Sheng X, Wang K. Local anesthetic effects of bupivacaine loaded lipid-polymer hybrid nanoparticles: in vitro and in vivo evaluation. Biomed Pharmacother. 2017;89:689–95. doi:10.1016/j.biopha.2017.01.175.
   PubMed Web of Science ®Google Scholar
• Makadia HK, Siegel SJ. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers (Basel). 2011;3(3):1377–97. doi:10.3390/polym3031377.
   PubMed Web of Science ®Google Scholar
• McAlvin JB, Padera RF, Shankarappa SA, Reznor G, Kwon AH, Chiang HH, Yang J, Kohane DS. Multivesicular liposomal bupivacaine at the sciatic nerve. Biomaterials. 2014;35(15):4557–64. doi:10.1016/j.biomaterials.2014.02.015.
   PubMed Web of Science ®Google Scholar
• Kohane DS, Lipp M, Kinney RC, Anthony DC, Louis DN, Lotan N, Langer R. Biocompatibility of lipid‐protein‐sugar particles containing bupivacaine in the epineurium. J Biomed Mater Res. 2002;59(3):450–9. doi:10.1002/jbm.1261.
   PubMed Web of Science ®Google Scholar
• McAlvin JB, Reznor G, Shankarappa SA, Stefanescu CF, Kohane DS. Local toxicity from local anesthetic ­polymeric microparticles. Anesth Analg. 2013;116(4):794–803. doi:10.1213/ANE.0b013e31828174a7.
   PubMed Web of Science ®Google Scholar
• Bale S, Khurana A, Reddy ASS, Singh M, Godugu C. Overview on therapeutic applications of microparticulate drug delivery systems. Crit Rev Ther Drug Carrier Syst. 2016;33(4):309–61. doi:10.1615/CritRevTherDrugCarrierSyst.2016015798.
   PubMed Web of Science ®Google Scholar
• Tian X, Zhu H, Du S, Zhang X-Q, Lin F, Ji F, Tsou Y-H, Li Z, Feng Y, Ticehurst K, et al. Injectable PLGA-coated ropivacaine produces a long-lasting analgesic effect on incisional pain and neuropathic pain. J Pain. 2021;22(2):180–95. doi:10.1016/j.jpain.2020.03.009.
   PubMed Web of Science ®Google Scholar
• Padalkar DA, Shahi S, Thube Patil M. Micro particles: an approach for betterment of drug delivery system. Int J Pharm Res Dev. 2011;3(1):99–115.
   Google Scholar
• Yehia SA, Abdel-Halim SA, Aziz MY. Formulation and evaluation of injectable in situ forming microparticles for sustained delivery of lornoxicam. Drug Dev Ind Pharm. 2017;43(2):319–28. doi:10.1080/03639045.2016.1241259.
   PubMed Web of Science ®Google Scholar
• Sakurai H, Ikeuchi-Takahashi Y, Kobayashi A, Yoshimura N, Ishihara C, Aomori T, Onishi H. Formulation Development of Mucoadhesive Microparticle-Laden Gels for Oral Mucositis: An In Vitro and In Vivo Study. Pharmaceutics. 2020;12(7):603. doi:10.3390/pharmaceutics12070603.
   Web of Science ®Google Scholar
• Gaware S, Bala P, Dhobale S, Joshi A, Wagh N, Pal K, Kale SN. Studies on control of erratic release of ketoprofen from commercial patches for sustained pain-relief using silica microparticles. NHC. 2016;12:88–97. doi:10.4028/www.scientific.net/NHC.12.88.
   Google Scholar
• Whelehan M, Marison IW. Microencapsulation using vibrating technology. J Microencapsul. 2011;28(8):669–88. doi:10.3109/02652048.2011.586068.
   PubMed Web of Science ®Google Scholar
• Kim KK, Pack DW. Microspheres for drug delivery. In: Ferrari M, Lee AP, Lee LJ, eds. BioMEMS and Biomedical Nanotechnology: Volume I Biological and Biomedical Nanotechnology. Boston, MA: Springer US; 2006: 19–50.
   Google Scholar
• Liu Q-R, Dai Y-C, Ji L-J, Gong M-D, Li X, Fang J, Yang J-J. Preparation of ropivacaine-loaded mesoporous bioactive glass microspheres and evaluation of their efficacy for sciatic nerve block. J Drug Deliv Sci Technol. 2020;58:101810. doi:10.1016/j.jddst.2020.101810.
   Web of Science ®Google Scholar
• Ni Q, Chen W, Tong L, Cao J, Ji C. Preparation of novel biodegradable ropivacaine microspheres and evaluation of their efficacy in sciatic nerve block in mice. Drug Des Devel Ther. 2016;10:2499. doi:10.2147/DDDT.S110742.
   PubMed Web of Science ®Google Scholar
• Kao H-W, Lin Y-Y, Gwathney WJ, Hong K. Formulation and evaluation of multilamellar vesicles ropivacaine in pain management. Int J Nanomedicine. 2019;14:7891. doi:10.2147/IJN.S215952.
   PubMed Web of Science ®Google Scholar
• Chai F, Maton M, Degoutin S, Vermet G, Simon N, Rousseaux C, et al. In vivo evaluation of post-operative pain reduction on rat model after implantation of ­intraperitoneal PET meshes functionalised with ­cyclodextrins and loaded with ropivacaine. Biomaterials. 2019;192:260–70. doi:10.1016/j.biomaterials.2018.07.032.
   PubMed Web of Science ®Google Scholar
• Hawkins S, Wolf M, Guyard G, Greenberg S, Dayan N. 9 - Microcapsules as a delivery system. In: Rosen MR, ed. Delivery System Handbook for Personal Care and Cosmetic Products. Norwich, NY: William Andrew Publishing; 2005: 191–213.
   Google Scholar
• Baek J-S, Yeo EW, Lee YH, Tan NS, Loo SCJ. Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases. Drug Des Devel Ther. 2017;11:1707. doi:10.2147/DDDT.S133344.
   PubMed Web of Science ®Google Scholar
• Kopach O, Zheng K, Dong L, Sapelkin A, Voitenko N, Sukhorukov GB, et al. Nano-engineered microcapsules boost the treatment of persistent pain. Drug Deliv. 2018;25(1):435–47. doi:10.1080/10717544.2018.1431981.
   PubMed Web of Science ®Google Scholar
• Ceglie A, Das K, Lindman B. Effect of oil on the microscopic structure in four-component cosurfactant microemulsions. J Colloid Interface Sci. 1987;115(1):115–20. doi:10.1016/0021-9797(87)90015-4.
   Web of Science ®Google Scholar
• Kreilgaard M. Influence of microemulsions on cutaneous drug delivery. Adv Drug Del Rev. 2002;54:S77–S98. doi:10.1016/S0169-409X(02)00116-3.
   PubMed Web of Science ®Google Scholar
• Callender SP, Mathews JA, Kobernyk K, Wettig SD. Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery. Int J Pharm. 2017;526(1):425–42. doi:10.1016/j.ijpharm.2017.05.005.
   PubMed Web of Science ®Google Scholar
• Zhang J, Froelich A, Michniak-Kohn B. Topical delivery of meloxicam using liposome and microemulsion formulation approaches. Pharmaceutics. 2020;12(3):282. doi:10.3390/pharmaceutics12030282.
   PubMed Web of Science ®Google Scholar
• Subongkot T, Sirirak T. Development and skin penetration pathway evaluation of microemulsions for enhancing the dermal delivery of celecoxib. Colloids Surf B Biointerfaces. 2020; 193:111103. doi:10.1016/j.colsurfb.2020.111103.
   PubMed Web of Science ®Google Scholar
• Zhang D, Ye D, Jing P, Tan X, Qiu L, Li T, et al. Design, optimization and evaluation of co-surfactant free microemulsion-based hydrogel with low surfactant for enhanced transdermal delivery of lidocaine. Int J Pharm. 2020;586:119415. doi:10.1016/j.ijpharm.2020.119415.
   PubMed Web of Science ®Google Scholar
• Zhu M, Whittaker AK, Smith MT, Han FY. Bioerodable ketamine-loaded microparticles fabricated using dissolvable hydrogel template technology. J Pharm Sci. 2019;108(3):1220–6. doi:10.1016/j.xphs.2018.10.029.
   PubMed Web of Science ®Google Scholar
• Han F, Whittaker A, Howdle S, Naylor A, Shabir-Ahmed A, Zhang C, Smith M. Formulation of bioerodible ketamine microparticles as an analgesic adjuvant treatment produced by supercritical fluid polymer encapsulation. Pharmaceutics. 2018;10(4):264. doi:10.3390/pharmaceutics10040264.
   Web of Science ®Google Scholar
• Dai H, Tilley DM, Mercedes G, Doherty C, Gulati A, Mehta N, Khalil A, Holzhaus K, Reynolds FM. Opiate‐free pain therapy using carbamazepine‐loaded microparticles provides up to 2 weeks of pain relief in a neuropathic pain model. Pain Pract. 2018;18(8):1024–35. doi:10.1111/papr.12705.
   PubMed Web of Science ®Google Scholar
• Shepherd SD, O’Buckley SC, Harrington JM, Haines LG, Rothrock GD, Johnson LM, Nackley AG. A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain. Sci Rep. 2018;8(1):1–9. doi:10.1038/s41598-018-29696-w.
   PubMedGoogle Scholar
• Kim S-N, Choi BH, Kim HK, Choy YB. Poly (lactic-co-glycolic acid) microparticles in fibrin glue for local, sustained delivery of bupivacaine. J Ind Eng Chem. 2019;75:86–92. doi:10.1016/j.jiec.2019.02.028.
   Web of Science ®Google Scholar
• Li X, Wei Y, Lv P, Wu Y, Ogino K, Ma G. Preparation of ropivacaine loaded PLGA microspheres as controlled-release system with narrow size distribution and high loading efficiency. Colloids Surf Physicochem Eng Aspects. 2019;562:237–46. doi:10.1016/j.colsurfa.2018.11.014.
   Web of Science ®Google Scholar
• Han FY, Whittaker A, Howdle SM, Naylor A, Shabir-Ahmed A, Smith MT. Sustained-release hydromorphone microparticles produced by supercritical fluid polymer encapsulation. J Pharm Sci. 2019;108(2):811–4. doi:10.1016/j.xphs.2018.09.021.
   PubMed Web of Science ®Google Scholar
• Rudnik-Jansen I, Schrijver K, Woike N, Tellegen A, Versteeg S, Emans P, et al. Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model. Drug Deliv. 2019;26(1):226–36.
   PubMed Web of Science ®Google Scholar
• Ceschan NE, Bucalá V, Mateos MV, Smyth HDC, Ramírez-Rigo MV. Carrier free indomethacin microparticles for dry powder inhalation. Int J Pharm. 2018;549(1-2):169–78. doi:10.1016/j.ijpharm.2018.07.065.
   PubMedGoogle Scholar
• Khattab A, Abouhussein DMN, Mohammad F E. Development of injectable tenoxicam in situ forming microparticles based on sesame oil and poly-DL-lactide: characterization, efficacy and acute toxicity. J Drug Deliv Sci Technol. 2019;51:682–94. doi:10.1016/j.jddst.2019.04.001.
   Web of Science ®Google Scholar
• Tellegen AR, Rudnik-Jansen I, Beukers M, Miranda-Bedate A, Bach FC, de Jong W, Woike N, Mihov G, Thies JC, Meij BP, et al. Intradiscal delivery of celecoxib-loaded microspheres restores intervertebral disc integrity in a preclinical canine model. J Control Release. 2018;286:439–50. doi:10.1016/j.jconrel.2018.08.019.
   PubMed Web of Science ®Google Scholar
• Qi X, Qin X, Yang R, Qin J, Li W, Luan K, et al. Intra-articular administration of chitosan thermosensitive in situ hydrogels combined with diclofenac sodium–loaded alginate microspheres. J Pharm Sci. 2016;105(1):122–30. doi:10.1016/j.xphs.2015.11.019.
   PubMed Web of Science ®Google Scholar
• Abd-Allah H, Kamel AO, Sammour OA. Injectable long acting chitosan/tripolyphosphate microspheres for the intra-articular delivery of lornoxicam: optimization and in vivo evaluation. Carbohydr Polym. 2016;149:263–73. doi:10.1016/j.carbpol.2016.04.096.
   PubMed Web of Science ®Google Scholar
• Kim SE, Yun Y-P, Shim K-S, Jeon DI, Park K, Kim H-J. In vitro and in vivo anti-inflammatory and tendon-healing effects in Achilles tendinopathy of long-term curcumin delivery using porous microspheres. J Ind Eng Chem. 2018;58:123–30. doi:10.1016/j.jiec.2017.09.016.
   Web of Science ®Google Scholar
• Ratanavaraporn J, Soontornvipart K, Shuangshoti S, Shuangshoti S, Damrongsakkul S. Localized delivery of curcumin from injectable gelatin/Thai silk fibroin microspheres for anti-inflammatory treatment of osteoarthritis in a rat model. Inflammopharmacol. 2017;25(2):211–21. doi:10.1007/s10787-017-0318-3.
   PubMed Web of Science ®Google Scholar
• Park JW, Yun Y-P, Park K, Lee JY, Kim H-J, Kim SE, Song H-R. Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model. Colloids Surf B Biointerfaces. 2016;147:265–73. doi:10.1016/j.colsurfb.2016.07.050.
   PubMed Web of Science ®Google Scholar
• ALQuadeib BT, Eltahir EK, Alagili MF. The oral administration of lidocaine HCl biodegradable microspheres: formulation and optimization. Int J Nanomedicine. 2020;15:857. doi:10.2147/IJN.S236273.
   PubMed Web of Science ®Google Scholar
• Sharma N, Arora S, Madan J. Nefopam hydrochloride loaded microspheres for post-operative pain management: synthesis, physicochemical characterization and in-vivo evaluation. Artif Cells Nanomed Biotechnol. 2018;46(1):138–46. doi:10.1080/21691401.2017.1301459.
   PubMed Web of Science ®Google Scholar
• Bédouet L, Moine L, Servais E, Beilvert A, Labarre D, Laurent A. Tunable delivery of niflumic acid from resorbable embolization microspheres for uterine fibroid embolization. Int J Pharm. 2016;511(1):253–61. doi:10.1016/j.ijpharm.2016.06.128.
   PubMedGoogle Scholar
• Ozdabak‐Sert AB, Sen B, Kok FN. Construction of a sandwich‐type wound dressing with pain‐reliever and pH‐responsive antibiotic delivery system. J Appl Polym Sci. 2019;136(47):48252. doi:10.1002/app.48252.
   Web of Science ®Google Scholar
• Prosapio V, Reverchon E, De Marco I. Formation of PVP/nimesulide microspheres by supercritical antisolvent coprecipitation. J Supercrit Fluid. 2016;118:19–26. doi:10.1016/j.supflu.2016.07.023.
   Web of Science ®Google Scholar
• Marin MM, Ignat M, Ghica MV, Albu Kaya M, Dinu Pirvu C, Anuta V, Popa L. Collagen—Lidocaine microcapsules with controlled release for tooth extraction pain. Rev Chim. 2018;69(5):1213–5. doi:10.37358/RC.18.5.6291.
   Web of Science ®Google Scholar
• Zhang X, Dang M, Zhang W, Lei Y, Zhou W. Sustained delivery of prilocaine and lidocaine using depot microemulsion system: in vitro, ex vivo and in vivo animal studies. Drug Dev Ind Pharm. 2020;46(2):264–71. doi:10.1080/03639045.2020.1716377.
   PubMed Web of Science ®Google Scholar
• Zhang H, Zhao Z, Chen W, Lv M, Cheng J, Sun Z. In vitro and in vivo studies of micro-depots using tailored microemulsion for sustained local anaesthesia. Pharm Dev Technol. 2020;:1–8.
   Web of Science ®Google Scholar
• Maulvi FA, Pillai LV, Patel KP, Desai AR, Shukla MR, Desai DT, Patel HP, Ranch KM, Shah SA, Shah DO. Lidocaine tripotassium phosphate complex laden microemulsion for prolonged local anaesthesia: In vitro and in vivo studies. Colloids Surf B Biointerfaces. 2020;185:110632. doi:10.1016/j.colsurfb.2019.110632.
   PubMed Web of Science ®Google Scholar
• Khaled SA, Alexander MR, Wildman RD, Wallace MJ, Sharpe S, Yoo J, Roberts CJ. 3D extrusion printing of high drug loading immediate release paracetamol tablets. Int J Pharm. 2018;538(1-2):223–30. doi:10.1016/j.ijpharm.2018.01.024.
   PubMedGoogle Scholar
• Shetu AA, Sharmin S, Rony SR, Moni F, Samaddar PR, Sohrab MH. Formulation and pharmacopoeial quality evaluation of ketorolac tromethamine IR tablet and comparison with marketed product. J Appl Pharm Sci. 2019;9(05):082–7.
   Google Scholar
• Kim Y, Beck-Broichsitter M, Banga AK. Design and evaluation of a poly (lactide-co-glycolide)-based in situ film-forming system for topical delivery of trolamine salicylate. Pharmaceutics. 2019;11(8):409. doi:10.3390/pharmaceutics11080409.
   Web of Science ®Google Scholar
• Rahman SAU, Siddique S, Abdul MIM, Lateef D, Dan S, Bose A. Development of novel chitosan based ketorolac implant controlled release formulation for subcutaneous drug delivery. Biomed Res. 2018;29(13):2735–9.
   Google Scholar
• Oh D-W, Kang J-H, Lee H-J, Han S-D, Kang M-H, Kwon Y-H, et al. Formulation and in vitro/in vivo evaluation of chitosan-based film forming gel containing ketoprofen. Drug Deliv. 2017;24(1):1056–66. doi:10.1080/10717544.2017.1346001.
   PubMed Web of Science ®Google Scholar
• Di Martino A, Drannikov A, Surgutskaia NS, Ozaltin K, Postnikov PS, Marina TE, et al. Chitosan-collagen based film for controlled delivery of a combination of short life anesthetics. Int J Biol Macromol. 2019;140:1183–93. doi:10.1016/j.ijbiomac.2019.08.228.
   PubMed Web of Science ®Google Scholar
• Burki IK, Khan MK, Khan BA, Uzair B, Braga VA, Jamil QA. Formulation development, characterization, and evaluation of a novel dexibuprofen-capsaicin skin emulgel with improved in vivo anti-inflammatory and analgesic effects. AAPS PharmSciTech. 2020;21(6):1–14. doi:10.1208/s12249-020-01760-7.
   Web of Science ®Google Scholar
• de Lima EN, de Andrade ARB, Leal LB, de Santana DP. Levobupivacaine thermogel for long-acting analgesia. AAPS PharmSciTech. 2018;19(6):2533–42. doi:10.1208/s12249-018-1083-3.
   PubMed Web of Science ®Google Scholar
• Naik A, Kalia YN, Guy RH. Transdermal drug delivery: overcoming the skin’s barrier function. Pharm Sci Technol Today. 2000;3(9):318–26. doi:10.1016/S1461-5347(00)00295-9.
   PubMedGoogle Scholar
• Oliveira LJ, Veiga A, Stofella NC, Cunha AC, Toledo MGT, Andreazza IF, et al. Development and evaluation of orodispersible tablets containing ketoprofen. Curr Drug Del. 2020.
   Web of Science ®Google Scholar
• Saleem MU, Nasiri MI, Zaman S-u, Khan N, Azeem M. Formulation development and characterization of cellulose/polyacrylic acid–based polymers on the release of celecoxib from extended release tablets. J Polym Res. 2020;27(8):1–7. doi:10.1007/s10965-020-02201-6.
   Web of Science ®Google Scholar
• ElMeshad AN, Abdel-Haleem KM, Gawad NAA, El-Nabarawi MA, Sheta NM. Core in cup ethylmorphine hydrochloride tablet for dual fast and sustained pain relief: formulation, characterization, and pharmacokinetic study. AAPS PharmSciTech. 2020;21(7):1–11. doi:10.1208/s12249-020-01759-0.
   Web of Science ®Google Scholar
• Hamed R, Omran H. Development of dual–release pellets of the non-steroidal anti–inflammatory drug celecoxib. J Drug Deliv Sci Technol. 2020;55:101419. doi:10.1016/j.jddst.2019.101419.
   Web of Science ®Google Scholar
• Schug SA, Ting S. Fentanyl formulations in the management of pain: an update. Drugs. 2017;77(7):747–63. doi:10.1007/s40265-017-0727-z.
   PubMed Web of Science ®Google Scholar
• Stanley TH. The fentanyl story. J Pain. 2014;15(12):1215–26. doi:10.1016/j.jpain.2014.08.010.
   PubMed Web of Science ®Google Scholar
• Fisher A, Watling M, Smith A, Knight A. Pharmacokinetics and relative bioavailability of fentanyl pectin nasal spray 100 - 800 µg in healthy volunteers. Int J Clin Pharmacol Ther. 2010;48(12):860–7. doi:10.5414/cpp48860.
   PubMed Web of Science ®Google Scholar
• Zeppetella G, Davies A, Eijgelshoven I, Jansen JP. A network meta-analysis of the efficacy of opioid analgesics for the management of breakthrough cancer pain episodes. J Pain Symptom Manage. 2014;47(4):772–85.e5. doi:10.1016/j.jpainsymman.2013.05.020.
   PubMed Web of Science ®Google Scholar
• Darwish M, Hamed E, Messina J. Fentanyl buccal tablet for the treatment of breakthrough pain: pharmacokinetics of buccal mucosa delivery and clinical efficacy. Perspect Medicin Chem. 2010;4:11–21. doi:10.4137/pmc.s3928.
   PubMedGoogle Scholar
• Moore N, Darwish M, Amores X, Schneid H. A review of the pharmacokinetic profile of transmucosal fentanyl formulations. Curr Med Res Opin. 2012;28(11):1781–90. doi:10.1185/03007995.2012.735227.
   PubMed Web of Science ®Google Scholar
• Scott LJ. Fentanyl iontophoretic transdermal system: a review in acute postoperative pain. Clin Drug Investig. 2016;36(4):321–30. doi:10.1007/s40261-016-0387-x.
   PubMed Web of Science ®Google Scholar
• Rane MM, Bajaj A. Development and optimisation of novel oral formulation of an opioid analgesic using central composite design. Cogent Med. 2017;4(1):1326210. doi:10.1080/2331205X.2017.1326210.
   Google Scholar
• Jacques ER, Alexandridis P. Tablet scoring: current practice, fundamentals, and knowledge gaps. Appl Sci. 2019;9(15):3066. doi:10.3390/app9153066.
   Google Scholar
• Alexander L, Mannion RO, Weingarten B, Fanelli RJ, Stiles GL. Development and impact of prescription opioid abuse deterrent formulation technologies. Drug Alcohol Depend. 2014;138:1–6. doi:10.1016/j.drugalcdep.2014.02.006.
   PubMed Web of Science ®Google Scholar
• Schneider JP, Matthews M, Jamison RN. Abuse-deterrent and tamper-resistant opioid formulations. CNS Drugs. 2010;24(10):805–10. doi:10.2165/11584260-000000000-00000.
   PubMed Web of Science ®Google Scholar
• Darwish M, Bond M, Ma Y, Tracewell W, Robertson P, Jr., Webster LR. Abuse potential with oral route of administration of a hydrocodone extended-release tablet formulated with abuse-deterrence technology in nondependent, recreational opioid users. Pain Med. 2017;18(1):61–77. doi:10.1093/pm/pnw122.
   PubMed Web of Science ®Google Scholar
• Ong JJ, Awad A, Martorana A, Gaisford S, Stoyanov E, Basit AW, et al. 3D printed opioid medicines with alcohol-resistant and abuse-deterrent properties. Int J Pharm. 2020;579:119169. doi:10.1016/j.ijpharm.2020.119169.
   PubMedGoogle Scholar
• Carinci AJ. Abuse-deterrent opioid analgesics: a guide for clinicians. Pain Manag. 2020;10(1):55–62. doi:10.2217/pmt-2019-0052.
   PubMed Web of Science ®Google Scholar
• Hale ME, Moe D, Bond M, Gasior M, Malamut R. Abuse-deterrent formulations of prescription opioid analgesics in the management of chronic noncancer pain. Pain Manag. 2016;6(5):497–508. doi:10.2217/pmt-2015-0005.
   PubMed Web of Science ®Google Scholar
• Meruva S, Donovan MD. Polyethylene oxide (PEO) molecular weight effects on abuse-deterrent properties of matrix tablets. AAPS PharmSciTech. 2020;21(1):1–10. doi:10.1208/s12249-019-1565-y.
   Web of Science ®Google Scholar
• Nukala PK, Palekar S, Patki M, Patel K. Abuse deterrent immediate release egg-shaped tablet (egglets) using 3D printing technology: quality by design to optimize drug release and extraction. AAPS PharmSciTech. 2019;20(2):80. doi:10.1208/s12249-019-1298-y.
   PubMed Web of Science ®Google Scholar
• Palekar S, Kumar Nukala P, Vartak R, Patel K. Abuse deterrent immediate release film technology (ADRIFT): A novel bilayer film technology for limiting intentional drug abuse. Int J Pharm. 2020; 590:119944. doi:10.1016/j.ijpharm.2020.119944.
   PubMedGoogle Scholar
• Arya A, Chandra A, Sharma V, Pathak K. Fast dissolving oral films: an innovative drug delivery system and dosage form. 2010;2(1):576–83.
   Google Scholar
• El-Feky GS, Farouk Abdulmaguid R, Zayed GM, Kamel R. Mucosal co-delivery of ketorolac and lidocaine using polymeric wafers for dental application. Drug Deliv. 2018;25(1):35–42. doi:10.1080/10717544.2017.1413445.
   PubMed Web of Science ®Google Scholar
• Li X‐Q, Ye Z‐M, Wang J‐B, Fan C‐R, Pan A‐W, Li C, Zhang R‐B. Mucoadhesive buccal films of tramadol for effective pain management. Rev Bras Anestesiol. 2017;67(3):231–7. doi:10.1016/j.bjan.2016.10.006.
   PubMed Web of Science ®Google Scholar
• Zaman M, Hanif M, Shaheryar ZA. Development of tizanidine HCl-meloxicam loaded mucoadhesive buccal films: in-vitro and in-vivo evaluation. PLoS One. 2018;13(3):e0194410. doi:10.1371/journal.pone.0194410.
   PubMed Web of Science ®Google Scholar
• Zaman M, Hanif M. In vitro and ex vivo assessment of hydrophilic polymer‐and plasticizer‐based thin buccal films designed by using central composite rotatable design for the delivery of meloxicam. Adv Polym Technol. 2018;37(6):1823–36. doi:10.1002/adv.21841.
   Web of Science ®Google Scholar
• Zaman M, Hanif M, Qaiser AA. Effect of polymer and plasticizer on thin polymeric buccal films of meloxicam designed by using central composite rotatable design. Acta Pol Pharm. 2016;73(5):1351–60.
   PubMed Web of Science ®Google Scholar
• Vinklárková L, Masteiková R, Foltýnová G, Muselík J, Pavloková S, Bernatonienė J, Vetchý D. Film wound dressing with local anesthetic based on insoluble carboxymethycellulose matrix. J Appl Biomed. 2017;15(4):313–20. doi:10.1016/j.jab.2017.08.002.
   Web of Science ®Google Scholar
• Eleftheriadis GK, Monou PK, Bouropoulos N, Boetker J, Rantanen J, Jacobsen J, et al. Fabrication of ­mucoadhesive buccal films for local administration of ketoprofen and lidocaine hydrochloride by combining fused deposition modeling and inkjet printing. J Pharm Sci. 2020;109(9):2757–66. doi:10.1016/j.xphs.2020.05.022.
   PubMed Web of Science ®Google Scholar
• Mahrous GM, Shazly G, Zidan DE, Abdel Zaher AA, El-Mahdy M. Formulation and evaluation of buccoadhesive films of lidocaine hydrochloride. J Adv Biomed Pharmaceut Sci. 2020;0 (0):0– 9. doi:10.21608/jabps.2020.21927.1066.
   Google Scholar
• Alyahya MY. Lidocaine mucoadhesive film fabrication using fused deposition modeling 3D printing [Master’s dissertation]. MS 38677, United States: The University of Mississippi; 2020.
   Google Scholar
• Yaşayan G, Karaca G, Akgüner ZP, Bal Öztürk A. Chitosan/collagen composite films as wound dressings encapsulating allantoin and lidocaine hydrochloride. Int J Polymeric Mater Polymeric Biomater. 2021;70(9):623–13. doi:10.1080/00914037.2020.1740993.
   Web of Science ®Google Scholar
• Wannaphatchaiyong S, Heng PWS, Suksaeree J, Boonme P, Pichayakorn W. Lidocaine loaded gelatin/gelatinized tapioca starch films for buccal delivery and the irritancy evaluation using chick chorioallantoic membrane. Saudi Pharm J. 2019;27(8):1085–95. doi:10.1016/j.jsps.2019.09.005.
   PubMed Web of Science ®Google Scholar
• Goder D, Matsliah L, Giladi S, Reshef-Steinberger L, Zin I, Shaul A, Zilberman M. Mechanical, physical and biological characterization of soy protein films loaded with bupivacaine for wound healing applications. Int J Polymeric Mater Polymeric Biomater. 2021;70(5):345–11. doi:10.1080/00914037.2020.1716226.
   Web of Science ®Google Scholar
• Adelli GR, Balguri SP, Bhagav P, Raman V, Majumdar S. Diclofenac sodium ion exchange resin complex loaded melt cast films for sustained release ocular delivery. Drug Deliv. 2017;24(1):370–9. doi:10.1080/10717544.2016.1256000.
   PubMed Web of Science ®Google Scholar
• Eleftheriadis GK, Monou PK, Bouropoulos N, Fatouros DG. In vitro evaluation of 2D-printed edible films for the buccal delivery of diclofenac sodium. Materials. 2018;11(5):864. doi:10.3390/ma11050864.
   Web of Science ®Google Scholar
• Trevisol TC, Scartazzini L, Valério A, Guelli Ulson de Souza SMA, Bierhalz ACK, Valle JAB. Diclofenac release from alginate/carboxymethyl cellulose mono and bilayer films for wound dressing applications. Cellulose. 2020;27(11):6629–42. doi:10.1007/s10570-020-03217-3.
   Web of Science ®Google Scholar
• Aycan D, Selmi B, Kelel E, Yildirim T, Alemdar N. Conductive polymeric film loaded with ibuprofen as a wound dressing material. Eur Polym J. 2019;121:109308. doi:10.1016/j.eurpolymj.2019.109308.
   Web of Science ®Google Scholar
• Aycan D, Yayla NA, Aydin YA. Chitosan polyvinyl alcohol blend films for ibuprofen encapsulation: Fabrication, characterization and kinetics. Polym Degradation Stab. 2020;181:109346. doi:10.1016/j.polymdegradstab.2020.109346.
   Web of Science ®Google Scholar
• Oustadi F, Haghbin NM, Mansouri M, Ketabat F. Preparation, characterization, and drug release study of ibuprofen-loaded poly (vinyl alcohol)/poly (vinyl pyrrolidone) bilayer antibacterial membrane. Int J Polymeric Mater Polymeric Biomater. 2020:1–10.
   Web of Science ®Google Scholar
• Janssen EM, Schliephacke R, Breitenbach A, Breitkreutz J. Drug-printing by flexographic printing technology—a new manufacturing process for orodispersible films. Int J Pharm. 2013;441(1-2):818–25. doi:10.1016/j.ijpharm.2012.12.023.
   PubMed Web of Science ®Google Scholar
• Perumal V, Govender T, Lutchman D, Mackraj I. Investigating a new approach to film casting for enhanced drug content uniformity in polymeric films. Drug Dev Ind Pharm. 2008;34(10):1036–47. doi:10.1080/03639040801928952.
   PubMed Web of Science ®Google Scholar
• Sharma D, Kaur D, Verma S, Singh D, Singh M, Singh G, et al. Fast dissolving oral films technology: a recent trend for an innovative oral drug delivery system. Int J Drug Deliv. 2015;7(2):60–75.
   Google Scholar
• Amin PM, Gangurde A, Alai P. Oral film technology: challenges and future scope for pharmaceutical industry. Int J Pharm Pharm Res. 2015;3(3):184–203.
   Google Scholar
• Stewart S, Domínguez-Robles J, McIlorum V, Mancuso E, Lamprou D, Donnelly R, Larrañeta E. Development of a biodegradable subcutaneous implant for prolonged drug delivery using 3D printing. Pharmaceutics. 2020;12(2):105. doi:10.3390/pharmaceutics12020105.
   Web of Science ®Google Scholar
• Wan D, Zhao M, Zhang J, Luan L. Development and in vitro-in vivo evaluation of a novel sustained-release loxoprofen pellet with double coating layer. Pharmaceutics. 2019;11(6):260. doi:10.3390/pharmaceutics11060260.
   PubMed Web of Science ®Google Scholar
• Svirskis D, Procter G, Sharma M, Bhusal P, Dravid A, MacFater W, Barazanchi A, Bennet L, Chandramouli K, Sreebhavan S, et al. A non-opioid analgesic implant for sustained post-operative intraperitoneal delivery of lidocaine, characterized using an ovine model. Biomaterials. 2020; 263:120409. doi:10.1016/j.biomaterials.2020.120409.
   PubMed Web of Science ®Google Scholar
• Li Y, Shi X. In vitro and in vivo evaluation of lidocaine hydrochloride-loaded injectable poly (lactic-co-glycolic acid) implants. Curr Drug Del. 2018;15(10):1411–6. doi:10.2174/1567201815666180912123137.
   PubMed Web of Science ®Google Scholar
• Wu K, Zhi X-D, Wang Y-S, Yu D-S. Localized delivery of ketoprofen from biodegradable in-situ hydrogel in effective management of pain and inflammation in intervertebral disc disorders. J Biomater Tissue Eng. 2016;6(12):987–91. doi:10.1166/jbt.2016.1530.
   Web of Science ®Google Scholar
• Batool F, Agossa K, Lizambard M, Petit C, Bugueno IM, Delcourt-Debruyne E, Benkirane-Jessel N, Tenenbaum H, Siepmann J, Siepmann F, et al. In-situ forming implants loaded with chlorhexidine and ibuprofen for periodontal treatment: Proof of concept study in vivo. Int J Pharm. 2019;569:118564. doi:10.1016/j.ijpharm.2019.118564.
   PubMedGoogle Scholar
• Sweed NM, Basalious EB, Nour SA. Combined site-specific release retardant mini-matrix tablets (C-SSRRMT) for extended oral delivery of dexketoprofen trometamol: in vitro evaluation and single versus multiple doses pharmacokinetic study in human volunteers. Drug Dev Ind Pharm. 2019;45(11):1777–87. doi:10.1080/03639045.2019.1656737.
   PubMed Web of Science ®Google Scholar
• Yin M, Xiao L, Liu Q, Kwon S‐Y, Zhang Y, Sharma PR, Jin L, Li X, Xu B. 3D printed microheater sensor‐integrated, drug‐encapsulated microneedle patch system for pain management. Adv Healthcare Mater. 2019;8(23):1901170. doi:10.1002/adhm.201901170.
   Web of Science ®Google Scholar
• Rao R, Nanda S. Sonophoresis: recent advancements and future trends. J Pharm Pharmacol. 2009;61(6):689–705. doi:10.1211/jpp.61.06.0001.
   PubMed Web of Science ®Google Scholar
• Tachibana K, Tachibana S. Use of ultrasound to enhance the local anesthetic effect of topically applied aqueous lidocaine. Anesthesiology. 1993;78(6):1091–6. doi:10.1097/00000542-199306000-00011.
   PubMed Web of Science ®Google Scholar
• Mutoh M, Ueda H, Nakamura Y, Hirayama K, Atobe M, Kobayashi D, et al. Characterization of transdermal solute transport induced by low-frequency ultrasound in the hairless rat skin. J Control Release. 2003;92(1-2):137–46. doi:10.1016/S0168-3659(03)00306-7.
   PubMed Web of Science ®Google Scholar
• Vaidya J, Shende P. Potential of sonophoresis as a skin penetration technique in the treatment of rheumatoid arthritis with transdermal patch. AAPS PharmSciTech. 2020;21(5):180. doi:10.1208/s12249-020-01725-w.
   PubMed Web of Science ®Google Scholar
• Masterson J, Kluge B, Burdette A, Sr GL. Sustained acoustic medicine; sonophoresis for nonsteroidal anti-inflammatory drug delivery in arthritis. Ther Deliv. 2020;11(6):363–72. doi:10.4155/tde-2020-0009.
   PubMed Web of Science ®Google Scholar
• Subongkot T. Combined effect of sonophoresis and a microemulsion on the dermal delivery of celecoxib. Drug Deliv. 2020;27(1):1087–93. doi:10.1080/10717544.2020.1797244.
   PubMed Web of Science ®Google Scholar
• Tian A-p, Yin Y-k, Yu L, Yang B-y, Li N, Li J-y. Low-frequency sonophoresis of chinese medicine formula improves efficacy of malignant pleural effusion treatment. Chin J Integr Med. 2020;26(4):263–9. doi:10.1007/s11655-019-3167-7.
   PubMed Web of Science ®Google Scholar
• Tian A-p, Yin Y-k, Yu L, Yang B-y, Li N, J-y L, et al. Topical delivery of modified da-cheng-qi decoction (加味大承气汤) using low-frequency ultrasound sonophoresis for refractory metastatic malignant bowel obstruction: an open-label single-arm clinical trial. Chin J Integr Med. 2019;26(5):1–6.
   Web of Science ®Google Scholar
• Ryu YC, Kim DI, Kim SH, Wang H-MD, Hwang BH, Engineering B. Synergistic transdermal delivery of biomacromolecules using sonophoresis after microneedle treatment. Biotechnol Bioproc E. 2018;23(3):286–92. doi:10.1007/s12257-018-0070-6.
   Web of Science ®Google Scholar
• Park J, Lee H, Lim G-S, Kim N, Kim D, Kim Y-C. Enhanced transdermal drug delivery by sonophoresis and simultaneous application of sonophoresis and iontophoresis. AAPS PharmSciTech. 2019;20(3):1–7. doi:10.1208/s12249-019-1309-z.
   Web of Science ®Google Scholar
• Baji S, Hegde AR, Kulkarni M, Raut SY, Manikkath J, Reddy MS, Mutalik S. Skin permeation of gemcitabine hydrochloride by passive diffusion, iontophoresis and sonophoresis: in vitro and in vivo evaluations. J Drug Deliv Sci Technol. 2018;47:49–54. doi:10.1016/j.jddst.2018.06.019.
   Web of Science ®Google Scholar
• Singh P, Maibach HI. Iontophoresis in drug delivery: basic principles and applications. Crit Rev Ther Drug Carrier Syst. 1994;11(2-3):161–213.
   PubMed Web of Science ®Google Scholar
• Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev Drug Discovery. 2004;3(2):115–24. doi:10.1038/nrd1304.
   PubMed Web of Science ®Google Scholar
• Pikal MJ. The role of electroosmotic flow in transdermal iontophoresis. Adv Drug Deliv Rev. 2001;46(1-3):281–305. doi:10.1016/S0169-409X(00)00138-1.
   PubMed Web of Science ®Google Scholar
• Higuchi WI, Li SK, Ghanem AH, Zhu H, Song Y. Mechanistic aspects of iontophoresis in human epidermal membrane. J Control Release. 1999;62(1-2):13–23. doi:10.1016/S0168-3659(99)00026-7.
   PubMed Web of Science ®Google Scholar
• Sheikh NK, Dua A. Iontophoresis Analgesic Medications. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing LLC; 2021.
   Google Scholar
• Mahajan A, Derian A. Local Anesthetic Toxicity. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing LLC.; 2021.
   Google Scholar
• Arunkumar S, Shivakumar HN, Narasimha Murthy S. Effect of terpenes on transdermal iontophoretic delivery of diclofenac potassium under constant voltage. Pharm Dev Technol. 2018;23(8):806–14. doi:10.1080/10837450.2017.1369110.
   PubMed Web of Science ®Google Scholar
• Kubota K, Miyamoto T, Inoue T, Fukayama H. Alternating current iontophoresis for control of postoperative pain. Anesth Prog. 2018;65(2):106–10. doi:10.2344/anpr-64-04-03.
   PubMedGoogle Scholar
• Indulekha S, Arunkumar P, Bahadur D, Srivastava R. Thermoresponsive polymeric gel as an on-demand transdermal drug delivery system for pain management. Mater Sci Eng, C. 2016;62:113–22. doi:10.1016/j.msec.2016.01.021.
   PubMed Web of Science ®Google Scholar
• Polat BE, Hart D, Langer R, Blankschtein D. Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends. J Control Release. 2011;152(3):330–48. doi:10.1016/j.jconrel.2011.01.006.
   PubMed Web of Science ®Google Scholar
• Almurisi SH, Doolaanea AA, Akkawi ME, Chatterjee B, Ahmed Saeed Aljapairai K, Islam Sarker MZ. Formulation development of paracetamol instant jelly for pediatric use. Drug Dev Ind Pharm. 2020;46(8):1373–83. doi:10.1080/03639045.2020.1791165.
   PubMed Web of Science ®Google Scholar
• Mei L, Xie Y, Huang Y, Wang B, Chen J, Quan G, et al. Injectable in situ forming gel based on lyotropic liquid crystal for persistent postoperative analgesia. Acta Biomater. 2018;67:99–110. doi:10.1016/j.actbio.2017.11.057.
   PubMed Web of Science ®Google Scholar