Infusion of HLA-matched and static magnetic field-exposed allogenic lymphocytes treating lymphocytopenia and cytokine storm syndrome: A treatment proposal for COVID-19 patients

References

• Bettelli, E., Y. Carrier, W. Gao, T. Korn, T. B. Strom, M. Oukka, H. L. Weiner, V. K. Kuchroo. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235–38. doi:10.1038/nature04753.
   PubMed Web of Science ®Google Scholar
• Borish, L., A. Aarons, J. Rumbyrt, P. Cvietusa, J. Negri, S. Wenzel. 1996. Interleukin-10 regulation in normal subjects and patients with asthma. J. Allergy Clin. Immunol. 97:1288–96. doi:10.1016/S0091-6749(96)70197-5.
   PubMed Web of Science ®Google Scholar
• Bork, P., L. Holm, and C. Sander. 1994. The immunoglobulin fold. Structural classification, sequence patterns and common core. J. Mol. Biol. 242:309–20.
   PubMed Web of Science ®Google Scholar
• Calabrese, L. H., and S. Rose-John. 2014. IL-6 biology: Implications for clinical targeting in rheumatic disease. Nat. Rev. Rheumatol. 10:720–27. doi:10.1038/nrrheum.2014.127.
   PubMed Web of Science ®Google Scholar
• Charron, D. 2007. Autologous white blood cell transfusion: Toward a younger immunity. Hum. Immunol. 68:805–12. doi:10.1016/j.humimm.2007.07.004.
   PubMed Web of Science ®Google Scholar
• Chen, G., D. Wu, W. Guo, Y. Cao, D. Huang, H. Wang, T. Wang, X. Zhang, H. Chen, H. Yu, et al. 2020a. Clinical and immunological features of severe and moderate coronavirus disease 2019. J. Clin. Invest. 130:2620–29. doi:10.1172/JCI137244.
   PubMed Web of Science ®Google Scholar
• Chen, L., J. Xiong, L. Bao, Y. Shi. 2020c. Convalescent plasma as a potential therapy for COVID-19. Lancet Infect. Dis. 20:398–400. doi:10.1016/S1473-3099(20)30141-9.
   PubMed Web of Science ®Google Scholar
• Chen, X., B. Zhao, Y. Qu, Y. Chen, J. Xiong, Y. Feng, D. Men, Q. Huang, Y. Liu, B. Yang, et al. 2020b. Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients. Clin. Infect. Dis. ciaa449. doi:10.1101/2020.02.29.20029520
   Google Scholar
• Chinese Clinical Trial Registry (ChiCTR). 2020. Data from: A multicenter, randomized controlled trial for the efficacy and safety of tocilizumab in the treatment of new coronavirus pneumonia (COVID-19). Accessed June 16, 2020. http://www.chictr.org.cn/showprojen.aspx?proj=49409
   Google Scholar
• Couper, K. N., D. G. Blount, and E. M. Riley. 2008. IL-10: The master regulator of immunity to infection. J. Immunol. 180:5771–77. doi:10.4049/jimmunol.180.9.5771.
   PubMed Web of Science ®Google Scholar
• Daya, S., and J. Gunby. 1994. The recurrent miscarriage immunotherapy trialists group (1994) The effectiveness of allogeneic leukocyte immunization in unexplained primary recurrent spontaneous abortion. Am. J. Reprod. Immunol. 32:294–302. doi:10.1111/j.1600-0897.1994.tb01129.x.
   PubMed Web of Science ®Google Scholar
• de Vos, A. M., M. Ultsch, and A. A. Kossiakoff. 1992. Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex. Science 255:306–12.
   PubMed Web of Science ®Google Scholar
• de Vries, E. F., M. Roca, F. Jamar, O. Israel, A. Signore. 2010. Guidelines for the labelling of leucocytes with (99m)Tc-HMPAO. Eur. J. Nucl. Med. Mol. Imaging 37:842–48. doi:10.1007/s00259-010-1394-4.
   PubMed Web of Science ®Google Scholar
• DeDiego, M. L., J. L. Nieto-Torres, J. A. Regla-Nava, J. M. Jimenez-Guardeno, R. Fernandez-Delgado, C. Fett, C. Castano-Rodriguez, S. Perlman, L. Enjuanes. 2014. Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival. J. Virol. 88:913–24. doi:10.1128/JVI.02576-13.
   PubMed Web of Science ®Google Scholar
• Dumoutier, L., and J. C. Renauld. 2002. Viral and cellular interleukin-10 (IL-10)-related cytokines: From structures to functions. Eur. Cytokine Netw. 13:5‐15.
   PubMed Web of Science ®Google Scholar
• Fielding, C. A., R. M. McLoughlin, L. McLeod, C. S. Colmont, M. Najdovska, D. Grail, M. Ernst, S. A. Jones, N. Topley, B. J. Jenkins, et al. 2008. IL-6 regulates neutrophil trafficking during acute inflammation via STAT3. J. Immunol. 181:2189–95. doi:10.4049/jimmunol.181.3.2189.
   PubMed Web of Science ®Google Scholar
• Frazier, W. J., and M. W. Hall. 2008. Immunoparalysis and adverse outcomes from critical illness. Pediatr. Clin. N. Am. 55:647–68. doi:10.1016/j.pcl.2008.02.009.
   PubMed Web of Science ®Google Scholar
• Gastl, G. A., J. S. Abrams, D. M. Nanus, R. Oosterkamp, J. Silver, F. Liu, M. Chen, A. P. Albino, N. H. Bander. 1993. Interleukin-10 production by human carcinoma cell lines and its relationship to interleukin-6 expression. Int. J. Cancer 55:96–101. doi:10.1002/ijc.2910550118.
   PubMed Web of Science ®Google Scholar
• Gilman, A. L., W. Leung, M. J. Cowan, M. Cannon, S. Epstein, C. Barnhart, K. Shah, M. Hyland, T. Fukes, A. Ivanova, et al. 2018. Donor lymphocyte infusion and methotrexate for immune recovery after T-cell depleted haploidentical transplantation. Am. J. Hematol. 82:169–78. doi:10.1002/ajh.24949.
   Google Scholar
• Guo, Y. R., Q. D. Cao, Z. S. Hong, Y. Y. Tan, S. D. Chen, H. J. Jin, K. S. Tan, D. Y. Wang, Y. Yan. 2020. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil. Med. Res. 7:11.
   PubMed Web of Science ®Google Scholar
• Han, H., Q. Ma, C. Li, R. Liu, L. Zhao, W. Wang, P. Zhang, X. Liu, G. Gao, F. Liu, et al. 2020. Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Emerg. Microbes. Infect. 9:1123–30. doi:10.1080/22221751.2020.1770129.
   PubMed Web of Science ®Google Scholar
• Hibi, M., M. Murakami, M. Saito, T. Hirano, T. Taga, T. Kishimoto. 1990. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63:1149–57. doi:10.1016/0092-8674(90)90411-7.
   PubMed Web of Science ®Google Scholar
• Hirano, T., T. Matsuda, M. Turner, N. Miyasaka, G. Buchan, B. Tang, K. Sato, M. Shimi, R. Maid, M. Feldmann, et al. 1988. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur. J. Immunol. 18:1797–801. doi:10.1002/eji.1830181122.
   PubMed Web of Science ®Google Scholar
• Hirano, T., T. Taga, K. Yasukawa, K. Nakajima, N. Nakano, F. Takatsuki, M. Shimizu, A. Murashima, S. Tsunasawa, F. Sakiyama, et al. 1987. Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production. Proc. Natl. Acad. Sci. USA 84:228–31. doi:10.1073/pnas.84.1.228.
   PubMed Web of Science ®Google Scholar
• Huang, C., Y. Wang, X. Li, L. Ren, J. Zhao, Y. Hu, L. Zhang, G. Fan, J. Xu, X. Gu, et al. 2020a. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395:497–506. doi:10.1016/S0140-6736(20)30183-5.
   PubMed Web of Science ®Google Scholar
• Huang, G., A. J. Kovalic, and C. J. Graber. 2020b. Prognostic value of leukocytosis and lymphopenia for coronavirus disease severity. Emerg. Infect. Dis. 26:1839–41. doi:10.3201/eid2608.201160.
   PubMed Web of Science ®Google Scholar
• Hunter, C. A., and S. A. Jones. 2015. IL-6 as a keystone cytokine in health and disease. Nat. Immunol. 16:448–57. doi:10.1038/ni.3153.
   PubMed Web of Science ®Google Scholar
• Iyer, S. S., and G. Cheng. 2012. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit. Rev. Immunol. 32:23–63. doi:10.1615/CritRevImmunol.v32.i1.30.
   PubMed Web of Science ®Google Scholar
• Karam, R. A., H. E. Zidan, and M. H. Khater. 2014. Polymorphisms in the TNF-α and IL-10 gene promoters and risk of psoriasis and correlation with disease severity. Cytokine 66:101–05. doi:10.1016/j.cyto.2014.01.008.
   PubMed Web of Science ®Google Scholar
• Kawano, M., T. Hirano, T. Matsuda, T. Taga, Y. Horii, K. Iwato, H. Asaoku, B. Tang, O. Tanabe, H. Tanaka, et al. 1988. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332:83–85. doi:10.1038/332083a0.
   PubMed Web of Science ®Google Scholar
• Kim, E. C., J. Park, G. Noh, S.-J. Park, K. Noh, I.-K. Kwon, S.-J. Ahn. 2018. Effects of moderate intensity static magnetic fields on osteoclastic differentiation in mouse bone marrow cells. Bioelectromagnetics 39:394–404. doi:10.1002/bem.22126.
   PubMed Web of Science ®Google Scholar
• Kim, J. M., C. I. Brannan, N. G. Copeland, N. A. Jenkins, T. A. Khan, K. W. Moore. 1992. Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes. J. Immunol. 148:3618‐23.
   Web of Science ®Google Scholar
• Kimura, A., and T. Kishimoto. 2010. IL-6: Regulator of Treg/Th17 balance. Eur. J. Immunol. 40:1830–35. doi:10.1002/eji.201040391.
   PubMed Web of Science ®Google Scholar
• Kolb, H. J., J. Mittermüller, C. Clemm, E. Holler, G. Ledderose, G. Brehm, M. Heim, W. Wilmanns. 1990. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 76:2462–65. doi:10.1182/blood.V76.12.2462.2462.
   PubMed Web of Science ®Google Scholar
• Kono, K., A. Takahashi, F. Ichihara, H. Amemiya, H. Iizuka, H. Fujii, T. Sekikawa, Y. Matsumoto. 2002. Prognostic significance of adoptive immunotherapy with tumor-associated lymphocytes in patients with advanced gastric cancer: A randomized trial. Clin. Cancer Res. 8:1767–71.
   PubMed Web of Science ®Google Scholar
• Korn, T., M. Mitsdoerffer, A. L. Croxford, A. Awasthi, V. A. Dardalhon, G. Galileos, P. Vollmar, G. L. Stritesky, M. H. Kaplan, A. Waisman, et al. 2008. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 105:18460–65. doi:10.1073/pnas.0809850105.
   PubMed Web of Science ®Google Scholar
• Kumar, N., Z. T. Xin, Y. Liang, H. Ly, Y. Liang. 2008. NF-κB signaling differentially regulates influenza virus RNA synthesis. J. Virol. 82:9880–89. doi:10.1128/JVI.00909-08.
   PubMed Web of Science ®Google Scholar
• Letko, M., A. Marzi, and V. Munster. 2020. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nat. Microbiol. 5:562–69. doi:10.1038/s41564-020-0688-y.
   PubMed Web of Science ®Google Scholar
• Liu, B., M. Li, Z. Zhou, X. Guan, Y. Xiang. 2020. Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? J. Autoimmun. 111:102452. doi:10.1016/j.jaut.2020.102452.
   PubMed Web of Science ®Google Scholar
• Lowenthal, R. M., L. Grossman, J. M. Goldman, B. C. Murphy, L. Grossman, R. A. Storring, D. S. Park, A. S. D. Spiers, D. A. G. Galton. 1975. Granulocyte transfusions in treatment of infections in patients with acute leukaemia and aplastic anaemia. Lancet 1:353–58. doi:10.1016/S0140-6736(75)91276-3.
   PubMed Web of Science ®Google Scholar
• Luban, N. L. 2005. Transfusion safety: Where are we today? Ann. NY Acad. Sci. 1054:325–41. doi:10.1196/annals.1345.040.
   PubMed Web of Science ®Google Scholar
• Luznik, L., and E. J. Fuchs. 2002. Donor lymphocyte infusions to treat hematologic malignancies in relapse after allogeneic blood or marrow transplantation. Cancer Control 9:123–37. doi:10.1177/107327480200900205.
   PubMedGoogle Scholar
• Mauer, J., B. Chaurasia, J. Goldau, M. C. Vogt, J. Ruud, K. D. Nguyen, S. Theurich, A. C. Hausen, J. Schmitz, H. S. Brönneke, et al. 2014. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat. Immunol. 15:423–30.
   PubMed Web of Science ®Google Scholar
• McGonagle, D., K. Sharif, A. O’Regan, C. Bridgewood. 2020. The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease. Autoimmun. Rev. 19:102537. doi:10.1016/j.autrev.2020.102537.
   PubMed Web of Science ®Google Scholar
• Mehta, P., D. F. McAuley, M. Brown, E. Sanchez, R. S. Tattersall, J. J. Manson. 2020. COVID-19: Consider cytokine storm syndromes and immunosuppression. Lancet 395:1033–34. doi:10.1016/S0140-6736(20)30628-0.
   PubMed Web of Science ®Google Scholar
• Miller, J. S., D. J. Weisdorf, L. J. Burns, A. Slungaard, J. E. Wagner, M. R. Verneris, S. Cooley, R. Wangen, S. K. Fautsch, R. Nicklow, et al. 2007. Lymphodepletion followed by donor lymphocyte infusion (DLI) causes significantly more acute graft-versus-host disease than DLI alone. Blood 110:2761–63. doi:10.1182/blood-2007-05-090340.
   PubMed Web of Science ®Google Scholar
• Muraguchi, A., T. Hirano, B. Tang, T. Matsuda, Y. Horii, K. Nakajima, T. Kishimoto. 1988. The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J. Exp. Med. 167:332–44. doi:10.1084/jem.167.2.332.
   PubMed Web of Science ®Google Scholar
• Murray, P. J. 2006. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response. Curr. Opin. Pharmacol. 6:379–86. doi:10.1016/j.coph.2006.01.010.
   PubMed Web of Science ®Google Scholar
• Murray, P. J. 2007. The JAK-STAT signaling pathway: Input and output integration. J. Immunol. 178:2623–29. doi:10.4049/jimmunol.178.5.2623.
   PubMed Web of Science ®Google Scholar
• National Institutes of Health (NIH). 2020. Data from: COVID 19 treatment guidelines, interleukin-6 inhibitors. Accessed July 20, 2020. https://www.covid19treatmentguidelines.nih.gov/immune-based-therapy/interleukin-6-inhibitors/.
   Google Scholar
• Navarrete, C. V. 2000. The HLA system in blood transfusion. Bailliere’s Clin. Haematol. 13:511–32. doi:10.1053/beha.2000.0097.
   PubMed Web of Science ®Google Scholar
• Nishimoto, N., Y. Kanakura, K. Aozasa, T. Johkoh, M. Nakamura, S. Nakano, N. Nakano, Y. Ikeda, T. Sasaki, K. Nishioka, et al. 2005. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood 106:2627–32. doi:10.1182/blood-2004-12-4602.
   PubMed Web of Science ®Google Scholar
• Norris, C. A., M. He, L. I. Kang, M. Q. Ding, J. E. Radder, M. M. Haynes, Y. Yang, S. Paranjpe, W. C. Bowen, A. Orr, et al. 2014. Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli. PLoS One 9:e96053. doi:10.1371/journal.pone.0096053.
   PubMed Web of Science ®Google Scholar
• Ogura, H., M. Murakami, Y. Okuyama, M. Tsuruoka, C. Kitabayashi, M. Kanamoto, M. Nishihara, Y. Iwakura, T. Hirano. 2008. Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity 29:628–36. doi:10.1016/j.immuni.2008.07.018.
   PubMed Web of Science ®Google Scholar
• Okano, H., and C. Ohkubo. 2003. Effects of static magnetic fields on plasma levels of angiotensin II and aldosterone associated with arterial blood pressure in genetically hypertensive rats. Bioelectromagnetics 24:403–12.
   PubMed Web of Science ®Google Scholar
• Ota, M., M. Yanagisawa, H. Tachibana, K. Yokota, Y. Araki, K. Sato, T. Mimura. 2015. A significant induction of neutrophilic chemoattractants but not RANKL in synoviocytes stimulated with interleukin 17. J. Bone Miner. Metab 33:40–47. doi:10.1007/s00774-014-0565-y.
   PubMed Web of Science ®Google Scholar
• Paradowska-Gorycka, A., J. Trefler, J. Maciejewska-Stelmach, J. K. Łącki. 2010. Interleukin-10 gene promoter polymorphism in Polish rheumatoid arthritis patients. Int. J. Immunogenet. 37:225–31. doi:10.1111/j.1744-313X.2010.00913.x.
   PubMed Web of Science ®Google Scholar
• Pedersen, S. F., and Y.-C. Ho. 2020. SARS-CoV-2: A storm is raging. J. Clin. Invest. 130:2202–05. doi:10.1172/JCI137647.
   PubMed Web of Science ®Google Scholar
• Pisa, P., E. Halapi, E. K. Pisa, E. Gerdin, C. Hising, A. Bucht, B. Gerdin, R. Kiessling. 1992. Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies. Proc. Natl. Acad. Sci. USA 89:7708–12. doi:10.1073/pnas.89.16.7708.
   PubMed Web of Science ®Google Scholar
• Presnell, S. R., and F. E. Cohen. 1989. Topological distribution of four-alpha-helix bundles. Proc. Natl. Acad. Sci. USA 86:6592–96. doi:10.1073/pnas.86.17.6592.
   PubMed Web of Science ®Google Scholar
• Rahman, A. 2003. Cytokines in systemic lupus erythematosus, London, UK. Arthritis Res. Ther. 5:160–64. doi:10.1186/ar767.
   PubMed Web of Science ®Google Scholar
• Rahmati, M., and M. A. Moosavi. 2020. Cytokine-targeted therapy in severely ill COVID-19 patients: Options and cautions. EJMO 4:179–80.
   Google Scholar
• Rooney, C. M., C. A. Smith, C. Y. Ng, S. K. Loftin, J. W. Sixbey, Y. Gan, D.-K. Srivastava, L. C. Bowman, R. A. Krance, M. K. Brenner, et al. 1998. Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients. Blood 92:1549–55. doi:10.1182/blood.V92.5.1549.
   PubMed Web of Science ®Google Scholar
• Rose-John, S., and P. C. Heinrich. 1994. Soluble receptors for cytokines and growth factors: Generation and biological function. Biochem. J. 300:281–90. doi:10.1042/bj3000281.
   PubMed Web of Science ®Google Scholar
• Rosenberg, S. A. 1984. Adoptive immunotherapy of cancer: Accomplishments and prospects. Cancer Treat. Rep. 68:233–55.
   PubMedGoogle Scholar
• Rothaug, M., C. Becker-Pauly, and S. Rose-John. 2016. The role of interleukin-6 signaling in nervous tissue. Biochim. Biophys. Acta 1863:1218‐1227.
   PubMed Web of Science ®Google Scholar
• Roumier, M., R. Paule, M. Groh, A. Vallée, F. Ackermann. 2020. Interleukin-6 blockade for severe COVID-19. MedRxiv. In press. doi:10.1101/2020.04.20.20061861.
   Google Scholar
• Ruan, Q., K. Yang, W. Wang, L. Jiang, J. Song. 2020. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 6:1–4.
   Google Scholar
• Saeidi, A., K. Zandi, Y. Y. Cheok, H. Saeidi, W. F. Wong, C. Y. Q. Lee, H. C. Cheong, Y. K. Yong, M. Larsson, E. M. Shankar. 2018. T-cell exhaustion in chronic infections: Reversing the state of exhaustion and reinvigorating optimal protective immune responses. Front. Immunol. 9:2569. doi:10.3389/fimmu.2018.02569.
   PubMed Web of Science ®Google Scholar
• Scheller, J., A. Chalaris, D. Schmidt-Arras, S. Rose-John. 2011. The pro and anti-inflammatory properties of the cytokine interleukin-6. Biochim. Biophys. Acta 1813:878–88. doi:10.1016/j.bbamcr.2011.01.034.
   PubMed Web of Science ®Google Scholar
• Schirrmacher, V. 2014. Complete remission of cancer in late-stage disease by radiation and transfer of allogeneic MHC-matched immune T cells: Lessons from GvL studies in animals. Cancer Immunol. Immunother. 63:535–43. doi:10.1007/s00262-014-1530-2.
   PubMed Web of Science ®Google Scholar
• Shang, W., G. Chen, Y. Li, Y. Zhuo, Y. Wang, Z. Fang, Y. Yu, H. Ren. 2019. Static magnetic field accelerates diabetic wound healing by facilitating resolution of inflammation. J. Diabetes Res. 2019:1–11. doi:10.1155/2019/5641271.
   Web of Science ®Google Scholar
• Shouval, D. S., J. Ouahed, A. Biswas, J. A. Goettel, B. H. Horwitz, C. Klein, A. M. Muise, S. B. Snapper. 2014. Interleukin 10 receptor signaling: Master regulator of intestinal mucosal homeostasis in mice and humans. Adv. Immunol. 122:177–210.
   PubMed Web of Science ®Google Scholar
• Somers, W., M. Stahl, and J. S. Seehra. 1997. 1.9 A crystal structure of interleukin 6: Implications for a novel mode of receptor dimerization and signalling. Embo J. 16:989‐97. doi:10.1093/emboj/16.5.989
   Web of Science ®Google Scholar
• Somers, W., M. Ultsch, A. M. De Vos, A. A. Kossiakoff. 1994. The X-ray structure of a growth hormone-prolactin receptor complex. Nature 372:478–81. doi:10.1038/372478a0.
   PubMed Web of Science ®Google Scholar
• Taga, T., M. Narazaki, K. Yasukawa, T. Saito, D. Miki, M. Hamaguchi, S. Davis, M. Shoyab, G. D. Yancopoulos, T. Kishimoto, et al. 1992. Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130. Proc. Natl. Acad. Sci. USA 89:10998–1001. doi:10.1073/pnas.89.22.10998.
   PubMed Web of Science ®Google Scholar
• Tan, L., Q. Wang, D. Zhang, J. Ding, Q. Huang, Y.-Q. Tang, Q. Wang, H. Miao. 2020. Lymphopenia predicts disease severity of COVID-19: A descriptive and predictive study. Signal Transduct. Target Ther. 5:33. doi:10.1038/s41392-020-0148-4.
   PubMed Web of Science ®Google Scholar
• Tanaka, T., M. Narazaki, and T. Kishimoto. 2014. IL-6 in inflammation, immunity, and disease. Cold Spring Harb. Perspect. Biol. 6:a016295. doi:10.1101/cshperspect.a016295.
   PubMed Web of Science ®Google Scholar
• Tikellis, C., and M. C. Thomas. 2012. Angiotensin-Converting Enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease. Int. J. Pept. (2012):256294.
   PubMedGoogle Scholar
• Trandem, K., J. Zhao, E. Fleming, S. Perlman. 2011. Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis. J. Immunol. 186:3642–52. doi:10.4049/jimmunol.1003292.
   PubMed Web of Science ®Google Scholar
• Trifunović, J., L. Miller, Ž. Debeljak, V. Horvat. 2015. Pathologic patterns of interleukin 10 expression - a review. Biochem. Med. (Zagreb) 25:36–48. doi:10.11613/BM.2015.004.
   PubMed Web of Science ®Google Scholar
• Verbon, A., N. Juffermans, S. J. Van Deventer, P. Speelman, H. Van Deutekom, T. Van Der Poll. 1999. Serum concentrations of cytokines in patients with active tuberculosis (TB) and after treatment. Clin. Exp. Immunol. 115:110–13. doi:10.1046/j.1365-2249.1999.00783.x.
   PubMed Web of Science ®Google Scholar
• Vergallo, C., and L. Dini. 2018. Comparative analysis of biological effects induced on different cell types by magnetic fields with magnetic flux densities in the range of 1-60 mT and frequencies up to 50 Hz. Sustainability 10:2776. doi:10.3390/su10082776.
   Web of Science ®Google Scholar
• Vergallo, C., L. Dini, Z. Szamosvölgyi, B. A. Tenuzzo, E. Carata, E. Panzarini, J. F. László. 2013. In vitro analysis of the anti-inflammatory effect of inhomogeneous static magnetic field-exposure on human macrophages and lymphocytes. PLoS One 8:e72374. doi:10.1371/journal.pone.0072374.
   PubMed Web of Science ®Google Scholar
• Vieira, P., R. de Waal-malefyt, M. N. Dang, K. E. Johnson, R. Kastelein, D. F. Fiorentino, J. E. deVries, M. G. Roncarolo, T. R. Mosmann, K. W. Moore, et al. 1991. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRFI. Proc. Natl. Acad. Sci. USA 88:1172–76. doi:10.1073/pnas.88.4.1172.
   PubMed Web of Science ®Google Scholar
• Walter, E. A., P. D. Greenberg, M. J. Gilbert, R. J. Finch, K. S. Watanabe, E. D. Thomas, S. R. Riddell. 1995. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N. Engl. J. Med. 33:1038–44. doi:10.1056/NEJM199510193331603.
   Google Scholar
• Walter, M. R., and T. L. Nagabhushan. 1995. Crystal structure of interleukin 10 reveals an interferon gamma-like fold. Biochemistry 34:12118–25. doi:10.1021/bi00038a004.
   PubMed Web of Science ®Google Scholar
• Windsor, W. T., R. Syto, A. Tsarbopoulos, R. Zhang, J. Durkin, S. Baldwin, S. Paliwal, P. W. Mui, B. Pramanik. 1993. Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10. Biochemistry 32:8807–15. doi:10.1021/bi00085a011.
   PubMed Web of Science ®Google Scholar
• World Health Organization (WHO). 2020a. Data from: Coronavirus disease (COVID-19) situation report - 182. Accessed July 20, 2020. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/.
   Google Scholar
• World Health Organization (WHO). 2020b. Clinical management of COVID-19: Interim guidance 27 May 2020. Geneva: WHO.
   Google Scholar
• Yan, Y., S. Shastry, C. Richards, C. Wang, D. G. Bowen, A. F. Sharland, D. M. Painter, G. W. McCaughan, G. A. Bishop. 2001. Posttransplant administration of donor leukocytes induces long-term acceptance of kidney or liver transplants by an activation-associated immune mechanism. J. Immunol. 166:5258–64. doi:10.4049/jimmunol.166.8.5258.
   PubMed Web of Science ®Google Scholar
• Yoon, S. I., N. J. Logsdon, F. Sheikh, R. P. Donnelly, M. R. Walter. 2006. Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J. Biol. Chem. 281:35088–96. doi:10.1074/jbc.M606791200.
   PubMedGoogle Scholar
• Yoshizaki, K., T. Matsuda, N. Nishimoto, T. Kuritani, L. Taeho, K. Aozasa, T. Nakahata, H. Kawai, H. Tagoh, T. Komori, et al. 1989. Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman’s disease. Blood 74:1360–67. doi:10.1182/blood.V74.4.1360.1360.
   PubMed Web of Science ®Google Scholar
• Zdanov, A., C. Schalk-Hihi, A. Gustchina, M. Tsang, J. Weatherbee, A. Wlodawer. 1995. Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma. Structure 3:591‐601. doi:10.1016/S0969-2126(01)00193-9.
   PubMed Web of Science ®Google Scholar
• Zdanov, A., C. Schalk-Hihi, and A. Wlodawer. 1996. Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor. Protein Sci. 5:1955‐1962. doi:10.1002/pro.5560051001.
   Web of Science ®Google Scholar
• Zhu, H., X. Lei, Q. Liu, and Y. Wang. 2013. Interleukin-10-1082A/G polymorphism and inflammatory bowel disease susceptibility: A meta-analysis based on 17,585 subjects. Cytokine 61:146–53. doi:10.1016/j.cyto.2012.09.009.
   PubMed Web of Science ®Google Scholar