305
Views
0
CrossRef citations to date
0
Altmetric
ARTICLES

Topical Morphine Gel as a Systemic Opioid Sparing Technique

ORCID Icon & ORCID Icon
Pages 159-165 | Received 20 Dec 2021, Accepted 26 May 2022, Published online: 09 Jun 2022

References

  • LeBon B, Zeppetella G, Higginson IJ. Effectiveness of topical administration of opioids in palliative care: a systematic review. J Pain Symptom Manage. 2009;37(5):913–7. doi:10.1016/j.jpainsymman.2008.06.007. Cited in: PMID: 19321297.
  • Gutierrez Y, Pourali SP, Kohn AH, Jones ME, Rajkumar JR, Armstrong AW. Topical opioid use in dermatologic disease: a systematic review. Dermatol Ther. 2021;34(6):e15150. doi:10.1111/dth.15150. Cited in: PMID: 34605133.
  • Farley P. Should topical opioid analgesics be regarded as effective and safe when applied to chronic cutaneous lesions? J Pharm Pharmacol. 2011;63(6):747–56. doi:10.1111/j.2042-7158.2011.01252.x. PMID: 21585371.
  • Stein C. Peripheral mechanisms of opioid analgesia. Anesth Analg. 1993;76(1):182–91. doi:10.1213/00000539-199301000-00031. Cited in: PMID: 8380316.
  • Ribeiro MD, Joel SP, Zeppetella G. The bioavailability of morphine applied topically to cutaneous ulcers. J Pain Symptom Manage. 2004;27(5):434–9. doi:10.1016/j.jpainsymman.2003.09.011. Cited in: PMID: 15120772.
  • Back IN, Finlay I. Analgesic effect of topical opioids on painful skin ulcers. J Pain Symptom Manage. 1995;10(7):493. Cited in: PMID: 8537690. doi:10.1016/0885-3924(95)00101-4.
  • Twillman RK, Long TD, Cathers TA, Mueller DW. Treatment of painful skin ulcers with topical opioids. J Pain Symptom Manage. 1999;17(4):288–92. doi:10.1016/s0885-3924(98)00140-7. Cited in: PMID: 10203881.
  • Krajnik M, Zylicz Z, Finlay I, Luczak J, van Sorge AA. Potential uses of topical opioids in palliative care-report of 6 cases. Pain. 1999;80(1–2):121–5. Cited in: PMID: 10204724. doi:10.1016/S0304-3959(98)00211-5.
  • Bastami S, Frodin T, Ahlner J, Uppugunduri S. Topical morphine gel in the treatment of painful leg ulcers, a double-blind, placebo-controlled clinical trial: a pilot study. Int Wound J. 2012;9(4):419–27. doi:10.1111/j.1742-481X.2011.00901.x. Cited in: PMID: 22151619,
  • Ballas S. Treatment of painful sickle cell leg ulcers with topical opioids. Blood. 2002;99(3):1096. doi:10.1182/blood.v99.3.1096. Cited in: PMID: 11822360.
  • Long TD, Cathers TA, Twillman R, O’Donnell T, Garrigues N, Jones T. Morphine-infused silver sulfadiazine (MISS) cream for burn analgesia: a pilot study. J Burn Care Rehabil. 2001;22(2):118–23. doi:10.1097/00004630-200103000-00006. Cited in: PMID: 11302598.
  • Porzio G, Aielli F, Verna L, Cannita K, Marchetti P, Ficorella C. Topical morphine in the treatment of painful ulcers. J Pain Symptom Manage. 2005;30(4):304–5. doi:10.1016/j.jpainsymman.2005.08.011. Cited in: PMID: 16256893.
  • Zeppetella G, Porzio G, Aielli F. Opioids applied topically to painful cutaneous malignant ulcers in a palliative care setting. J Opioid Manag. 2007;3(3):161–6. doi:10.5055/jom.2007.0054. Cited in: PMID: 18027542.
  • DiScala SL, Basri D, Vartan CM, Silverman MA. Use of topical morphine to relieve painful pressure ulcers. Consult Pharm. 2018;33(4):215–21. doi:10.4140/TCP.n.2018.215. Cited in: PMID: 29609700.
  • Welling A. A randomised controlled trial to test the analgesic efficacy of topical morphine on minor superficial and partial thickness burns in accident and emergency departments. Emerg Med J. 2007;24(6):408–12. doi:10.1136/emj.2007.047324. Cited in: PMID: 17513537.
  • Ashfield T. The use of topical opioids to relieve pressure ulcer pain. Nurs Stand. 2005;19(45):90–2. doi:10.7748/ns2005.07.19.45.90.c3918. Cited in: PMID: 16050237.
  • Jansen MM, van der Horst JC, van der Valk PG, Kuks PF, Zylicz Z, van Sorge AA. Pain-relieving properties of topically applied morphine on arterial leg ulcers: a pilot study. J Wound Care. 2009;18(7):306–11. doi:10.12968/jowc.2009.18.7.43115. Cited in: PMID: 19827484.
  • Walker PW, Palla S, Pei B-L, Kaur G, Zhang K, Hanohano J, Munsell M, Bruera E. Switching from methadone to a different opioid: what is the equianalgesic dose ratio? J Palliat Med. 2008;11(8):1103–8. Cited in: PMID: 18980450. doi:10.1089/jpm.2007.0285.
  • Whelan CT, Jin L, Meltzer D. Pain and satisfaction with pain control in hospitalized medical patients: No such thing as low risk. Arch Intern Med. 2004;164(2):175–80. doi:10.1001/archinte.164.2.175. Cited in: PMID: 14744841.
  • Ballantyne JC, Sullivan MD. Intensity of chronic Pain-The Wrong Metric? N Engl J Med. 2015;373(22):2098–9. doi:10.1056/NEJMp1507136. Cited in: PMID: 26605926.
  • Nugent SM, Lovejoy TI, Shull S, Dobscha SK, Morasco BJ. Associations of pain numeric rating scale scores collected during usual care with research administered patient reported pain outcomes. Pain Med. 2021;22(10):2235–41. doi:10.1093/pm/pnab110. Cited in: PMID: 33749760.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.