Psychophysiological Responses to Emotional Stimuli in Children and Adolescents with Autism and Fragile X Syndrome

REFERENCES

• Althaus , M. , Mulder , L. J. , Mulder , G. , Aarnoudse , C. C. , & Minderaa , R. B. ( 1999 ). Cardiac adaptivity to attention-demanding tasks in children with a pervasive developmental disorder not otherwise specified (PDD–NOS) . Biological Psychiatry , 46 , 799 – 809 .
   PubMed Web of Science ®Google Scholar
• Althaus , M. , Van Roon , A. M. , Mulder , L. J. , Mulder , G. , Aarnoudse , C. C. , & Minderaa , R. B. ( 2004 ). Autonomic response patterns observed during the performance of an attention-demanding task in two groups of children with autistic-type difficulties in social adjustment . Psychophysiology , 41 , 893 – 904 .
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association . ( 1994 ). Diagnostic and statistical manual of mental disorders , (4th ed.) . Washington , DC : Author .
   Google Scholar
• Anderson , C. J. , & Colombo , J. ( 2007 ). Larger tonic pupil size in young children with autism spectrum disorder . Developmental Psychobiology , 51 , 207 – 211 .
   Web of Science ®Google Scholar
• Bailey , D. B. , Jr., Mesibov , G. B. , Hatton , D. D. , Clark , R. D. , Roberts , J. E. , & Mayhew , L. ( 1998 ). Autistic behavior in young boys with fragile X syndrome . Journal of Autism and Developmental Disorders , 28 , 499 – 508 .
   PubMed Web of Science ®Google Scholar
• Bal , E. , Harden , E. , Lamb , D. , Vaughan Van Hecke , A. , Denver , J. W. , & Porges , S. W. ( 2010 ). Emotion regulation in children with autism spectrum disorders: Relations to eye gaze and autonomic state . Journal of Autism and Developmental Disorders , 40 , 358 – 370 .
   PubMed Web of Science ®Google Scholar
• Belser , R. , & Sudhalter , V. ( 1995 ). Arousal difficulties in males with fragile X syndrome: A preliminary report . Development and Brain Dysfunction 8 , 270 – 279 .
   Google Scholar
• Ben Shalom , D. , Mostofsky , S. H. , Hazlett , R. L. , Goldberg , M. C. , Landa , R. J. , et al. . ( 2006 ). Normal physiological emotions but differences in expression of conscious feelings in children with high-functioning autism . Journal of Autism and Developmental Disorders , 36 , 395 – 400 .
   PubMed Web of Science ®Google Scholar
• Berry-Kravis , E. , Hessl , D. , Rathmell , B. , Zarevics , P. , Cherubini , M. , et al. . ( 2012 ). Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: A randomized, controlled, Phase 2 trial . Science Translational Medicine , 4 ( 152 ), 152ra127 .
   PubMed Web of Science ®Google Scholar
• Berry-Kravis , E. , Knox , A. , & Hervey , C. ( 2011 ). Targeted treatments for fragile X syndrome . Journal of Neurodevelopmental Disorders , 3 , 193 – 210 .
   PubMed Web of Science ®Google Scholar
• Bormann-Kischkel , C. , Vilsmeier , M. , & Baude , B. ( 1995 ). The development of emotional concepts in autism . Journal of Child Psychology Psychiatry , 36 , 1243 – 1259 .
   PubMed Web of Science ®Google Scholar
• Bradley , M. M. , Cuthbert , B. N. , & Lang , P. J. ( 1990 ). Startle reflex modification: Emotion or attention? Psychophysiology , 27 , 513 – 522 .
   PubMed Web of Science ®Google Scholar
• Bradley , M. M. , Cuthbert , B. N. , & Lang , P. J. ( 1996 ). Picture media and emotion: Effects of a sustained affective context . Psychophysiology , 33 , 662 – 670 .
   PubMed Web of Science ®Google Scholar
• Bregman , J. D. , Leckman , J. F. , & Ort , S. I. ( 1988 ). Fragile X syndrome: Genetic predisposition to psychopathology . Journal of Autism and Developmental Disorders , 18 , 343 – 354 .
   PubMed Web of Science ®Google Scholar
• Capps , L. , Yirmiya , N. , & Sigman , M. ( 1992 ). Understanding of simple and complex emotions in non-retarded children with autism . Journal of Child Psychology and Psychiatry , 33 , 1169 – 1182 .
   PubMed Web of Science ®Google Scholar
• Center for the Study of Emotion and Attention . ( 1998 ). The International Affective Picture System . Gainesville : University of Florida .
   Google Scholar
• Clifford , S. , Dissanayake , C. , Quang , M. B. , Huggins , R. , Taylor , A. K. , & Loesch , D. V. ( 2007 ). Autism spectrum phenotype in males and females with fragile X full mutation and premutation . Journal of Autism and Developmental Disorders , 37 , 738 – 747 .
   PubMed Web of Science ®Google Scholar
• Cohen , I. L. ( 1995 ). A theoretical analysis of the role of hyperarousal in the learning and behavior of fragile X males . Mental Retardation and Developmental Disabilities Research Reviews , 1 , 286 – 291 .
   Google Scholar
• Cordeiro , L. , Ballinger , E. , Hagerman , R. J. , & Hessl , D. ( 2011 ). Clinical assessment of DSM–IV anxiety disorders in fragile X syndrome: Prevalence and characterization . Journal of Neurodevelopmental Disorders , 3 , 57 – 67 .
   PubMed Web of Science ®Google Scholar
• Dalton , K. M. , Holsen , L. , Abbeduto , L. L. , & Davidson , R. J. ( 2008 ). Brain function and gaze-fixation during facial emotion processing in Fragile-X and autism . Autism Research , 1 , 231 – 239 .
   PubMed Web of Science ®Google Scholar
• Davis , M. ( 1989 ). Neural systems involved in fear-potentiated startle . Annals of the New York Academy of Sciences , 563 , 165 – 183 .
   PubMed Web of Science ®Google Scholar
• Davis , M. , & Astrachan , D. I. ( 1978 ). Conditioned fear and startle magnitude: Effects of different footshock or backshock intensities used in training . Journal of Experimental Psychology: Animal Behavior Processes , 4 , 95 – 103 .
   PubMed Web of Science ®Google Scholar
• Davis , M. , Walker , D. L. , & Lee , Y. ( 1997 ). Amygdala and bed nucleus of the stria terminalis: Differential roles in fear and anxiety measured with the acoustic startle reflex . Philosophical Transactions of the Royal Society B: Biological Sciences , 352 , 1675 – 1687 .
   PubMed Web of Science ®Google Scholar
• Dawson , G. , Meltzoff , A. N. , Osterling , J. , Rinaldi , J. , & Brown , E. ( 1998 ). Children with autism fail to orient to naturally occurring social stimuli . Journal of Autism and Developmental Disorders , 28 , 479 – 485 .
   PubMed Web of Science ®Google Scholar
• Dennis , M. , Francis , D. J. , Cirino , P. T. , Schachar , R. , Barnes , M. A. , & Fletcher , J. M. (2009). Why IQ is not a covariate in cognitive studies of neurodevelopmental disorders. Journal of the International Neuropsychological Society , 15, 331–343.
   PubMed Web of Science ®Google Scholar
• Deruelle , C. , Rondan , C. , Gepner , B. , & Tardif , C. ( 2004 ). Spatial frequency and face processing in children with autism and Asperger syndrome . Journal of Autism and Developmental Disorders , 34 , 199 – 210 .
   PubMed Web of Science ®Google Scholar
• Farzin , F. , Rivera , S. M. , & Hessl , D. ( 2009 ). Face processing in individuals with fragile X syndrome: An eye tracking study . Journal of Autism and Developmental Disorders , 39 , 946 – 952 .
   PubMed Web of Science ®Google Scholar
• Farzin , F. , Scaggs , F. , Hervey , C. , Berry-Kravis , E. , & Hessl , D. ( 2011 ). Reliability of eye tracking and pupillometry measures in individuals with fragile X syndrome . Journal of Autism and Developmental Disorders , 41 , 1515 – 1522 .
   PubMed Web of Science ®Google Scholar
• Garrett , A. S. , Menon , V. , MacKenzie , K. , & Reiss , A. L. ( 2004 ). Here's looking at you, kid: neural systems underlying face and gaze processing in fragile X syndrome . Archives of General Psychiatry , 61 , 281 – 288 .
   PubMed Web of Science ®Google Scholar
• Gothelf , D. , Furfaro , J. A. , Hoeft , F. , Eckert , M. A. , Hall , S. S. , et al. . ( 2008 ). Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP) . Annals of Neurology , 63 , 40 – 51 .
   PubMed Web of Science ®Google Scholar
• Grelotti , D. J. , Gauthier , I. , & Schultz , R. T. ( 2002 ). Social interest and the development of cortical face specialization: What autism teaches us about face processing . Developmental Psychobiology , 40 , 213 – 225 .
   PubMed Web of Science ®Google Scholar
• Hagerman , R. J. ( 2002 ). The physical and behavioral phenotype . In R. J. Hagerman & P. J. Hagerman (Eds.), Fragile X syndrome: Diagnosis, treatment, and research (Vol. 3 , 3 – 109 ). Baltimore : Johns Hopkins University Press .
   Google Scholar
• Hall , S. S. , Lightbody , A. A. , Huffman , L. C. , Lazzeroni , L. C. , & Reiss , A. L. ( 2009 ). Physiological correlates of social avoidance behavior in children and adolescents with fragile X syndrome . Journal of the American Academy of Child and Adolescent Psychiatry , 48 ( 3 ), 320 – 329 .
   PubMed Web of Science ®Google Scholar
• Harris , S. W. , Hessl , D. , Goodlin-Jones , B. , Ferranti , J. , Bacalman , S. , et al. . ( 2008 ). Autism profiles of males with fragile X syndrome . American Journal on Mental Retardation , 113 , 427 – 438 .
   PubMedGoogle Scholar
• Hazlett , H. C. , Lightbody , A. A. , Gerig , G. , Macfall , J. R. , Ross , A. K. , et al. . ( 2009 ). Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism . Journal of Neurodevelopmental Disorders , 1 , 81 – 90 .
   PubMed Web of Science ®Google Scholar
• Hessl , D. , Glaser , B. , Dyer-Friedman , J. , Blasey , C. , Gunnar , M. , et al. . ( 2002 ). Cortisol and behavior in fragile X syndrome . Psychoneuroendocrinology , 27 , 855 – 872 .
   PubMed Web of Science ®Google Scholar
• Hessl , D. , Rivera , S. M. , & Reiss , A. L. ( 2004 ). The neuroanatomy and neuroendocrinology of fragile X syndrome . Mental Retardation and Developmental Disabilities Research Reviews , 10 , 17 – 24 .
   PubMedGoogle Scholar
• Hirstein , W. , Iversen , P. , & Ramachandran , V. S. ( 2001 ). Autonomic responses of autistic children to people and objects . Proceedings of the Royal Society of London , 268 , 1883 – 1888 .
   Google Scholar
• Hobson , R. P. , & Lee , A. ( 1998 ). Hello and goodbye: A study of social engagement in autism . Journal of Autism and Developmental Disorders , 28 , 117 – 127 .
   PubMed Web of Science ®Google Scholar
• Insel , T. , Cuthbert , B. , Garvey , M. , Heinssen , R. , Pine , D. S. , et al. . ( 2010 ). Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders . The American Journal of Psychiatry , 167 , 748 – 757 .
   PubMed Web of Science ®Google Scholar
• Jacquemont , S. , Curie , A. , des Portes , V. , Torrioli , M. G. , Berry-Kravis , E. , et al. . ( 2011 ). Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056 . Science Translational Medicine , 3 , 64ra61 .
   Web of Science ®Google Scholar
• Kaufmann , W. E. , Cortell , R. , Kau , A. S. M. , Bukelis , I. , Tierney , E. , et al. . ( 2004 ). Autism spectrum disorder in fragile X syndrome: Communication, social interaction and specific behaviors . American Journal of Medical Genetics, 129A , 225 – 234 .
   Web of Science ®Google Scholar
• Keysor , C. S. , Mazzocco , M. M. , McLeod , D. R. , & Hoehn-Saric , R. ( 2002 ). Physiological arousal in females with fragile X or Turner syndrome . Developmental Psychobiology , 41 , 133 – 146 .
   PubMed Web of Science ®Google Scholar
• Kim , S. Y. , Burris , J. , Bassal , F. , Koldewyn , K. , Chattarji , S. , et al. . ( 2012 ). Fear-specific amygdala function in children and adolescents on the Fragile X spectrum: A dosage response of the FMR1 gene . Cerebral Cortex . doi: 10.1093/cercor/bhs341
   Web of Science ®Google Scholar
• Lang , P. J. , Bradley , M. M. , & Cuthbert , B. N. ( 1998 ). Emotion, motivation, and anxiety: Brain mechanisms and psychophysiology . Biological Psychiatry , 44 , 1248 – 1263 .
   PubMed Web of Science ®Google Scholar
• LeDoux , J. E. , Farb , C. , & Ruggiero , D. A. ( 1990 ). Topographic organization of neurons in the acoustic thalamus that project to the amygdala . Journal of Neuroscience , 10 , 1043 – 1054 .
   PubMed Web of Science ®Google Scholar
• Malliani , A. ( 1999 ). The pattern of sympathovagal balance explored in the frequency domain . News in Physiological Sciences , 14 , 111 – 117 .
   PubMedGoogle Scholar
• Miller , L. J. , McIntosh , D. N. , McGrath , J. , Shyu , V. , Lampe , M. , et al. . ( 1999 ). Electrodermal responses to sensory stimuli in individuals with fragile X syndrome . American Journal of Medical Genetics , 83 , 268 – 279 .
   PubMed Web of Science ®Google Scholar
• Ming , X. , Julu , P. O. , Brimacombe , M. , Connor , S. , & Daniels , M. L. ( 2005 ). Reduced cardiac parasympathetic activity in children with autism . Brain and Development , 27 , 509 – 516 .
   PubMed Web of Science ®Google Scholar
• Murphy , M. , Bolton , P. F. , Pickles , A. , Fombonne , E. , Piven , J. , & Rutter , M. ( 2000 ). Personality traits of the relatives of autistic probands . Psychological Medicine , 30 , 1411 – 1424 .
   PubMed Web of Science ®Google Scholar
• Osterling , J. , & Dawson , G. ( 1994 ). Early recognition of children with autism: A study of first birthday home videotapes . Journal of Autism and Developmental Disorders , 24 , 247 – 257 .
   PubMed Web of Science ®Google Scholar
• Pagani , M. , Montano , N. , Porta , A. , Malliani , A. , Abboud , F. M. , et al. . ( 1997 ). Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans . Circulation , 95 , 1441 – 1448 .
   PubMed Web of Science ®Google Scholar
• Pelphrey , K. A. , Sosson , N. J. , Reznick , J. S. Paul , G., Goldman , B. D. , & Piven , J. ( 2002 ). Visual scanning of faces in autism . Journal of Autism and Developmental Disorders , 32 , 249 – 261 .
   PubMed Web of Science ®Google Scholar
• Platisa , M. M. , & Gal , V. ( 2006 ). Reflection of heart rate regulation on linear and nonlinear heart rate variability measures . Physiological Measurement , 27 , 145 – 154 .
   PubMed Web of Science ®Google Scholar
• Porges , S. W. ( 2007 ). The polyvagal perspective . Biological Psychology , 74 , 116 – 143 .
   PubMed Web of Science ®Google Scholar
• Roberts , J. E. , Boccia , M. L. , Bailey , D. B. J. , Hatton , D. D. , & Skinner , M. ( 2001 ). Cardiovascular indices of physiological arousal in boys with fragile X syndrome . Developmental Psychobiology , 39 , 107 – 123 .
   PubMed Web of Science ®Google Scholar
• Roberts , N. A. , & Levenson , R. W. ( 2006 ). Subjective, behavioral, and physiological reactivity to ethnically matched and ethnically mismatched film clips . Emotion , 6 , 635 – 646 .
   PubMed Web of Science ®Google Scholar
• Rogers , S. J. , Ozonoff , S. , & Hansen , R. L. ( 2013 ). Autism spectrum disorders . In R. L. Hansen & S. J. Rogers (Eds.), Autism and other neurodevelopmental disorders (pp. 1 – 28 ). Washington , DC : American Psychiatric Publishing .
   Google Scholar
• Rogers , S. J. , Wehner , D. E. , & Hagerman , R. ( 2001 ). The behavioral phenotype in fragile X: Symptoms of autism in very young children with fragile X syndrome, idiopathic autism, and other developmental disorders . Journal of Developmental and Behavioral Pediatrics , 22 , 409 – 417 .
   PubMed Web of Science ®Google Scholar
• Saul , J. P. , Rea , R. F. , Eckberg , D. L. , Berger , R. D. , & Cohen , R. J. ( 1990 ). Heart rate and muscle sympathetic nerve variability during reflex changes of autonomic activity . American Journal of Physiology , 258 ( Part 2 ), H713 – 721 .
   PubMedGoogle Scholar
• Schultz , R. T. (2005). Developmental deficits in social perception in autism: The role of the amygdala and fusiform face area. International Journal of Developmental Neuroscience , 23, 125–141.
   PubMed Web of Science ®Google Scholar
• Sidak , Z. ( 1967 ). Rectangular confidence regions for the means of multivariate normal distributions . Journal of the American Statistical Association , 62 , 626 – 633 .
   Web of Science ®Google Scholar
• Sloan , R. P. , Shapiro , P. A. , Bagiella , E. , Bigger , J. T. , Jr. , Lo , E. S. , & Gorman , J. M. ( 1996 ). Relationships between circulating catecholamines and low frequency heart period variability as indices of cardiac sympathetic activity during mental stress . Psychosomatic Medicine , 58 , 25 – 31 .
   PubMed Web of Science ®Google Scholar
• Suvrathan , A. , & Chattarji , S. ( 2011 ). Fragile X syndrome and the amygdala . Current Opinions in Neurobiology , 21 , 509 – 515 .
   PubMed Web of Science ®Google Scholar
• Task force of the European Society of Cardiology, & North American Society of Pacing, & Electrophysiology . ( 1996 ). Heart rate variability: Standards of measurement, physiological interpretation, and clinical use . European Heart Journal , 17 , 354 – 381 .
   PubMed Web of Science ®Google Scholar
• Tassone , F. , Hagerman , R. J. , Garcia-Arocena , D. , Khandjian , E. W. , Greco , C. M. , & Hagerman , P. J. ( 2004 ). Intranuclear inclusions in neural cells with premutation alleles in fragile X associated tremor/ataxia syndrome . Journal of Medical Genetics , 41 , e43 .
   PubMed Web of Science ®Google Scholar
• Teunisse , J. P. , & De Gelder , B. ( 1994 ). Do autistics have a generalized face processing deficit? International Journal of Neuroscience , 77 , 1 – 10 .
   PubMed Web of Science ®Google Scholar
• Tottenham , N. , Borscheid , A. , Ellersten , K. , Marcus , D. J. , & Nelson , C. A. ( 2002 , April ). Categorization of facial expressions in children and adults: Establishing a larger stimulus set. Paper presented at the annual Cognitive Neuroscience Society meeting, San Francisco.
   Google Scholar
• Vaughan Van Hecke , A. , Lebow , J. , Bal , E. , Lamb , D. , Harden , E. , et al. . ( 2009 ). Electroencephalogram and heart rate regulation to familiar and unfamiliar people in children with autism spectrum disorders . Child Development , 80 , 1118 – 1133 .
   PubMed Web of Science ®Google Scholar
• Vrana , S. R. , Spence , E. L. , & Lang , P. J. ( 1988 ). The startle probe response: a new measure of emotion? Journal of Abnormal Psychology , 97 , 487 – 491 .
   PubMed Web of Science ®Google Scholar
• Wang , A. T. , Dapretto , M. , Hariri , A. R. , Sigman , M. , & Bookheimer , S. Y. ( 2004 ). Neural correlates of facial affect processing in children and adolescents with autism spectrum disorder . Journal of the American Academy of Child and Adolescent Psychiatry , 43 , 481 – 490 .
   PubMed Web of Science ®Google Scholar
• Watson , C. , Hoeft , F. , Garrett , A. , Hall , S. , & Reiss , A. ( 2008 ). Aberrant brain activation during gaze processing in boys with Fragile X Syndrome . Archives of General Psychiatry , 65 , 1315 – 1323 .
   PubMed Web of Science ®Google Scholar
• Watson , L. R. , Roberts , J. E. , Baranek , G. T. , Mandulak , K. C. , & Dalton , J. C. ( 2012 ). Behavioral and physiological responses to child-directed speech of children with autism spectrum disorder or typical development . Journal of Autism and Developmental Disorders , 42 , 1616 – 1629 .
   PubMed Web of Science ®Google Scholar
• Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/hcap.
   Google Scholar