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Research Article

Effect of captopril and telmisartan on methotrexate-induced hepatotoxicity in rats: impact of oxidative stress, inflammation and apoptosis

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Pages 371-377 | Received 06 Apr 2016, Accepted 15 May 2016, Published online: 07 Jun 2016

References

  • Aithal GP. (2011). Hepatotoxicity related to antirheumatic drugs. Nat Rev Rheumatol 7:139–50.
  • Arias JM, Morton KA, Albro JE, et al. (1993). Comparison of methods for identifying early methotrexate-induced hepatotoxicity in patients with rheumatoid arthritis. J Nuclear Med 34:1905–9.
  • Asdaq SM, Inamdar MN. (2010). Potential of garlic and its active constituent, S-allyl cysteine, as antihypertensive and cardioprotective in presence of captopril. Phytomedicine 17:1016–26.
  • Brogden RN, Todd PA, Sorkin EM. (1988). Captopril. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure. Drugs 36:540–600.
  • Buege JA, Aust SD. (1978). Microsomal lipid peroxidation. Methods Enzymol 52:302–10.
  • Buster JE, Carson SA. (1995). Ectopic pregnancy: new advances in diagnosis and treatment. Curr Opin Obstet Gynecol 7:168–76.
  • El-Khatib AS, Mansour MA. (2001). Prior treatment with captopril attenuates carbon tetrachloride-induced liver injury in mice. Res Commun Mol Pathol Pharmacol 110:3–16.
  • El-Sayed el SM, Abd-Ellah MF, Attia SM. (2008). Protective effect of captopril against cisplatin-induced nephrotoxicity in rats. Pak J Pharm Sci 21:255–61.
  • El Hassar C, Merzouk H, Merzouk SA, et al. (2015). Long-term use of angiotensin II receptor antagonists and calcium-channel antagonists in Algerian hypertensive patients: effects on metabolic and oxidative parameters. Free Radic Biol Med 79:147–53.
  • Eslami H, Sharifi AM, Rahimi H, Rahati M. (2014). Protective effect of telmisartan against oxidative damage induced by high glucose in neuronal PC12 cell. Neurosci Lett 558:31–6.
  • Fouad AA, Al-Mulhim AS, Jresat I. (2012). Telmisartan treatment attenuates arsenic-induced hepatotoxicity in mice. Toxicology 300:149–57.
  • Fouad AA, Al-Mulhim AS, Jresat I, Morsy MA. (2013). Protective effects of captopril in diabetic rats exposed to ischemia/reperfusion renal injury. J Pharm Pharmacol 65:243–52.
  • Fouad AA, Jresat I. (2013). Captopril and telmisartan treatments attenuate cadmium-induced testicular toxicity in rats. Fundam Clin Pharmacol 27:152–60.
  • Fox R. (2005). Methotrexate in patients with arthralgias in scleroderma/CREST syndrome. Available from: http://www.medscape.com/viewarticle/515726.
  • Hadi N, Yousif NG, Al-amran FG, et al. (2012). Vitamin E and telmisartan attenuates doxorubicin induced cardiac injury in rat through down regulation of inflammatory response. BMC Cardiovasc Disord 12:63.
  • Hess JA, Khasawneh MK. (2015). Cancer metabolism and oxidative stress: insights into carcinogenesis and chemotherapy via the non-dihydrofolate reductase effects of methotrexate. BBA Clin 3:152–61.
  • Hoekstra M, van Ede AE, Haagsma CJ, et al. (2003). Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis. Ann Rheum Dis 62:423–6.
  • Hrenak J, Arendasova K, Rajkovicova R, et al. (2013). Protective effect of captopril, olmesartan, melatonin and compound 21 on doxorubicin-induced nephrotoxicity in rats. Physiol Res Acad Sci Bohemoslovaca 62:S181–S9.
  • Ibrahim MA, Ashour OM, Ibrahim YF, et al. (2009). Angiotensin-converting enzyme inhibition and angiotensin AT(1)-receptor antagonism equally improve doxorubicin-induced cardiotoxicity and nephrotoxicity. Pharmacol Res 60:373–81.
  • Kafa IM, Uysal M, Bakirci S, Ayberk Kurt M. (2010). Sepsis induces apoptotic cell death in different regions of the brain in a rat model of sepsis. Acta Neurobiologiae Experimentalis 70:246–60.
  • Kevat S, Ahern M, Hall P. (1988). Hepatotoxicity of methotrexate in rheumatic diseases. Med Toxicol Adver Drug Exp 3:197–208.
  • Kim S, Iwao H. (2000). Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacol Rev 52:11–34.
  • Kose E, Sapmaz HI, Sarihan E, et al. (2012). Beneficial effects of montelukast against methotrexate-induced liver toxicity: a biochemical and histological study. Sci World J 2012:987508.
  • Kushwaha S, Jena GB. (2013). Telmisartan ameliorates germ cell toxicity in the STZ-induced diabetic rat: studies on possible molecular mechanisms. Mutat Res 755:11–23.
  • Liu JK, Shen YH, Liu XC, et al. (2011). [Effects of telmisartan on nonalcoholic steatohepatitis rat model by activating peroxisome proliferator-activated receptor r]. Chinese J Hepatol 19:614–8.
  • Marklund S, Marklund G. (1974). Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Euro J Biochem FEBS 47:469–74.
  • Mutlu-Turkoglu U, Akalin Z, Ilhan E, et al. (2005). Increased plasma malondialdehyde and protein carbonyl levels and lymphocyte DNA damage in patients with angiographically defined coronary artery disease. Clin Biochem 38:1059–65.
  • Nouri HS, Azarmi Y, Movahedin M. (2009). Effect of growth hormone on testicular dysfunction induced by methotrexate in rats. Andrologia 41:105–10.
  • Pandit A, Sachdeva T, Bafna P. (2012). Drug-induced hepatotoxicity: a review. J Appl Pharm Sci 02:233–43.
  • Pereira N, Gerber D, Gerber RS, et al. (2015). Effect of methotrexate or salpingectomy for ectopic pregnancy on subsequent in vitro fertilization-embryo transfer outcomes. J Minim Invas Gynecol 22:870–6.
  • Phillips DC, Woollard KJ, Griffiths HR. (2003). The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species. Br J Pharmacol 138:501–11.
  • Qiu XX, Li JM, Zhao J, et al. (2013). [The effects of ACEI on calpain-mediated cardiomyocytes apoptosis and cardiac function in diabetic rats]. Chinese J Appl Physiol 29:359–62.
  • Remuzzi A, Remuzzi G. (2006). Potential protective effects of telmisartan on renal function deterioration. J Renin Angiotensin Aldosterone Syst 7:185–91.
  • Roenigk HH, Jr., Auerbach R, Maibach HI, Weinstein GD. (1982). Methotrexate guidelines-revised. J Am Acad Dermatol 6:145–55.
  • Romankiewicz JA, Brogden RN, Heel RC, et al. (1983). Captopril: an update review of its pharmacological properties and therapeutic efficacy in congestive heart failure. Drugs 25:6–40.
  • Sastry KV, Moudgal RP, Mohan J, et al. (2002). Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy. Anal Biochem 306:79–82.
  • Sun HY, Xue FS, Xu YC, et al. (2009). Propofol improves cardiac functional recovery after ischemia-reperfusion by upregulating nitric oxide synthase activity in the isolated rat hearts. Chinese Med J 122:3048–54.
  • Wolf G. (2000). Free radical production and angiotensin. Curr Hypertension Rep 2:167–73.
  • Yoshihara D, Kugita M, Sasaki M, et al. (2013). Telmisartan ameliorates fibrocystic liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. PloS One 8:e81480.

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