Studying the Effects of Lead on DNA Fragmentation and Proapoptotic Bax and Antiapoptotic Bcl-2 Protein Expression in PC12 Cells

REFERENCES

• Adhikari N., Sinha N., Narayan R., Saxena D. K. Lead induced cell death in testes of young rats. J. Appl. Toxicol. 2001; 21: 275–277
   PubMed Web of Science ®Google Scholar
• Ashkenazi A., Dixit V. M. Death receptors: signaling and modulation. Science 1998; 281: 1305–1308
   PubMed Web of Science ®Google Scholar
• Bernald A. Mechanisms of lead toxicity and carcinogenecity. In: Proceedings of the IARC Gargnano Conference, I.3. Italy, 7–9 June 1999. 1999
   Google Scholar
• Borowitz J. L., Kanthasamy A. G., Mitchell P. J., Isom G. E. Use of PC12 cells as a neurotoxicological screen: characterization of anticyanide compounds. Fund. Appl. Toxicol. 1993; 20: 133–140
   Google Scholar
• Bressler J. P., Goldstein G. W. Mechanisms of lead neurotoxicity. Biochem. Pharmacol. 1991; 41: 479–484
   PubMed Web of Science ®Google Scholar
• Bressler J., Kim K. A., Chakraborti T., Goldstein G. Molecular mechanisms of lead neurotoxicity. Neurochem. Res. 1999; 24: 595–600
   PubMed Web of Science ®Google Scholar
• Chen L., Yang X., Jiao H., Zhao B. Tea catechins protect against lead-induced ROS formation, mitochondrial dysfunction, and calcium dysregulation in PC12 cells. Chem. Res. Toxicol. 2003; 16: 1155–1161
   PubMed Web of Science ®Google Scholar
• Choi D. W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988; 1: 623–634
   PubMed Web of Science ®Google Scholar
• Eskes R., Antonsson B., Osen-Sand A., Montessuit S., Richter C., Sadoul R., Azzei G., Nichols A., Martinou J. C. Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions. J. Cell. Biol. 1998; 143: 217–224
   PubMed Web of Science ®Google Scholar
• Ferri K. F., Kroemer G. Organelle-specific initiation of cell death pathways. Nat. Cell. Biol. 2001; 3: 255–263
   PubMed Web of Science ®Google Scholar
• Fox D. A., He L., Poblenz A. T., Medrano C. J., Blocker Y. S., Srivastava D. Lead-induced alterations in retinal cGMP phosphodiesterase trigger calcium overload, mitochondrial dysfunction and rod photoreceptor apoptosis. Toxicol. Lett. 1998; 28: 359–361
   Google Scholar
• Franclin J. L., Johnson E. M., Jr. Suppression of programmed cell death by sustained elevation of cytoplasmic calcium. Trends. Neurosci. 1992; 15: 501–508
   Google Scholar
• Goldstein G. W. Neurologic concepts of lead poisoning in children. Pediatr. Ann. 1992; 21: 384–388
   PubMedGoogle Scholar
• Green D. R., Reed J. C. Mitochondria and apoptosis. Science 1998; 281: 1309–1312
   PubMed Web of Science ®Google Scholar
• Greene L. A., Tischler A. S. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. 1976; 73: 2424–2428
   PubMed Web of Science ®Google Scholar
• Gross A., McDonnell J. M., Korsmeyer S. J. BCL-2 family members and the mitochondria in apoptosis. Genes. Dev. 1999; 13: 1899–1911
   PubMed Web of Science ®Google Scholar
• Gurr J. R., Bau D. T., Liu F., Lynn S., Jan K. Y. Dithiothreitol enhances arsenic trioxide-induced apoptosis in NB4 cells. Mol. Pharmacol. 1999; 56: 102–109
   PubMed Web of Science ®Google Scholar
• He L., Perkins G. A., Poblenz A. T., Harris J. B., Hung M., Ellisman M. H., Fox D. A. Bcl-xL overexpression blocks baxmediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc. Natl. Acad. Sci. USA 2003; 100: 1022–1027
   PubMed Web of Science ®Google Scholar
• He L., Poblenz A. T., Medrano C. J., Fox D. A. Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore. J. Biol. Chem. 2000; 275: 12175–12184
   PubMed Web of Science ®Google Scholar
• Hillion J. A., Takahashi K., Maric D., Ruetzler C., Barker J. L., Hallenbeck J. M. Development of an ischemic tolerance model in a PC12 cell line. J. Cereb. Blood Flow Metab. 2005; 25: 154–162
   PubMed Web of Science ®Google Scholar
• Iavicoli I., Carelli G., Sgambato A., Masci O., Ardito R., Cittadini A., Castellino N. Lead inhibits growth and induces apoptosis in normal rat fibroblasts. Altern. Lab. Anim. 2001; 29: 461–469
   PubMed Web of Science ®Google Scholar
• Itano Y., Kitamura Y., Nomura Y. 1-Methyl-4-phenylpyridium (MPPþ)-induced cell death in PC12 sells: inhibitory effects of several drugs. Neurochem. Int. 1994; 25: 419–424
   Google Scholar
• Lidsky T. I., Schneider J. S. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 2003; 126: 5–19
   PubMed Web of Science ®Google Scholar
• Marchetti C. Molecular targets of lead in brain neurotoxicity. Neurotox. Res. 2003; 5: 221–236
   PubMed Web of Science ®Google Scholar
• Martin T. F., Grishanin R. N. PC12 cells as a model for studies of regulated secretion in neuronal and endocrine cells. Methods Cell. Biol. 2003; 71: 267–286
   PubMed Web of Science ®Google Scholar
• Mosmann T. R. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay. J. Immunol. Methods 1983; 65: 55–63
   PubMed Web of Science ®Google Scholar
• Oberto A., Marks N., Evans H. L., Guidotti A. Lead promotes apoptosis in newborn rat cerebellar neurons: pathological implications. J. Pharmacol. Exp. Ther. 1996; 279
   Google Scholar
• Ostergren A., Svensson A. L., Lindquist N. G., Brittebo E. B. Dopamine melanin-loaded PC12 cells: a model for studies on pigmented neurons. Pigment Cell Res. 2005; 18: 306–314
   Google Scholar
• Papanikolaou N. C., Hatzidaki E. G., Belivanis S., Tzanakakis G. N., Tsatsakis A. M. Lead toxicity update. A brief review. Med. Sci. Monit. 2005; 11: 329–336
   Web of Science ®Google Scholar
• Pulido M. D., Parrish A. R. Metal-induced apoptosis: mechanisms. Mutat. Res. 2003; 533: 227–241
   PubMed Web of Science ®Google Scholar
• Rafalowska U., Struzynska L., Dabrowska-Bouta B., Lenkiewicz A. Is lead toxicosis a reaction of altered energy metabolism in brain synaptosomes?. Acta Neurobiol. Exp. 1996; 56: 611–617
   Google Scholar
• Sandhir R., Gill K. D. Effect of lead on the biological activity of calmodulin in rat brain. Exp. Mol. Pathol. 1994; 61: 69–75
   Google Scholar
• Shabani A., Rabbani A. Lead nitrate induced apoptosis in alveolar macrophages from rat lung. Toxicology 2000; 149: 109–114
   PubMed Web of Science ®Google Scholar
• Sharifi A. M., Baniasadi S., Jorjani M., Rahimi F., Bakhshayesh M. Investigation of acute lead poisoning on apoptosis in rat hippocampus in vivo. Neurosci. Lett. 2002; 329: 45–48
   PubMed Web of Science ®Google Scholar
• Sharifi A. M., Mousavi S. H., Bakhshayesh M., Tehrani F. K., Mahmoudian M., Oryan S. Study of correlation between lead-induced cytotoxicity and nitric oxide production in PC12 cells. Toxicol. Lett. 2005; 160: 43–48
   PubMed Web of Science ®Google Scholar
• Sharifi A. M., Schiffrin E. L. Apoptosis in vasculature of spontaneously hypertensive rats. Am. J. Hypertens. 1998; 11: 1108–1116
   PubMed Web of Science ®Google Scholar
• Shukla G. S., Singhal R. L. The present status of biological effects of toxic metals in the environment: lead, cadmium and manganese. Can. J. Physiol. Pharmacol. 1984; 62: 1015–1031
   PubMed Web of Science ®Google Scholar
• Silbergeld E. K. Mechanisms of lead neurotoxicity, or looking beyond the lamppost. FASEB. J. 1992; 6: 3201–3206
   PubMed Web of Science ®Google Scholar
• Silbergeld E. K. Facilitative mechanisms of lead as a carcinogen. Mutat. Res. 2003; 533: 121–133
   PubMed Web of Science ®Google Scholar
• Sombers L. A., Colliver T. L., Ewing A. G. Differentiated PC12 cells: a better model system for the study of the VMAT's effects on neuronal communication. Ann. N Y Acad. Sci. 2002; 971: 86–88
   PubMedGoogle Scholar
• Tavakoli-Nezhad M., Barron A. J., Pitts D. K. Postnatal inorganic lead exposure decreases the number of spontaneously active midbrain dopamine neurons in the rat. Neurotoxicology 2001; 22: 259–269
   Google Scholar
• Tong S., von Schirnding Y. E., Prapamontol T. Environmental lead exposure: a public health problem of global dimensions. Bull. World. Health Organ. 2000; 78: 1068–1077
   PubMed Web of Science ®Google Scholar
• Tsujimoto Y., Shimizu S. Bcl-2 family: life-or-death switch. FEBS. Lett. 2001; 466: 6–10
   Web of Science ®Google Scholar
• Webb S. J., Harrison D. J., Wyllie A. H. Apoptosis: an overview of the process and its relevance in disease. Adv. Pharmacol. 1997; 41: 1–34
   PubMedGoogle Scholar
• Wyllie A. H. Apoptosis: an overview. Br. Med. Bull. 1997; 53: 451–465
   PubMed Web of Science ®Google Scholar