A Case Report of Opium Body Packer; Review of the Treatment Protocols and Mechanisms of Poisoning

REFERENCES

• Abdollahi M., Jalali N., Sabzevari O., Hoseini R., Ghanea T. A retrospective study of poisoning in Tehran. J. Toxicol. Clin. Toxicol. 1997; 35: 387–393
   PubMed Web of Science ®Google Scholar
• Aldrighetti L., Graci C., Paganelli M., Vercesi M., Catena M., Ferla G. Intestinal occlusion in cocaine-packet ingestion. Minerva. Chir. 1993; 48: 1233–1237
   Google Scholar
• Aldrighetti L., Paganelli M., Giacomelli M., Villa G., Ferla G. Conservative management of cocaine packet ingestion: experience in Milan, the main Italian smuggling center of South American cocaine. Panminerva. Med. 1996; 38: 111–116
   Google Scholar
• American Academy of Clinical Toxicology and European Association of Poison Control Centers and Clinical Toxicologists. Position statement: Single-dose activated charcoal. J. Toxicol. Clin. Toxicol. 1997; 35: 721–741
   PubMed Web of Science ®Google Scholar
• Beck N. E., Hale J. E. Cocaine ‘body packers.’. Br. J. Surg. 1993; 80: 1513–1516
   Google Scholar
• Beerman R., Nunez D. Jr., Wetli C. V. Radiographic evaluation of the cocaine smuggler. Gastrointest. Radiol. 1986; 11: 351–354
   PubMedGoogle Scholar
• Bettinger J. Cocaine intoxication: massive oral overdose. Ann. Emerg. Med. 1980; 9: 429–430
   PubMed Web of Science ®Google Scholar
• Boehnert M. T., Lewander W. J., Gaudreault P., Lovejoy F. H. Advances in clinical toxicology. Pediatr. Clin. North. Am. 1985; 32: 193–211
   PubMed Web of Science ®Google Scholar
• Bogusz M. J., Althoff H., Erkens M., Maier R. D., Hofmann R. Internally concealed cocaine: analytical and diagnostic aspects. J. Forensic Sci. 1995; 40: 811–815
   PubMed Web of Science ®Google Scholar
• Boodram A. Drug mules the Jamaican connection. 2003, Available at: http://www.caribvoice.org/Features/drugmules.html Accessed October 9, 2006.
   Google Scholar
• Brunton L. L. Agents affecting gastrointestinal water flux and motility; emesis and anti-emetics; bile acids and pancreatic enzymes. Goodman & Gilman's The Pharmacological Basis of Therapeutics, J. G. Hardman, L. E. Limbird, P. B. Molinoff. New York: McGraw-Hill. 1996; 917–936
   Google Scholar
• Bulstrode N., Banks F., Shrotria S. The outcome of drug smuggling by ‘body-packers’-the British experience. Ann. R. Coll. Surg. Engl. 2002; 84: 35–38
   Google Scholar
• Caruana D. S., Weinbach B., Goerg D., Gardner L. B. Cocaine-packet ingestion: diagnosis, management, and natural history. Ann. Intern. Med. 1984; 100: 73–74
   PubMedGoogle Scholar
• Claffey M. Stampede of drug mules at Kennedy: after 9/11 lulls, heroin & ecstasy busts soar. New York Daily News 2002; May 5: 5
   Google Scholar
• The Chicago swallowers—today are a good day to die. Washington, DC, US. Customs News, June 1997. Available at http://www.customs.gov/hot-new/pressrel/1997/0612 01.htm. Accessed December 1, 2003
   Google Scholar
• Dassel P. M., Punjabi E. Ingested marihuana-filled balloons. Gastroenterology 1979; 76: 166–169
   Google Scholar
• Deitel M., Syed A. K. Intestinal obstruction by an unusual foreign body. Can. Med. Assoc. J. 1973; 109: 211–212
   PubMed Web of Science ®Google Scholar
• Di Matteo V., Pierucci M., Esposito E. Selective stimulation of serotonin2c receptors blocks the enhancement of striatal and accumbal dopamine release induced by nicotine administration. J. Neurochem. 2004; 89(2)418–429
   Google Scholar
• Drug Situation in the I.R. of Iran. UNDCP. Tehran, May 2002
   Google Scholar
• Dunne J. W. Drug smuggling by internal bodily concealment. Med. J. Aust. 1983; 2: 436–439
   Google Scholar
• Fishbain D. A, Wetli C. V. Cocaine intoxication, delirium, and death in a body packer. Ann. Emerg. Med. 1981; 10: 531–532
   PubMed Web of Science ®Google Scholar
• Freed T. A., Sweet L. N., Gauder P. J. Case reports balloon obturation bowel obstruction: a hazard of drug smuggling. Am. J. Roentgenol. 1976; 127: 1033–1034
   PubMed Web of Science ®Google Scholar
• Gherardi R. K., Baud F. J., Leporc P., Marc B., Dupeyron J. P., Diamant-Berger O. Detection of drugs in the urine of body packers. Lancet 1988; 1: 1076–1078
   PubMed Web of Science ®Google Scholar
• Gill J. R., Graham S. M. Ten years of “body packers” in New York City: 50 deaths. J. Forensic Sci. 2002; 47: 843–846
   PubMed Web of Science ®Google Scholar
• Glass J. M., Scott H. J. Surgical mules: the smuggling of drugs in the gastrointestinal tract. J. R. Soc. Med. 1995; 88: 450–453
   Google Scholar
• Gobert A., Rivet J. M., Lejeune F., Newman-Tancredi A., Adhumeau-Auclair A., Nicolas J. P., Cistarelli L., Melon C., Millan M. J. Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: a combined dialysis and electrophysiological analysis in the rat. Synapse. 2000; 36(3)205–221
   PubMed Web of Science ®Google Scholar
• Gomez A. M., Cuenca C. C., Farfan S. A., Villalba M. V., del Toro Cervera J., Garcia C. J. Complications of intestinal transporting of cocaine packets, study of 215 cases. Med. Clin. Barc. 1998; 111: 336–337
   Google Scholar
• Greenberg M. I., Shrethra M. Management of the pregnant body packer. J. Toxicol. Clin. Toxicol. 2000; 38: 176–177, (abstract)
   Google Scholar
• Hoffman R. S., Smilkstein M. J., Goldfrank L. R. Whole bowel irrigation and the cocaine body packer: a new approach to a common problem. Am. J. Emerg. Med. 1990; 8: 523–527
   PubMed Web of Science ®Google Scholar
• Hollander J. E., Hoffman R. S. Cocaine. Goldfrank's Toxicology Emergencies., L. R. Goldfrank, N. E. Flomenbaum, N. A. et al. Lewin. Stamford, CT: Appleton and Lange. 1998; 1071–1089
   Google Scholar
• Horrocks A. W. Abdominal radiography in suspected ‘body-packers’. Clin. Radiol. 1992; 45: 322–325
   Google Scholar
• Huang C. L., Huang N. K., Shyue S. K., Chern Y. Hydrogen peroxide induces loss of dopamine transporter activity: a calcium-dependent oxidative mechanism. J. Neurochem. 2003; 86(5)1247–1259
   Google Scholar
• Hutchins K. D., Pierre-Louis P. J. B., Zaretski L., Williams A. W., Lin R. L., Natarajan G. A. Heroin body packing: three fatal cases of intestinal perforation. J. Forensic Sci. 2000; 45: 427
   Google Scholar
• Johnson J. A., Landreneau R. J. Esophageal obstruction and mediastinitis: a hard pill to swallow for drug smugglers. Am. Surg. 1991; 57: 723–726
   Google Scholar
• Jones O. M., Shorey B. A. Body packers: grading of risk as a guide to management and intervention. Ann. R. Coll. Surg. Engl. 2002; 84: 131–132
   Google Scholar
• Jonsson S., Omeara M., Young J. B. Acute cocaine poisoning: importance of treating seizures and acidosis. Am. J. Med. 1983; 75: 1061–1064
   PubMed Web of Science ®Google Scholar
• Kenny D., Pagel P. S., Warltier D. C. Attenuation of the systemic and coronary hemodynamic effects of cocaine in conscious dogs: propranolol versus labetalol. Basic. Res. Cardiol. 1992; 87(5)465–477
   Google Scholar
• Krishnan A., Brown R. Plain abdominal radiography in the diagnosis of the “body packer”. J. Accid. Emerg. Med. 1999; 16: 381
   Google Scholar
• Lancashire M. J. R., Legg P. K., Lowe M., Davidson S. M., Ellis B. W. Surgical aspects of international drug smuggling. BMJ. 1988; 296: 1035–1037
   PubMed Web of Science ®Google Scholar
• Ling G. S., Spiegel K., Lockhart S. H., Pasternak G. W. Separation of opioid analgesia from respiratory depression: evidence for different receptor mechanisms. J. Pharmacol. Exp. Ther. 1985; 232(1)149–155
   Google Scholar
• Lopez H. H., Goldman S. M., Liberman I. I., Barnes D. T. Cannabis-accidental peroral intoxication. The hashish smuggler roentgeno-graphically unmasked. J. Am. Med. Assoc. 1974; 227: 1041–1042
   PubMed Web of Science ®Google Scholar
• Macedo D. S., Vasconcelos S. M. M., Belchior L. D., Santos R. S., Viana G. S. B., Sousa F. C. F. Alterations in monoamine levels after cocaine-induced status epilepticus and death in striatum and prefrontal cortex of mice. Neurosci. Lett. 2004; 362: 185–188
   Google Scholar
• Marc B., Baud F. J., Aelion M. J., Gherardi R., Diamant-Berger O., Blery M., Bismuth C. The cocaine body-packer syndrome: evaluation of a method of contrast study of the bowel. J. Forensic Sci. 1990; 35: 345–355
   PubMed Web of Science ®Google Scholar
• Marc B., Baud F. J., Maison-Blanche P., Leporc P., Garnier M., Gherardi R. Cardiac monitoring during medical management of cocaine body packers. J. Toxicol. Clin. Toxicol. 1992; 30: 387–397
   PubMed Web of Science ®Google Scholar
• McCarron M. M., Wood J. D. The cocaine ‘body-packer’ syndrome: diagnosis and treatment. JAMA. 1983; 250: 1417–1420
   PubMed Web of Science ®Google Scholar
• Mebane C., DeVito J. J. P. Cocaine intoxication-a unique case. J. Florida Med. Assoc. 1975; 62: 19–20
   PubMedGoogle Scholar
• Morin-Surun M. P., Boudinot E., Gacel G., Champagnat J., Roques B. P., Denavit-Saubie M. Different effects of mu and delta opiate agonists on respiration. Eur. J. Pharmacol. 1984; 98(2)235–240
   Google Scholar
• Navailles S., De Deurwaerdere P., Porras G., Spampinato U. In vivo evidence that 5-HT2 C receptor antagonist but not agonist modulates cocaine-induced dopamine outflow in the rat nucleus accumbens and striatum. Neuropsychopharmacology. 2004; 29(2)319–326
   PubMed Web of Science ®Google Scholar
• Olmedo R., Nelson L., Chu J., Hoffman R. S. Is surgical decontamination definitive treatment of “body-packers”?. Am. J. Emerg. Med. 2001; 7: 593–596
   Google Scholar
• Patel F. A high fatal postmortem blood concentration of cocaine in a drug courier. Forensic Sci. Int. 1996; 79: 167–174
   Google Scholar
• Pidoto R. R., Agliata A. M., Bertoline R., Nainini A., Rossi G., Giani G. A new method of packaging cocaine for international traffic and implications for the management of cocaine body packers. J. Emerg. Med. 2002; 23: 149–153
   Google Scholar
• Ramrakha P. S., Barton I. Drug smuggler's delirium. BMJ. 1993; 306: 470–471
   Google Scholar
• Riggs D., Weibley R. E. Acute toxicity from oral ingestion of crack cocaine: a report of four cases. Ped. Emerg. Care 1990; 6: 24–26
   PubMedGoogle Scholar
• Roberts J. R., Price D., Goldfrank L., Hartnett L. The body stuffer syndrome: a clandestine form of drug overdose. Am. J. Emerg. Med. 1986; 4: 24–27
   PubMed Web of Science ®Google Scholar
• Robinson T., Birrer R., Mandava N., Pizzi W. F. Body smuggling of illicit drugs: two cases requiring surgical intervention. Surgery 1993; 113: 709–711
   Google Scholar
• Silverberg D., Menes T., Kim U. Surgery for “body packers”—A 15-year experience. World J. Surg. 2006; 30: 541–546
   Google Scholar
• Sinner W. N. The gastrointestinal tract as a vehicle for drug smuggling. Gastrointest. Radiol. 1981; 6: 319–323
   PubMedGoogle Scholar
• Stewart A., Heaton N. D., Hogbin B. Body packing—a case report and review of the literature. Postgrad. Med. J. 1990; 66: 659–661
   Google Scholar
• Suarez C. A., Arango A., Lester L. Cocaine-condom ingestion: Surgical treatment. JAMA. 1977; 238: 1391–1392
   PubMed Web of Science ®Google Scholar
• Taylor D., Ho B. T. Comparison of inhibition of monoamine uptake by cocaine, methylphenidate andamphetamine. Res. Commun. Chem. Pathol. Pharmacol. 1978; 21(1)67–75
   Google Scholar
• Thompson J. P. Acute effects of drugs of abuse. Clin. Med. 2003; 3: 123–126
   PubMed Web of Science ®Google Scholar
• Tomaszewski C., McKinney P., Phillips S., Brent J., Kulig K. Prevention of toxicity from oral cocaine by activated charcoal in mice. Ann. Emerg. Med. 1993; 22: 1804–1806
   PubMed Web of Science ®Google Scholar
• Traub S. J., Hoffman R. S., Nelson L. S. Body packing—the internal concealment of illicit drugs. N. Engl. J. Med. 2003; 26: 2519–2526
   Google Scholar
• Traub S. J., Kohn G. L., Hoffman R. S., Nelson L. S. Pediatric “body-packing”. Arch. Pediatr. Adolesc. Med. 2003; 157: 174–177
   PubMed Web of Science ®Google Scholar
• Traub S. J., Mark S. U., Hoffman R. S., Nelson L. S. Use of pharmaceutical promotility agents in the treatment of body packers. Am. J. Emerg. Med. 2003; 6: 511–512
   Google Scholar
• Trent M. S., Kim U. Cocaine packet ingestion: surgical or medical management?. Arch. Surg. 1987; 122: 1179–1181
   PubMed Web of Science ®Google Scholar
• Utretch M. J., Stone A. F., McCarron M. M. Heroin body packers. J. Emerg. Med. 1993; 11: 33–40
   Google Scholar
• Visser L., Sticker B., Hoogendoorn M., Vinks A. Do not give paraffin to packers. Lancet 1998; 352: 1352
   Google Scholar
• Watson C. J. E., Thomson H. J., Johnston P. S. Body-packing with amphetamines-an indication for surgery. J. R. Soc. Med. 1991; 84: 311–312
   Google Scholar
• Weber F., Williams G., Swartz M. A. Effect of ipecac in ‘body packers’. Ann. Emerg. Med. 1982; 11: 699–700
   Google Scholar
• Wetli C. V., Mittleman R. E. The ‘body packer syndrome’-toxicity following ingestion of illicit drugs packaged for transportation. J. Forensic Sci. 1981; 26: 492–500
   PubMed Web of Science ®Google Scholar
• Wetli C. V., Rao A., Rao V. J. Fatal heroin body packing. Am. J. Forensic Med. Pathol. 1997; 18: 312–318
   Google Scholar
• White N., Taylor K., Lyszkowski A., Tullett J., Morris C. Dangers of lubricants used with condoms. Nature 1988; 335: 19
   PubMed Web of Science ®Google Scholar
• Zilker T. Body-packing-Surgical intervention or wait and see? EAPCCT;. XX International Congress. Amsterdam, The Netherlands 2000, (abstract 160)
   Google Scholar