Advanced search
Publication Cover
Toxicology Mechanisms and Methods Volume 27, 2017 - Issue 2
Submit an article Journal homepage
166
Views
22
CrossRef citations to date
0
Altmetric
Original Article

Toxicity and oxidative stress induced by T-2 toxin in cultured mouse Leydig cells

Yong Fa ZhangCollege of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, Henan, PR China; ;College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, Henan, PR ChinaView further author information
,
Jian Ying YangCollege of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, Henan, PR China; Correspondence[email protected]
View further author information
,
Yong Kai LiCollege of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, Henan, PR China; View further author information
&
Wei ZhouCollege of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, Henan, PR China; View further author information
Pages 100-106 | Received 18 Jul 2016, Accepted 05 Nov 2016, Published online: 29 Nov 2016

References

  • Abarikwu SO, Farombi EO, Kashyap M, et al. (2011). Atrazine induces transcriptional change in steroidogenesis marker genes in primary cultures of rat Leydig cells. Toxicol In Vitro 25:1588–95.
  • Chaudhari M, Jayaraj R, Bhaskar AS, et al. (2009). Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells. Toxicology 262:153–61.
  • Collins A, Dusinská M, Franklin M, et al. (1997). Comet assay in human biomonitoring studies: reliability, validation, and applications. Environ Mol Mutagen 30:139–46.
  • Eslami H, Sharifi AM, Rahimi H, et al. (2014). Protective effect of telmisartan against oxidative damage induced by high glucose in neuronal PC12 cell. Neurosci Lett 558:31–6.
  • Fang H, Wu Y, Guo J, et al. (2012). T-2 toxin induces apoptosis in differentiated murine embryonic stem cells through reactive oxygen species-mediated mitochondrial pathway. Apoptosis 17:895–907.
  • Gao Y, Dong C, Yin J, et al. (2012). Neuroprotective effect of fucoidan on H2O2-induced apoptosis in PC12 cells via activation of PI3K/Akt pathway. Cell Mol Neurobiol 32:523–9.
  • Hartmann A, Plappert U, Poetter F, et al. (2003). Comparative study with the alkaline Comet assay and the chromosome aberration test. Mutat Res 536:27–38.
  • Hoelzl C, Knasmüller S, Misík M, et al. (2009). Use of single cell gel electrophoresis assays for the detection of DNA-protective effects of dietary factors in humans: recent results and trends. Mutat Res 681:68–79.
  • Horvatovich K, Hafner D, Bodnár Z, et al. (2013). Dose-related genotoxic effect of T-2 toxin measured by comet assay using peripheral blood mononuclear cells of healthy pigs. Acta Vet Hung 61:175–86.
  • Königs M, Mulac D, Schwerdt G, et al. (2009). Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture. Toxicology 258:106–15.
  • Lattanzio VM, Visconti A, Haidukowski M, et al. (2012). Identification and characterization of new Fusarium masked mycotoxins, T2 and HT2 glycosyl derivatives, in naturally contaminated wheat and oats by liquid chromatography- high-resolution mass spectrometry. J Mass Spectrom 47:466–75.
  • Li Y, Wang Z, Beier RC, et al. (2011). T-2 toxin, a trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods. J Agric Food Chem 59:3441–53.
  • Liu J, Jia L, Kan J, et al. (2013). In vitro and in vivo antioxidant activity of ethanolic extract of white button mushroom (Agaricus bisporus). Food Chem Toxicol 51:310–6.
  • Ning YJ, Wang X, Ren L, et al. (2013). Effects of dietary factors on selenium levels of children to prevent Kashin-Beck disease during a high-prevalence period in an endemic area: a cohort study. Biol Trace Elem Res 153:58–68.
  • Ostling O, Johanson KJ. (1984). Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem Biophys Res Commun 123:291–8.
  • Schollenberger M, Drochner W, Müller HM. (2007). Fusarium toxins of the scirpentriol subgroup: a review. Mycopathologia 164:101–8.
  • Singh NP, McCoy MT, Tice RR, et al. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184–91.
  • Wu J, Jing L, Yuan H, et al. (2011). T-2 toxin induces apoptosis in ovarian granulosa cells of rats through reactive oxygen species-mediated mitochondrial pathway. Toxicol Lett 202:168–77.
  • Wu J, Tu D, Yuan LY, et al. (2013). T-2 toxin exposure induces apoptosis in rat ovarian granulosa cells through oxidative stress. Environ Toxicol Pharmacol 36:493–500.
  • Wu QH, Wang X, Yang W, et al. (2014). Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update. Arch Toxicol 88:1309–26.
  • Yang J, Zhang Y, Jing A, et al. (2014). Effects of T-2 toxin on testosterone biosynthesis in mouse Leydig cells. Toxicol Ind Health 30:873–7.
  • Yang JY, Zhang YF, Liang AM, et al. (2010). Toxic effects of T-2 toxin on reproductive system in male mice. Toxicol Ind Health 26:25–31.
  • Yang JY, Zhang YF, Meng XP, et al. (2015). T-2 toxin inhibits gene expression and activity of key steroidogenesis enzymes in mouse Leydig cells. Toxicol In Vitro 29:1166–71.
  • Yuan Z, Matias FB, Yi JE, et al. (2016). T-2 toxin-induced cytotoxicity and damage on TM3 Leydig cells. Comp Biochem Physiol C Toxicol Pharmacol 181-182:47–54.
  • Yuan G, Wang Y, Yuan X, et al. (2014). T-2 toxin induces developmental toxicity and apoptosis in zebrafish embryos. J Environ Sci (China) 26:917–25.
  • Zhao J, Zhai L, Liu Z, et al. (2014). Leptin level and oxidative stress contribute to obesity-induced low testosterone in murine testicular tissue. Oxid Med Cell Longev 2014:190945

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.