95
Views
29
CrossRef citations to date
0
Altmetric
Research Article

Beneficial Effect of Phosphodiesterase-5 Inhibitor in Experimental Inflammatory Bowel Disease; Molecular Evidence for Involvement of Oxidative Stress

, , , , &
Pages 281-288 | Received 26 Aug 2006, Accepted 20 Nov 2006, Published online: 09 Oct 2008

REFERENCES

  • Abdollahi M., Bahreini-Moghadam A., Emami B., Fooladian F., Zafari K. Increasing intracellular cAMP and cGMP inhibits cadmium-induced oxidative stress in rat submandibular saliva. Comp. Biochem. Physio. C. Toxicol. Pharmacol. 2003b; 135: 331–336
  • Abdollahi M., Chan T. S., Subrahmanyam V., O'Brien P. J. Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin. Mol. Cell. Biochem. 2003a; 252: 205–211
  • Abdollahi M., Fooladian F., Emami B., Zafari K., Bahreini-Moghadam A. Protection by sildenafil and theophylline of lead acetate-induced oxidative stress in rat submandibular gland and saliva. Hum. Exp. Toxicol. 2003c; 22: 587–592
  • Abdollahi M., Ranjbar A., Shadnia S., Nikfar S., Rezaiee A. Pesticides and oxidative stress. Med. Sci. Monit. 2004; 10: RA144–RA147
  • Abdollahi M., Simaiee B. Stimulation by theophylline and sildenafil of rat submandibular secretion of protein, epidermal growth factor and flow rate. Pharmacol. Res. 2003; 48: 445–449
  • Aghababaeian R., Ghazi-Khansari M., Abdi K., Taghadosinejad F., Abdollahi M. Protective effects of sildenafil and dipyridamol from lead-induced lipid peroxidation in perfused rat liver. Intl. J. Pharmaol. 2005; 1: 157–160
  • Ahnfelt-Ronne I., Nielsen O. H. The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger. Agents. Actions. 1987; 21: 191–194
  • Allgayer H. Clinical relevance of oxygen radicals in inflammatory bowel disease–facts and fashion. Klin. Wochenschr. Rev. 1991; 69: 1001–1003
  • Arnhold J. Properties, functions, and secretion of human myeloperoxidase. Biochemistry. (Mosc). 2004; 69: 4–9
  • Banner K. H., Trevethick M. A. PDE4 inhibition: a novel approach for the treatment of inflammatory bowel disease. Trends. Pharmacol. Sci. Rev. 2004; 25: 430–436
  • Barbosa D. S., Cecchini R., El Kadri M. Z., Rodriguez M. A., Burini R. C., Dichi I. Decreased oxidative stress in patients with ulcerative colitis supplemente with fish oil omega-3 fatty acids. Nutrition 2003; 19: 837–842
  • Bortolotti M., Mari C., Lopilato C., La, Rovere L., Miglioli M. Sildenafil inhibits gastroduodenal motility. Aliment. Pharmacol. Ther. 2001; 15: 157–161
  • Dias-Junior C. A., Souza-Costa D. C., Zerbini T., da Rocha J. B., Gerlach R. F., Tanus-Santos J. E. The effect of sildenafil on pulmonary embolism-induced oxidative stress and pulmonary hypertension. Anesth. Analg. 2005; 101: 115–120
  • D'Odorico A., Bortolan S., Cardin R., D'Inca’ R., Martines D., Ferronato A., Sturniolo G. C. Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease. Scand. J. Gastroenterol. 2001; 36: 1289–1294
  • Elson C. O., Cong Y., Brandwein S., Weaver C. T., McCabe R. P., Mahler M., Sundberg J. P., Leiter E. H. Experimental models to study molecular mechanisms underlying intestinal inflammation. Ann. N. Y. Acad. Sci. 1998; 859: 85–95
  • Elson C. O., Sartor R. B., Tennyson G.S., Riddell R. H. Experimental models of inflammatory bowel disease. Gastroenterology 1995; 109: 1344–1367
  • Ghafari H., Yasa N., Mohammadirad A., Minaie B., Zamani M. J., Nikfar S., Dehghan G. H., Khorasani R., Abdollahi M. Protection by Ziziphora Clinopoides of acetic acid-induced toxic bowel inflammation through reduction of cellular lipid peroxidation and myeloperoxidase activity. Hum. Exp. Toxicol. 2006; 25: 325–332
  • Ghazanfari G., Minaie B., Yasa N., Ashtaral-Nakhai L., Mohammadirad A., Nikfar S., Dehghan G., Shetab-Boushehri V., Jamshidi H., Khorasani R., Salehnia A., Abdollahi M. Biochemical and histopathological evidences for beneficial effects of Satureja Khuzestanica Jamzad essential oil on the mouse model of inflammatory bowel diseases. Toxicol. Mech. Methods 2006; 16(7)365–372
  • Gibson P. R., Iser J. Inflammatory bowel disease. Aust. Fam. Physician 2005; 34: 233–237
  • Grisham M. B. Oxidants and free radicals in inflammatory bowel disease. Lancet 1994; 344: 859–861
  • Gupta R. C. Toxicology of Organophosphates and Carbamate Compounds, , et al. Elsevier Academic Press, San Diego 2006
  • Hadjibabaie M., Rastkari N., Rezaie A., Abdollahi M. The adverse drug reaction in the gastrointestinal tract: an overview. Intl. J. Pharmacol. 2005; 1: 1–8
  • Hatoum O. A., Miura H., Binion D. G. The vascular contribution in the pathogenesis of inflammatory bowel disease. Am. J. Physiol. Heart. Circ. Physiol. Rev. 2003; 285: H1791–1796
  • Jagtap A. G., Shirke S. S., Phadke A. S. Effect of polyherbal formulation on experimental models of inflammatory bowel diseases. J. Ethnopharmacol. 2004; 90: 195–204
  • Jahanshahi G., Motavasel V., Rezaie A., Hashtroudi A. A., Daryani N. E., Abdollahi M. Alterations in antioxidant power and levels of epidermal growth factor and nitric oxide in saliva of patients with inflammatory bowel diseases. Dig. Dis. Sci. 2004; 49: 1752–1757
  • Jeremy J. Y., Angelini G. D., Khan M., Mikhailidis D. P., Morgan R. J., Thompson C. S., Bruckdorfer K. R., Naseem K. M. Platelets, oxidant stress and erectile dysfunction: an hypothesis. Cardiovasc. Res. Rev. 2000; 46: 50–54
  • Jurjus A. R., Khoury N. N., Reimund J. M. Animal models of inflammatory bowel disease. J. Pharmacol. Toxicol. Methods 2004; 50: 81–92
  • Katzung B. G. Basic & Clinical Pharmacology 8th edition. Appleton & Lange. 2000
  • Koupparis A. J., Jeremy J. Y., Muzaffar S., Persad R., Shukla N. Sildenafil inhibits the formation of superoxide and the expression of gp47 NAD[P]H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells. BJU. Int. 2005; 96: 423–427
  • Koutroubakis I. E., Malliaraki N., Dimoulios P. D., Karmiris K., Castanas E., Kouroumalis E. A. Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease. Dig. Dis. Sci. 2004; 49: 1433–1437
  • Krawisz J. E., Sharon P., Stenson W. F. Qualitative assay for acute intestinal inflammation based on myeloperoxidase activity. Gastroenterology 1984; 87: 1344–1350
  • Kruidenier L., Kuiper I., Van Duijn W., Mieremet-Ooms M. A., van Hogezand R. A., Lamers C. B., Verspaget H. W. Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease. J. Pathol. 2003; 201: 17–27
  • Kvietys P. R., Inauen W., Bacon B. R., Grisham M. B. Xanthine oxidase-induced injury to endothelium: role of intracellular iron and hydroxyl radical. Am. J. Physiol. 1989; 257: H1640–1646
  • Langtry H. D., Markham A. Sildenafil: a review of its use in erectile dysfunction. Drugs. Rev. 1999; 57: 967–989
  • Lih-Brody L., Powell S. R., Collier K. P., Reddy G. M., Cerchia R., Kahn E., Weissman G. S., Katz S., Floyd R. A., McKinley M. J., Fisher S. E., Mullin G. E. Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease. Dig. Dis. Sci. 1996; 41: 2078–2086
  • Lindsey I., George B., Kettlewell M., Mortensen N. Randomized, double-blind, placebo-controlled trial of sildenafil (Viagra) for erectile dysfunction after rectal excision for cancer and inflammatory bowel disease. Dis. Colon Rectum 2002; 45: 727–732
  • MacPherson B., Pfeiffer C. J. Experimental colitis. Digestion 1976; 14: 424–452
  • McKenzie S. J., Baker M. S., Buffinton G. D., Doe W. F. Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease. J. Clin. Invest. 1996; 98: 136–141
  • Milani E., Nikfar S., Khorasani R., Zamani M. J., Abdollahi M. Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in rats. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 2005; 140: 251–255
  • Muzaffar S., Shukla N., Lobo C., Angelini G. D., Jeremy J. Y. Iloprost inhibits superoxide formation and gp91phox expression induced by the thromboxane A2 analogue U46619, 8-isoprostane F2alpha, prostaglandin F2alpha, cytokines and endotoxin in the pig pulmonary artery. Br. J. Pharmacol. 2004; 141: 488–496
  • Nielsen O. H., Ahnfelt-Ronne I. Involvement of oxygen-derived free radicals in the pathogenesis of chronic inflammatory bowel disease. Klin. Wochenschr. Rev. 1991; 69: 995–1000
  • Noronha-Blob L., Lowe V. C., Muhlhauser R. O., Burch R. M. NPC 15669, an inhibitor of neutrophil recruitment, is efficacious in acetic acid-induced colitis in rats. Gastroenterology 1993; 104: 1021–1029
  • Podolsky D. K. Inflammatory bowel disease. N. Engl. J. Med. Rev. 2002; 347: 417–429
  • Radfar M., Larijani B., Hadjibabaie M., Rajabipour B., Mojtahedi A., Abdollahi M. Effects of pentoxifylline on oxidative stress and levels of EGF and NO in blood of diabetic type-2 patients; a randomized, double-blind placebo-controlled clinical trial. Biomed. Pharmacoth. 2005; 59: 302–306
  • Rezaie A., Taghavi B., Abdollahi M. Biologic management of fistulizing Crohn's disease. Intl. J. Pharmacol. 2005; 1: 17–24
  • Rosen R. C., Kostis J. B. Overview of phosphodiesterase 5 inhibition in erectile dysfunction. Am. J. Cardiol. Rev. 2003; 92: 9M–18M
  • Saiki T. Myeloperoxidase concentrations in the stool as a new parameter of inflammatory bowel disease. Kurume. Med. J. 1998; 45: 69–73
  • Satho K. Serum lipid peroxidation in cerebrovascular disorders determined by a new colorimetric method. Clin. Chem. Acta. 1978; 90: 37–43
  • Sharon P., Stenson W. F. Metabolism of arachidonic acid in acetic acid colitis in rats. Gastroenterology 1985; 88: 55–63
  • Shukla N., Jones R., Persad R., Angelini G. D., Jeremy J. Y. Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation inhypercholesterolaemic rabbits. Eur. J. Pharmacol. 2005; 517: 224–231
  • Simmonds N. J., Millar A. D., Blake D. R., Rampton D. S. Antioxidant effects of aminosalicylates and potential new drugs for inflammatory bowel disease: assessment in cell-free systems and inflamed human colorectal biopsies. Aliment. Pharmacol. Ther. 1999; 13: 363–372
  • Soderling S. H., Beavo J. A. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Curr. Opin. Cell. Biol. Rev. 2000; 12: 174–179
  • Souness J. E., Aldous D., Sargent C. Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors. Immunopharmacol. Rev. 2000; 47: 127–162
  • Tuzun A., Erdil A., Inal V., Aydin A., Bagci S., Yesilova Z., Sayal A., Karaeren N., Dagalp K. Oxidative stress and antioxidant capacity in patients with inflammatory bowel disease. Clin. Biochem. 2002; 35: 569–572
  • Wakefield A. J., Sankey E. A., Dhillon A. P., Sawyerr A. M., More L., Sim R., Pittilo R. M., Rowles P. M., Hudson M., Lewis A. A. Granulomatous vasculitis in Crohn's disease. Gastroenterology 1991; 100: 1279–1287, Erratum in Gastroenterology 101:595
  • Zamani M. J., Sharifzadeh M., Rezaie A., Mashayekhi F., Abdollahi M. Effects of sildenafil on rat irritable bowel syndrome. Therapy 2005; 2: 237–242

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.